Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1L2P5

- HXD3_XENLA

UniProt

A1L2P5 - HXD3_XENLA

Protein

Homeobox protein Hox-D3

Gene

hoxd3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi178 – 23760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D3
    Gene namesi
    Name:hoxd3
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-865180. hoxd3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413Homeobox protein Hox-D3PRO_0000363948Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA1L2P5.
    SMRiA1L2P5. Positions 178-237.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi142 – 1476Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    HOVERGENiHBG107984.
    KOiK09303.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1L2P5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFIDKGASPL PIREAKMQKT AYYENSGLFG GYTYAKPESY SYGPSQQQYP    50
    QSSLDNDYPS TACSVQPAAI RAPNHKTNDI SNSCMRTTSS QNSNQTPSIS 100
    NQQHQAPSLP PSSPSHSNTS AQKKSKSSNS SGSSQSTMNK QIFPWMKESR 150
    QNSKQKNSSS TPPAGENCEE KSPTGPSSKR VRTAYTSAQL VELEKEFHFN 200
    RYLCRPRRVE MANLLNLTER QIKIWFQNRR MKYKKDQKAK GIMHSPTGQS 250
    PDRSPPLSGP NLVGYSSQLP TVNSLSYDAP SPTSFAKSQQ NMYGLAAYTA 300
    PLSSCLPQQK RYPGAEYEHH TMQGNSGFAN PNLQGSPVYV GGNFVDSMPA 350
    SGPMFNVGHL SHPSSASVDY SCAAQIPGNH HHGPCDPHPT YTDLSSHHTT 400
    QGRMQEAPKL THL 413
    Length:413
    Mass (Da):45,375
    Last modified:February 6, 2007 - v1
    Checksum:iD17893B1155687D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129640 mRNA. Translation: AAI29641.1.
    RefSeqiNP_001091156.1. NM_001097687.1.
    UniGeneiXl.15901.

    Genome annotation databases

    GeneIDi100036911.
    KEGGixla:100036911.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129640 mRNA. Translation: AAI29641.1 .
    RefSeqi NP_001091156.1. NM_001097687.1.
    UniGenei Xl.15901.

    3D structure databases

    ProteinModelPortali A1L2P5.
    SMRi A1L2P5. Positions 178-237.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100036911.
    KEGGi xla:100036911.

    Organism-specific databases

    CTDi 3232.
    Xenbasei XB-GENE-865180. hoxd3.

    Phylogenomic databases

    HOVERGENi HBG107984.
    KOi K09303.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Forelimb and Hind limb.

    Entry informationi

    Entry nameiHXD3_XENLA
    AccessioniPrimary (citable) accession number: A1L2P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-17 is the initiator.Curated

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3