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A1L1L7 (ZN426_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Zinc finger protein 426
Gene names
Name:Znf426
Synonyms:Zfp426
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 11 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Zinc finger protein 426
PRO_0000284701

Regions

Domain40 – 11172KRAB
Zinc finger222 – 24423C2H2-type 1
Zinc finger277 – 29923C2H2-type 2
Zinc finger305 – 32723C2H2-type 3
Zinc finger333 – 35523C2H2-type 4
Zinc finger361 – 38323C2H2-type 5
Zinc finger389 – 41123C2H2-type 6
Zinc finger417 – 43923C2H2-type 7
Zinc finger445 – 46723C2H2-type 8
Zinc finger473 – 49523C2H2-type 9
Zinc finger501 – 52525C2H2-type 10
Zinc finger531 – 55323C2H2-type 11

Sequences

Sequence LengthMass (Da)Tools
A1L1L7 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 358C5C0EFB5BA73C

FASTA55363,005
        10         20         30         40         50         60 
MAAPDSLSHG PSGDSVCLQE EKVSAEMMLV DCLTNYQELV SFDDVIVDFT QEEWTSLNPD 

        70         80         90        100        110        120 
QRTLYREVML ENYKNLATVG YQLIKPSVIS WLEQEEFSTG QKIVFPEWKI QLETQCSASQ 

       130        140        150        160        170        180 
QELLRGNISN GMQTQTGSDT GRGLCDGTQY GDFFSELSPL RTVMKTRPAQ DNYDSSQCRK 

       190        200        210        220        230        240 
DFLMLQRKKC AGEKLSEFNQ SEETGAIPGK AYQKMATQEK CFECSDCGKS FMNQSHLQTH 

       250        260        270        280        290        300 
QRTHSGDKLY ELNECGRSFI NSRLAVLIET LNAKKPHRCK ECGKGYRYPA YLNIHMRTHT 

       310        320        330        340        350        360 
GEKPYECKEC GKAFNYSNSF QIHGRTHTGE KPYVCNQCGK AFTQHSGLSI HVRSHNGDKP 

       370        380        390        400        410        420 
YACKECGKAF LTSSRLIQHI RTHTGEKPFV CVKCGKAFAI SSNLNGHLKM HAEEKTCECK 

       430        440        450        460        470        480 
ICGKAFGYLS CLNNHMRTHN AKKSYTCKEC GKAFNYSTHL KIHMRIHTGE KPYECKQCGK 

       490        500        510        520        530        540 
AFSHSTSFQI HERTHTGEKP YECKECGKAF ICPSSFRIHE ISHTHTEEKP YKCQQCGKAY 

       550 
SHPRSLRRHE RIH

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC129125 mRNA. Translation: AAI29126.1.
IPIIPI00565610.
RefSeqNP_001073412.1. NM_001079943.1.
UniGeneRn.120278.

3D structure databases

ProteinModelPortalA1L1L7.
SMRA1L1L7. Positions 302-384.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000038875.

Proteomic databases

PaxDbA1L1L7.
PRIDEA1L1L7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000038069; ENSRNOP00000038875; ENSRNOG00000033624.
GeneID690895.
KEGGrno:690895.
UCSCRGD:1308643. rat.

Organism-specific databases

CTD235028.
RGD1308643. Zfp426.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00530000063830.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidA1L1L7.
KOK09228.
OrthoDBEOG4K6G3T.

Gene expression databases

GenevestigatorA1L1L7.

Family and domain databases

Gene3D3.30.160.60. 12 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMSSF109640. Krueppel-associated_box. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio741910.

Entry information

Entry nameZN426_RAT
AccessionPrimary (citable) accession number: A1L1L7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 6, 2007
Last modified: April 3, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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