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Protein

Tyrosine-protein phosphatase non-receptor type 20

Gene

Ptpn20

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei324 – 3241SubstrateBy similarity
Active sitei354 – 3541Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei398 – 3981SubstrateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 20 (EC:3.1.3.48)
Gene namesi
Name:Ptpn20
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1309812. Ptpn20.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Tyrosine-protein phosphatase non-receptor type 20PRO_0000295757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei122 – 1221Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA1L1L3.

PTM databases

PhosphoSiteiA1L1L3.

Expressioni

Gene expression databases

GenevestigatoriA1L1L3.

Structurei

3D structure databases

ProteinModelPortaliA1L1L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini160 – 413254Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni354 – 3607Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00780000121879.
HOGENOMiHOG000243992.
HOVERGENiHBG095763.
InParanoidiA1L1L3.
KOiK18039.
OMAiAMITREI.
OrthoDBiEOG7K9K22.
PhylomeDBiA1L1L3.
TreeFamiTF315573.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L1L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPGNVRQK HGRDNDEHEG DSDDLNLQKS LPSSSQQKTP TKPVFGNKVN
60 70 80 90 100
SESVKTSHHM SFSNKYDLVF PEPVESDNDE TLWDVRDLSH RNRWSSVDPE
110 120 130 140 150
SAGPSKTVST VLSESSTDTA VSERELTQLA QIRPLIFNSS SRAALRDCLK
160 170 180 190 200
ALQKKEELDI IREFLELEEM IPPDDFKSGY ELQNRDKNRY RDILPYDSTR
210 220 230 240 250
VPLGKNKDYI NASYIRIVNH EEEYFYIATQ GPLPDTIEDF WQMVLENNCN
260 270 280 290 300
VIAMITREIE GGVIKCCSYW PVSLKEPLEF KHFHVLLENF QITQYFVIRI
310 320 330 340 350
FQIVKKSTGK SHSVKHLQFI KWPDHGTPAS ADFFIKYVRY VRKSHITGPL
360 370 380 390 400
LVHCSAGVGR TGVFICVDVV FCTIEKNYSF NIMNIVTQMR KQRFGMIQTK
410 420
EQYQFCYEIV LEVLQNLLAL N
Length:421
Mass (Da):48,580
Last modified:February 6, 2007 - v1
Checksum:iE908283346F8C0B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129117 mRNA. Translation: AAI29118.1.
RefSeqiNP_001073618.1. NM_001080149.1.
XP_006252827.1. XM_006252765.2.
XP_006252829.1. XM_006252767.2.
XP_008769321.1. XM_008771099.1.
UniGeneiRn.128630.

Genome annotation databases

EnsembliENSRNOT00000027352; ENSRNOP00000027352; ENSRNOG00000020203.
GeneIDi306281.
KEGGirno:306281.
UCSCiRGD:1309812. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129117 mRNA. Translation: AAI29118.1.
RefSeqiNP_001073618.1. NM_001080149.1.
XP_006252827.1. XM_006252765.2.
XP_006252829.1. XM_006252767.2.
XP_008769321.1. XM_008771099.1.
UniGeneiRn.128630.

3D structure databases

ProteinModelPortaliA1L1L3.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA1L1L3.

Proteomic databases

PRIDEiA1L1L3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027352; ENSRNOP00000027352; ENSRNOG00000020203.
GeneIDi306281.
KEGGirno:306281.
UCSCiRGD:1309812. rat.

Organism-specific databases

CTDi26095.
RGDi1309812. Ptpn20.

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00780000121879.
HOGENOMiHOG000243992.
HOVERGENiHBG095763.
InParanoidiA1L1L3.
KOiK18039.
OMAiAMITREI.
OrthoDBiEOG7K9K22.
PhylomeDBiA1L1L3.
TreeFamiTF315573.

Miscellaneous databases

NextBioi655789.
PROiA1L1L3.

Gene expression databases

GenevestigatoriA1L1L3.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTN20_RAT
AccessioniPrimary (citable) accession number: A1L1L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: February 6, 2007
Last modified: April 29, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.