ID S47A1_DANRE Reviewed; 590 AA. AC A1L1P9; DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot. DT 06-FEB-2007, sequence version 1. DT 27-MAR-2024, entry version 105. DE RecName: Full=Multidrug and toxin extrusion protein 1; DE Short=MATE-1; DE AltName: Full=Solute carrier family 47 member 1; GN Name=slc47a1; Synonyms=mate1; ORFNames=zgc:158231; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Solute transporter for tetraethylammonium (TEA), cimetidine, CC metformin, guanidine, N-methylnicotinamide (NMN) and also the CC zwitterionic cephalosporin cephalexin. Responsible for the secretion of CC cationic drugs across the brush border membranes (By similarity). CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane CC protein {ECO:0000250}. CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) CC (TC 2.A.66.1) family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC129166; AAI29167.1; -; mRNA. DR RefSeq; NP_001073648.1; NM_001080179.1. DR AlphaFoldDB; A1L1P9; -. DR SMR; A1L1P9; -. DR STRING; 7955.ENSDARP00000078672; -. DR PaxDb; 7955-ENSDARP00000078672; -. DR PeptideAtlas; A1L1P9; -. DR GeneID; 560024; -. DR KEGG; dre:560024; -. DR AGR; ZFIN:ZDB-GENE-070112-1472; -. DR CTD; 560024; -. DR ZFIN; ZDB-GENE-070112-1472; slc47a2.1. DR eggNOG; KOG1347; Eukaryota. DR HOGENOM; CLU_012893_1_3_1; -. DR InParanoid; A1L1P9; -. DR OMA; WFFVWKL; -. DR OrthoDB; 10858at2759; -. DR PhylomeDB; A1L1P9; -. DR TreeFam; TF324441; -. DR Reactome; R-DRE-425366; Transport of bile salts and organic acids, metal ions and amine compounds. DR PRO; PR:A1L1P9; -. DR Proteomes; UP000000437; Chromosome 21. DR Bgee; ENSDARG00000060051; Expressed in mesonephros and 13 other cell types or tissues. DR ExpressionAtlas; A1L1P9; baseline and differential. DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB. DR GO; GO:0016020; C:membrane; IBA:GO_Central. DR GO; GO:0015297; F:antiporter activity; ISS:UniProtKB. DR GO; GO:0015101; F:organic cation transmembrane transporter activity; ISS:UniProtKB. DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central. DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; ISS:UniProtKB. DR GO; GO:0015695; P:organic cation transport; ISS:UniProtKB. DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; ISS:UniProtKB. DR CDD; cd13132; MATE_eukaryotic; 1. DR InterPro; IPR045069; MATE_euk. DR InterPro; IPR002528; MATE_fam. DR NCBIfam; TIGR00797; matE; 1. DR PANTHER; PTHR11206:SF268; MULTIDRUG AND TOXIN EXTRUSION PROTEIN-RELATED; 1. DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1. DR Pfam; PF01554; MatE; 2. PE 2: Evidence at transcript level; KW Cell membrane; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix; Transport. FT CHAIN 1..590 FT /note="Multidrug and toxin extrusion protein 1" FT /id="PRO_0000312850" FT TOPO_DOM 1..59 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 60..80 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 81..88 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 89..109 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 110..137 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 138..158 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 159..167 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 168..188 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 189..199 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 200..222 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 223..231 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 232..254 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 255..274 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 275..294 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 295..313 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 314..334 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 335..351 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 352..372 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 373..395 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 396..416 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 417..430 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 431..451 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 452 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 453..473 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 474..565 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 566..586 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 587..590 FT /note="Extracellular" FT /evidence="ECO:0000255" SQ SEQUENCE 590 AA; 63759 MW; 06362BFF041A6CB1 CRC64; MDSITSYNVT QMNGDTKQEK CDDVLSTSST QKFCGGCRKK LRSLLPVNYK TEIVELLKLA GPVFISQLMI FLISFVSTVF CGHLGKTELA GVALAIAVIN VTGISIGSGL ASACDTLISQ TFGSNNLKRV GVILQRGILI LLLACFPCWA LLINTEPILL AVRQSPNVAS LSQLYVKIFM PALPAAFMYQ LQGRYLQNQG IIWPQVITGA AGNILNALIN YVFLHLLELG VAGSAAANTI SQYSLAVFLY VYIRWKNLHK ATWDGWSRDC LQEWGAFIRL ALPSMLMLCV EWWTYEIGGF LAGLISETEL GAQSVVYELA TIAYMFPLGF AVAASVRVGN ALGAGNTERA KLSAKVALVC GVLVSCVVAT LIGCTKDVIA YIFTTEEEIV SRVSQVMIMY GFFHLFDAIA GITGGIVRGA GKQLLGALCN IVGYYFVGFP TGVSLMFALS MGIIGLWIGF FGCVFLQSLF FIILIYKLDW KKATQEALIR AGVQLTETKD ESFGLENKGC TEEAAKESQI TEEGLTDANT DLEGLSKGGE GISEAGAKTT VGAVLTTKQL IVRRGLAVLL MVLILAGGIV LNEMLVRYLR //