A1L1J6 (ZN652_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 652

Gene names

Name:	Znf652
Synonyms:	Zfp652

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	608 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Functions as a transcriptional repressor By similarity.
Subunit structure	Interacts with CBFA2T3 By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 9 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 608	608	Zinc finger protein 652		PRO_0000280430
Regions
	Zinc finger	244 – 267	24	C2H2-type 1
	Zinc finger	271 – 293	23	C2H2-type 2; degenerate
	Zinc finger	298 – 321	24	C2H2-type 3
	Zinc finger	328 – 350	23	C2H2-type 4
	Zinc finger	356 – 378	23	C2H2-type 5
	Zinc finger	384 – 406	23	C2H2-type 6
	Zinc finger	412 – 434	23	C2H2-type 7
	Zinc finger	440 – 462	23	C2H2-type 8
	Zinc finger	468 – 491	24	C2H2-type 9; degenerate
	Region	497 – 608	112	Mediates interaction with CBFA2T3 By similarity
	Compositional bias	104 – 108	5	Poly-Glu
	Compositional bias	151 – 159	9	Poly-Glu
	Compositional bias	496 – 574	79	Pro-rich
Amino acid modifications
	Modified residue	196	1	Phosphoserine By similarity
	Modified residue	203	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1L1J6 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 65EEE1086C2C2EF9	FASTA	608	69,558
	10 20 30 40 50 60 MSYTASPCQE LVEPCAVHAE GMAQEESHRS QAPPTFYHGA SQELDLSTKV YKRESGSPYS 70 80 90 100 110 120 VLADSKMSKP HLHETEEQPY FREPRAVSDV HTVKEDRENS DDTEEEEEVS YKREQIIVEV 130 140 150 160 170 180 NLNNQTLNVS KGEKGVSSQS KETPVLKTSS EEEEEETEED ATDNSSDYGE NGRQKKKEKQ 190 200 210 220 230 240 VEKVRVTQRR TRRAASVAAA TTSPTPRTTR GRRKSAELPK RKKRAAKEPK APVQKAKCDE 250 260 270 280 290 300 KETLTCEKCP RVFNTRWYLE KHMNVTHRRM QICDKCGKKF VLESELSLHQ QTDCEKNIQC 310 320 330 340 350 360 VSCNKSFKKL WSLHEHIKIV HGYAEKKFAC EICEKKFYTM AHVRKHMVAH TKDMPFTCET 370 380 390 400 410 420 CGKSFKRSMS LKVHSLQHSG EKPFRCENCD ERFQYKYQLR SHMSIHIGHK QFMCQWCGKD 430 440 450 460 470 480 FNMKQYFDEH MKTHTGEKPF ICEICGKSFT SRPNMKRHRR THTGEKPYPC DVCGQRFRFS 490 500 510 520 530 540 NMLKAHKEKC FRVTSPVNVP PAVQIPLASA PAAPAPAVAN TPTSPAPAVS MNPVGSALPS 550 560 570 580 590 600 RPVPHPFSHL HIHTHPHHSH HLPIPPVPHL PPPPALFKSE PLNHRSQSED TFLRHLAEKN SPAQAQHH

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC129097 mRNA. Translation: AAI29098.1.
IPI	IPI00554313.
RefSeq	NP_001073676.1. NM_001080207.1.
UniGene	Rn.137198.
3D structure databases
ProteinModelPortal	A1L1J6.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000052376.
PTM databases
PhosphoSite	A1L1J6.
Proteomic databases
PaxDb	A1L1J6.
PRIDE	A1L1J6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000022811; ENSRNOP00000052376; ENSRNOG00000017001.
GeneID	497984.
KEGG	rno:497984.
UCSC	RGD:1566329. rat.
Organism-specific databases
CTD	268469.
RGD	1566329. Znf652.
Phylogenomic databases
eggNOG	COG5048.
GeneTree	ENSGT00440000037877.
HOGENOM	HOG000231037.
HOVERGEN	HBG064823.
InParanoid	A1L1J6.
OMA	DYGENER.
OrthoDB	EOG4SXNCH.
Gene expression databases
ArrayExpress	A1L1J6.
Genevestigator	A1L1J6.
Family and domain databases
Gene3D	3.30.160.60. 6 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00355. ZnF_C2H2. 9 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 7 hits. PS50157. ZINC_FINGER_C2H2_2. 9 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	698291.

Entry information

Entry name

ZN652_RAT

Accession

Primary (citable) accession number: A1L1J6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	February 6, 2007
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program