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A1L1L3

- PTN20_RAT

UniProt

A1L1L3 - PTN20_RAT

Protein

Tyrosine-protein phosphatase non-receptor type 20

Gene

Ptpn20

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei324 – 3241SubstrateBy similarity
    Active sitei354 – 3541Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei398 – 3981SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 20 (EC:3.1.3.48)
    Gene namesi
    Name:Ptpn20
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 16

    Organism-specific databases

    RGDi1309812. Ptpn20.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
    Note: Colocalizes with the microtubule-organizing center and intracellular membrane compartments.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. microtubule Source: UniProtKB-KW
    3. microtubule organizing center Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 421421Tyrosine-protein phosphatase non-receptor type 20PRO_0000295757Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei122 – 1221Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiA1L1L3.

    PTM databases

    PhosphoSiteiA1L1L3.

    Expressioni

    Gene expression databases

    GenevestigatoriA1L1L3.

    Structurei

    3D structure databases

    ProteinModelPortaliA1L1L3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini160 – 413254Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni354 – 3607Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117233.
    HOGENOMiHOG000243992.
    HOVERGENiHBG095763.
    InParanoidiA1L1L3.
    KOiK18039.
    OMAiFCAIVKN.
    OrthoDBiEOG7K9K22.
    PhylomeDBiA1L1L3.
    TreeFamiTF315573.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1L1L3-1 [UniParc]FASTAAdd to Basket

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    MSSPGNVRQK HGRDNDEHEG DSDDLNLQKS LPSSSQQKTP TKPVFGNKVN    50
    SESVKTSHHM SFSNKYDLVF PEPVESDNDE TLWDVRDLSH RNRWSSVDPE 100
    SAGPSKTVST VLSESSTDTA VSERELTQLA QIRPLIFNSS SRAALRDCLK 150
    ALQKKEELDI IREFLELEEM IPPDDFKSGY ELQNRDKNRY RDILPYDSTR 200
    VPLGKNKDYI NASYIRIVNH EEEYFYIATQ GPLPDTIEDF WQMVLENNCN 250
    VIAMITREIE GGVIKCCSYW PVSLKEPLEF KHFHVLLENF QITQYFVIRI 300
    FQIVKKSTGK SHSVKHLQFI KWPDHGTPAS ADFFIKYVRY VRKSHITGPL 350
    LVHCSAGVGR TGVFICVDVV FCTIEKNYSF NIMNIVTQMR KQRFGMIQTK 400
    EQYQFCYEIV LEVLQNLLAL N 421
    Length:421
    Mass (Da):48,580
    Last modified:February 6, 2007 - v1
    Checksum:iE908283346F8C0B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129117 mRNA. Translation: AAI29118.1.
    RefSeqiNP_001073618.1. NM_001080149.1.
    XP_006252827.1. XM_006252765.1.
    XP_006252828.1. XM_006252766.1.
    XP_006252829.1. XM_006252767.1.
    XP_006252830.1. XM_006252768.1.
    UniGeneiRn.128630.

    Genome annotation databases

    EnsembliENSRNOT00000027352; ENSRNOP00000027352; ENSRNOG00000020203.
    GeneIDi306281.
    KEGGirno:306281.
    UCSCiRGD:1309812. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129117 mRNA. Translation: AAI29118.1 .
    RefSeqi NP_001073618.1. NM_001080149.1.
    XP_006252827.1. XM_006252765.1.
    XP_006252828.1. XM_006252766.1.
    XP_006252829.1. XM_006252767.1.
    XP_006252830.1. XM_006252768.1.
    UniGenei Rn.128630.

    3D structure databases

    ProteinModelPortali A1L1L3.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A1L1L3.

    Proteomic databases

    PRIDEi A1L1L3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000027352 ; ENSRNOP00000027352 ; ENSRNOG00000020203 .
    GeneIDi 306281.
    KEGGi rno:306281.
    UCSCi RGD:1309812. rat.

    Organism-specific databases

    CTDi 26095.
    RGDi 1309812. Ptpn20.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117233.
    HOGENOMi HOG000243992.
    HOVERGENi HBG095763.
    InParanoidi A1L1L3.
    KOi K18039.
    OMAi FCAIVKN.
    OrthoDBi EOG7K9K22.
    PhylomeDBi A1L1L3.
    TreeFami TF315573.

    Miscellaneous databases

    NextBioi 655789.

    Gene expression databases

    Genevestigatori A1L1L3.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPTN20_RAT
    AccessioniPrimary (citable) accession number: A1L1L3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3