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A1L1J6

- ZN652_RAT

UniProt

A1L1J6 - ZN652_RAT

Protein

Zinc finger protein 652

Gene

Znf652

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Functions as a transcriptional repressor.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri244 – 26724C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29323C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri298 – 32124C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri328 – 35023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri356 – 37823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri384 – 40623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri412 – 43423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri440 – 46223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri468 – 49124C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 652
    Gene namesi
    Name:Znf652
    Synonyms:Zfp652
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1566329. Zfp652.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 608608Zinc finger protein 652PRO_0000280430Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei196 – 1961PhosphoserineBy similarity
    Modified residuei203 – 2031PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiA1L1J6.
    PRIDEiA1L1J6.

    PTM databases

    PhosphoSiteiA1L1J6.

    Expressioni

    Gene expression databases

    GenevestigatoriA1L1J6.

    Interactioni

    Subunit structurei

    Interacts with CBFA2T3.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000052376.

    Structurei

    3D structure databases

    ProteinModelPortaliA1L1J6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni497 – 608112Mediates interaction with CBFA2T3By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi104 – 1085Poly-Glu
    Compositional biasi151 – 1599Poly-Glu
    Compositional biasi496 – 57479Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri244 – 26724C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri271 – 29323C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri298 – 32124C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri328 – 35023C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri356 – 37823C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri384 – 40623C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri412 – 43423C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri440 – 46223C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri468 – 49124C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00440000037877.
    HOGENOMiHOG000231037.
    HOVERGENiHBG064823.
    InParanoidiA1L1J6.
    OMAiDYGENER.
    OrthoDBiEOG7JQBN4.
    PhylomeDBiA1L1J6.
    TreeFamiTF332655.

    Family and domain databases

    Gene3Di3.30.160.60. 6 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1L1J6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYTASPCQE LVEPCAVHAE GMAQEESHRS QAPPTFYHGA SQELDLSTKV    50
    YKRESGSPYS VLADSKMSKP HLHETEEQPY FREPRAVSDV HTVKEDRENS 100
    DDTEEEEEVS YKREQIIVEV NLNNQTLNVS KGEKGVSSQS KETPVLKTSS 150
    EEEEEETEED ATDNSSDYGE NGRQKKKEKQ VEKVRVTQRR TRRAASVAAA 200
    TTSPTPRTTR GRRKSAELPK RKKRAAKEPK APVQKAKCDE KETLTCEKCP 250
    RVFNTRWYLE KHMNVTHRRM QICDKCGKKF VLESELSLHQ QTDCEKNIQC 300
    VSCNKSFKKL WSLHEHIKIV HGYAEKKFAC EICEKKFYTM AHVRKHMVAH 350
    TKDMPFTCET CGKSFKRSMS LKVHSLQHSG EKPFRCENCD ERFQYKYQLR 400
    SHMSIHIGHK QFMCQWCGKD FNMKQYFDEH MKTHTGEKPF ICEICGKSFT 450
    SRPNMKRHRR THTGEKPYPC DVCGQRFRFS NMLKAHKEKC FRVTSPVNVP 500
    PAVQIPLASA PAAPAPAVAN TPTSPAPAVS MNPVGSALPS RPVPHPFSHL 550
    HIHTHPHHSH HLPIPPVPHL PPPPALFKSE PLNHRSQSED TFLRHLAEKN 600
    SPAQAQHH 608
    Length:608
    Mass (Da):69,558
    Last modified:February 6, 2007 - v1
    Checksum:i65EEE1086C2C2EF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129097 mRNA. Translation: AAI29098.1.
    RefSeqiNP_001073676.1. NM_001080207.1.
    UniGeneiRn.137198.

    Genome annotation databases

    EnsembliENSRNOT00000022811; ENSRNOP00000052376; ENSRNOG00000017001.
    GeneIDi497984.
    KEGGirno:497984.
    UCSCiRGD:1566329. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC129097 mRNA. Translation: AAI29098.1 .
    RefSeqi NP_001073676.1. NM_001080207.1.
    UniGenei Rn.137198.

    3D structure databases

    ProteinModelPortali A1L1J6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000052376.

    PTM databases

    PhosphoSitei A1L1J6.

    Proteomic databases

    PaxDbi A1L1J6.
    PRIDEi A1L1J6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022811 ; ENSRNOP00000052376 ; ENSRNOG00000017001 .
    GeneIDi 497984.
    KEGGi rno:497984.
    UCSCi RGD:1566329. rat.

    Organism-specific databases

    CTDi 268469.
    RGDi 1566329. Zfp652.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00440000037877.
    HOGENOMi HOG000231037.
    HOVERGENi HBG064823.
    InParanoidi A1L1J6.
    OMAi DYGENER.
    OrthoDBi EOG7JQBN4.
    PhylomeDBi A1L1J6.
    TreeFami TF332655.

    Miscellaneous databases

    NextBioi 698291.
    PROi A1L1J6.

    Gene expression databases

    Genevestigatori A1L1J6.

    Family and domain databases

    Gene3Di 3.30.160.60. 6 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 9 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiZN652_RAT
    AccessioniPrimary (citable) accession number: A1L1J6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3