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A1L2T6

- ZCHC7_XENLA

UniProt

A1L2T6 - ZCHC7_XENLA

Protein

Zinc finger CCHC domain-containing protein 7

Gene

zcchc7

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 2 (14 Apr 2009)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri265 – 28218CCHC-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri287 – 30418CCHC-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri305 – 32218CCHC-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri328 – 34518CCHC-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri372 – 38918CCHC-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger CCHC domain-containing protein 7
    Alternative name(s):
    TRAMP-like complex RNA-binding factor ZCCHC7
    Gene namesi
    Name:zcchc7
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6255854. zcchc7.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 563563Zinc finger CCHC domain-containing protein 7PRO_0000370243Add
    BLAST

    Interactioni

    Subunit structurei

    Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Contains 5 CCHC-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri265 – 28218CCHC-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri287 – 30418CCHC-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri305 – 32218CCHC-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri328 – 34518CCHC-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri372 – 38918CCHC-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Family and domain databases

    Gene3Di4.10.60.10. 4 hits.
    InterProiIPR001878. Znf_CCHC.
    [Graphical view]
    PfamiPF00098. zf-CCHC. 1 hit.
    [Graphical view]
    SMARTiSM00343. ZnF_C2HC. 5 hits.
    [Graphical view]
    SUPFAMiSSF57756. SSF57756. 2 hits.
    PROSITEiPS50158. ZF_CCHC. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1L2T6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFNCDEDLKA YEDELYHEET SSDESIDSEL EFHLYSQVHY SQNLSESKPE    50
    EDTGGDSVTY VPGAKQQNNA CTEKDDKLVD IIILSDSDAK VSDTCPVIIL 100
    SDTTEEDSVY SSKIKKKYSS TYVQGESLCG PCSHSTPKVS APQSNNFKSQ 150
    KSCQNSSSKN YSGGYVQEVL VIRGSSEDEE ANKSENDIII SESDMSDVEN 200
    WMLLGRAKED GDASIQLNLE GYKILSDDEG ERGAAWSISE KDVEAQIGNY 250
    TPLRRSNRYY TDKNVVCRNC DKRGHLSKNC PVPKKLPACC LCGERGHYQN 300
    SCPSRYCLNC FLPGHFFKEC IERAYWRKTC HRCSMPGHYA DACPEIWRQY 350
    HLTIKAGPIK KPKSHSGQKD IVYCCNCAKK GHCIYECKER RMNSDKLPTC 400
    QLVFSYDHEY DIRKRNERTK SKIKDFQKAG LLTCEMREFS ESKVDAKPPA 450
    KKRKKKHPSK KERKGTIRDY ECAETKQKKK HKKRKSGLQE IEGDFPRGIP 500
    NSYVELKKPS KKYDGSFLHL DKTKDMFKNR QKKTRRGKRC SSAVDQDLLI 550
    IKQKKKKSKR KVA 563
    Length:563
    Mass (Da):64,410
    Last modified:April 14, 2009 - v2
    Checksum:i4D4C83EBFBB177D6
    GO

    Sequence cautioni

    The sequence AAI29702.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129701 mRNA. Translation: AAI29702.1. Different initiation.
    UniGeneiXl.19467.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129701 mRNA. Translation: AAI29702.1 . Different initiation.
    UniGenei Xl.19467.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Xenbasei XB-GENE-6255854. zcchc7.

    Family and domain databases

    Gene3Di 4.10.60.10. 4 hits.
    InterProi IPR001878. Znf_CCHC.
    [Graphical view ]
    Pfami PF00098. zf-CCHC. 1 hit.
    [Graphical view ]
    SMARTi SM00343. ZnF_C2HC. 5 hits.
    [Graphical view ]
    SUPFAMi SSF57756. SSF57756. 2 hits.
    PROSITEi PS50158. ZF_CCHC. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.

    Entry informationi

    Entry nameiZCHC7_XENLA
    AccessioniPrimary (citable) accession number: A1L2T6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 27 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3