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A1L1R6

- ZN423_DANRE

UniProt

A1L1R6 - ZN423_DANRE

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Protein

Zinc finger protein 423

Gene
znf423, si:ch211-216l23.1, zgc:158272
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri76 – 9823C2H2-type 1Add
BLAST
Zinc fingeri150 – 17223C2H2-type 2Add
BLAST
Zinc fingeri178 – 20023C2H2-type 3Add
BLAST
Zinc fingeri206 – 22823C2H2-type 4Add
BLAST
Zinc fingeri234 – 25623C2H2-type 5Add
BLAST
Zinc fingeri286 – 30924C2H2-type 6Add
BLAST
Zinc fingeri318 – 34124C2H2-type 7Add
BLAST
Zinc fingeri346 – 36823C2H2-type 8Add
BLAST
Zinc fingeri437 – 46125C2H2-type 9; degenerateAdd
BLAST
Zinc fingeri469 – 49224C2H2-type 10Add
BLAST
Zinc fingeri513 – 53624C2H2-type 11Add
BLAST
Zinc fingeri555 – 57824C2H2-type 12Add
BLAST
Zinc fingeri603 – 62826C2H2-type 13; atypicalAdd
BLAST
Zinc fingeri675 – 69723C2H2-type 14Add
BLAST
Zinc fingeri705 – 72824C2H2-type 15Add
BLAST
Zinc fingeri736 – 75924C2H2-type 16Add
BLAST
Zinc fingeri764 – 78724C2H2-type 17Add
BLAST
Zinc fingeri794 – 81724C2H2-type 18Add
BLAST
Zinc fingeri831 – 85323C2H2-type 19Add
BLAST
Zinc fingeri857 – 88024C2H2-type 20Add
BLAST
Zinc fingeri954 – 97623C2H2-type 21; degenerateAdd
BLAST
Zinc fingeri1000 – 102223C2H2-type 22Add
BLAST
Zinc fingeri1029 – 105123C2H2-type 23Add
BLAST
Zinc fingeri1090 – 111223C2H2-type 24Add
BLAST
Zinc fingeri1201 – 122424C2H2-type 25Add
BLAST
Zinc fingeri1249 – 127123C2H2-type 26Add
BLAST
Zinc fingeri1279 – 130123C2H2-type 27Add
BLAST
Zinc fingeri1310 – 133324C2H2-type 28Add
BLAST
Zinc fingeri1340 – 136324C2H2-type 29Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 423
Gene namesi
Name:znf423
ORF Names:si:ch211-216l23.1, zgc:158272
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 18

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13651365Zinc finger protein 423PRO_0000308598Add
BLAST

Expressioni

Gene expression databases

BgeeiA1L1R6.

Structurei

3D structure databases

ProteinModelPortaliA1L1R6.

Family & Domainsi

Sequence similaritiesi

Contains 29 C2H2-type zinc fingers.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri76 – 9823C2H2-type 1Add
BLAST
Zinc fingeri150 – 17223C2H2-type 2Add
BLAST
Zinc fingeri178 – 20023C2H2-type 3Add
BLAST
Zinc fingeri206 – 22823C2H2-type 4Add
BLAST
Zinc fingeri234 – 25623C2H2-type 5Add
BLAST
Zinc fingeri286 – 30924C2H2-type 6Add
BLAST
Zinc fingeri318 – 34124C2H2-type 7Add
BLAST
Zinc fingeri346 – 36823C2H2-type 8Add
BLAST
Zinc fingeri437 – 46125C2H2-type 9; degenerateAdd
BLAST
Zinc fingeri469 – 49224C2H2-type 10Add
BLAST
Zinc fingeri513 – 53624C2H2-type 11Add
BLAST
Zinc fingeri555 – 57824C2H2-type 12Add
BLAST
Zinc fingeri603 – 62826C2H2-type 13; atypicalAdd
BLAST
Zinc fingeri675 – 69723C2H2-type 14Add
BLAST
Zinc fingeri705 – 72824C2H2-type 15Add
BLAST
Zinc fingeri736 – 75924C2H2-type 16Add
BLAST
Zinc fingeri764 – 78724C2H2-type 17Add
BLAST
Zinc fingeri794 – 81724C2H2-type 18Add
BLAST
Zinc fingeri831 – 85323C2H2-type 19Add
BLAST
Zinc fingeri857 – 88024C2H2-type 20Add
BLAST
Zinc fingeri954 – 97623C2H2-type 21; degenerateAdd
BLAST
Zinc fingeri1000 – 102223C2H2-type 22Add
BLAST
Zinc fingeri1029 – 105123C2H2-type 23Add
BLAST
Zinc fingeri1090 – 111223C2H2-type 24Add
BLAST
Zinc fingeri1201 – 122424C2H2-type 25Add
BLAST
Zinc fingeri1249 – 127123C2H2-type 26Add
BLAST
Zinc fingeri1279 – 130123C2H2-type 27Add
BLAST
Zinc fingeri1310 – 133324C2H2-type 28Add
BLAST
Zinc fingeri1340 – 136324C2H2-type 29Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117220.
HOGENOMiHOG000155793.
HOVERGENiHBG052773.
InParanoidiQ1LX66.
OMAiFIEHCQM.
OrthoDBiEOG7NGQB0.
PhylomeDBiA1L1R6.
TreeFamiTF331504.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 30 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 27 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L1R6-1 [UniParc]FASTAAdd to Basket

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MSRRKQAKPR SVKAVEEAES TECASGWDSS VQTDAAVSER DSDRKESRAV     50
GEDGEQSVTS HDERVGEEDL DDDSIFTCDN CQQDFECLAD LTEHRTNHCP 100
ADGDDDPGLS WVASSPSSKD VASPSQMLGD GCCDMGMGTG EEEGGSGLPY 150
PCQFCDKSFS RLSYLKRHEQ IHSDKLPFKC TFCSRLFKHK RSRDRHVKLH 200
TGDKKYSCQE CEAAFSRSDH LKIHLKTHSS SKPFKCSICK RGFSSTSSLQ 250
SHMQAHRKNK EHLAKKDQGK RDGSSSDVTE QDQDLYMCDY CEETFSQTDE 300
LEKHVLTQHP QLSDRAELQC IHCPEIFSDE GTLLTHIDRT HANKKHKCPM 350
CAEQFPSVED VYCHLDSHRQ PDSSNHSASP DPVLGSVASM SSATPDSSAS 400
LERGSTPDST LKPGQSRRKL APSSDHDDGT WSGKVTYSCP YCSKRDFNSL 450
AVLEIHLKTI HADKPQQSHT CQLCLETLPT LYNLNEHVRK AHRSSGNSAS 500
NFPLLQFSNV SAFHCNYCPD MFADINSLQE HIRVSHCLSG GVVAGSTTLE 550
GNHAFFCNQC SMGFLTESSL TEHIQQTHCS SVGGVTKMES PVLQPSQSFM 600
EVYSCPYCTN SPIFGSLLKL TKHIKENHKN IPLANNKRKV KVADLSPASS 650
DVEISSPKRH RVTGDSTPAV ANGDYPCNQC DLRFSSFEGF QAHLKSHLEL 700
LLRRQSCPQC NKEDFDSQEA LLQHLTIHYT TTSTQYVCES CDKQFSSVDD 750
LQKHLLDMHT FVLYHCTLCQ EVFDSKVSIQ VHLAVKHSNE KKMYRCTACA 800
WDFRKESDLQ LHVKHSHLGH PASTGAPGKA RKCIFCGETF GTEVELQCHI 850
TTHSKKYNCR LCGKAFHAIV LLERHLREKH CIFDGGNGNG NGGSQNGTPN 900
GVTQSSKRST AGSTAAAEQA DLQNMLLKGG SQETANSHEA SGGEEELDAS 950
EPMYACDICG AAYTMESLLQ NHRLRDHNIR PGEDDAGSRK KKADFIKGNH 1000
KCNVCSRTFF SENGLREHAQ THRGPAKHYM CPICGERFPS LLTLTEHKVT 1050
HSKSLDTGTC RICKMPLQSE EEFIEHCQMH PDLRNSLTGF RCVVCMQTVT 1100
STLELKIHGT FHMQKLSSSG GSGGGGGSAS SSPNGQLQAH KLYKCALCLK 1150
DFKNKQELVK IDVNGLPYGL CAGCMSRGTN GQSPTVVVTP QEAGDKGTTG 1200
LRCSECAVKF ETLEDLESHI QVDHTEMSPE TSGAKKVTDA SPVPKKKTYQ 1250
CIKCQMTFET EREIQIHVAN HMIEEGINHE CKLCNQMFDS PAKLLCHLIE 1300
HSFEGMGGTF KCPVCFTVFV QANKLQQHIF AVHGQEDKIY DCSQCPQKFF 1350
FQTELQNHTL SQHAQ 1365
Length:1,365
Mass (Da):151,465
Last modified:February 6, 2007 - v1
Checksum:i5B53BE488AE40D49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX470162 Genomic DNA. Translation: CAK04518.1.
CR387935 Genomic DNA. Translation: CAK04486.1.
BC129184 mRNA. Translation: AAI29185.1.
RefSeqiNP_001073499.1. NM_001080030.1.
UniGeneiDr.161769.

Genome annotation databases

EnsembliENSDART00000083296; ENSDARP00000077731; ENSDARG00000059707.
GeneIDi566696.
KEGGidre:566696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX470162 Genomic DNA. Translation: CAK04518.1 .
CR387935 Genomic DNA. Translation: CAK04486.1 .
BC129184 mRNA. Translation: AAI29185.1 .
RefSeqi NP_001073499.1. NM_001080030.1.
UniGenei Dr.161769.

3D structure databases

ProteinModelPortali A1L1R6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000083296 ; ENSDARP00000077731 ; ENSDARG00000059707 .
GeneIDi 566696.
KEGGi dre:566696.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00750000117220.
HOGENOMi HOG000155793.
HOVERGENi HBG052773.
InParanoidi Q1LX66.
OMAi FIEHCQM.
OrthoDBi EOG7NGQB0.
PhylomeDBi A1L1R6.
TreeFami TF331504.

Miscellaneous databases

NextBioi 20888324.
PROi A1L1R6.

Gene expression databases

Bgeei A1L1R6.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 3 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 30 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 27 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiZN423_DANRE
AccessioniPrimary (citable) accession number: A1L1R6
Secondary accession number(s): Q1L943, Q1LX66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi