Unreviewed, UniProtKB/TrEMBL A1L1M0 (A1L1M0_RAT)

Names and origin

Protein names

Submitted name:
    Protein kinase, cAMP-dependent, catalytic, alpha EMBL AAI29129.1

Gene names

Name:

Prkaca EMBL AAI29129.1

Organism

Rattus norvegicus (Rat) EMBL AAI29129.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. Spearmint SPM000961
Sequence similarities	Belongs to the protein kinase superfamily. Contains 1 AGC-kinase C-terminal domain.

Ontologies

Keywords
Ligand	ATP-binding Spearmint SPM000961 RuleBase RU000304V2 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Spearmint SPM000961 RuleBase RU000305V3 Transferase
Gene Ontology (GO)
Biological process	mesoderm formation Inferred from electronic annotation. Source: Compara negative regulation of meiotic cell cycle Inferred from direct assay. Source: RGD peptidyl-serine phosphorylation Inferred from direct assay. Source: RGD positive regulation of protein export from nucleus Inferred from electronic annotation. Source: Compara protein amino acid autophosphorylation Inferred from electronic annotation. Source: Compara regulation of cellular respiration Inferred from direct assay. Source: RGD regulation of synaptic transmission, glutamatergic Inferred from direct assay. Source: RGD
Cellular component	Golgi apparatus Inferred from direct assay. Source: RGD cAMP-dependent protein kinase complex Inferred from direct assay. Source: RGD membrane fraction Inferred from direct assay. Source: RGD mitochondrion Inferred from electronic annotation. Source: Compara neuromuscular junction Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay. Source: RGD perinuclear region of cytoplasm Inferred from direct assay. Source: RGD plasma membrane Inferred from electronic annotation. Source: Compara soluble fraction Inferred from direct assay. Source: RGD
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cAMP-dependent protein kinase activity Inferred from direct assay. Source: RGD protein complex binding Inferred from physical interaction. Source: RGD protein kinase A regulatory subunit binding Inferred by curator. Source: RGD protein kinase binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1L1M0-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 3065123824A47880	FASTA	351	40,606
	10 20 30 40 50 60 MGNAAAAKKG SEQESVKEFL AKAKEDFLKK WETPSQNTAQ LDHFDRIKTL GTGSFGRVML 70 80 90 100 110 120 VKHKESGNHY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVKLEFS FKDNSNLYMV 130 140 150 160 170 180 MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDQQGY 190 200 210 220 230 240 IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF 250 260 270 280 290 300 ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVN DIKNHKWFAT 310 320 330 340 350 TDWIAIYQRK VEAPFIPKFK GPGDTSNFDD YEEEEIRVSI NEKCGKEFTE F

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAI29129.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC129128 mRNA. Translation: AAI29129.1.
IPI	IPI00829427.
RefSeq	NP_001094392.1.
UniGene	Rn.20
3D structure databases
SMR	A1L1M0. Positions 13-351.
ModBase	Search...
Protein-protein interaction databases
STRING	A1L1M0.
Proteomic databases
PRIDE	A1L1M0.
Genome annotation databases
Ensembl	ENSRNOT00000041717; ENSRNOP00000044732; ENSRNOG00000005257; Rattus norvegicus. [Genome view]
GeneID	25636.
KEGG	rno:25636.
Organism-specific databases
CTD	25636.
Phylogenomic databases
eggNOG	maNOG17276.
HOVERGEN	A1L1M0.
OMA	GKEFTEF.
PhylomeDB	A1L1M0.
Gene expression databases
Genevestigator	A1L1M0.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	607455.

Entry information

Entry name

A1L1M0_RAT

Accession

Primary (citable) accession number: A1L1M0

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)