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A1L251

- ENASE_DANRE

UniProt

A1L251 - ENASE_DANRE

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Protein

Cytosolic endo-beta-N-acetylglucosaminidase

Gene
engase, zgc:158649
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol By similarity.

Catalytic activityi

Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)2)Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.

GO - Molecular functioni

  1. mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH85. Glycoside Hydrolase Family 85.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic endo-beta-N-acetylglucosaminidase (EC:3.2.1.96)
Short name:
ENGase
Gene namesi
Name:engase
ORF Names:zgc:158649
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-070112-1332. engase.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 713713Cytosolic endo-beta-N-acetylglucosaminidasePRO_0000328870Add
BLAST

Proteomic databases

PRIDEiA1L251.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000005952.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini270 – 36293BRCTAdd
BLAST

Sequence similaritiesi

Contains 1 BRCT domain.

Phylogenomic databases

eggNOGiCOG4724.
HOGENOMiHOG000082678.
HOVERGENiHBG107848.
InParanoidiA1L251.
KOiK01227.

Family and domain databases

InterProiIPR005201. Glyco_hydro_85.
[Graphical view]
PfamiPF03644. Glyco_hydro_85. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L251-1 [UniParc]FASTAAdd to Basket

« Hide

MIARKRKSNG SETTSGKIPK DDVSSESCLD QPADESVHEV VTFEPSTLPS    50
VHYDPDTTEP ISCSLKSLDE LLSWKRNEAS IFNVSSVPLA SRYPPLESCP 100
RRTLVSHDMM GGYLEDRFIQ GAEVETPYAF YHWEYIDIFN YFSHQMVTIP 150
PAVWTNAAHR HGVLSIGTFI TEWTDGAKTC EAFLADEESY RAAADKLVQI 200
SHCNGFDGWL INIENELSET AVNNTGPFLR YLTDQMHERV PGSVVIWYDS 250
VLKDGKLLWQ NELNDNNRMF FDACDGFFTN YNWTEQSLEG MKSYAAAQGR 300
FADIYVGVDV FARGKVIGGK YETNKALELI RKYDLSTAIF APDWVYECHE 350
KADFRQNQDK FWSLLSDFLY IHRPSSNLPF VSSFCQGFGK SLYWRGKVET 400
ERSWFNLHAQ EIQPLYLSES FGNGGWLRTR GCSEDAWIGG SSLMLEGMIP 450
SGLSDVCARI FSLHVPLAAR TFVSFVFKPP VGVKVSLELK TIDGPLCTFD 500
GTEEIASRSV FPEALAESNQ LVEQFAQNCG QWASDGWATR CFLLKMIGCS 550
LREVCIRVSR DGGDEDINFN CRIGEIMLLD ADNLQAPLQS VEGICVNDVV 600
WQTGVLKGDG HTLKVLLNAT LRWQYPTRQV RHFRIHWRHL RGPDPRIPSG 650
PLTLIGRSYS ALYRVVELEV PAAPGLIELV VEPVSKEGFS VPEAQWGRQT 700
LSYSQSPSGN PSH 713
Length:713
Mass (Da):80,255
Last modified:February 6, 2007 - v1
Checksum:iC168C63E9C587DED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC129351 mRNA. Translation: AAI29352.1.
RefSeqiNP_001074047.2. NM_001080578.2.
UniGeneiDr.110643.

Genome annotation databases

GeneIDi561239.
KEGGidre:561239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC129351 mRNA. Translation: AAI29352.1 .
RefSeqi NP_001074047.2. NM_001080578.2.
UniGenei Dr.110643.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000005952.

Protein family/group databases

CAZyi GH85. Glycoside Hydrolase Family 85.

Proteomic databases

PRIDEi A1L251.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 561239.
KEGGi dre:561239.

Organism-specific databases

CTDi 64772.
ZFINi ZDB-GENE-070112-1332. engase.

Phylogenomic databases

eggNOGi COG4724.
HOGENOMi HOG000082678.
HOVERGENi HBG107848.
InParanoidi A1L251.
KOi K01227.

Miscellaneous databases

NextBioi 20883830.
PROi A1L251.

Family and domain databases

InterProi IPR005201. Glyco_hydro_85.
[Graphical view ]
Pfami PF03644. Glyco_hydro_85. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiENASE_DANRE
AccessioniPrimary (citable) accession number: A1L251
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: February 6, 2007
Last modified: March 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi