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A1L1L7

- ZN426_RAT

UniProt

A1L1L7 - ZN426_RAT

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Protein

Zinc finger protein 426

Gene
Znf426, Zfp426
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 24423C2H2-type 1Add
BLAST
Zinc fingeri277 – 29923C2H2-type 2Add
BLAST
Zinc fingeri305 – 32723C2H2-type 3Add
BLAST
Zinc fingeri333 – 35523C2H2-type 4Add
BLAST
Zinc fingeri361 – 38323C2H2-type 5Add
BLAST
Zinc fingeri389 – 41123C2H2-type 6Add
BLAST
Zinc fingeri417 – 43923C2H2-type 7Add
BLAST
Zinc fingeri445 – 46723C2H2-type 8Add
BLAST
Zinc fingeri473 – 49523C2H2-type 9Add
BLAST
Zinc fingeri501 – 52525C2H2-type 10Add
BLAST
Zinc fingeri531 – 55323C2H2-type 11Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 426
Gene namesi
Name:Znf426
Synonyms:Zfp426
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi1308643. Zfp426.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Zinc finger protein 426PRO_0000284701Add
BLAST

Proteomic databases

PaxDbiA1L1L7.
PRIDEiA1L1L7.

Expressioni

Gene expression databases

GenevestigatoriA1L1L7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038875.

Structurei

3D structure databases

ProteinModelPortaliA1L1L7.
SMRiA1L1L7. Positions 302-384.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 11172KRABAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA1L1L7.
KOiK09228.
OMAiAFNYSTH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiA1L1L7.
TreeFamiTF342172.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L1L7-1 [UniParc]FASTAAdd to Basket

« Hide

MAAPDSLSHG PSGDSVCLQE EKVSAEMMLV DCLTNYQELV SFDDVIVDFT    50
QEEWTSLNPD QRTLYREVML ENYKNLATVG YQLIKPSVIS WLEQEEFSTG 100
QKIVFPEWKI QLETQCSASQ QELLRGNISN GMQTQTGSDT GRGLCDGTQY 150
GDFFSELSPL RTVMKTRPAQ DNYDSSQCRK DFLMLQRKKC AGEKLSEFNQ 200
SEETGAIPGK AYQKMATQEK CFECSDCGKS FMNQSHLQTH QRTHSGDKLY 250
ELNECGRSFI NSRLAVLIET LNAKKPHRCK ECGKGYRYPA YLNIHMRTHT 300
GEKPYECKEC GKAFNYSNSF QIHGRTHTGE KPYVCNQCGK AFTQHSGLSI 350
HVRSHNGDKP YACKECGKAF LTSSRLIQHI RTHTGEKPFV CVKCGKAFAI 400
SSNLNGHLKM HAEEKTCECK ICGKAFGYLS CLNNHMRTHN AKKSYTCKEC 450
GKAFNYSTHL KIHMRIHTGE KPYECKQCGK AFSHSTSFQI HERTHTGEKP 500
YECKECGKAF ICPSSFRIHE ISHTHTEEKP YKCQQCGKAY SHPRSLRRHE 550
RIH 553
Length:553
Mass (Da):63,005
Last modified:February 6, 2007 - v1
Checksum:i358C5C0EFB5BA73C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC129125 mRNA. Translation: AAI29126.1.
RefSeqiNP_001073412.1. NM_001079943.1.
XP_006242728.1. XM_006242666.1.
XP_006242729.1. XM_006242667.1.
XP_006242730.1. XM_006242668.1.
XP_006242731.1. XM_006242669.1.
XP_006242732.1. XM_006242670.1.
UniGeneiRn.120278.

Genome annotation databases

EnsembliENSRNOT00000038069; ENSRNOP00000038875; ENSRNOG00000033624.
GeneIDi690895.
KEGGirno:690895.
UCSCiRGD:1308643. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC129125 mRNA. Translation: AAI29126.1 .
RefSeqi NP_001073412.1. NM_001079943.1.
XP_006242728.1. XM_006242666.1.
XP_006242729.1. XM_006242667.1.
XP_006242730.1. XM_006242668.1.
XP_006242731.1. XM_006242669.1.
XP_006242732.1. XM_006242670.1.
UniGenei Rn.120278.

3D structure databases

ProteinModelPortali A1L1L7.
SMRi A1L1L7. Positions 302-384.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000038875.

Proteomic databases

PaxDbi A1L1L7.
PRIDEi A1L1L7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000038069 ; ENSRNOP00000038875 ; ENSRNOG00000033624 .
GeneIDi 690895.
KEGGi rno:690895.
UCSCi RGD:1308643. rat.

Organism-specific databases

CTDi 235028.
RGDi 1308643. Zfp426.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00530000063830.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi A1L1L7.
KOi K09228.
OMAi AFNYSTH.
OrthoDBi EOG7KSX7Q.
PhylomeDBi A1L1L7.
TreeFami TF342172.

Miscellaneous databases

NextBioi 741910.

Gene expression databases

Genevestigatori A1L1L7.

Family and domain databases

Gene3Di 3.30.160.60. 12 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN426_RAT
AccessioniPrimary (citable) accession number: A1L1L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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