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Protein
Submitted name:

TNR protein

Gene

TNR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. associative learning Source: Ensembl
  2. extracellular matrix organization Source: Ensembl
  3. locomotory exploration behavior Source: Ensembl
  4. long-term synaptic potentiation Source: Ensembl
  5. negative regulation of axon extension involved in regeneration Source: Ensembl
  6. negative regulation of cell-cell adhesion Source: Ensembl
  7. negative regulation of synaptic transmission Source: Ensembl
  8. neuromuscular process controlling balance Source: Ensembl
  9. neuron cell-cell adhesion Source: Ensembl
  10. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
  11. positive regulation of transmission of nerve impulse Source: Ensembl
  12. synapse organization Source: Ensembl
  13. telencephalon cell migration Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
TNR proteinImported
Gene namesi
Name:TNRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. membrane raft Source: Ensembl
  3. perineuronal net Source: Ensembl
  4. proteinaceous extracellular matrix Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36642.

Expressioni

Gene expression databases

BgeeiA1L306.
ExpressionAtlasiA1L306. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA1L306.
SMRiA1L306. Positions 402-670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains fibrinogen C-terminal domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG008949.
KOiK06252.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF07974. EGF_2. 2 hits.
PF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 9 hits.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
SM00060. FN3. 9 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 4 hits.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQTSDHESQ VTFTHRINFP KKACPCASSA QVLQELLSRI EMLEREVSVL
60 70 80 90 100
RDQCNANCCQ ESAATGQLDY IPHCSGHGNF SFESCGCICN EGWFGKNCSE
110 120 130 140 150
PYCPLGCSSR GVCVDGQCIC DSEYSGDDCS ELRCPTDCSS RGLCVDGECV
160 170 180 190 200
CEEPYTGEDC RELRCPGDCS GKGRCANGTC LCEEGYVGED CGQRQCLNAC
210 220 230 240 250
SGRGQCEEGL CVCEEGYQGP DCSAVAPPED LRVAGISDRS IELEWDGPMA
260 270 280 290 300
VTEYVISYQP TALGGLQLQQ RVPGDWSGVT ITELEPGLTY NISVYAVISN
310 320 330 340 350
ILSLPITAKV ATHLSTPQGL QFKTITETTV EVQWEPFSFS FDGWEISFIP
360 370 380 390 400
KNNEGGVIAQ VPSDVTSFNQ TGLKPGEEYI VNVVALKEQA RSPPTSASVS
410 420 430 440 450
TVIDGPTQIL VRDVSDTVAF VEWIPPRAKV DFILLKYGLV GGEGGRTTFR
460 470 480 490 500
LQPPLSQYSV QALRPGSRYE VSVSAVRGTN ESDSATTQFT TEIDAPKNLR
510 520 530 540 550
VGSRTATSLD LEWDNSEAEV QEYKVVYSTL AGEQYHEVLV PRGIGPTTRA
560 570 580 590 600
TLTDLVPGTE YGVGISAVMN SQQSVPATMN ARTELDSPRD LMVTASSETS
610 620 630 640 650
ISLIWTKASG PIDHYRITFT PSSGIASEVT VPKDRTSYTL TDLEPGAEYI
660 670 680 690 700
ISVTAERGRQ QSLESTVDAF TGFRPISHLH FSHVTSSSVN ITWSDPSPPA
710 720 730 740 750
DRLILNYSPR DEEEEMMEVS LDATKRHAVL MGLQPATEYI VNLVAVHGTV
760 770 780 790 800
TSEPIVGSIT TGIDPPKDIT ISNVTKDSVM VSWSPPVASF DYYRVSYRPT
810 820 830 840 850
QVGRLDSSVV PNTVTEFTIT RLNPATEYEI SLNSVRGREE SERICTLVHT
860 870 880 890 900
AMDNPVDLIA TNITPTEALL QWKAPVGEVE NYVIVLTHFA VAGETILVDG
910 920 930 940 950
VSEEFRLVDL LPSTHYTATM YATNGPLTSG TISTNFSTLL DPPANLTASE
960 970 980 990 1000
VTRQSALISW QPPRAEIENY VLTYKSTDGS RKELIVDAED TWIRLEGLLE
1010 1020 1030 1040 1050
NTDYTVLLQA AQDTTWSSIT STAFTTGGRV FPHPQDCAQH LMNGDTLSGV
1060 1070 1080 1090 1100
YPIFLNGELS QKLQVYCDMT TDGGGWIVFQ RRQNGQTDFF RKWADYRVGF
1110 1120 1130 1140 1150
GNVEDEFWLG LDNIHRITSQ GRYELRVDMR DGQEAAFASY DRFSVEDSRN
1160 1170 1180 1190 1200
LYKLRIGSYN GTAGDSLSYH QGRPFSTEDR DNDVAVTNCA MSYKGAWWYK
1210 1220 1230 1240 1250
NCHRTNLNGK YGESRHSQGI NWYHWKGHEF SIPFVEMKMR PYNHRLMAGR

KRQSLQF
Length:1,257
Mass (Da):138,577
Last modified:February 5, 2007 - v1
Checksum:iC91D34380A00E43F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129830 mRNA. Translation: AAI29831.1.
RefSeqiNP_003276.3. NM_003285.2.
UniGeneiHs.659864.

Genome annotation databases

GeneIDi7143.
KEGGihsa:7143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129830 mRNA. Translation: AAI29831.1.
RefSeqiNP_003276.3. NM_003285.2.
UniGeneiHs.659864.

3D structure databases

ProteinModelPortaliA1L306.
SMRiA1L306. Positions 402-670.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7143.
KEGGihsa:7143.

Organism-specific databases

CTDi7143.
PharmGKBiPA36642.

Phylogenomic databases

HOVERGENiHBG008949.
KOiK06252.

Miscellaneous databases

GenomeRNAii7143.
NextBioi27961.

Gene expression databases

BgeeiA1L306.
ExpressionAtlasiA1L306. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF07974. EGF_2. 2 hits.
PF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 9 hits.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
SM00060. FN3. 9 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 4 hits.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiA1L306_HUMAN
AccessioniPrimary (citable) accession number: A1L306
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2007
Last sequence update: February 5, 2007
Last modified: January 6, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.