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Protein

Multidrug and toxin extrusion protein 1

Gene

slc47a1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Responsible for the secretion of cationic drugs across the brush border membranes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-DRE-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 1
Short name:
MATE-1
Alternative name(s):
Solute carrier family 47 member 1
Gene namesi
Name:slc47a1
Synonyms:mate1
ORF Names:zgc:158231
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-070112-1472. slc47a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 59CytoplasmicSequence analysisAdd BLAST59
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 88ExtracellularSequence analysis8
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 137CytoplasmicSequence analysisAdd BLAST28
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 167ExtracellularSequence analysis9
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 199CytoplasmicSequence analysisAdd BLAST11
Transmembranei200 – 222HelicalSequence analysisAdd BLAST23
Topological domaini223 – 231ExtracellularSequence analysis9
Transmembranei232 – 254HelicalSequence analysisAdd BLAST23
Topological domaini255 – 274CytoplasmicSequence analysisAdd BLAST20
Transmembranei275 – 294HelicalSequence analysisAdd BLAST20
Topological domaini295 – 313ExtracellularSequence analysisAdd BLAST19
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 351CytoplasmicSequence analysisAdd BLAST17
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 395ExtracellularSequence analysisAdd BLAST23
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 430CytoplasmicSequence analysisAdd BLAST14
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Topological domaini452ExtracellularSequence analysis1
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
Topological domaini474 – 565CytoplasmicSequence analysisAdd BLAST92
Transmembranei566 – 586HelicalSequence analysisAdd BLAST21
Topological domaini587 – 590ExtracellularSequence analysis4

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003128501 – 590Multidrug and toxin extrusion protein 1Add BLAST590

Proteomic databases

PaxDbiA1L1P9.
PeptideAtlasiA1L1P9.
PRIDEiA1L1P9.

Expressioni

Gene expression databases

BgeeiENSDARG00000060051.
ExpressionAtlasiA1L1P9. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000078672.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1347. Eukaryota.
COG0534. LUCA.
GeneTreeiENSGT00390000015713.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiA1L1P9.
KOiK03327.
OMAiLEWWIFE.
OrthoDBiEOG091G06X2.
PhylomeDBiA1L1P9.
TreeFamiTF324441.

Family and domain databases

InterProiIPR002528. MATE_fam.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A1L1P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSITSYNVT QMNGDTKQEK CDDVLSTSST QKFCGGCRKK LRSLLPVNYK
60 70 80 90 100
TEIVELLKLA GPVFISQLMI FLISFVSTVF CGHLGKTELA GVALAIAVIN
110 120 130 140 150
VTGISIGSGL ASACDTLISQ TFGSNNLKRV GVILQRGILI LLLACFPCWA
160 170 180 190 200
LLINTEPILL AVRQSPNVAS LSQLYVKIFM PALPAAFMYQ LQGRYLQNQG
210 220 230 240 250
IIWPQVITGA AGNILNALIN YVFLHLLELG VAGSAAANTI SQYSLAVFLY
260 270 280 290 300
VYIRWKNLHK ATWDGWSRDC LQEWGAFIRL ALPSMLMLCV EWWTYEIGGF
310 320 330 340 350
LAGLISETEL GAQSVVYELA TIAYMFPLGF AVAASVRVGN ALGAGNTERA
360 370 380 390 400
KLSAKVALVC GVLVSCVVAT LIGCTKDVIA YIFTTEEEIV SRVSQVMIMY
410 420 430 440 450
GFFHLFDAIA GITGGIVRGA GKQLLGALCN IVGYYFVGFP TGVSLMFALS
460 470 480 490 500
MGIIGLWIGF FGCVFLQSLF FIILIYKLDW KKATQEALIR AGVQLTETKD
510 520 530 540 550
ESFGLENKGC TEEAAKESQI TEEGLTDANT DLEGLSKGGE GISEAGAKTT
560 570 580 590
VGAVLTTKQL IVRRGLAVLL MVLILAGGIV LNEMLVRYLR
Length:590
Mass (Da):63,759
Last modified:February 6, 2007 - v1
Checksum:i06362BFF041A6CB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129166 mRNA. Translation: AAI29167.1.
RefSeqiNP_001073648.1. NM_001080179.1.
UniGeneiDr.87105.

Genome annotation databases

EnsembliENSDART00000084237; ENSDARP00000078672; ENSDARG00000060051.
GeneIDi560024.
KEGGidre:560024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129166 mRNA. Translation: AAI29167.1.
RefSeqiNP_001073648.1. NM_001080179.1.
UniGeneiDr.87105.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000078672.

Proteomic databases

PaxDbiA1L1P9.
PeptideAtlasiA1L1P9.
PRIDEiA1L1P9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000084237; ENSDARP00000078672; ENSDARG00000060051.
GeneIDi560024.
KEGGidre:560024.

Organism-specific databases

CTDi146802.
ZFINiZDB-GENE-070112-1472. slc47a2.

Phylogenomic databases

eggNOGiKOG1347. Eukaryota.
COG0534. LUCA.
GeneTreeiENSGT00390000015713.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiA1L1P9.
KOiK03327.
OMAiLEWWIFE.
OrthoDBiEOG091G06X2.
PhylomeDBiA1L1P9.
TreeFamiTF324441.

Enzyme and pathway databases

ReactomeiR-DRE-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

PROiA1L1P9.

Gene expression databases

BgeeiENSDARG00000060051.
ExpressionAtlasiA1L1P9. differential.

Family and domain databases

InterProiIPR002528. MATE_fam.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS47A1_DANRE
AccessioniPrimary (citable) accession number: A1L1P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 6, 2007
Last modified: November 30, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.