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A1L251

- ENASE_DANRE

UniProt

A1L251 - ENASE_DANRE

Protein

Cytosolic endo-beta-N-acetylglucosaminidase

Gene

engase

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol By similarity.By similarity

    Catalytic activityi

    Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)2)Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.

    GO - Molecular functioni

    1. mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH85. Glycoside Hydrolase Family 85.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytosolic endo-beta-N-acetylglucosaminidase (EC:3.2.1.96)
    Short name:
    ENGase
    Gene namesi
    Name:engase
    ORF Names:zgc:158649
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-070112-1332. engase.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 713713Cytosolic endo-beta-N-acetylglucosaminidasePRO_0000328870Add
    BLAST

    Proteomic databases

    PRIDEiA1L251.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000005952.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini270 – 36293BRCTAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 85 family.Curated
    Contains 1 BRCT domain.Curated

    Phylogenomic databases

    eggNOGiCOG4724.
    HOGENOMiHOG000082678.
    HOVERGENiHBG107848.
    InParanoidiA1L251.
    KOiK01227.

    Family and domain databases

    InterProiIPR005201. Glyco_hydro_85.
    [Graphical view]
    PfamiPF03644. Glyco_hydro_85. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1L251-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIARKRKSNG SETTSGKIPK DDVSSESCLD QPADESVHEV VTFEPSTLPS    50
    VHYDPDTTEP ISCSLKSLDE LLSWKRNEAS IFNVSSVPLA SRYPPLESCP 100
    RRTLVSHDMM GGYLEDRFIQ GAEVETPYAF YHWEYIDIFN YFSHQMVTIP 150
    PAVWTNAAHR HGVLSIGTFI TEWTDGAKTC EAFLADEESY RAAADKLVQI 200
    SHCNGFDGWL INIENELSET AVNNTGPFLR YLTDQMHERV PGSVVIWYDS 250
    VLKDGKLLWQ NELNDNNRMF FDACDGFFTN YNWTEQSLEG MKSYAAAQGR 300
    FADIYVGVDV FARGKVIGGK YETNKALELI RKYDLSTAIF APDWVYECHE 350
    KADFRQNQDK FWSLLSDFLY IHRPSSNLPF VSSFCQGFGK SLYWRGKVET 400
    ERSWFNLHAQ EIQPLYLSES FGNGGWLRTR GCSEDAWIGG SSLMLEGMIP 450
    SGLSDVCARI FSLHVPLAAR TFVSFVFKPP VGVKVSLELK TIDGPLCTFD 500
    GTEEIASRSV FPEALAESNQ LVEQFAQNCG QWASDGWATR CFLLKMIGCS 550
    LREVCIRVSR DGGDEDINFN CRIGEIMLLD ADNLQAPLQS VEGICVNDVV 600
    WQTGVLKGDG HTLKVLLNAT LRWQYPTRQV RHFRIHWRHL RGPDPRIPSG 650
    PLTLIGRSYS ALYRVVELEV PAAPGLIELV VEPVSKEGFS VPEAQWGRQT 700
    LSYSQSPSGN PSH 713
    Length:713
    Mass (Da):80,255
    Last modified:February 6, 2007 - v1
    Checksum:iC168C63E9C587DED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129351 mRNA. Translation: AAI29352.1.
    RefSeqiNP_001074047.2. NM_001080578.2.
    UniGeneiDr.110643.

    Genome annotation databases

    GeneIDi561239.
    KEGGidre:561239.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129351 mRNA. Translation: AAI29352.1 .
    RefSeqi NP_001074047.2. NM_001080578.2.
    UniGenei Dr.110643.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000005952.

    Protein family/group databases

    CAZyi GH85. Glycoside Hydrolase Family 85.

    Proteomic databases

    PRIDEi A1L251.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 561239.
    KEGGi dre:561239.

    Organism-specific databases

    CTDi 64772.
    ZFINi ZDB-GENE-070112-1332. engase.

    Phylogenomic databases

    eggNOGi COG4724.
    HOGENOMi HOG000082678.
    HOVERGENi HBG107848.
    InParanoidi A1L251.
    KOi K01227.

    Miscellaneous databases

    NextBioi 20883830.
    PROi A1L251.

    Family and domain databases

    InterProi IPR005201. Glyco_hydro_85.
    [Graphical view ]
    Pfami PF03644. Glyco_hydro_85. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiENASE_DANRE
    AccessioniPrimary (citable) accession number: A1L251
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3