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A1L1P9

- S47A1_DANRE

UniProt

A1L1P9 - S47A1_DANRE

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Protein
Multidrug and toxin extrusion protein 1
Gene
slc47a1, mate1, zgc:158231
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Responsible for the secretion of cationic drugs across the brush border membranes By similarity.

GO - Molecular functioni

  1. antiporter activity Source: InterPro
  2. drug transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 1
Short name:
MATE-1
Alternative name(s):
Solute carrier family 47 member 1
Gene namesi
Name:slc47a1
Synonyms:mate1
ORF Names:zgc:158231
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-070112-1472. slc47a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5959Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei60 – 8021Helical; Reviewed prediction
Add
BLAST
Topological domaini81 – 888Extracellular Reviewed prediction
Transmembranei89 – 10921Helical; Reviewed prediction
Add
BLAST
Topological domaini110 – 13728Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei138 – 15821Helical; Reviewed prediction
Add
BLAST
Topological domaini159 – 1679Extracellular Reviewed prediction
Transmembranei168 – 18821Helical; Reviewed prediction
Add
BLAST
Topological domaini189 – 19911Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei200 – 22223Helical; Reviewed prediction
Add
BLAST
Topological domaini223 – 2319Extracellular Reviewed prediction
Transmembranei232 – 25423Helical; Reviewed prediction
Add
BLAST
Topological domaini255 – 27420Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei275 – 29420Helical; Reviewed prediction
Add
BLAST
Topological domaini295 – 31319Extracellular Reviewed prediction
Add
BLAST
Transmembranei314 – 33421Helical; Reviewed prediction
Add
BLAST
Topological domaini335 – 35117Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei352 – 37221Helical; Reviewed prediction
Add
BLAST
Topological domaini373 – 39523Extracellular Reviewed prediction
Add
BLAST
Transmembranei396 – 41621Helical; Reviewed prediction
Add
BLAST
Topological domaini417 – 43014Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei431 – 45121Helical; Reviewed prediction
Add
BLAST
Topological domaini452 – 4521Extracellular Reviewed prediction
Transmembranei453 – 47321Helical; Reviewed prediction
Add
BLAST
Topological domaini474 – 56592Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei566 – 58621Helical; Reviewed prediction
Add
BLAST
Topological domaini587 – 5904Extracellular Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 590590Multidrug and toxin extrusion protein 1
PRO_0000312850Add
BLAST

Proteomic databases

PRIDEiA1L1P9.

Expressioni

Gene expression databases

BgeeiA1L1P9.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000078672.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiA1L1P9.
KOiK03327.
OMAiKLAFNIN.
OrthoDBiEOG7RRF71.
PhylomeDBiA1L1P9.
TreeFamiTF324441.

Family and domain databases

InterProiIPR002528. MATE.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A1L1P9-1 [UniParc]FASTAAdd to Basket

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MDSITSYNVT QMNGDTKQEK CDDVLSTSST QKFCGGCRKK LRSLLPVNYK    50
TEIVELLKLA GPVFISQLMI FLISFVSTVF CGHLGKTELA GVALAIAVIN 100
VTGISIGSGL ASACDTLISQ TFGSNNLKRV GVILQRGILI LLLACFPCWA 150
LLINTEPILL AVRQSPNVAS LSQLYVKIFM PALPAAFMYQ LQGRYLQNQG 200
IIWPQVITGA AGNILNALIN YVFLHLLELG VAGSAAANTI SQYSLAVFLY 250
VYIRWKNLHK ATWDGWSRDC LQEWGAFIRL ALPSMLMLCV EWWTYEIGGF 300
LAGLISETEL GAQSVVYELA TIAYMFPLGF AVAASVRVGN ALGAGNTERA 350
KLSAKVALVC GVLVSCVVAT LIGCTKDVIA YIFTTEEEIV SRVSQVMIMY 400
GFFHLFDAIA GITGGIVRGA GKQLLGALCN IVGYYFVGFP TGVSLMFALS 450
MGIIGLWIGF FGCVFLQSLF FIILIYKLDW KKATQEALIR AGVQLTETKD 500
ESFGLENKGC TEEAAKESQI TEEGLTDANT DLEGLSKGGE GISEAGAKTT 550
VGAVLTTKQL IVRRGLAVLL MVLILAGGIV LNEMLVRYLR 590
Length:590
Mass (Da):63,759
Last modified:February 6, 2007 - v1
Checksum:i06362BFF041A6CB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC129166 mRNA. Translation: AAI29167.1.
RefSeqiNP_001073648.1. NM_001080179.1.
UniGeneiDr.87105.

Genome annotation databases

EnsembliENSDART00000084237; ENSDARP00000078672; ENSDARG00000060051.
GeneIDi560024.
KEGGidre:560024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC129166 mRNA. Translation: AAI29167.1 .
RefSeqi NP_001073648.1. NM_001080179.1.
UniGenei Dr.87105.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000078672.

Proteomic databases

PRIDEi A1L1P9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000084237 ; ENSDARP00000078672 ; ENSDARG00000060051 .
GeneIDi 560024.
KEGGi dre:560024.

Organism-specific databases

CTDi 146802.
ZFINi ZDB-GENE-070112-1472. slc47a2.

Phylogenomic databases

eggNOGi COG0534.
HOGENOMi HOG000060313.
HOVERGENi HBG056043.
InParanoidi A1L1P9.
KOi K03327.
OMAi KLAFNIN.
OrthoDBi EOG7RRF71.
PhylomeDBi A1L1P9.
TreeFami TF324441.

Miscellaneous databases

NextBioi 20883253.
PROi A1L1P9.

Gene expression databases

Bgeei A1L1P9.

Family and domain databases

InterProi IPR002528. MATE.
[Graphical view ]
Pfami PF01554. MatE. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00797. matE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiS47A1_DANRE
AccessioniPrimary (citable) accession number: A1L1P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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