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A1L1P9 (S47A1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug and toxin extrusion protein 1

Short name=MATE-1
Alternative name(s):
Solute carrier family 47 member 1
Gene names
Name:slc47a1
Synonyms:mate1
ORF Names:zgc:158231
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length590 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Responsible for the secretion of cationic drugs across the brush border membranes By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. [View classification]

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 590590Multidrug and toxin extrusion protein 1
PRO_0000312850

Regions

Topological domain1 – 5959Cytoplasmic Potential
Transmembrane60 – 8021Helical; Potential
Topological domain81 – 888Extracellular Potential
Transmembrane89 – 10921Helical; Potential
Topological domain110 – 13728Cytoplasmic Potential
Transmembrane138 – 15821Helical; Potential
Topological domain159 – 1679Extracellular Potential
Transmembrane168 – 18821Helical; Potential
Topological domain189 – 19911Cytoplasmic Potential
Transmembrane200 – 22223Helical; Potential
Topological domain223 – 2319Extracellular Potential
Transmembrane232 – 25423Helical; Potential
Topological domain255 – 27420Cytoplasmic Potential
Transmembrane275 – 29420Helical; Potential
Topological domain295 – 31319Extracellular Potential
Transmembrane314 – 33421Helical; Potential
Topological domain335 – 35117Cytoplasmic Potential
Transmembrane352 – 37221Helical; Potential
Topological domain373 – 39523Extracellular Potential
Transmembrane396 – 41621Helical; Potential
Topological domain417 – 43014Cytoplasmic Potential
Transmembrane431 – 45121Helical; Potential
Topological domain4521Extracellular Potential
Transmembrane453 – 47321Helical; Potential
Topological domain474 – 56592Cytoplasmic Potential
Transmembrane566 – 58621Helical; Potential
Topological domain587 – 5904Extracellular Potential

Sequences

Sequence LengthMass (Da)Tools
A1L1P9 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 06362BFF041A6CB1

FASTA59063,759
        10         20         30         40         50         60 
MDSITSYNVT QMNGDTKQEK CDDVLSTSST QKFCGGCRKK LRSLLPVNYK TEIVELLKLA 

        70         80         90        100        110        120 
GPVFISQLMI FLISFVSTVF CGHLGKTELA GVALAIAVIN VTGISIGSGL ASACDTLISQ 

       130        140        150        160        170        180 
TFGSNNLKRV GVILQRGILI LLLACFPCWA LLINTEPILL AVRQSPNVAS LSQLYVKIFM 

       190        200        210        220        230        240 
PALPAAFMYQ LQGRYLQNQG IIWPQVITGA AGNILNALIN YVFLHLLELG VAGSAAANTI 

       250        260        270        280        290        300 
SQYSLAVFLY VYIRWKNLHK ATWDGWSRDC LQEWGAFIRL ALPSMLMLCV EWWTYEIGGF 

       310        320        330        340        350        360 
LAGLISETEL GAQSVVYELA TIAYMFPLGF AVAASVRVGN ALGAGNTERA KLSAKVALVC 

       370        380        390        400        410        420 
GVLVSCVVAT LIGCTKDVIA YIFTTEEEIV SRVSQVMIMY GFFHLFDAIA GITGGIVRGA 

       430        440        450        460        470        480 
GKQLLGALCN IVGYYFVGFP TGVSLMFALS MGIIGLWIGF FGCVFLQSLF FIILIYKLDW 

       490        500        510        520        530        540 
KKATQEALIR AGVQLTETKD ESFGLENKGC TEEAAKESQI TEEGLTDANT DLEGLSKGGE 

       550        560        570        580        590 
GISEAGAKTT VGAVLTTKQL IVRRGLAVLL MVLILAGGIV LNEMLVRYLR 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC129166 mRNA. Translation: AAI29167.1.
RefSeqNP_001073648.1. NM_001080179.1.
UniGeneDr.87105.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000078672.

Proteomic databases

PRIDEA1L1P9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000084237; ENSDARP00000078672; ENSDARG00000060051.
GeneID560024.
KEGGdre:560024.

Organism-specific databases

CTD146802.
ZFINZDB-GENE-070112-1472. slc47a2.

Phylogenomic databases

eggNOGCOG0534.
HOGENOMHOG000060313.
HOVERGENHBG056043.
InParanoidA1L1P9.
KOK03327.
OMAKLAFNIN.
OrthoDBEOG7RRF71.
PhylomeDBA1L1P9.
TreeFamTF324441.

Gene expression databases

BgeeA1L1P9.

Family and domain databases

InterProIPR002528. MATE.
[Graphical view]
PfamPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsTIGR00797. matE. 1 hit.
ProtoNetSearch...

Other

NextBio20883253.
PROA1L1P9.

Entry information

Entry nameS47A1_DANRE
AccessionPrimary (citable) accession number: A1L1P9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families