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A1L2P5 (HXD3_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D3
Gene names
Name:hoxd3
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length413 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Caution

It is uncertain whether Met-1 or Met-17 is the initiator.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 413413Homeobox protein Hox-D3
PRO_0000363948

Regions

DNA binding178 – 23760Homeobox
Motif142 – 1476Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
A1L2P5 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: D17893B1155687D5

FASTA41345,375
        10         20         30         40         50         60 
MFIDKGASPL PIREAKMQKT AYYENSGLFG GYTYAKPESY SYGPSQQQYP QSSLDNDYPS 

        70         80         90        100        110        120 
TACSVQPAAI RAPNHKTNDI SNSCMRTTSS QNSNQTPSIS NQQHQAPSLP PSSPSHSNTS 

       130        140        150        160        170        180 
AQKKSKSSNS SGSSQSTMNK QIFPWMKESR QNSKQKNSSS TPPAGENCEE KSPTGPSSKR 

       190        200        210        220        230        240 
VRTAYTSAQL VELEKEFHFN RYLCRPRRVE MANLLNLTER QIKIWFQNRR MKYKKDQKAK 

       250        260        270        280        290        300 
GIMHSPTGQS PDRSPPLSGP NLVGYSSQLP TVNSLSYDAP SPTSFAKSQQ NMYGLAAYTA 

       310        320        330        340        350        360 
PLSSCLPQQK RYPGAEYEHH TMQGNSGFAN PNLQGSPVYV GGNFVDSMPA SGPMFNVGHL 

       370        380        390        400        410 
SHPSSASVDY SCAAQIPGNH HHGPCDPHPT YTDLSSHHTT QGRMQEAPKL THL 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Forelimb and Hind limb.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC129640 mRNA. Translation: AAI29641.1.
RefSeqNP_001091156.1. NM_001097687.1.
UniGeneXl.15901.

3D structure databases

ProteinModelPortalA1L2P5.
SMRA1L2P5. Positions 178-237.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100036911.
KEGGxla:100036911.

Organism-specific databases

CTD3232.
XenbaseXB-GENE-865180. hoxd3.

Phylogenomic databases

HOVERGENHBG107984.
KOK09303.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXD3_XENLA
AccessionPrimary (citable) accession number: A1L2P5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries