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A1L1J6 (ZN652_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 652
Gene names
Name:Znf652
Synonyms:Zfp652
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length608 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Functions as a transcriptional repressor By similarity.

Subunit structure

Interacts with CBFA2T3 By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 9 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionRepressor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 608608Zinc finger protein 652
PRO_0000280430

Regions

Zinc finger244 – 26724C2H2-type 1
Zinc finger271 – 29323C2H2-type 2; degenerate
Zinc finger298 – 32124C2H2-type 3
Zinc finger328 – 35023C2H2-type 4
Zinc finger356 – 37823C2H2-type 5
Zinc finger384 – 40623C2H2-type 6
Zinc finger412 – 43423C2H2-type 7
Zinc finger440 – 46223C2H2-type 8
Zinc finger468 – 49124C2H2-type 9; degenerate
Region497 – 608112Mediates interaction with CBFA2T3 By similarity
Compositional bias104 – 1085Poly-Glu
Compositional bias151 – 1599Poly-Glu
Compositional bias496 – 57479Pro-rich

Amino acid modifications

Modified residue1961Phosphoserine By similarity
Modified residue2031Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
A1L1J6 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 65EEE1086C2C2EF9

FASTA60869,558
        10         20         30         40         50         60 
MSYTASPCQE LVEPCAVHAE GMAQEESHRS QAPPTFYHGA SQELDLSTKV YKRESGSPYS 

        70         80         90        100        110        120 
VLADSKMSKP HLHETEEQPY FREPRAVSDV HTVKEDRENS DDTEEEEEVS YKREQIIVEV 

       130        140        150        160        170        180 
NLNNQTLNVS KGEKGVSSQS KETPVLKTSS EEEEEETEED ATDNSSDYGE NGRQKKKEKQ 

       190        200        210        220        230        240 
VEKVRVTQRR TRRAASVAAA TTSPTPRTTR GRRKSAELPK RKKRAAKEPK APVQKAKCDE 

       250        260        270        280        290        300 
KETLTCEKCP RVFNTRWYLE KHMNVTHRRM QICDKCGKKF VLESELSLHQ QTDCEKNIQC 

       310        320        330        340        350        360 
VSCNKSFKKL WSLHEHIKIV HGYAEKKFAC EICEKKFYTM AHVRKHMVAH TKDMPFTCET 

       370        380        390        400        410        420 
CGKSFKRSMS LKVHSLQHSG EKPFRCENCD ERFQYKYQLR SHMSIHIGHK QFMCQWCGKD 

       430        440        450        460        470        480 
FNMKQYFDEH MKTHTGEKPF ICEICGKSFT SRPNMKRHRR THTGEKPYPC DVCGQRFRFS 

       490        500        510        520        530        540 
NMLKAHKEKC FRVTSPVNVP PAVQIPLASA PAAPAPAVAN TPTSPAPAVS MNPVGSALPS 

       550        560        570        580        590        600 
RPVPHPFSHL HIHTHPHHSH HLPIPPVPHL PPPPALFKSE PLNHRSQSED TFLRHLAEKN 


SPAQAQHH 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC129097 mRNA. Translation: AAI29098.1.
RefSeqNP_001073676.1. NM_001080207.1.
UniGeneRn.137198.

3D structure databases

ProteinModelPortalA1L1J6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000052376.

PTM databases

PhosphoSiteA1L1J6.

Proteomic databases

PaxDbA1L1J6.
PRIDEA1L1J6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000022811; ENSRNOP00000052376; ENSRNOG00000017001.
GeneID497984.
KEGGrno:497984.
UCSCRGD:1566329. rat.

Organism-specific databases

CTD268469.
RGD1566329. Zfp652.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00440000037877.
HOGENOMHOG000231037.
HOVERGENHBG064823.
InParanoidA1L1J6.
OMADYGENER.
OrthoDBEOG7JQBN4.
PhylomeDBA1L1J6.
TreeFamTF332655.

Gene expression databases

GenevestigatorA1L1J6.

Family and domain databases

Gene3D3.30.160.60. 6 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio698291.
PROA1L1J6.

Entry information

Entry nameZN652_RAT
AccessionPrimary (citable) accession number: A1L1J6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families