Reviewed, UniProtKB/Swiss-Prot A1L2Q8 (P5CR3_XENLA)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase 3
      Short name=P5C reductase 3
      Short name=P5CR 3
    EC=1.5.1.2
Alternative name(s):
    Pyrroline-5-carboxylate reductase-like protein

Gene names

Name:

pycrl

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subunit structure	Homodecamer; composed of 5 homodimers By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Pyrroline-5-carboxylate reductase 3		PRO_0000324566

Sequences

	Sequence		Length	Mass (Da)
	A1L2Q8-1 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: 9BE2A785FE78184F	FASTA	274	28,875
	10 20 30 40 50 60 MAASPRVSLP VGCIGAGRMA QGILEGILHK GEITPQNVMV SAPTDRNLEK LKARGCCTSH 70 80 90 100 110 120 DNRSVVSNCR VVFLATKPHI IPSVLQEIYP KVTADHLIIS MAAGVTLETL EKNLPPGSKV 130 140 150 160 170 180 IRMMPNLPCV LQEGAIVFSR GRCAGEVEAD VFESLVRTCG LCVEVPQSCI DIHTGVSGSG 190 200 210 220 230 240 VAYVYTFAEA LADGAVKMGM PSALARQIVA QTLLGAGKML LQSEEHPASL RADVCTPGGT 250 260 270 TIFGLHELEK GGLRAAVMNA VEAATTRAMD MGRK

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-274. Tissue: Olfactory bulb.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC129663 mRNA. Translation: AAI29664.1.
UniGene	Xl.78300
3D structure databases
SMR	A1L2Q8. Positions 8-274.
ModBase	Search...
Phylogenomic databases
HOVERGEN	A1L2Q8.
Enzyme and pathway databases
BRENDA	1.5.1.2. 648.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR3_XENLA

Accession

Primary (citable) accession number: A1L2Q8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	February 9, 2010
This is version 22 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project