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A1L2P5

- HXD3_XENLA

UniProt

A1L2P5 - HXD3_XENLA

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Protein
Homeobox protein Hox-D3
Gene
hoxd3
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi178 – 23760Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D3
Gene namesi
Name:hoxd3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865180. hoxd3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Homeobox protein Hox-D3
PRO_0000363948Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA1L2P5.
SMRiA1L2P5. Positions 178-237.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi142 – 1476Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG107984.
KOiK09303.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L2P5-1 [UniParc]FASTAAdd to Basket

« Hide

MFIDKGASPL PIREAKMQKT AYYENSGLFG GYTYAKPESY SYGPSQQQYP    50
QSSLDNDYPS TACSVQPAAI RAPNHKTNDI SNSCMRTTSS QNSNQTPSIS 100
NQQHQAPSLP PSSPSHSNTS AQKKSKSSNS SGSSQSTMNK QIFPWMKESR 150
QNSKQKNSSS TPPAGENCEE KSPTGPSSKR VRTAYTSAQL VELEKEFHFN 200
RYLCRPRRVE MANLLNLTER QIKIWFQNRR MKYKKDQKAK GIMHSPTGQS 250
PDRSPPLSGP NLVGYSSQLP TVNSLSYDAP SPTSFAKSQQ NMYGLAAYTA 300
PLSSCLPQQK RYPGAEYEHH TMQGNSGFAN PNLQGSPVYV GGNFVDSMPA 350
SGPMFNVGHL SHPSSASVDY SCAAQIPGNH HHGPCDPHPT YTDLSSHHTT 400
QGRMQEAPKL THL 413
Length:413
Mass (Da):45,375
Last modified:February 6, 2007 - v1
Checksum:iD17893B1155687D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC129640 mRNA. Translation: AAI29641.1.
RefSeqiNP_001091156.1. NM_001097687.1.
UniGeneiXl.15901.

Genome annotation databases

GeneIDi100036911.
KEGGixla:100036911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC129640 mRNA. Translation: AAI29641.1 .
RefSeqi NP_001091156.1. NM_001097687.1.
UniGenei Xl.15901.

3D structure databases

ProteinModelPortali A1L2P5.
SMRi A1L2P5. Positions 178-237.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100036911.
KEGGi xla:100036911.

Organism-specific databases

CTDi 3232.
Xenbasei XB-GENE-865180. hoxd3.

Phylogenomic databases

HOVERGENi HBG107984.
KOi K09303.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Forelimb and Hind limb.

Entry informationi

Entry nameiHXD3_XENLA
AccessioniPrimary (citable) accession number: A1L2P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi