Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A1L2T6 (ZCHC7_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger CCHC domain-containing protein 7
Alternative name(s):
TRAMP-like complex RNA-binding factor ZCCHC7
Gene names
Name:zcchc7
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length563 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Contains 5 CCHC-type zinc fingers.

Sequence caution

The sequence AAI29702.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
Gene Ontology (GO)
   Cellular_componentnucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 563563Zinc finger CCHC domain-containing protein 7
PRO_0000370243

Regions

Zinc finger265 – 28218CCHC-type 1
Zinc finger287 – 30418CCHC-type 2
Zinc finger305 – 32218CCHC-type 3
Zinc finger328 – 34518CCHC-type 4
Zinc finger372 – 38918CCHC-type 5

Sequences

Sequence LengthMass (Da)Tools
A1L2T6 [UniParc].

Last modified April 14, 2009. Version 2.
Checksum: 4D4C83EBFBB177D6

FASTA56364,410
        10         20         30         40         50         60 
MFNCDEDLKA YEDELYHEET SSDESIDSEL EFHLYSQVHY SQNLSESKPE EDTGGDSVTY 

        70         80         90        100        110        120 
VPGAKQQNNA CTEKDDKLVD IIILSDSDAK VSDTCPVIIL SDTTEEDSVY SSKIKKKYSS 

       130        140        150        160        170        180 
TYVQGESLCG PCSHSTPKVS APQSNNFKSQ KSCQNSSSKN YSGGYVQEVL VIRGSSEDEE 

       190        200        210        220        230        240 
ANKSENDIII SESDMSDVEN WMLLGRAKED GDASIQLNLE GYKILSDDEG ERGAAWSISE 

       250        260        270        280        290        300 
KDVEAQIGNY TPLRRSNRYY TDKNVVCRNC DKRGHLSKNC PVPKKLPACC LCGERGHYQN 

       310        320        330        340        350        360 
SCPSRYCLNC FLPGHFFKEC IERAYWRKTC HRCSMPGHYA DACPEIWRQY HLTIKAGPIK 

       370        380        390        400        410        420 
KPKSHSGQKD IVYCCNCAKK GHCIYECKER RMNSDKLPTC QLVFSYDHEY DIRKRNERTK 

       430        440        450        460        470        480 
SKIKDFQKAG LLTCEMREFS ESKVDAKPPA KKRKKKHPSK KERKGTIRDY ECAETKQKKK 

       490        500        510        520        530        540 
HKKRKSGLQE IEGDFPRGIP NSYVELKKPS KKYDGSFLHL DKTKDMFKNR QKKTRRGKRC 

       550        560 
SSAVDQDLLI IKQKKKKSKR KVA 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC129701 mRNA. Translation: AAI29702.1. Different initiation.
UniGeneXl.19467.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

XenbaseXB-GENE-6255854. zcchc7.

Family and domain databases

Gene3D4.10.60.10. 4 hits.
InterProIPR001878. Znf_CCHC.
[Graphical view]
PfamPF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTSM00343. ZnF_C2HC. 5 hits.
[Graphical view]
SUPFAMSSF57756. SSF57756. 2 hits.
PROSITEPS50158. ZF_CCHC. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameZCHC7_XENLA
AccessionPrimary (citable) accession number: A1L2T6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: April 16, 2014
This is version 26 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families