ID   FOXF1_DANRE             Reviewed;         380 AA.
AC   A1L1S5;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   RecName: Full=Forkhead box protein F1;
GN   Name=foxf1; ORFNames=si:dkey-199i24.2, zgc:158301;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BX571798; CAM56581.1; -; Genomic_DNA.
DR   EMBL; BC129194; AAI29195.1; -; mRNA.
DR   RefSeq; NP_001073655.1; NM_001080186.1.
DR   AlphaFoldDB; A1L1S5; -.
DR   SMR; A1L1S5; -.
DR   STRING; 7955.ENSDARP00000022888; -.
DR   PaxDb; 7955-ENSDARP00000022888; -.
DR   PeptideAtlas; A1L1S5; -.
DR   GeneID; 566407; -.
DR   KEGG; dre:566407; -.
DR   AGR; ZFIN:ZDB-GENE-050419-153; -.
DR   CTD; 2294; -.
DR   ZFIN; ZDB-GENE-050419-153; foxf1.
DR   eggNOG; KOG2294; Eukaryota.
DR   HOGENOM; CLU_039845_1_0_1; -.
DR   InParanoid; A1L1S5; -.
DR   OMA; SGVMEPH; -.
DR   OrthoDB; 5385885at2759; -.
DR   PhylomeDB; A1L1S5; -.
DR   TreeFam; TF351598; -.
DR   PRO; PR:A1L1S5; -.
DR   Proteomes; UP000000437; Chromosome 18.
DR   Bgee; ENSDARG00000015399; Expressed in pharyngeal gill and 16 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0002040; P:sprouting angiogenesis; IMP:ZFIN.
DR   CDD; cd20049; FH_FOXF1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR46262; FORKHEAD BOX PROTEIN BINIOU; 1.
DR   PANTHER; PTHR46262:SF1; FORKHEAD BOX PROTEIN F1; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..380
FT                   /note="Forkhead box protein F1"
FT                   /id="PRO_0000375225"
FT   DNA_BIND        52..146
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   380 AA;  41476 MW;  C57C9816CB04CF82 CRC64;
     MTAEVQQPSV QTPAHSSPMT EKPVQTPVME TSSSSSSTKA KKTNAGIRRP EKPPYSYIAL
     IVMAIQSSPT KRLTLSEIYQ FLQSRFPFFR GSYQGWKNSV RHNLSLNECF IKLPKGLGRP
     GKGHYWTIDP ASEFMFEEGS FRRRPRGFRR KCQALKPSMY SMMNGLGFNH IPESYNFQGG
     GGGLSCPPNS LSLESGIGMM NGHLASNMEG MGLAGHSMPH LSTNSGHSYM GSCTGSSGTE
     YPHHDSSASP LLTSGGVMDP HAVYSSTASA WPSAPPTSLN NGTSYIKQQP LSPCNPGASS
     LQPSLPTHSL EQSYLHQNGH GTTDLQGIPR YHTQSPSMCD RKEFVFSFNA MTSSSMHSPG
     SSSYYHHQQV SYQDIKPCVM
//