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A1L1L7

- ZN426_RAT

UniProt

A1L1L7 - ZN426_RAT

Protein

Zinc finger protein 426

Gene

Znf426

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.Curated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri222 – 24423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri277 – 29923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri305 – 32723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 35523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri361 – 38323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri389 – 41123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri417 – 43923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri445 – 46723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri473 – 49523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri501 – 52525C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri531 – 55323C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 426
    Gene namesi
    Name:Znf426
    Synonyms:Zfp426
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi1308643. Zfp426.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Zinc finger protein 426PRO_0000284701Add
    BLAST

    Proteomic databases

    PaxDbiA1L1L7.
    PRIDEiA1L1L7.

    Expressioni

    Gene expression databases

    GenevestigatoriA1L1L7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000038875.

    Structurei

    3D structure databases

    ProteinModelPortaliA1L1L7.
    SMRiA1L1L7. Positions 302-384.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 11172KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri222 – 24423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri277 – 29923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri305 – 32723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 35523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri361 – 38323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri389 – 41123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri417 – 43923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri445 – 46723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri473 – 49523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri501 – 52525C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri531 – 55323C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00530000063830.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiA1L1L7.
    KOiK09228.
    OMAiAFNYSTH.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiA1L1L7.
    TreeFamiTF342172.

    Family and domain databases

    Gene3Di3.30.160.60. 12 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 11 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 11 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1L1L7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPDSLSHG PSGDSVCLQE EKVSAEMMLV DCLTNYQELV SFDDVIVDFT    50
    QEEWTSLNPD QRTLYREVML ENYKNLATVG YQLIKPSVIS WLEQEEFSTG 100
    QKIVFPEWKI QLETQCSASQ QELLRGNISN GMQTQTGSDT GRGLCDGTQY 150
    GDFFSELSPL RTVMKTRPAQ DNYDSSQCRK DFLMLQRKKC AGEKLSEFNQ 200
    SEETGAIPGK AYQKMATQEK CFECSDCGKS FMNQSHLQTH QRTHSGDKLY 250
    ELNECGRSFI NSRLAVLIET LNAKKPHRCK ECGKGYRYPA YLNIHMRTHT 300
    GEKPYECKEC GKAFNYSNSF QIHGRTHTGE KPYVCNQCGK AFTQHSGLSI 350
    HVRSHNGDKP YACKECGKAF LTSSRLIQHI RTHTGEKPFV CVKCGKAFAI 400
    SSNLNGHLKM HAEEKTCECK ICGKAFGYLS CLNNHMRTHN AKKSYTCKEC 450
    GKAFNYSTHL KIHMRIHTGE KPYECKQCGK AFSHSTSFQI HERTHTGEKP 500
    YECKECGKAF ICPSSFRIHE ISHTHTEEKP YKCQQCGKAY SHPRSLRRHE 550
    RIH 553
    Length:553
    Mass (Da):63,005
    Last modified:February 6, 2007 - v1
    Checksum:i358C5C0EFB5BA73C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129125 mRNA. Translation: AAI29126.1.
    RefSeqiNP_001073412.1. NM_001079943.1.
    XP_006242728.1. XM_006242666.1.
    XP_006242729.1. XM_006242667.1.
    XP_006242730.1. XM_006242668.1.
    XP_006242731.1. XM_006242669.1.
    XP_006242732.1. XM_006242670.1.
    UniGeneiRn.120278.

    Genome annotation databases

    EnsembliENSRNOT00000038069; ENSRNOP00000038875; ENSRNOG00000033624.
    GeneIDi690895.
    KEGGirno:690895.
    UCSCiRGD:1308643. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129125 mRNA. Translation: AAI29126.1 .
    RefSeqi NP_001073412.1. NM_001079943.1.
    XP_006242728.1. XM_006242666.1.
    XP_006242729.1. XM_006242667.1.
    XP_006242730.1. XM_006242668.1.
    XP_006242731.1. XM_006242669.1.
    XP_006242732.1. XM_006242670.1.
    UniGenei Rn.120278.

    3D structure databases

    ProteinModelPortali A1L1L7.
    SMRi A1L1L7. Positions 302-384.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000038875.

    Proteomic databases

    PaxDbi A1L1L7.
    PRIDEi A1L1L7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000038069 ; ENSRNOP00000038875 ; ENSRNOG00000033624 .
    GeneIDi 690895.
    KEGGi rno:690895.
    UCSCi RGD:1308643. rat.

    Organism-specific databases

    CTDi 235028.
    RGDi 1308643. Zfp426.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00530000063830.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi A1L1L7.
    KOi K09228.
    OMAi AFNYSTH.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi A1L1L7.
    TreeFami TF342172.

    Miscellaneous databases

    NextBioi 741910.

    Gene expression databases

    Genevestigatori A1L1L7.

    Family and domain databases

    Gene3Di 3.30.160.60. 12 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 11 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 11 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TestisImported.

    Entry informationi

    Entry nameiZN426_RAT
    AccessioniPrimary (citable) accession number: A1L1L7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3