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A1L1K7

- ACBG2_RAT

UniProt

A1L1K7 - ACBG2_RAT

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Protein

Long-chain-fatty-acid--CoA ligase ACSBG2

Gene

Acsbg2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis By similarity.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei496 – 4961ATPBy similarity
Binding sitei511 – 5111ATPBy similarity
Binding sitei624 – 6241ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi227 – 2359ATPBy similarity
Nucleotide bindingi418 – 4236ATPBy similarity

GO - Molecular functioni

  1. acyl-CoA hydrolase activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ligase

Keywords - Biological processi

Differentiation, Fatty acid metabolism, Lipid metabolism, Spermatogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Gene namesi
Name:Acsbg2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1588580. Acsbg2.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. membrane Source: UniProtKB-KW
  3. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 667667Long-chain-fatty-acid--CoA ligase ACSBG2PRO_0000315814Add
BLAST

Proteomic databases

PRIDEiA1L1K7.

Expressioni

Gene expression databases

ExpressionAtlasiA1L1K7. baseline.
GenevestigatoriA1L1K7.

Structurei

3D structure databases

ProteinModelPortaliA1L1K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00690000101725.
HOVERGENiHBG054660.
InParanoidiA1L1K7.
KOiK15013.
OMAiIWEKMHE.
OrthoDBiEOG7B5WVB.
PhylomeDBiA1L1K7.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L1K7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQEKKAEDP DRGMDTTSAA PRLWSTHCDG EVLLRLSKHG PGHETPMTIP
60 70 80 90 100
ELFQESVERF GAYPALASKN GKKWDTLTFS QYYDVCRKAA RSLIKLGLQR
110 120 130 140 150
FHGVGILGFN SVEWVVAALG AILAGGLCVG IYATNSAEAC QYVIKQANVN
160 170 180 190 200
VLIVENDQQL QKILSIPPDK METVKAIVQY RLPLMENSTN LYSWQDFMEL
210 220 230 240 250
GNAIPNIQLD RVILSQKANQ CAVIIYTSGT TGSPKGVMLS HDNITWTAGA
260 270 280 290 300
MAREIELIHV SGKQDTIVSY LPLSHIAAQL MDIWIPIKVG VLTFFAQPDA
310 320 330 340 350
LRGTLVYTLQ EVKPTYFLGV PRVWEKMQDT IKENVAKSSN LRKKAFAWAK
360 370 380 390 400
MLGLKVNTKK MLGKRDIPMN YRMAKALVFT KVRTSLGLDN CHTFFSGASP
410 420 430 440 450
LSQDVSEFFL SLDIPIGEIY GMTECSGPHT VSCKSIYRVL SCGKVLNGCK
460 470 480 490 500
NMLYKQNKDG VGEVCMWGRH VFMGYLGKED ATLEVLDEDG WLHSGDIGRL
510 520 530 540 550
DSHDFLYITG RIKEVLITAG GENIWPIPIE TLVKEKIPII SHAMLVGDKA
560 570 580 590 600
KFLSMLLTLK CETDQMSGEP LDKLNLEAIS FCQMLGSQAV TVSDILKIRD
610 620 630 640 650
PVVYTAIQYG IDIVNQQAVS DSHRIRKWII LEKDFSIQGG ELGPTSKLKR
660
DLITQKYKAQ IDNMYSS
Length:667
Mass (Da):74,266
Last modified:February 6, 2007 - v1
Checksum:iCE929821D95D6700
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC129110 mRNA. Translation: AAI29111.1.
RefSeqiNP_001073565.1. NM_001080096.1.
UniGeneiRn.109833.

Genome annotation databases

EnsembliENSRNOT00000074555; ENSRNOP00000066937; ENSRNOG00000045947.
GeneIDi301120.
KEGGirno:301120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC129110 mRNA. Translation: AAI29111.1 .
RefSeqi NP_001073565.1. NM_001080096.1.
UniGenei Rn.109833.

3D structure databases

ProteinModelPortali A1L1K7.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A1L1K7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000074555 ; ENSRNOP00000066937 ; ENSRNOG00000045947 .
GeneIDi 301120.
KEGGi rno:301120.

Organism-specific databases

CTDi 81616.
RGDi 1588580. Acsbg2.

Phylogenomic databases

GeneTreei ENSGT00690000101725.
HOVERGENi HBG054660.
InParanoidi A1L1K7.
KOi K15013.
OMAi IWEKMHE.
OrthoDBi EOG7B5WVB.
PhylomeDBi A1L1K7.

Miscellaneous databases

NextBioi 648177.
PROi A1L1K7.

Gene expression databases

ExpressionAtlasi A1L1K7. baseline.
Genevestigatori A1L1K7.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiACBG2_RAT
AccessioniPrimary (citable) accession number: A1L1K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3