ID   A1L306_HUMAN            Unreviewed;      1257 AA.
AC   A1L306;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   13-SEP-2023, entry version 108.
DE   SubName: Full=TNR protein {ECO:0000313|EMBL:AAI29831.1};
GN   Name=TNR {ECO:0000313|EMBL:AAI29831.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAI29831.1};
RN   [1] {ECO:0000313|EMBL:AAI29831.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       A1L306; Q8IYE0-2: CCDC146; NbExp=3; IntAct=EBI-10182881, EBI-10247802;
CC       A1L306; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-10182881, EBI-10274069;
CC       A1L306; O15481: MAGEB4; NbExp=3; IntAct=EBI-10182881, EBI-751857;
CC       A1L306; O43639: NCK2; NbExp=3; IntAct=EBI-10182881, EBI-713635;
CC       A1L306; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10182881, EBI-741158;
CC       A1L306; Q9BUI4: POLR3C; NbExp=3; IntAct=EBI-10182881, EBI-5452779;
CC       A1L306; P25786: PSMA1; NbExp=3; IntAct=EBI-10182881, EBI-359352;
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
CC   -!- SIMILARITY: Belongs to the tenascin family.
CC       {ECO:0000256|ARBA:ARBA00008673}.
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DR   EMBL; BC129830; AAI29831.1; -; mRNA.
DR   RefSeq; NP_003276.3; NM_003285.2.
DR   AlphaFoldDB; A1L306; -.
DR   IntAct; A1L306; 7.
DR   PeptideAtlas; A1L306; -.
DR   DNASU; 7143; -.
DR   GeneID; 7143; -.
DR   KEGG; hsa:7143; -.
DR   CTD; 7143; -.
DR   PharmGKB; PA36642; -.
DR   OrthoDB; 5489847at2759; -.
DR   BioGRID-ORCS; 7143; 16 hits in 1148 CRISPR screens.
DR   ChiTaRS; TNR; human.
DR   GenomeRNAi; 7143; -.
DR   CDD; cd00063; FN3; 9.
DR   CDD; cd00087; FReD; 1.
DR   Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR   Gene3D; 2.10.25.10; Laminin; 4.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR041161; EGF_Tenascin.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   NCBIfam; NF040941; GGGWT_bact; 1.
DR   PANTHER; PTHR46708; TENASCIN; 1.
DR   PANTHER; PTHR46708:SF6; TENASCIN-R; 1.
DR   Pfam; PF07974; EGF_2; 1.
DR   Pfam; PF18720; EGF_Tenascin; 2.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   Pfam; PF00041; fn3; 9.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00186; FBG; 1.
DR   SMART; SM00060; FN3; 9.
DR   SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 5.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR   PROSITE; PS50853; FN3; 8.
DR   Genevisible; A1L306; HS.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT   DOMAIN          227..319
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          405..494
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          495..586
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          587..676
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          677..764
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          765..854
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          855..941
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          942..1029
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1028..1243
FT                   /note="Fibrinogen C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51406"
FT   COILED          26..53
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1257 AA;  138577 MW;  C91D34380A00E43F CRC64;
     MGQTSDHESQ VTFTHRINFP KKACPCASSA QVLQELLSRI EMLEREVSVL RDQCNANCCQ
     ESAATGQLDY IPHCSGHGNF SFESCGCICN EGWFGKNCSE PYCPLGCSSR GVCVDGQCIC
     DSEYSGDDCS ELRCPTDCSS RGLCVDGECV CEEPYTGEDC RELRCPGDCS GKGRCANGTC
     LCEEGYVGED CGQRQCLNAC SGRGQCEEGL CVCEEGYQGP DCSAVAPPED LRVAGISDRS
     IELEWDGPMA VTEYVISYQP TALGGLQLQQ RVPGDWSGVT ITELEPGLTY NISVYAVISN
     ILSLPITAKV ATHLSTPQGL QFKTITETTV EVQWEPFSFS FDGWEISFIP KNNEGGVIAQ
     VPSDVTSFNQ TGLKPGEEYI VNVVALKEQA RSPPTSASVS TVIDGPTQIL VRDVSDTVAF
     VEWIPPRAKV DFILLKYGLV GGEGGRTTFR LQPPLSQYSV QALRPGSRYE VSVSAVRGTN
     ESDSATTQFT TEIDAPKNLR VGSRTATSLD LEWDNSEAEV QEYKVVYSTL AGEQYHEVLV
     PRGIGPTTRA TLTDLVPGTE YGVGISAVMN SQQSVPATMN ARTELDSPRD LMVTASSETS
     ISLIWTKASG PIDHYRITFT PSSGIASEVT VPKDRTSYTL TDLEPGAEYI ISVTAERGRQ
     QSLESTVDAF TGFRPISHLH FSHVTSSSVN ITWSDPSPPA DRLILNYSPR DEEEEMMEVS
     LDATKRHAVL MGLQPATEYI VNLVAVHGTV TSEPIVGSIT TGIDPPKDIT ISNVTKDSVM
     VSWSPPVASF DYYRVSYRPT QVGRLDSSVV PNTVTEFTIT RLNPATEYEI SLNSVRGREE
     SERICTLVHT AMDNPVDLIA TNITPTEALL QWKAPVGEVE NYVIVLTHFA VAGETILVDG
     VSEEFRLVDL LPSTHYTATM YATNGPLTSG TISTNFSTLL DPPANLTASE VTRQSALISW
     QPPRAEIENY VLTYKSTDGS RKELIVDAED TWIRLEGLLE NTDYTVLLQA AQDTTWSSIT
     STAFTTGGRV FPHPQDCAQH LMNGDTLSGV YPIFLNGELS QKLQVYCDMT TDGGGWIVFQ
     RRQNGQTDFF RKWADYRVGF GNVEDEFWLG LDNIHRITSQ GRYELRVDMR DGQEAAFASY
     DRFSVEDSRN LYKLRIGSYN GTAGDSLSYH QGRPFSTEDR DNDVAVTNCA MSYKGAWWYK
     NCHRTNLNGK YGESRHSQGI NWYHWKGHEF SIPFVEMKMR PYNHRLMAGR KRQSLQF
//