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Protein

Hexokinase

Gene

hk2

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:hk2Imported
Synonyms:LOC100036846Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5817417. hk2.

Structurei

3D structure databases

ProteinModelPortaliA1L2H2.
SMRiA1L2H2. Positions 18-905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG005020.
KOiK00844.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L2H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSPKGDQTH NDQQARHEQI ESCLQPFHLS QAQLLSVRDL MLGDMERGLM
60 70 80 90 100
KTPQKPSTLK MLPTYVRSTP DGTERGDFLV LDLGGAQFRI LHVELKDSAK
110 120 130 140 150
VEMESQVYAI PDEVMHGTGQ QLFDHVAECL GQFLRQQKLH QKVLPLGFTF
160 170 180 190 200
SFPCVQSQLD KSVLISWTKG FHCSEVEGKD VVHLFREAIR RQGGYDVDVI
210 220 230 240 250
AIVNDTVGAM MSCGYQDHSC EVGFIVGTGT NLCYMEEMGN VESVEGDEGK
260 270 280 290 300
MCINTEWGAL GDDGELSSVQ TEVDEQVDQN SLVPGKQCFD KLVSGMYMGE
310 320 330 340 350
IVRLILVKLA NQGLLFDGTT SQSLLTKGCI ETKHVSAIED DHFGLAAARK
360 370 380 390 400
MLSVLGLNPS EQDCVNVQHV CSAVSTRSAN LCAAGLAAVA TRLQLNNHNL
410 420 430 440 450
KITIGVDGSV YKQHPKFSER LHSALQHLAP ECQIKFLISE DGSGKGTAIV
460 470 480 490 500
TAVAKRLAAQ RHQIDDILAP FQLSQAKLEE VKSQMRAEID IGLCKETHAG
510 520 530 540 550
ATVKMLPTYV RSTPDGTERG DFIALDLGGT NFRVLYVHIG RREDAGVQIV
560 570 580 590 600
SKTYTLPQEI IQGTGGQLFD HIIDCISEFQ SENNLRGRRL PLGFTFSFPC
610 620 630 640 650
KQTNLDQGIL ITWTKGFSAS GCVGKDVVTL LREAALRKKN NDIIVVALVN
660 670 680 690 700
DTVGTMMSCG YNDPACEIGL IVGTGTNACY MEELKNVELL DGDEGQMCVN
710 720 730 740 750
MEWGAFGDNN CLEDITTSFD HDVDTFSINP GKQRYEKMIS GMYLGEIVRQ
760 770 780 790 800
ILIVLTRRGI LFGGKISERL LTRDLFPTRF LSLIESDTLG LVQVRSILTE
810 820 830 840 850
LGLRSTCDDT MLVKEVCTTV SRRAAQLCAA GVAAVVEKMR ANRGLDQLKV
860 870 880 890 900
TVGVDGTLYK LHPHFAGVVQ ETVKILAPKC DVTFLQSDDG SGRGAALITA
910
VACRIAGAEA RAA
Length:913
Mass (Da):99,813
Last modified:February 6, 2007 - v1
Checksum:i3B7D4656B5996153
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129526 mRNA. Translation: AAI29527.1.
RefSeqiNP_001090603.1. NM_001097134.1.
UniGeneiXl.14870.

Genome annotation databases

GeneIDi100036846.
KEGGixla:100036846.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129526 mRNA. Translation: AAI29527.1.
RefSeqiNP_001090603.1. NM_001097134.1.
UniGeneiXl.14870.

3D structure databases

ProteinModelPortaliA1L2H2.
SMRiA1L2H2. Positions 18-905.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100036846.
KEGGixla:100036846.

Organism-specific databases

CTDi3099.
XenbaseiXB-GENE-5817417. hk2.

Phylogenomic databases

HOVERGENiHBG005020.
KOiK00844.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: SpleenImported.

Entry informationi

Entry nameiA1L2H2_XENLA
AccessioniPrimary (citable) accession number: A1L2H2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 22, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.