A1L243 (MESD_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
LDLR chaperone MESD

Alternative name(s):
Mesoderm development candidate 2
Mesoderm development protein

Gene names

Name:	mesdc2
ORF Names:	zgc:158636

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Endoplasmic reticulum By similarity.
Domain	The LDLR maturation activity resides in the N- and C-terminal unstructured regions By similarity.
Sequence similarities	Belongs to the MESD family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Endoplasmic reticulum
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A1L243-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A1L243-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: MASSVGCRTLSVLFLLVLFITVHCTDTKPKKKKDIRDYNDADMARLLEEWE → MFEC

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 206	182	LDLR chaperone MESD		PRO_0000385020
Regions
	Region	93 – 166	74	Structured core By similarity
	Motif	203 – 206	4	Prevents secretion from ER
Natural variations
	Alternative sequence	1 – 51	51	MASSV…LEEWE → MFEC in isoform 2.		VSP_038093

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: 7F3E8C76841FA15A	FASTA	206	23,307
	10 20 30 40 50 60 MASSVGCRTL SVLFLLVLFI TVHCTDTKPK KKKDIRDYND ADMARLLEEW EKDDDIEEGD 70 80 90 100 110 120 LPEHKRSPPP IDFSKIDASK PEELLKMSKK GKTLMVFASV SGNPTEKETE EITGLWQGSL 130 140 150 160 170 180 FNANYDVQRF VVGSNRVIFM LRDGSYAWEI KDFLVSQDRC EDVTVEGQVF PGKNAKKDAK 190 200 GKEQNETKKK GDKKAANRAN KGKQEL
	Isoform 2 [UniParc]. Checksum: EA3709CF23829EF6	FASTA	159	17,933
	10 20 30 40 50 60 MFECKDDDIE EGDLPEHKRS PPPIDFSKID ASKPEELLKM SKKGKTLMVF ASVSGNPTEK 70 80 90 100 110 120 ETEEITGLWQ GSLFNANYDV QRFVVGSNRV IFMLRDGSYA WEIKDFLVSQ DRCEDVTVEG 130 140 150 QVFPGKNAKK DAKGKEQNET KKKGDKKAAN RANKGKQEL

References

[1]	"Zebrafish transcriptome characterization." Mathavan S., Yao F., Wong E., Thoreau H., Nayudu M., Govindarajan K.R., Ruan Y., Wei C. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: Tuebingen. Tissue: Embryo.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EH610226 mRNA. No translation available. BC129340 mRNA. Translation: AAI29341.1.
IPI	IPI00804403. IPI00944859.
RefSeq	NP_001074173.1. NM_001080704.1.
UniGene	Dr.79372.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000093291.
Proteomic databases
PRIDE	A1L243.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000102515; ENSDARP00000093291; ENSDARG00000063030.
GeneID	791222.
KEGG	dre:791222.
Organism-specific databases
CTD	23184.
ZFIN	ZDB-GENE-070112-2142. mesdc2.
Phylogenomic databases
eggNOG	NOG286690.
GeneTree	ENSGT00390000000993.
HOGENOM	HOG000230558.
OrthoDB	EOG4QRH59.
Family and domain databases
InterPro	IPR019330. Mesoderm_development_cand-2. [Graphical view]
Pfam	PF10185. Mesd. 1 hit. [Graphical view]
PROSITE	PS00014. ER_TARGET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20930618.

Entry information

Entry name

MESD_DANRE

Accession

Primary (citable) accession number: A1L243

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	September 22, 2009
Last modified:	April 3, 2013
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program