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A1L1K7 (ACBG2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2

EC=6.2.1.3
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Gene names
Name:Acsbg2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length667 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Subcellular location

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 667667Long-chain-fatty-acid--CoA ligase ACSBG2
PRO_0000315814

Regions

Nucleotide binding227 – 2359ATP By similarity
Nucleotide binding418 – 4236ATP By similarity

Sites

Binding site4961ATP By similarity
Binding site5111ATP By similarity
Binding site6241ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1L1K7 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: CE929821D95D6700

FASTA66774,266
        10         20         30         40         50         60 
MTQEKKAEDP DRGMDTTSAA PRLWSTHCDG EVLLRLSKHG PGHETPMTIP ELFQESVERF 

        70         80         90        100        110        120 
GAYPALASKN GKKWDTLTFS QYYDVCRKAA RSLIKLGLQR FHGVGILGFN SVEWVVAALG 

       130        140        150        160        170        180 
AILAGGLCVG IYATNSAEAC QYVIKQANVN VLIVENDQQL QKILSIPPDK METVKAIVQY 

       190        200        210        220        230        240 
RLPLMENSTN LYSWQDFMEL GNAIPNIQLD RVILSQKANQ CAVIIYTSGT TGSPKGVMLS 

       250        260        270        280        290        300 
HDNITWTAGA MAREIELIHV SGKQDTIVSY LPLSHIAAQL MDIWIPIKVG VLTFFAQPDA 

       310        320        330        340        350        360 
LRGTLVYTLQ EVKPTYFLGV PRVWEKMQDT IKENVAKSSN LRKKAFAWAK MLGLKVNTKK 

       370        380        390        400        410        420 
MLGKRDIPMN YRMAKALVFT KVRTSLGLDN CHTFFSGASP LSQDVSEFFL SLDIPIGEIY 

       430        440        450        460        470        480 
GMTECSGPHT VSCKSIYRVL SCGKVLNGCK NMLYKQNKDG VGEVCMWGRH VFMGYLGKED 

       490        500        510        520        530        540 
ATLEVLDEDG WLHSGDIGRL DSHDFLYITG RIKEVLITAG GENIWPIPIE TLVKEKIPII 

       550        560        570        580        590        600 
SHAMLVGDKA KFLSMLLTLK CETDQMSGEP LDKLNLEAIS FCQMLGSQAV TVSDILKIRD 

       610        620        630        640        650        660 
PVVYTAIQYG IDIVNQQAVS DSHRIRKWII LEKDFSIQGG ELGPTSKLKR DLITQKYKAQ 


IDNMYSS 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC129110 mRNA. Translation: AAI29111.1.
RefSeqNP_001073565.1. NM_001080096.1.
UniGeneRn.109833.

3D structure databases

ProteinModelPortalA1L1K7.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA1L1K7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000074555; ENSRNOP00000066937; ENSRNOG00000045947.
GeneID301120.
KEGGrno:301120.

Organism-specific databases

CTD81616.
RGD1588580. Acsbg2.

Phylogenomic databases

GeneTreeENSGT00690000101725.
HOVERGENHBG054660.
KOK15013.
OMAIWEKMHE.
OrthoDBEOG7B5WVB.
PhylomeDBA1L1K7.

Gene expression databases

GenevestigatorA1L1K7.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio648177.
PROA1L1K7.

Entry information

Entry nameACBG2_RAT
AccessionPrimary (citable) accession number: A1L1K7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families