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Protein

Epithelial splicing regulatory protein 1

Gene

esrp1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial splicing regulatory protein 1
Alternative name(s):
RNA-binding motif protein 35A
RNA-binding protein 35A
Gene namesi
Name:esrp1
Synonyms:rbm35a
ORF Names:zgc:154050
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-070112-1732. esrp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714Epithelial splicing regulatory protein 1PRO_0000282349Add
BLAST

Proteomic databases

PaxDbiA1L1G1.

Expressioni

Gene expression databases

BgeeiA1L1G1.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094207.

Structurei

3D structure databases

ProteinModelPortaliA1L1G1.
SMRiA1L1G1. Positions 314-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 30278RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini326 – 40681RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini450 – 53081RRM 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ESRP family.Curated
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1365. Eukaryota.
ENOG410XPZU. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000112401.
InParanoidiA1L1G1.
KOiK14947.
OMAiILFVRYP.
OrthoDBiEOG76QFGV.
PhylomeDBiA1L1G1.
TreeFamiTF316157.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
SM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
SSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L1G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVNPDYLVL LFTTTSGASG DKLGSDEKEI VQLVWQVVDL ATKKAGQVNE
60 70 80 90 100
LLVKPDHIEL SEECQELSGL TDEALTPVDP LEVAIDQLNQ RLCAEVDTGA
110 120 130 140 150
GNTFYLCTDG QLHVRQVLHP EASSKNILLP DCFFSFFDLR KEFKKEFPSE
160 170 180 190 200
VKLKDLNLQV MADHLNVAVD SSLHAFTAYK VQQMVDIVLA LISEPTCHEF
210 220 230 240 250
TFPEKVNEKF ETGTCSKMER VDDNTVIRAR GLPWQSSDQD IARFFRGLNI
260 270 280 290 300
AKGGAALCLN AQGRRNGEAL VRFESEEHRD LALQRHKHHM GGRYIEVYKA
310 320 330 340 350
TGEDFLKIAG GTSNEVASFL SRENQIIVRM RGLPFNATAE QVLQFFSPAC
360 370 380 390 400
PVTDGSEGIL FVRFPDGRPT GDAFVLFSCE EHAQNALKKH KDMLGKRYIE
410 420 430 440 450
LFKSTAAEVQ QVLNKYSSAP LIPVAPSPIL SVVAPPTFVP QTAAVPGVRD
460 470 480 490 500
CVRLRGLPYD ASIQDILVFL GEYGADIKTH GVHMVLNHQG RPSGEAFIQM
510 520 530 540 550
RSAERAFLAA QRCHKRSMKE RYVEVFACSA QEVNIVLMGG TLNRSGLSPP
560 570 580 590 600
PCLSPPSYTF PHGAPVLPAG AVLPAGAVLP VESAGIYPSQ FLLGPRPPPH
610 620 630 640 650
TTTFYPASNT LYMNYTTYYP SPPGSPSNIS YFPTGHTPSA GSVLSAQPTA
660 670 680 690 700
LIRMQGHAHS HAYNNGVKEI LSMVQGYQPG NSDAFVTFPS MLSAKQPIGD
710
QTVGGGAYLD LQLL
Length:714
Mass (Da):78,136
Last modified:February 6, 2007 - v1
Checksum:i1957B95BC0FB300E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129044 mRNA. Translation: AAI29045.1.
BC134218 mRNA. Translation: AAI34219.1.
RefSeqiNP_001074045.1. NM_001080576.1.
UniGeneiDr.13001.

Genome annotation databases

EnsembliENSDART00000103431; ENSDARP00000094207; ENSDARG00000011245.
GeneIDi560190.
KEGGidre:560190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129044 mRNA. Translation: AAI29045.1.
BC134218 mRNA. Translation: AAI34219.1.
RefSeqiNP_001074045.1. NM_001080576.1.
UniGeneiDr.13001.

3D structure databases

ProteinModelPortaliA1L1G1.
SMRiA1L1G1. Positions 314-419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094207.

Proteomic databases

PaxDbiA1L1G1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000103431; ENSDARP00000094207; ENSDARG00000011245.
GeneIDi560190.
KEGGidre:560190.

Organism-specific databases

CTDi54845.
ZFINiZDB-GENE-070112-1732. esrp1.

Phylogenomic databases

eggNOGiKOG1365. Eukaryota.
ENOG410XPZU. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000112401.
InParanoidiA1L1G1.
KOiK14947.
OMAiILFVRYP.
OrthoDBiEOG76QFGV.
PhylomeDBiA1L1G1.
TreeFamiTF316157.

Miscellaneous databases

NextBioi20883322.
PROiA1L1G1.

Gene expression databases

BgeeiA1L1G1.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012677. Nucleotide-bd_a/b_plait.
IPR012337. RNaseH-like_dom.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
SM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
SSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiESRP1_DANRE
AccessioniPrimary (citable) accession number: A1L1G1
Secondary accession number(s): A4FVM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 6, 2007
Last modified: May 11, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.