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Protein

Multidrug and toxin extrusion protein 1

Gene

slc47a1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Responsible for the secretion of cationic drugs across the brush border membranes (By similarity).By similarity

GO - Molecular functioni

  1. antiporter activity Source: InterPro
  2. drug transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_296317. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 1
Short name:
MATE-1
Alternative name(s):
Solute carrier family 47 member 1
Gene namesi
Name:slc47a1
Synonyms:mate1
ORF Names:zgc:158231
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-070112-1472. slc47a2.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5959CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Topological domaini81 – 888ExtracellularSequence Analysis
Transmembranei89 – 10921HelicalSequence AnalysisAdd
BLAST
Topological domaini110 – 13728CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence AnalysisAdd
BLAST
Topological domaini159 – 1679ExtracellularSequence Analysis
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Topological domaini189 – 19911CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei200 – 22223HelicalSequence AnalysisAdd
BLAST
Topological domaini223 – 2319ExtracellularSequence Analysis
Transmembranei232 – 25423HelicalSequence AnalysisAdd
BLAST
Topological domaini255 – 27420CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei275 – 29420HelicalSequence AnalysisAdd
BLAST
Topological domaini295 – 31319ExtracellularSequence AnalysisAdd
BLAST
Transmembranei314 – 33421HelicalSequence AnalysisAdd
BLAST
Topological domaini335 – 35117CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei352 – 37221HelicalSequence AnalysisAdd
BLAST
Topological domaini373 – 39523ExtracellularSequence AnalysisAdd
BLAST
Transmembranei396 – 41621HelicalSequence AnalysisAdd
BLAST
Topological domaini417 – 43014CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei431 – 45121HelicalSequence AnalysisAdd
BLAST
Topological domaini452 – 4521ExtracellularSequence Analysis
Transmembranei453 – 47321HelicalSequence AnalysisAdd
BLAST
Topological domaini474 – 56592CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei566 – 58621HelicalSequence AnalysisAdd
BLAST
Topological domaini587 – 5904ExtracellularSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 590590Multidrug and toxin extrusion protein 1PRO_0000312850Add
BLAST

Proteomic databases

PRIDEiA1L1P9.

Expressioni

Gene expression databases

BgeeiA1L1P9.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000078672.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiA1L1P9.
KOiK03327.
OMAiIVAYINV.
OrthoDBiEOG7RRF71.
PhylomeDBiA1L1P9.
TreeFamiTF324441.

Family and domain databases

InterProiIPR002528. MATE.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A1L1P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSITSYNVT QMNGDTKQEK CDDVLSTSST QKFCGGCRKK LRSLLPVNYK
60 70 80 90 100
TEIVELLKLA GPVFISQLMI FLISFVSTVF CGHLGKTELA GVALAIAVIN
110 120 130 140 150
VTGISIGSGL ASACDTLISQ TFGSNNLKRV GVILQRGILI LLLACFPCWA
160 170 180 190 200
LLINTEPILL AVRQSPNVAS LSQLYVKIFM PALPAAFMYQ LQGRYLQNQG
210 220 230 240 250
IIWPQVITGA AGNILNALIN YVFLHLLELG VAGSAAANTI SQYSLAVFLY
260 270 280 290 300
VYIRWKNLHK ATWDGWSRDC LQEWGAFIRL ALPSMLMLCV EWWTYEIGGF
310 320 330 340 350
LAGLISETEL GAQSVVYELA TIAYMFPLGF AVAASVRVGN ALGAGNTERA
360 370 380 390 400
KLSAKVALVC GVLVSCVVAT LIGCTKDVIA YIFTTEEEIV SRVSQVMIMY
410 420 430 440 450
GFFHLFDAIA GITGGIVRGA GKQLLGALCN IVGYYFVGFP TGVSLMFALS
460 470 480 490 500
MGIIGLWIGF FGCVFLQSLF FIILIYKLDW KKATQEALIR AGVQLTETKD
510 520 530 540 550
ESFGLENKGC TEEAAKESQI TEEGLTDANT DLEGLSKGGE GISEAGAKTT
560 570 580 590
VGAVLTTKQL IVRRGLAVLL MVLILAGGIV LNEMLVRYLR
Length:590
Mass (Da):63,759
Last modified:February 5, 2007 - v1
Checksum:i06362BFF041A6CB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129166 mRNA. Translation: AAI29167.1.
RefSeqiNP_001073648.1. NM_001080179.1.
UniGeneiDr.87105.

Genome annotation databases

EnsembliENSDART00000084237; ENSDARP00000078672; ENSDARG00000060051.
GeneIDi560024.
KEGGidre:560024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129166 mRNA. Translation: AAI29167.1.
RefSeqiNP_001073648.1. NM_001080179.1.
UniGeneiDr.87105.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000078672.

Proteomic databases

PRIDEiA1L1P9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000084237; ENSDARP00000078672; ENSDARG00000060051.
GeneIDi560024.
KEGGidre:560024.

Organism-specific databases

CTDi146802.
ZFINiZDB-GENE-070112-1472. slc47a2.

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiA1L1P9.
KOiK03327.
OMAiIVAYINV.
OrthoDBiEOG7RRF71.
PhylomeDBiA1L1P9.
TreeFamiTF324441.

Enzyme and pathway databases

ReactomeiREACT_296317. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

NextBioi20883253.
PROiA1L1P9.

Gene expression databases

BgeeiA1L1P9.

Family and domain databases

InterProiIPR002528. MATE.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiS47A1_DANRE
AccessioniPrimary (citable) accession number: A1L1P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 3, 2007
Last sequence update: February 5, 2007
Last modified: March 31, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.