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Protein

Zinc finger protein 652

Gene

Znf652

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a transcriptional repressor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri244 – 26724C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32124C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49124C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 652
Gene namesi
Name:Znf652
Synonyms:Zfp652
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1566329. Zfp652.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 608608Zinc finger protein 652PRO_0000280430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei196 – 1961PhosphoserineBy similarity
Modified residuei203 – 2031PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1L1J6.
PRIDEiA1L1J6.

PTM databases

PhosphoSiteiA1L1J6.

Expressioni

Gene expression databases

GenevestigatoriA1L1J6.

Interactioni

Subunit structurei

Interacts with CBFA2T3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052376.

Structurei

3D structure databases

ProteinModelPortaliA1L1J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni497 – 608112Mediates interaction with CBFA2T3By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi104 – 1085Poly-Glu
Compositional biasi151 – 1599Poly-Glu
Compositional biasi496 – 57479Pro-richAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri244 – 26724C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri298 – 32124C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49124C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00440000037877.
HOGENOMiHOG000231037.
HOVERGENiHBG064823.
InParanoidiA1L1J6.
OMAiDYGENER.
OrthoDBiEOG7JQBN4.
PhylomeDBiA1L1J6.
TreeFamiTF332655.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L1J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYTASPCQE LVEPCAVHAE GMAQEESHRS QAPPTFYHGA SQELDLSTKV
60 70 80 90 100
YKRESGSPYS VLADSKMSKP HLHETEEQPY FREPRAVSDV HTVKEDRENS
110 120 130 140 150
DDTEEEEEVS YKREQIIVEV NLNNQTLNVS KGEKGVSSQS KETPVLKTSS
160 170 180 190 200
EEEEEETEED ATDNSSDYGE NGRQKKKEKQ VEKVRVTQRR TRRAASVAAA
210 220 230 240 250
TTSPTPRTTR GRRKSAELPK RKKRAAKEPK APVQKAKCDE KETLTCEKCP
260 270 280 290 300
RVFNTRWYLE KHMNVTHRRM QICDKCGKKF VLESELSLHQ QTDCEKNIQC
310 320 330 340 350
VSCNKSFKKL WSLHEHIKIV HGYAEKKFAC EICEKKFYTM AHVRKHMVAH
360 370 380 390 400
TKDMPFTCET CGKSFKRSMS LKVHSLQHSG EKPFRCENCD ERFQYKYQLR
410 420 430 440 450
SHMSIHIGHK QFMCQWCGKD FNMKQYFDEH MKTHTGEKPF ICEICGKSFT
460 470 480 490 500
SRPNMKRHRR THTGEKPYPC DVCGQRFRFS NMLKAHKEKC FRVTSPVNVP
510 520 530 540 550
PAVQIPLASA PAAPAPAVAN TPTSPAPAVS MNPVGSALPS RPVPHPFSHL
560 570 580 590 600
HIHTHPHHSH HLPIPPVPHL PPPPALFKSE PLNHRSQSED TFLRHLAEKN

SPAQAQHH
Length:608
Mass (Da):69,558
Last modified:February 6, 2007 - v1
Checksum:i65EEE1086C2C2EF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129097 mRNA. Translation: AAI29098.1.
RefSeqiNP_001073676.1. NM_001080207.1.
UniGeneiRn.137198.

Genome annotation databases

EnsembliENSRNOT00000022811; ENSRNOP00000052376; ENSRNOG00000017001.
GeneIDi497984.
KEGGirno:497984.
UCSCiRGD:1566329. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129097 mRNA. Translation: AAI29098.1.
RefSeqiNP_001073676.1. NM_001080207.1.
UniGeneiRn.137198.

3D structure databases

ProteinModelPortaliA1L1J6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052376.

PTM databases

PhosphoSiteiA1L1J6.

Proteomic databases

PaxDbiA1L1J6.
PRIDEiA1L1J6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022811; ENSRNOP00000052376; ENSRNOG00000017001.
GeneIDi497984.
KEGGirno:497984.
UCSCiRGD:1566329. rat.

Organism-specific databases

CTDi268469.
RGDi1566329. Zfp652.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00440000037877.
HOGENOMiHOG000231037.
HOVERGENiHBG064823.
InParanoidiA1L1J6.
OMAiDYGENER.
OrthoDBiEOG7JQBN4.
PhylomeDBiA1L1J6.
TreeFamiTF332655.

Miscellaneous databases

NextBioi698291.
PROiA1L1J6.

Gene expression databases

GenevestigatoriA1L1J6.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZN652_RAT
AccessioniPrimary (citable) accession number: A1L1J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 6, 2007
Last modified: March 4, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.