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A1L1L3 (PTN20_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 20

EC=3.1.3.48
Gene names
Name:Ptpn20
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Note: Colocalizes with the microtubule-organizing center and intracellular membrane compartments By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
Nucleus
   Molecular functionHydrolase
Protein phosphatase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Tyrosine-protein phosphatase non-receptor type 20
PRO_0000295757

Regions

Domain160 – 413254Tyrosine-protein phosphatase
Region354 – 3607Substrate binding By similarity

Sites

Active site3541Phosphocysteine intermediate By similarity
Binding site3241Substrate By similarity
Binding site3981Substrate By similarity

Amino acid modifications

Modified residue1221Phosphoserine Ref.2

Sequences

Sequence LengthMass (Da)Tools
A1L1L3 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: E908283346F8C0B6

FASTA42148,580
        10         20         30         40         50         60 
MSSPGNVRQK HGRDNDEHEG DSDDLNLQKS LPSSSQQKTP TKPVFGNKVN SESVKTSHHM 

        70         80         90        100        110        120 
SFSNKYDLVF PEPVESDNDE TLWDVRDLSH RNRWSSVDPE SAGPSKTVST VLSESSTDTA 

       130        140        150        160        170        180 
VSERELTQLA QIRPLIFNSS SRAALRDCLK ALQKKEELDI IREFLELEEM IPPDDFKSGY 

       190        200        210        220        230        240 
ELQNRDKNRY RDILPYDSTR VPLGKNKDYI NASYIRIVNH EEEYFYIATQ GPLPDTIEDF 

       250        260        270        280        290        300 
WQMVLENNCN VIAMITREIE GGVIKCCSYW PVSLKEPLEF KHFHVLLENF QITQYFVIRI 

       310        320        330        340        350        360 
FQIVKKSTGK SHSVKHLQFI KWPDHGTPAS ADFFIKYVRY VRKSHITGPL LVHCSAGVGR 

       370        380        390        400        410        420 
TGVFICVDVV FCTIEKNYSF NIMNIVTQMR KQRFGMIQTK EQYQFCYEIV LEVLQNLLAL 


N 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC129117 mRNA. Translation: AAI29118.1.
RefSeqNP_001073618.1. NM_001080149.1.
XP_006252827.1. XM_006252765.1.
XP_006252828.1. XM_006252766.1.
XP_006252829.1. XM_006252767.1.
XP_006252830.1. XM_006252768.1.
UniGeneRn.128630.

3D structure databases

ProteinModelPortalA1L1L3.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA1L1L3.

Proteomic databases

PRIDEA1L1L3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000027352; ENSRNOP00000027352; ENSRNOG00000020203.
GeneID306281.
KEGGrno:306281.
UCSCRGD:1309812. rat.

Organism-specific databases

CTD26095.
RGD1309812. Ptpn20.

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00750000117233.
HOGENOMHOG000243992.
HOVERGENHBG095763.
InParanoidA1L1L3.
KOK18039.
OMAFCAIVKN.
OrthoDBEOG7K9K22.
PhylomeDBA1L1L3.
TreeFamTF315573.

Gene expression databases

GenevestigatorA1L1L3.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio655789.

Entry information

Entry namePTN20_RAT
AccessionPrimary (citable) accession number: A1L1L3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: February 6, 2007
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families