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A1L1R6

- ZN423_DANRE

UniProt

A1L1R6 - ZN423_DANRE

Protein

Zinc finger protein 423

Gene

znf423

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri76 – 9823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri150 – 17223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri178 – 20023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri206 – 22823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri234 – 25623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri286 – 30924C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri318 – 34124C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri346 – 36823C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri437 – 46125C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri469 – 49224C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri513 – 53624C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri555 – 57824C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri603 – 62826C2H2-type 13; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri675 – 69723C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri705 – 72824C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri736 – 75924C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri764 – 78724C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri794 – 81724C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri831 – 85323C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri857 – 88024C2H2-type 20PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri954 – 97623C2H2-type 21; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1000 – 102223C2H2-type 22PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1029 – 105123C2H2-type 23PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1090 – 111223C2H2-type 24PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1201 – 122424C2H2-type 25PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1249 – 127123C2H2-type 26PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1279 – 130123C2H2-type 27PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1310 – 133324C2H2-type 28PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1340 – 136324C2H2-type 29PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. nervous system development Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein, Repressor

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 423
    Gene namesi
    Name:znf423
    ORF Names:si:ch211-216l23.1, zgc:158272
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 18

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13651365Zinc finger protein 423PRO_0000308598Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiA1L1R6.

    Structurei

    3D structure databases

    ProteinModelPortaliA1L1R6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 29 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri76 – 9823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri150 – 17223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri178 – 20023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri206 – 22823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri234 – 25623C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri286 – 30924C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri318 – 34124C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri346 – 36823C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri437 – 46125C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri469 – 49224C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri513 – 53624C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri555 – 57824C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri603 – 62826C2H2-type 13; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri675 – 69723C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri705 – 72824C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri736 – 75924C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri764 – 78724C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri794 – 81724C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri831 – 85323C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri857 – 88024C2H2-type 20PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri954 – 97623C2H2-type 21; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1000 – 102223C2H2-type 22PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1029 – 105123C2H2-type 23PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1090 – 111223C2H2-type 24PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1201 – 122424C2H2-type 25PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1249 – 127123C2H2-type 26PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1279 – 130123C2H2-type 27PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1310 – 133324C2H2-type 28PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1340 – 136324C2H2-type 29PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117220.
    HOGENOMiHOG000155793.
    HOVERGENiHBG052773.
    InParanoidiQ1LX66.
    OMAiFIEHCQM.
    OrthoDBiEOG7NGQB0.
    PhylomeDBiA1L1R6.
    TreeFamiTF331504.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 3 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 30 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 27 hits.
    PS50157. ZINC_FINGER_C2H2_2. 23 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1L1R6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRRKQAKPR SVKAVEEAES TECASGWDSS VQTDAAVSER DSDRKESRAV     50
    GEDGEQSVTS HDERVGEEDL DDDSIFTCDN CQQDFECLAD LTEHRTNHCP 100
    ADGDDDPGLS WVASSPSSKD VASPSQMLGD GCCDMGMGTG EEEGGSGLPY 150
    PCQFCDKSFS RLSYLKRHEQ IHSDKLPFKC TFCSRLFKHK RSRDRHVKLH 200
    TGDKKYSCQE CEAAFSRSDH LKIHLKTHSS SKPFKCSICK RGFSSTSSLQ 250
    SHMQAHRKNK EHLAKKDQGK RDGSSSDVTE QDQDLYMCDY CEETFSQTDE 300
    LEKHVLTQHP QLSDRAELQC IHCPEIFSDE GTLLTHIDRT HANKKHKCPM 350
    CAEQFPSVED VYCHLDSHRQ PDSSNHSASP DPVLGSVASM SSATPDSSAS 400
    LERGSTPDST LKPGQSRRKL APSSDHDDGT WSGKVTYSCP YCSKRDFNSL 450
    AVLEIHLKTI HADKPQQSHT CQLCLETLPT LYNLNEHVRK AHRSSGNSAS 500
    NFPLLQFSNV SAFHCNYCPD MFADINSLQE HIRVSHCLSG GVVAGSTTLE 550
    GNHAFFCNQC SMGFLTESSL TEHIQQTHCS SVGGVTKMES PVLQPSQSFM 600
    EVYSCPYCTN SPIFGSLLKL TKHIKENHKN IPLANNKRKV KVADLSPASS 650
    DVEISSPKRH RVTGDSTPAV ANGDYPCNQC DLRFSSFEGF QAHLKSHLEL 700
    LLRRQSCPQC NKEDFDSQEA LLQHLTIHYT TTSTQYVCES CDKQFSSVDD 750
    LQKHLLDMHT FVLYHCTLCQ EVFDSKVSIQ VHLAVKHSNE KKMYRCTACA 800
    WDFRKESDLQ LHVKHSHLGH PASTGAPGKA RKCIFCGETF GTEVELQCHI 850
    TTHSKKYNCR LCGKAFHAIV LLERHLREKH CIFDGGNGNG NGGSQNGTPN 900
    GVTQSSKRST AGSTAAAEQA DLQNMLLKGG SQETANSHEA SGGEEELDAS 950
    EPMYACDICG AAYTMESLLQ NHRLRDHNIR PGEDDAGSRK KKADFIKGNH 1000
    KCNVCSRTFF SENGLREHAQ THRGPAKHYM CPICGERFPS LLTLTEHKVT 1050
    HSKSLDTGTC RICKMPLQSE EEFIEHCQMH PDLRNSLTGF RCVVCMQTVT 1100
    STLELKIHGT FHMQKLSSSG GSGGGGGSAS SSPNGQLQAH KLYKCALCLK 1150
    DFKNKQELVK IDVNGLPYGL CAGCMSRGTN GQSPTVVVTP QEAGDKGTTG 1200
    LRCSECAVKF ETLEDLESHI QVDHTEMSPE TSGAKKVTDA SPVPKKKTYQ 1250
    CIKCQMTFET EREIQIHVAN HMIEEGINHE CKLCNQMFDS PAKLLCHLIE 1300
    HSFEGMGGTF KCPVCFTVFV QANKLQQHIF AVHGQEDKIY DCSQCPQKFF 1350
    FQTELQNHTL SQHAQ 1365
    Length:1,365
    Mass (Da):151,465
    Last modified:February 6, 2007 - v1
    Checksum:i5B53BE488AE40D49
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX470162 Genomic DNA. Translation: CAK04518.1.
    CR387935 Genomic DNA. Translation: CAK04486.1.
    BC129184 mRNA. Translation: AAI29185.1.
    RefSeqiNP_001073499.1. NM_001080030.1.
    UniGeneiDr.161769.

    Genome annotation databases

    EnsembliENSDART00000083296; ENSDARP00000077731; ENSDARG00000059707.
    GeneIDi566696.
    KEGGidre:566696.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX470162 Genomic DNA. Translation: CAK04518.1 .
    CR387935 Genomic DNA. Translation: CAK04486.1 .
    BC129184 mRNA. Translation: AAI29185.1 .
    RefSeqi NP_001073499.1. NM_001080030.1.
    UniGenei Dr.161769.

    3D structure databases

    ProteinModelPortali A1L1R6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000083296 ; ENSDARP00000077731 ; ENSDARG00000059707 .
    GeneIDi 566696.
    KEGGi dre:566696.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117220.
    HOGENOMi HOG000155793.
    HOVERGENi HBG052773.
    InParanoidi Q1LX66.
    OMAi FIEHCQM.
    OrthoDBi EOG7NGQB0.
    PhylomeDBi A1L1R6.
    TreeFami TF331504.

    Miscellaneous databases

    NextBioi 20888324.
    PROi A1L1R6.

    Gene expression databases

    Bgeei A1L1R6.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 3 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 30 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 27 hits.
    PS50157. ZINC_FINGER_C2H2_2. 23 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiZN423_DANRE
    AccessioniPrimary (citable) accession number: A1L1R6
    Secondary accession number(s): Q1L943, Q1LX66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3