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A1L1K7

- ACBG2_RAT

UniProt

A1L1K7 - ACBG2_RAT

Protein

Long-chain-fatty-acid--CoA ligase ACSBG2

Gene

Acsbg2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis By similarity.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei496 – 4961ATPBy similarity
    Binding sitei511 – 5111ATPBy similarity
    Binding sitei624 – 6241ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi227 – 2359ATPBy similarity
    Nucleotide bindingi418 – 4236ATPBy similarity

    GO - Molecular functioni

    1. acyl-CoA hydrolase activity Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Ligase

    Keywords - Biological processi

    Differentiation, Fatty acid metabolism, Lipid metabolism, Spermatogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
    Alternative name(s):
    Acyl-CoA synthetase bubblegum family member 2
    Gene namesi
    Name:Acsbg2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi1588580. Acsbg2.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 667667Long-chain-fatty-acid--CoA ligase ACSBG2PRO_0000315814Add
    BLAST

    Proteomic databases

    PRIDEiA1L1K7.

    Expressioni

    Gene expression databases

    GenevestigatoriA1L1K7.

    Structurei

    3D structure databases

    ProteinModelPortaliA1L1K7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00690000101725.
    HOVERGENiHBG054660.
    KOiK15013.
    OMAiIWEKMHE.
    OrthoDBiEOG7B5WVB.
    PhylomeDBiA1L1K7.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1L1K7-1 [UniParc]FASTAAdd to Basket

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    MTQEKKAEDP DRGMDTTSAA PRLWSTHCDG EVLLRLSKHG PGHETPMTIP    50
    ELFQESVERF GAYPALASKN GKKWDTLTFS QYYDVCRKAA RSLIKLGLQR 100
    FHGVGILGFN SVEWVVAALG AILAGGLCVG IYATNSAEAC QYVIKQANVN 150
    VLIVENDQQL QKILSIPPDK METVKAIVQY RLPLMENSTN LYSWQDFMEL 200
    GNAIPNIQLD RVILSQKANQ CAVIIYTSGT TGSPKGVMLS HDNITWTAGA 250
    MAREIELIHV SGKQDTIVSY LPLSHIAAQL MDIWIPIKVG VLTFFAQPDA 300
    LRGTLVYTLQ EVKPTYFLGV PRVWEKMQDT IKENVAKSSN LRKKAFAWAK 350
    MLGLKVNTKK MLGKRDIPMN YRMAKALVFT KVRTSLGLDN CHTFFSGASP 400
    LSQDVSEFFL SLDIPIGEIY GMTECSGPHT VSCKSIYRVL SCGKVLNGCK 450
    NMLYKQNKDG VGEVCMWGRH VFMGYLGKED ATLEVLDEDG WLHSGDIGRL 500
    DSHDFLYITG RIKEVLITAG GENIWPIPIE TLVKEKIPII SHAMLVGDKA 550
    KFLSMLLTLK CETDQMSGEP LDKLNLEAIS FCQMLGSQAV TVSDILKIRD 600
    PVVYTAIQYG IDIVNQQAVS DSHRIRKWII LEKDFSIQGG ELGPTSKLKR 650
    DLITQKYKAQ IDNMYSS 667
    Length:667
    Mass (Da):74,266
    Last modified:February 6, 2007 - v1
    Checksum:iCE929821D95D6700
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129110 mRNA. Translation: AAI29111.1.
    RefSeqiNP_001073565.1. NM_001080096.1.
    UniGeneiRn.109833.

    Genome annotation databases

    EnsembliENSRNOT00000074555; ENSRNOP00000066937; ENSRNOG00000045947.
    GeneIDi301120.
    KEGGirno:301120.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129110 mRNA. Translation: AAI29111.1 .
    RefSeqi NP_001073565.1. NM_001080096.1.
    UniGenei Rn.109833.

    3D structure databases

    ProteinModelPortali A1L1K7.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A1L1K7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000074555 ; ENSRNOP00000066937 ; ENSRNOG00000045947 .
    GeneIDi 301120.
    KEGGi rno:301120.

    Organism-specific databases

    CTDi 81616.
    RGDi 1588580. Acsbg2.

    Phylogenomic databases

    GeneTreei ENSGT00690000101725.
    HOVERGENi HBG054660.
    KOi K15013.
    OMAi IWEKMHE.
    OrthoDBi EOG7B5WVB.
    PhylomeDBi A1L1K7.

    Miscellaneous databases

    NextBioi 648177.
    PROi A1L1K7.

    Gene expression databases

    Genevestigatori A1L1K7.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiACBG2_RAT
    AccessioniPrimary (citable) accession number: A1L1K7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3