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Protein

Long-chain-fatty-acid--CoA ligase ACSBG2

Gene

Acsbg2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis (By similarity).By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei496 – 4961ATPBy similarity
Binding sitei511 – 5111ATPBy similarity
Binding sitei624 – 6241ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi227 – 2359ATPBy similarity
Nucleotide bindingi418 – 4236ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ligase

Keywords - Biological processi

Differentiation, Fatty acid metabolism, Lipid metabolism, Spermatogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Gene namesi
Name:Acsbg2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1588580. Acsbg2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 667667Long-chain-fatty-acid--CoA ligase ACSBG2PRO_0000315814Add
BLAST

Proteomic databases

PRIDEiA1L1K7.

Expressioni

Gene expression databases

ExpressionAtlasiA1L1K7. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066937.

Structurei

3D structure databases

ProteinModelPortaliA1L1K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00690000101725.
HOVERGENiHBG054660.
InParanoidiA1L1K7.
KOiK15013.
OMAiNITWTAG.
OrthoDBiEOG7B5WVB.
PhylomeDBiA1L1K7.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L1K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQEKKAEDP DRGMDTTSAA PRLWSTHCDG EVLLRLSKHG PGHETPMTIP
60 70 80 90 100
ELFQESVERF GAYPALASKN GKKWDTLTFS QYYDVCRKAA RSLIKLGLQR
110 120 130 140 150
FHGVGILGFN SVEWVVAALG AILAGGLCVG IYATNSAEAC QYVIKQANVN
160 170 180 190 200
VLIVENDQQL QKILSIPPDK METVKAIVQY RLPLMENSTN LYSWQDFMEL
210 220 230 240 250
GNAIPNIQLD RVILSQKANQ CAVIIYTSGT TGSPKGVMLS HDNITWTAGA
260 270 280 290 300
MAREIELIHV SGKQDTIVSY LPLSHIAAQL MDIWIPIKVG VLTFFAQPDA
310 320 330 340 350
LRGTLVYTLQ EVKPTYFLGV PRVWEKMQDT IKENVAKSSN LRKKAFAWAK
360 370 380 390 400
MLGLKVNTKK MLGKRDIPMN YRMAKALVFT KVRTSLGLDN CHTFFSGASP
410 420 430 440 450
LSQDVSEFFL SLDIPIGEIY GMTECSGPHT VSCKSIYRVL SCGKVLNGCK
460 470 480 490 500
NMLYKQNKDG VGEVCMWGRH VFMGYLGKED ATLEVLDEDG WLHSGDIGRL
510 520 530 540 550
DSHDFLYITG RIKEVLITAG GENIWPIPIE TLVKEKIPII SHAMLVGDKA
560 570 580 590 600
KFLSMLLTLK CETDQMSGEP LDKLNLEAIS FCQMLGSQAV TVSDILKIRD
610 620 630 640 650
PVVYTAIQYG IDIVNQQAVS DSHRIRKWII LEKDFSIQGG ELGPTSKLKR
660
DLITQKYKAQ IDNMYSS
Length:667
Mass (Da):74,266
Last modified:February 6, 2007 - v1
Checksum:iCE929821D95D6700
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129110 mRNA. Translation: AAI29111.1.
RefSeqiNP_001073565.1. NM_001080096.1.
UniGeneiRn.109833.

Genome annotation databases

EnsembliENSRNOT00000074555; ENSRNOP00000066937; ENSRNOG00000045947.
GeneIDi301120.
KEGGirno:301120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129110 mRNA. Translation: AAI29111.1.
RefSeqiNP_001073565.1. NM_001080096.1.
UniGeneiRn.109833.

3D structure databases

ProteinModelPortaliA1L1K7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066937.

Proteomic databases

PRIDEiA1L1K7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074555; ENSRNOP00000066937; ENSRNOG00000045947.
GeneIDi301120.
KEGGirno:301120.

Organism-specific databases

CTDi81616.
RGDi1588580. Acsbg2.

Phylogenomic databases

GeneTreeiENSGT00690000101725.
HOVERGENiHBG054660.
InParanoidiA1L1K7.
KOiK15013.
OMAiNITWTAG.
OrthoDBiEOG7B5WVB.
PhylomeDBiA1L1K7.

Miscellaneous databases

NextBioi648177.
PROiA1L1K7.

Gene expression databases

ExpressionAtlasiA1L1K7. baseline.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiACBG2_RAT
AccessioniPrimary (citable) accession number: A1L1K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: July 22, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.