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A1L1P9

- S47A1_DANRE

UniProt

A1L1P9 - S47A1_DANRE

Protein

Multidrug and toxin extrusion protein 1

Gene

slc47a1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Responsible for the secretion of cationic drugs across the brush border membranes By similarity.By similarity

    GO - Molecular functioni

    1. antiporter activity Source: InterPro
    2. drug transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug and toxin extrusion protein 1
    Short name:
    MATE-1
    Alternative name(s):
    Solute carrier family 47 member 1
    Gene namesi
    Name:slc47a1
    Synonyms:mate1
    ORF Names:zgc:158231
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 21

    Organism-specific databases

    ZFINiZDB-GENE-070112-1472. slc47a2.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 590590Multidrug and toxin extrusion protein 1PRO_0000312850Add
    BLAST

    Proteomic databases

    PRIDEiA1L1P9.

    Expressioni

    Gene expression databases

    BgeeiA1L1P9.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000078672.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5959CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini81 – 888ExtracellularSequence Analysis
    Topological domaini110 – 13728CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 1679ExtracellularSequence Analysis
    Topological domaini189 – 19911CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini223 – 2319ExtracellularSequence Analysis
    Topological domaini255 – 27420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini295 – 31319ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini335 – 35117CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini373 – 39523ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini417 – 43014CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini452 – 4521ExtracellularSequence Analysis
    Topological domaini474 – 56592CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini587 – 5904ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei275 – 29420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei352 – 37221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei396 – 41621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei431 – 45121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei453 – 47321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei566 – 58621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0534.
    HOGENOMiHOG000060313.
    HOVERGENiHBG056043.
    InParanoidiA1L1P9.
    KOiK03327.
    OMAiKLAFNIN.
    OrthoDBiEOG7RRF71.
    PhylomeDBiA1L1P9.
    TreeFamiTF324441.

    Family and domain databases

    InterProiIPR002528. MATE.
    [Graphical view]
    PfamiPF01554. MatE. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00797. matE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1L1P9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSITSYNVT QMNGDTKQEK CDDVLSTSST QKFCGGCRKK LRSLLPVNYK    50
    TEIVELLKLA GPVFISQLMI FLISFVSTVF CGHLGKTELA GVALAIAVIN 100
    VTGISIGSGL ASACDTLISQ TFGSNNLKRV GVILQRGILI LLLACFPCWA 150
    LLINTEPILL AVRQSPNVAS LSQLYVKIFM PALPAAFMYQ LQGRYLQNQG 200
    IIWPQVITGA AGNILNALIN YVFLHLLELG VAGSAAANTI SQYSLAVFLY 250
    VYIRWKNLHK ATWDGWSRDC LQEWGAFIRL ALPSMLMLCV EWWTYEIGGF 300
    LAGLISETEL GAQSVVYELA TIAYMFPLGF AVAASVRVGN ALGAGNTERA 350
    KLSAKVALVC GVLVSCVVAT LIGCTKDVIA YIFTTEEEIV SRVSQVMIMY 400
    GFFHLFDAIA GITGGIVRGA GKQLLGALCN IVGYYFVGFP TGVSLMFALS 450
    MGIIGLWIGF FGCVFLQSLF FIILIYKLDW KKATQEALIR AGVQLTETKD 500
    ESFGLENKGC TEEAAKESQI TEEGLTDANT DLEGLSKGGE GISEAGAKTT 550
    VGAVLTTKQL IVRRGLAVLL MVLILAGGIV LNEMLVRYLR 590
    Length:590
    Mass (Da):63,759
    Last modified:February 6, 2007 - v1
    Checksum:i06362BFF041A6CB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129166 mRNA. Translation: AAI29167.1.
    RefSeqiNP_001073648.1. NM_001080179.1.
    UniGeneiDr.87105.

    Genome annotation databases

    EnsembliENSDART00000084237; ENSDARP00000078672; ENSDARG00000060051.
    GeneIDi560024.
    KEGGidre:560024.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129166 mRNA. Translation: AAI29167.1 .
    RefSeqi NP_001073648.1. NM_001080179.1.
    UniGenei Dr.87105.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000078672.

    Proteomic databases

    PRIDEi A1L1P9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000084237 ; ENSDARP00000078672 ; ENSDARG00000060051 .
    GeneIDi 560024.
    KEGGi dre:560024.

    Organism-specific databases

    CTDi 146802.
    ZFINi ZDB-GENE-070112-1472. slc47a2.

    Phylogenomic databases

    eggNOGi COG0534.
    HOGENOMi HOG000060313.
    HOVERGENi HBG056043.
    InParanoidi A1L1P9.
    KOi K03327.
    OMAi KLAFNIN.
    OrthoDBi EOG7RRF71.
    PhylomeDBi A1L1P9.
    TreeFami TF324441.

    Miscellaneous databases

    NextBioi 20883253.
    PROi A1L1P9.

    Gene expression databases

    Bgeei A1L1P9.

    Family and domain databases

    InterProi IPR002528. MATE.
    [Graphical view ]
    Pfami PF01554. MatE. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00797. matE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiS47A1_DANRE
    AccessioniPrimary (citable) accession number: A1L1P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3