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A1L1K7

- ACBG2_RAT

UniProt

A1L1K7 - ACBG2_RAT

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Protein
Long-chain-fatty-acid--CoA ligase ACSBG2
Gene
Acsbg2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis By similarity.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei496 – 4961ATP By similarity
Binding sitei511 – 5111ATP By similarity
Binding sitei624 – 6241ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi227 – 2359ATP By similarity
Nucleotide bindingi418 – 4236ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acyl-CoA hydrolase activity Source: Ensembl
  3. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ligase

Keywords - Biological processi

Differentiation, Fatty acid metabolism, Lipid metabolism, Spermatogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Gene namesi
Name:Acsbg2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1588580. Acsbg2.

Subcellular locationi

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 667667Long-chain-fatty-acid--CoA ligase ACSBG2
PRO_0000315814Add
BLAST

Proteomic databases

PRIDEiA1L1K7.

Expressioni

Gene expression databases

GenevestigatoriA1L1K7.

Structurei

3D structure databases

ProteinModelPortaliA1L1K7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00690000101725.
HOVERGENiHBG054660.
KOiK15013.
OMAiIWEKMHE.
OrthoDBiEOG7B5WVB.
PhylomeDBiA1L1K7.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L1K7-1 [UniParc]FASTAAdd to Basket

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MTQEKKAEDP DRGMDTTSAA PRLWSTHCDG EVLLRLSKHG PGHETPMTIP    50
ELFQESVERF GAYPALASKN GKKWDTLTFS QYYDVCRKAA RSLIKLGLQR 100
FHGVGILGFN SVEWVVAALG AILAGGLCVG IYATNSAEAC QYVIKQANVN 150
VLIVENDQQL QKILSIPPDK METVKAIVQY RLPLMENSTN LYSWQDFMEL 200
GNAIPNIQLD RVILSQKANQ CAVIIYTSGT TGSPKGVMLS HDNITWTAGA 250
MAREIELIHV SGKQDTIVSY LPLSHIAAQL MDIWIPIKVG VLTFFAQPDA 300
LRGTLVYTLQ EVKPTYFLGV PRVWEKMQDT IKENVAKSSN LRKKAFAWAK 350
MLGLKVNTKK MLGKRDIPMN YRMAKALVFT KVRTSLGLDN CHTFFSGASP 400
LSQDVSEFFL SLDIPIGEIY GMTECSGPHT VSCKSIYRVL SCGKVLNGCK 450
NMLYKQNKDG VGEVCMWGRH VFMGYLGKED ATLEVLDEDG WLHSGDIGRL 500
DSHDFLYITG RIKEVLITAG GENIWPIPIE TLVKEKIPII SHAMLVGDKA 550
KFLSMLLTLK CETDQMSGEP LDKLNLEAIS FCQMLGSQAV TVSDILKIRD 600
PVVYTAIQYG IDIVNQQAVS DSHRIRKWII LEKDFSIQGG ELGPTSKLKR 650
DLITQKYKAQ IDNMYSS 667
Length:667
Mass (Da):74,266
Last modified:February 6, 2007 - v1
Checksum:iCE929821D95D6700
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC129110 mRNA. Translation: AAI29111.1.
RefSeqiNP_001073565.1. NM_001080096.1.
UniGeneiRn.109833.

Genome annotation databases

EnsembliENSRNOT00000074555; ENSRNOP00000066937; ENSRNOG00000045947.
GeneIDi301120.
KEGGirno:301120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC129110 mRNA. Translation: AAI29111.1 .
RefSeqi NP_001073565.1. NM_001080096.1.
UniGenei Rn.109833.

3D structure databases

ProteinModelPortali A1L1K7.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A1L1K7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000074555 ; ENSRNOP00000066937 ; ENSRNOG00000045947 .
GeneIDi 301120.
KEGGi rno:301120.

Organism-specific databases

CTDi 81616.
RGDi 1588580. Acsbg2.

Phylogenomic databases

GeneTreei ENSGT00690000101725.
HOVERGENi HBG054660.
KOi K15013.
OMAi IWEKMHE.
OrthoDBi EOG7B5WVB.
PhylomeDBi A1L1K7.

Miscellaneous databases

NextBioi 648177.
PROi A1L1K7.

Gene expression databases

Genevestigatori A1L1K7.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiACBG2_RAT
AccessioniPrimary (citable) accession number: A1L1K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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