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Protein

Lipase maturation factor 2

Gene

Lmf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase maturation factor 2
Gene namesi
Name:Lmf2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1306274. Lmf2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence analysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Transmembranei259 – 27921HelicalSequence analysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence analysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence analysisAdd
BLAST
Transmembranei396 – 41621HelicalSequence analysisAdd
BLAST
Transmembranei628 – 64821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 702702Lipase maturation factor 2PRO_0000324512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA1L1J9.
PeptideAtlasiA1L1J9.
PRIDEiA1L1J9.

Expressioni

Gene expression databases

GenevisibleiA1L1J9. RN.

Family & Domainsi

Sequence similaritiesi

Belongs to the lipase maturation factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFKQ. Eukaryota.
ENOG410XPYW. LUCA.
GeneTreeiENSGT00530000063702.
HOGENOMiHOG000019333.
HOVERGENiHBG108090.
InParanoidiA1L1J9.
OMAiWQQRTIH.
OrthoDBiEOG7B31MK.
PhylomeDBiA1L1J9.
TreeFamiTF314339.

Family and domain databases

InterProiIPR009613. LMF.
[Graphical view]
PfamiPF06762. LMF1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L1J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASARVPQQL FLQGVAAVYL FAFASLYTQI PGLYGPEGIL PARRTLRPQG
60 70 80 90 100
KGRWQQLWET PTILWEAPRL GLDTAQGLDL LTLLGTVLAL GALLLNSLRH
110 120 130 140 150
PFIYLLLWAA YLSACQVGQV FLYFQWDSLL LETGFLAILV APLRRPSKHK
160 170 180 190 200
IPQGGLAGAL PHEDLPFWLV RWLLFRLMFA SGVVKLTSRC PAWWGLTALT
210 220 230 240 250
YHYETQCLPT PAAWFAHHLP VWLHRLSVVA TFLIEIAVPP LFFAPIRRLR
260 270 280 290 300
LSAFYAQALL QILIIITGNY NFFNLLTLVL TTALLDDRHL SAEPELRCHK
310 320 330 340 350
KMPTSWPKTL LTSLSLMLEL TVYGLLAYGT IYYFGLEVDW QQQIVLSKTT
360 370 380 390 400
FTFHQFSQWL KMVTLPTVWL GTASLAWELL IALWRWIQVQ GWSRKFFAGI
410 420 430 440 450
QLSVLGTATV FLFLISLVPY SYVEPGTHGR LWTGAHRLFS SVEHLQLANS
460 470 480 490 500
YGLFRRMTGL GGRPEVVLEG SHDGHHWTEI EFMYKPGNVS RPPPFLIPHQ
510 520 530 540 550
PRLDWQMWFA ALGPHTHSPW FTSLVLRLLQ GKEPVIRLIQ NQVANYPFRE
560 570 580 590 600
QPPTYLRAQR YKYWFSKPGD QSRWWHRQWV EEFFPSVSLG DPTLETLLQQ
610 620 630 640 650
FGLKDKSPPR ARSSKNALAQ TLNWVRAQLS PLEPSILLWG LLGAVVAIRV
660 670 680 690 700
VRTLLTPRPL QSSKQTREEK RKQAPKKDSR AVSEQTAPNS NSNGSWAPRR

KK
Length:702
Mass (Da):80,254
Last modified:February 6, 2007 - v1
Checksum:i387813E87033960A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088333 mRNA. Translation: AAH88333.1.
BC129102 mRNA. Translation: AAI29103.1.
RefSeqiNP_001073408.1. NM_001079939.1.
UniGeneiRn.38271.

Genome annotation databases

EnsembliENSRNOT00000049538; ENSRNOP00000051363; ENSRNOG00000030633.
GeneIDi315218.
KEGGirno:315218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088333 mRNA. Translation: AAH88333.1.
BC129102 mRNA. Translation: AAI29103.1.
RefSeqiNP_001073408.1. NM_001079939.1.
UniGeneiRn.38271.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiA1L1J9.
PeptideAtlasiA1L1J9.
PRIDEiA1L1J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000049538; ENSRNOP00000051363; ENSRNOG00000030633.
GeneIDi315218.
KEGGirno:315218.

Organism-specific databases

CTDi91289.
RGDi1306274. Lmf2.

Phylogenomic databases

eggNOGiENOG410IFKQ. Eukaryota.
ENOG410XPYW. LUCA.
GeneTreeiENSGT00530000063702.
HOGENOMiHOG000019333.
HOVERGENiHBG108090.
InParanoidiA1L1J9.
OMAiWQQRTIH.
OrthoDBiEOG7B31MK.
PhylomeDBiA1L1J9.
TreeFamiTF314339.

Miscellaneous databases

PROiA1L1J9.

Gene expression databases

GenevisibleiA1L1J9. RN.

Family and domain databases

InterProiIPR009613. LMF.
[Graphical view]
PfamiPF06762. LMF1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiLMF2_RAT
AccessioniPrimary (citable) accession number: A1L1J9
Secondary accession number(s): Q5I0G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 6, 2007
Last modified: July 6, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.