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Protein

Zinc finger protein 423

Gene

znf423

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to bmp2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor involved in terminal olfactory receptor neurons differentiation. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri76 – 98C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 309C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri318 – 341C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri346 – 368C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 461C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri469 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri513 – 536C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri555 – 578C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri603 – 628C2H2-type 13; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri675 – 697C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri705 – 728C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri736 – 759C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri764 – 787C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri794 – 817C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri831 – 853C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri857 – 880C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri954 – 976C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1000 – 1022C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1029 – 1051C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1090 – 1112C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1201 – 1224C2H2-type 25PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1249 – 1271C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1279 – 1301C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1310 – 1333C2H2-type 28PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1340 – 1363C2H2-type 29PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 423
Gene namesi
Name:znf423
ORF Names:si:ch211-216l23.1, zgc:158272
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-060503-121 si:ch211-216l23.1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003085981 – 1365Zinc finger protein 423Add BLAST1365

Proteomic databases

PaxDbiA1L1R6
PeptideAtlasiA1L1R6
PRIDEiA1L1R6

Expressioni

Gene expression databases

BgeeiENSDARG00000059707
ExpressionAtlasiA1L1R6 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000077731

Structurei

3D structure databases

ProteinModelPortaliA1L1R6
SMRiA1L1R6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri76 – 98C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 309C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri318 – 341C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri346 – 368C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 461C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri469 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri513 – 536C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri555 – 578C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri603 – 628C2H2-type 13; atypicalPROSITE-ProRule annotationAdd BLAST26
Zinc fingeri675 – 697C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri705 – 728C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri736 – 759C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri764 – 787C2H2-type 17PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri794 – 817C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri831 – 853C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri857 – 880C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri954 – 976C2H2-type 21; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1000 – 1022C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1029 – 1051C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1090 – 1112C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1201 – 1224C2H2-type 25PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1249 – 1271C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1279 – 1301C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1310 – 1333C2H2-type 28PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1340 – 1363C2H2-type 29PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129874
HOGENOMiHOG000155793
HOVERGENiHBG052773
InParanoidiA1L1R6
OrthoDBiEOG091G00X5
PhylomeDBiA1L1R6
TreeFamiTF331504

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 30 hits
SUPFAMiSSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 27 hits
PS50157 ZINC_FINGER_C2H2_2, 23 hits

Sequencei

Sequence statusi: Complete.

A1L1R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRKQAKPR SVKAVEEAES TECASGWDSS VQTDAAVSER DSDRKESRAV
60 70 80 90 100
GEDGEQSVTS HDERVGEEDL DDDSIFTCDN CQQDFECLAD LTEHRTNHCP
110 120 130 140 150
ADGDDDPGLS WVASSPSSKD VASPSQMLGD GCCDMGMGTG EEEGGSGLPY
160 170 180 190 200
PCQFCDKSFS RLSYLKRHEQ IHSDKLPFKC TFCSRLFKHK RSRDRHVKLH
210 220 230 240 250
TGDKKYSCQE CEAAFSRSDH LKIHLKTHSS SKPFKCSICK RGFSSTSSLQ
260 270 280 290 300
SHMQAHRKNK EHLAKKDQGK RDGSSSDVTE QDQDLYMCDY CEETFSQTDE
310 320 330 340 350
LEKHVLTQHP QLSDRAELQC IHCPEIFSDE GTLLTHIDRT HANKKHKCPM
360 370 380 390 400
CAEQFPSVED VYCHLDSHRQ PDSSNHSASP DPVLGSVASM SSATPDSSAS
410 420 430 440 450
LERGSTPDST LKPGQSRRKL APSSDHDDGT WSGKVTYSCP YCSKRDFNSL
460 470 480 490 500
AVLEIHLKTI HADKPQQSHT CQLCLETLPT LYNLNEHVRK AHRSSGNSAS
510 520 530 540 550
NFPLLQFSNV SAFHCNYCPD MFADINSLQE HIRVSHCLSG GVVAGSTTLE
560 570 580 590 600
GNHAFFCNQC SMGFLTESSL TEHIQQTHCS SVGGVTKMES PVLQPSQSFM
610 620 630 640 650
EVYSCPYCTN SPIFGSLLKL TKHIKENHKN IPLANNKRKV KVADLSPASS
660 670 680 690 700
DVEISSPKRH RVTGDSTPAV ANGDYPCNQC DLRFSSFEGF QAHLKSHLEL
710 720 730 740 750
LLRRQSCPQC NKEDFDSQEA LLQHLTIHYT TTSTQYVCES CDKQFSSVDD
760 770 780 790 800
LQKHLLDMHT FVLYHCTLCQ EVFDSKVSIQ VHLAVKHSNE KKMYRCTACA
810 820 830 840 850
WDFRKESDLQ LHVKHSHLGH PASTGAPGKA RKCIFCGETF GTEVELQCHI
860 870 880 890 900
TTHSKKYNCR LCGKAFHAIV LLERHLREKH CIFDGGNGNG NGGSQNGTPN
910 920 930 940 950
GVTQSSKRST AGSTAAAEQA DLQNMLLKGG SQETANSHEA SGGEEELDAS
960 970 980 990 1000
EPMYACDICG AAYTMESLLQ NHRLRDHNIR PGEDDAGSRK KKADFIKGNH
1010 1020 1030 1040 1050
KCNVCSRTFF SENGLREHAQ THRGPAKHYM CPICGERFPS LLTLTEHKVT
1060 1070 1080 1090 1100
HSKSLDTGTC RICKMPLQSE EEFIEHCQMH PDLRNSLTGF RCVVCMQTVT
1110 1120 1130 1140 1150
STLELKIHGT FHMQKLSSSG GSGGGGGSAS SSPNGQLQAH KLYKCALCLK
1160 1170 1180 1190 1200
DFKNKQELVK IDVNGLPYGL CAGCMSRGTN GQSPTVVVTP QEAGDKGTTG
1210 1220 1230 1240 1250
LRCSECAVKF ETLEDLESHI QVDHTEMSPE TSGAKKVTDA SPVPKKKTYQ
1260 1270 1280 1290 1300
CIKCQMTFET EREIQIHVAN HMIEEGINHE CKLCNQMFDS PAKLLCHLIE
1310 1320 1330 1340 1350
HSFEGMGGTF KCPVCFTVFV QANKLQQHIF AVHGQEDKIY DCSQCPQKFF
1360
FQTELQNHTL SQHAQ
Length:1,365
Mass (Da):151,465
Last modified:February 6, 2007 - v1
Checksum:i5B53BE488AE40D49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX470162 Genomic DNA Translation: CAK04518.1
CR387935 Genomic DNA Translation: CAK04486.1
BC129184 mRNA Translation: AAI29185.1
RefSeqiNP_001073499.1, NM_001080030.1
UniGeneiDr.161769

Genome annotation databases

EnsembliENSDART00000083296; ENSDARP00000077731; ENSDARG00000059707
GeneIDi566696
KEGGidre:566696

Similar proteinsi

Entry informationi

Entry nameiZN423_DANRE
AccessioniPrimary (citable) accession number: A1L1R6
Secondary accession number(s): Q1L943, Q1LX66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health