Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A1L1R6 (ZN423_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 423
Gene names
Name:znf423
ORF Names:si:ch211-216l23.1, zgc:158272
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length1365 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 29 C2H2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13651365Zinc finger protein 423
PRO_0000308598

Regions

Zinc finger76 – 9823C2H2-type 1
Zinc finger150 – 17223C2H2-type 2
Zinc finger178 – 20023C2H2-type 3
Zinc finger206 – 22823C2H2-type 4
Zinc finger234 – 25623C2H2-type 5
Zinc finger286 – 30924C2H2-type 6
Zinc finger318 – 34124C2H2-type 7
Zinc finger346 – 36823C2H2-type 8
Zinc finger437 – 46125C2H2-type 9; degenerate
Zinc finger469 – 49224C2H2-type 10
Zinc finger513 – 53624C2H2-type 11
Zinc finger555 – 57824C2H2-type 12
Zinc finger603 – 62826C2H2-type 13; atypical
Zinc finger675 – 69723C2H2-type 14
Zinc finger705 – 72824C2H2-type 15
Zinc finger736 – 75924C2H2-type 16
Zinc finger764 – 78724C2H2-type 17
Zinc finger794 – 81724C2H2-type 18
Zinc finger831 – 85323C2H2-type 19
Zinc finger857 – 88024C2H2-type 20
Zinc finger954 – 97623C2H2-type 21; degenerate
Zinc finger1000 – 102223C2H2-type 22
Zinc finger1029 – 105123C2H2-type 23
Zinc finger1090 – 111223C2H2-type 24
Zinc finger1201 – 122424C2H2-type 25
Zinc finger1249 – 127123C2H2-type 26
Zinc finger1279 – 130123C2H2-type 27
Zinc finger1310 – 133324C2H2-type 28
Zinc finger1340 – 136324C2H2-type 29

Sequences

Sequence LengthMass (Da)Tools
A1L1R6 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 5B53BE488AE40D49

FASTA1,365151,465
        10         20         30         40         50         60 
MSRRKQAKPR SVKAVEEAES TECASGWDSS VQTDAAVSER DSDRKESRAV GEDGEQSVTS 

        70         80         90        100        110        120 
HDERVGEEDL DDDSIFTCDN CQQDFECLAD LTEHRTNHCP ADGDDDPGLS WVASSPSSKD 

       130        140        150        160        170        180 
VASPSQMLGD GCCDMGMGTG EEEGGSGLPY PCQFCDKSFS RLSYLKRHEQ IHSDKLPFKC 

       190        200        210        220        230        240 
TFCSRLFKHK RSRDRHVKLH TGDKKYSCQE CEAAFSRSDH LKIHLKTHSS SKPFKCSICK 

       250        260        270        280        290        300 
RGFSSTSSLQ SHMQAHRKNK EHLAKKDQGK RDGSSSDVTE QDQDLYMCDY CEETFSQTDE 

       310        320        330        340        350        360 
LEKHVLTQHP QLSDRAELQC IHCPEIFSDE GTLLTHIDRT HANKKHKCPM CAEQFPSVED 

       370        380        390        400        410        420 
VYCHLDSHRQ PDSSNHSASP DPVLGSVASM SSATPDSSAS LERGSTPDST LKPGQSRRKL 

       430        440        450        460        470        480 
APSSDHDDGT WSGKVTYSCP YCSKRDFNSL AVLEIHLKTI HADKPQQSHT CQLCLETLPT 

       490        500        510        520        530        540 
LYNLNEHVRK AHRSSGNSAS NFPLLQFSNV SAFHCNYCPD MFADINSLQE HIRVSHCLSG 

       550        560        570        580        590        600 
GVVAGSTTLE GNHAFFCNQC SMGFLTESSL TEHIQQTHCS SVGGVTKMES PVLQPSQSFM 

       610        620        630        640        650        660 
EVYSCPYCTN SPIFGSLLKL TKHIKENHKN IPLANNKRKV KVADLSPASS DVEISSPKRH 

       670        680        690        700        710        720 
RVTGDSTPAV ANGDYPCNQC DLRFSSFEGF QAHLKSHLEL LLRRQSCPQC NKEDFDSQEA 

       730        740        750        760        770        780 
LLQHLTIHYT TTSTQYVCES CDKQFSSVDD LQKHLLDMHT FVLYHCTLCQ EVFDSKVSIQ 

       790        800        810        820        830        840 
VHLAVKHSNE KKMYRCTACA WDFRKESDLQ LHVKHSHLGH PASTGAPGKA RKCIFCGETF 

       850        860        870        880        890        900 
GTEVELQCHI TTHSKKYNCR LCGKAFHAIV LLERHLREKH CIFDGGNGNG NGGSQNGTPN 

       910        920        930        940        950        960 
GVTQSSKRST AGSTAAAEQA DLQNMLLKGG SQETANSHEA SGGEEELDAS EPMYACDICG 

       970        980        990       1000       1010       1020 
AAYTMESLLQ NHRLRDHNIR PGEDDAGSRK KKADFIKGNH KCNVCSRTFF SENGLREHAQ 

      1030       1040       1050       1060       1070       1080 
THRGPAKHYM CPICGERFPS LLTLTEHKVT HSKSLDTGTC RICKMPLQSE EEFIEHCQMH 

      1090       1100       1110       1120       1130       1140 
PDLRNSLTGF RCVVCMQTVT STLELKIHGT FHMQKLSSSG GSGGGGGSAS SSPNGQLQAH 

      1150       1160       1170       1180       1190       1200 
KLYKCALCLK DFKNKQELVK IDVNGLPYGL CAGCMSRGTN GQSPTVVVTP QEAGDKGTTG 

      1210       1220       1230       1240       1250       1260 
LRCSECAVKF ETLEDLESHI QVDHTEMSPE TSGAKKVTDA SPVPKKKTYQ CIKCQMTFET 

      1270       1280       1290       1300       1310       1320 
EREIQIHVAN HMIEEGINHE CKLCNQMFDS PAKLLCHLIE HSFEGMGGTF KCPVCFTVFV 

      1330       1340       1350       1360 
QANKLQQHIF AVHGQEDKIY DCSQCPQKFF FQTELQNHTL SQHAQ 

« Hide

References

[1]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX470162 Genomic DNA. Translation: CAK04518.1.
CR387935 Genomic DNA. Translation: CAK04486.1.
BC129184 mRNA. Translation: AAI29185.1.
RefSeqNP_001073499.1. NM_001080030.1.
UniGeneDr.161769.

3D structure databases

ProteinModelPortalA1L1R6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000083296; ENSDARP00000077731; ENSDARG00000059707.
GeneID566696.
KEGGdre:566696.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117220.
HOGENOMHOG000155793.
HOVERGENHBG052773.
InParanoidQ1LX66.
OMAFIEHCQM.
OrthoDBEOG7NGQB0.
PhylomeDBA1L1R6.
TreeFamTF331504.

Gene expression databases

BgeeA1L1R6.

Family and domain databases

Gene3D3.30.160.60. 4 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 30 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 27 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20888324.
PROA1L1R6.

Entry information

Entry nameZN423_DANRE
AccessionPrimary (citable) accession number: A1L1R6
Secondary accession number(s): Q1L943, Q1LX66
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families