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Protein

Anaphase-promoting complex subunit 5

Gene

Anapc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 5
Short name:
APC5
Alternative name(s):
Cyclosome subunit 5
Gene namesi
Name:Anapc5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1306125. Anapc5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Anaphase-promoting complex subunit 5PRO_0000307377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei180 – 1801PhosphoserineBy similarity
Modified residuei217 – 2171PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1L1K3.
PeptideAtlasiA1L1K3.
PRIDEiA1L1K3.

PTM databases

iPTMnetiA1L1K3.
PhosphoSiteiA1L1K3.

Expressioni

Gene expression databases

GenevisibleiA1L1K3. RN.

Interactioni

Subunit structurei

The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001794.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati194 – 23441TPR 1Add
BLAST
Repeati235 – 28551TPR 2Add
BLAST
Repeati286 – 32237TPR 3Add
BLAST
Repeati323 – 35937TPR 4Add
BLAST
Repeati360 – 39031TPR 5Add
BLAST
Repeati391 – 43848TPR 6Add
BLAST
Repeati439 – 47234TPR 7Add
BLAST
Repeati473 – 51240TPR 8Add
BLAST
Repeati513 – 55240TPR 9Add
BLAST
Repeati553 – 59240TPR 10Add
BLAST
Repeati593 – 63240TPR 11Add
BLAST
Repeati633 – 66836TPR 12Add
BLAST
Repeati669 – 70840TPR 13Add
BLAST

Sequence similaritiesi

Belongs to the APC5 family.Curated
Contains 13 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4322. Eukaryota.
ENOG410YVZN. LUCA.
HOGENOMiHOG000033988.
HOVERGENiHBG001285.
InParanoidiA1L1K3.
KOiK03352.
OMAiLYWRSSC.
OrthoDBiEOG7T7GSR.
PhylomeDBiA1L1K3.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR026000. Apc5_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF12862. ANAPC5. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.

Sequencei

Sequence statusi: Complete.

A1L1K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTNGVVHAN LFGIKDWVTP YKIAVLVLLN EMGRTGEGAV SLVERRKLNQ
60 70 80 90 100
LLLPLLQGPD ITLSKLYKLI EESCPQLANS VQIRIKLMAE GELKDLEQFF
110 120 130 140 150
DDLSDSFSGT EPEVHKTSVV GLFLRHMILA YSKLSFSQVF KLYTALQQYF
160 170 180 190 200
QNGEKKTVED ADMDREDGER QMEKEELDVS VREEEVSCSG PLSQKQAEFF
210 220 230 240 250
LSQQAALLKN DETKALTPAS LQKELNNLLK FNPDFAEAHY LSYLNNLRVQ
260 270 280 290 300
DVFSSTHSLL HYFDRLILTG AEGKSNGEEG YGRSLRYAAL NLAALHCRFG
310 320 330 340 350
HYQQAELALQ EAIRIAQESN DHVCLQHCLS WLYVLGQKRA DSYVLLEHSV
360 370 380 390 400
KKAVHFGLPR AFAGKTANKL MDALKDSDLL HWKHSLSELI DISIAQKTAI
410 420 430 440 450
WRLYGRSTMA LQQAQMLLSM NSLESLSAGV QQNNTESFAV ALCHLAELHA
460 470 480 490 500
EQGCFAAAGE VLKHLKERFP PNSQHAQLWM LCDQKIQFDR AMNDGKFHLA
510 520 530 540 550
DSLVTGITAL NGIEGVYRKA VVLQAQNQMT EAHKLLQKLL TYCQKLKNTE
560 570 580 590 600
MVISVLLSVA ELYWRSSSPT IAMPVLLEAL ALSKEYRLQY LASETVLNLA
610 620 630 640 650
YAQLILGIPE QALTLLHMAI EPILADGAIL DKGRAMFLVS KCQVASAASY
660 670 680 690 700
DPVKKAEALE AAIQNLTEAK NYFAKVDCRE RIRDVSYFQA RLYHALGKTQ
710 720
ERNHCAMVFR QLHQELPSHG VPLINHL
Length:727
Mass (Da):81,739
Last modified:February 6, 2007 - v1
Checksum:iA5017E5A91BC9958
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129106 mRNA. Translation: AAI29107.1.
RefSeqiNP_001073616.1. NM_001080147.1.
UniGeneiRn.101004.

Genome annotation databases

GeneIDi288671.
KEGGirno:288671.
UCSCiRGD:1306125. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129106 mRNA. Translation: AAI29107.1.
RefSeqiNP_001073616.1. NM_001080147.1.
UniGeneiRn.101004.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001794.

PTM databases

iPTMnetiA1L1K3.
PhosphoSiteiA1L1K3.

Proteomic databases

PaxDbiA1L1K3.
PeptideAtlasiA1L1K3.
PRIDEiA1L1K3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi288671.
KEGGirno:288671.
UCSCiRGD:1306125. rat.

Organism-specific databases

CTDi51433.
RGDi1306125. Anapc5.

Phylogenomic databases

eggNOGiKOG4322. Eukaryota.
ENOG410YVZN. LUCA.
HOGENOMiHOG000033988.
HOVERGENiHBG001285.
InParanoidiA1L1K3.
KOiK03352.
OMAiLYWRSSC.
OrthoDBiEOG7T7GSR.
PhylomeDBiA1L1K3.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiA1L1K3.

Gene expression databases

GenevisibleiA1L1K3. RN.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR026000. Apc5_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF12862. ANAPC5. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiAPC5_RAT
AccessioniPrimary (citable) accession number: A1L1K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 6, 2007
Last modified: July 6, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.