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Protein

Lipase maturation factor 2

Gene

Lmf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-8963889 Assembly of active LPL and LIPC lipase complexes

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase maturation factor 2
Gene namesi
Name:Lmf2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1306274 Lmf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Transmembranei628 – 648HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245121 – 702Lipase maturation factor 2Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi488N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA1L1J9
PeptideAtlasiA1L1J9
PRIDEiA1L1J9

Expressioni

Gene expression databases

BgeeiENSRNOG00000030633
GenevisibleiA1L1J9 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051363

Family & Domainsi

Sequence similaritiesi

Belongs to the lipase maturation factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFKQ Eukaryota
ENOG410XPYW LUCA
GeneTreeiENSGT00530000063702
HOGENOMiHOG000019333
HOVERGENiHBG108090
InParanoidiA1L1J9
OMAiWVEEFFP
OrthoDBiEOG091G05XZ
PhylomeDBiA1L1J9
TreeFamiTF314339

Family and domain databases

InterProiView protein in InterPro
IPR009613 LMF
PfamiView protein in Pfam
PF06762 LMF1, 1 hit

Sequencei

Sequence statusi: Complete.

A1L1J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASARVPQQL FLQGVAAVYL FAFASLYTQI PGLYGPEGIL PARRTLRPQG
60 70 80 90 100
KGRWQQLWET PTILWEAPRL GLDTAQGLDL LTLLGTVLAL GALLLNSLRH
110 120 130 140 150
PFIYLLLWAA YLSACQVGQV FLYFQWDSLL LETGFLAILV APLRRPSKHK
160 170 180 190 200
IPQGGLAGAL PHEDLPFWLV RWLLFRLMFA SGVVKLTSRC PAWWGLTALT
210 220 230 240 250
YHYETQCLPT PAAWFAHHLP VWLHRLSVVA TFLIEIAVPP LFFAPIRRLR
260 270 280 290 300
LSAFYAQALL QILIIITGNY NFFNLLTLVL TTALLDDRHL SAEPELRCHK
310 320 330 340 350
KMPTSWPKTL LTSLSLMLEL TVYGLLAYGT IYYFGLEVDW QQQIVLSKTT
360 370 380 390 400
FTFHQFSQWL KMVTLPTVWL GTASLAWELL IALWRWIQVQ GWSRKFFAGI
410 420 430 440 450
QLSVLGTATV FLFLISLVPY SYVEPGTHGR LWTGAHRLFS SVEHLQLANS
460 470 480 490 500
YGLFRRMTGL GGRPEVVLEG SHDGHHWTEI EFMYKPGNVS RPPPFLIPHQ
510 520 530 540 550
PRLDWQMWFA ALGPHTHSPW FTSLVLRLLQ GKEPVIRLIQ NQVANYPFRE
560 570 580 590 600
QPPTYLRAQR YKYWFSKPGD QSRWWHRQWV EEFFPSVSLG DPTLETLLQQ
610 620 630 640 650
FGLKDKSPPR ARSSKNALAQ TLNWVRAQLS PLEPSILLWG LLGAVVAIRV
660 670 680 690 700
VRTLLTPRPL QSSKQTREEK RKQAPKKDSR AVSEQTAPNS NSNGSWAPRR

KK
Length:702
Mass (Da):80,254
Last modified:February 6, 2007 - v1
Checksum:i387813E87033960A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088333 mRNA Translation: AAH88333.1
BC129102 mRNA Translation: AAI29103.1
RefSeqiNP_001073408.1, NM_001079939.1
UniGeneiRn.38271

Genome annotation databases

EnsembliENSRNOT00000049538; ENSRNOP00000051363; ENSRNOG00000030633
GeneIDi315218
KEGGirno:315218

Similar proteinsi

Entry informationi

Entry nameiLMF2_RAT
AccessioniPrimary (citable) accession number: A1L1J9
Secondary accession number(s): Q5I0G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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