ID ZN426_RAT Reviewed; 553 AA. AC A1L1L7; DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot. DT 06-FEB-2007, sequence version 1. DT 27-MAR-2024, entry version 102. DE RecName: Full=Zinc finger protein 426; GN Name=Znf426; Synonyms=Zfp426; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] {ECO:0000312|EMBL:AAI29126.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis {ECO:0000312|EMBL:AAI29126.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC129125; AAI29126.1; -; mRNA. DR RefSeq; NP_001073412.1; NM_001079943.1. DR RefSeq; XP_006242728.1; XM_006242666.1. DR RefSeq; XP_006242729.1; XM_006242667.3. DR RefSeq; XP_006242730.1; XM_006242668.3. DR RefSeq; XP_006242732.1; XM_006242670.2. DR RefSeq; XP_008764203.1; XM_008765981.2. DR AlphaFoldDB; A1L1L7; -. DR SMR; A1L1L7; -. DR STRING; 10116.ENSRNOP00000069966; -. DR PhosphoSitePlus; A1L1L7; -. DR PaxDb; 10116-ENSRNOP00000038875; -. DR Ensembl; ENSRNOT00000117071.1; ENSRNOP00000084731.1; ENSRNOG00000033624.4. DR Ensembl; ENSRNOT00055021615; ENSRNOP00055017529; ENSRNOG00055012659. DR Ensembl; ENSRNOT00060046577; ENSRNOP00060038726; ENSRNOG00060026845. DR Ensembl; ENSRNOT00065019207; ENSRNOP00065014682; ENSRNOG00065011810. DR GeneID; 690895; -. DR KEGG; rno:690895; -. DR UCSC; RGD:1308643; rat. DR AGR; RGD:1590942; -. DR CTD; 235028; -. DR RGD; 1590942; Zfp426. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000163292; -. DR HOGENOM; CLU_002678_0_2_1; -. DR InParanoid; A1L1L7; -. DR OrthoDB; 4747146at2759; -. DR PhylomeDB; A1L1L7; -. DR TreeFam; TF342172; -. DR Reactome; R-RNO-212436; Generic Transcription Pathway. DR PRO; PR:A1L1L7; -. DR Proteomes; UP000002494; Chromosome 8. DR Bgee; ENSRNOG00000033624; Expressed in cerebellum and 20 other cell types or tissues. DR ExpressionAtlas; A1L1L7; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro. DR CDD; cd07765; KRAB_A-box; 1. DR Gene3D; 6.10.140.140; -; 1. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 11. DR InterPro; IPR001909; KRAB. DR InterPro; IPR036051; KRAB_dom_sf. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR24381; ZINC FINGER PROTEIN; 1. DR PANTHER; PTHR24381:SF426; ZINC FINGER PROTEIN 846; 1. DR Pfam; PF01352; KRAB; 1. DR Pfam; PF00096; zf-C2H2; 9. DR Pfam; PF13465; zf-H2C2_2; 1. DR SMART; SM00349; KRAB; 1. DR SMART; SM00355; ZnF_C2H2; 11. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7. DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1. DR PROSITE; PS50805; KRAB; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11. DR Genevisible; A1L1L7; RN. PE 2: Evidence at transcript level; KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; KW Transcription; Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1..553 FT /note="Zinc finger protein 426" FT /id="PRO_0000284701" FT DOMAIN 40..111 FT /note="KRAB" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119" FT ZN_FING 222..244 FT /note="C2H2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 277..299 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 305..327 FT /note="C2H2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 333..355 FT /note="C2H2-type 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 361..383 FT /note="C2H2-type 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 389..411 FT /note="C2H2-type 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 417..439 FT /note="C2H2-type 7" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 445..467 FT /note="C2H2-type 8" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 473..495 FT /note="C2H2-type 9" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 501..525 FT /note="C2H2-type 10" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 531..553 FT /note="C2H2-type 11" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" SQ SEQUENCE 553 AA; 63005 MW; 358C5C0EFB5BA73C CRC64; MAAPDSLSHG PSGDSVCLQE EKVSAEMMLV DCLTNYQELV SFDDVIVDFT QEEWTSLNPD QRTLYREVML ENYKNLATVG YQLIKPSVIS WLEQEEFSTG QKIVFPEWKI QLETQCSASQ QELLRGNISN GMQTQTGSDT GRGLCDGTQY GDFFSELSPL RTVMKTRPAQ DNYDSSQCRK DFLMLQRKKC AGEKLSEFNQ SEETGAIPGK AYQKMATQEK CFECSDCGKS FMNQSHLQTH QRTHSGDKLY ELNECGRSFI NSRLAVLIET LNAKKPHRCK ECGKGYRYPA YLNIHMRTHT GEKPYECKEC GKAFNYSNSF QIHGRTHTGE KPYVCNQCGK AFTQHSGLSI HVRSHNGDKP YACKECGKAF LTSSRLIQHI RTHTGEKPFV CVKCGKAFAI SSNLNGHLKM HAEEKTCECK ICGKAFGYLS CLNNHMRTHN AKKSYTCKEC GKAFNYSTHL KIHMRIHTGE KPYECKQCGK AFSHSTSFQI HERTHTGEKP YECKECGKAF ICPSSFRIHE ISHTHTEEKP YKCQQCGKAY SHPRSLRRHE RIH //