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Protein

Homeobox protein Hox-D3

Gene

hoxd3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi178 – 23760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D3
Gene namesi
Name:hoxd3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865180. hoxd3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Homeobox protein Hox-D3PRO_0000363948Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA1L2P5.
SMRiA1L2P5. Positions 178-237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi142 – 1476Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG107984.
KOiK09303.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L2P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIDKGASPL PIREAKMQKT AYYENSGLFG GYTYAKPESY SYGPSQQQYP
60 70 80 90 100
QSSLDNDYPS TACSVQPAAI RAPNHKTNDI SNSCMRTTSS QNSNQTPSIS
110 120 130 140 150
NQQHQAPSLP PSSPSHSNTS AQKKSKSSNS SGSSQSTMNK QIFPWMKESR
160 170 180 190 200
QNSKQKNSSS TPPAGENCEE KSPTGPSSKR VRTAYTSAQL VELEKEFHFN
210 220 230 240 250
RYLCRPRRVE MANLLNLTER QIKIWFQNRR MKYKKDQKAK GIMHSPTGQS
260 270 280 290 300
PDRSPPLSGP NLVGYSSQLP TVNSLSYDAP SPTSFAKSQQ NMYGLAAYTA
310 320 330 340 350
PLSSCLPQQK RYPGAEYEHH TMQGNSGFAN PNLQGSPVYV GGNFVDSMPA
360 370 380 390 400
SGPMFNVGHL SHPSSASVDY SCAAQIPGNH HHGPCDPHPT YTDLSSHHTT
410
QGRMQEAPKL THL
Length:413
Mass (Da):45,375
Last modified:February 6, 2007 - v1
Checksum:iD17893B1155687D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129640 mRNA. Translation: AAI29641.1.
RefSeqiNP_001091156.1. NM_001097687.1.
UniGeneiXl.15901.

Genome annotation databases

GeneIDi100036911.
KEGGixla:100036911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129640 mRNA. Translation: AAI29641.1.
RefSeqiNP_001091156.1. NM_001097687.1.
UniGeneiXl.15901.

3D structure databases

ProteinModelPortaliA1L2P5.
SMRiA1L2P5. Positions 178-237.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100036911.
KEGGixla:100036911.

Organism-specific databases

CTDi3232.
XenbaseiXB-GENE-865180. hoxd3.

Phylogenomic databases

HOVERGENiHBG107984.
KOiK09303.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Forelimb and Hind limb.

Entry informationi

Entry nameiHXD3_XENLA
AccessioniPrimary (citable) accession number: A1L2P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 6, 2007
Last modified: January 7, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.Curated

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.