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A1L167

- U2QL1_HUMAN

UniProt

A1L167 - U2QL1_HUMAN

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Protein

Ubiquitin-conjugating enzyme E2Q-like protein 1

Gene

UBE2QL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiA1L167.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2Q-like protein 1 (EC:6.3.2.19)
Gene namesi
Name:UBE2QL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:37269. UBE2QL1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165660602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Ubiquitin-conjugating enzyme E2Q-like protein 1PRO_0000335811Add
BLAST

Proteomic databases

PaxDbiA1L167.
PRIDEiA1L167.

PTM databases

PhosphoSiteiA1L167.

Expressioni

Gene expression databases

BgeeiA1L167.
GenevestigatoriA1L167.

Organism-specific databases

HPAiHPA057414.

Interactioni

Protein-protein interaction databases

BioGridi126384. 2 interactions.
STRINGi9606.ENSP00000382713.

Structurei

3D structure databases

ProteinModelPortaliA1L167.
SMRiA1L167. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG272407.
GeneTreeiENSGT00390000018573.
HOGENOMiHOG000007757.
HOVERGENiHBG061368.
InParanoidiA1L167.
KOiK10582.
OMAiQDMKETS.
OrthoDBiEOG7F512D.
PhylomeDBiA1L167.
TreeFamiTF313338.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L167-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKELQDIARL SDRFISVELV DESLFDWNVK LHQVDKDSVL WQDMKETNTE
60 70 80 90 100
FILLNLTFPD NFPFSPPFMR VLSPRLENGY VLDGGAICME LLTPRGWSSA
110 120 130 140 150
YTVEAVMRQF AASLVKGQGR ICRKAGKSKK SFSRKEAEAT FKSLVKTHEK
160
YGWVTPPVSD G
Length:161
Mass (Da):18,338
Last modified:May 20, 2008 - v2
Checksum:iB2062702B5EFB2A2
GO

Sequence cautioni

The sequence AAI27724.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAI50555.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC127723 mRNA. Translation: AAI27724.1. Different initiation.
BC150554 mRNA. Translation: AAI50555.1. Different initiation.
CCDSiCCDS47189.1.
RefSeqiNP_001138633.1. NM_001145161.2.
UniGeneiHs.126856.
Hs.731466.

Genome annotation databases

EnsembliENST00000399816; ENSP00000382713; ENSG00000215218.
GeneIDi134111.
KEGGihsa:134111.
UCSCiuc003jdp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC127723 mRNA. Translation: AAI27724.1 . Different initiation.
BC150554 mRNA. Translation: AAI50555.1 . Different initiation.
CCDSi CCDS47189.1.
RefSeqi NP_001138633.1. NM_001145161.2.
UniGenei Hs.126856.
Hs.731466.

3D structure databases

ProteinModelPortali A1L167.
SMRi A1L167. Positions 1-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126384. 2 interactions.
STRINGi 9606.ENSP00000382713.

PTM databases

PhosphoSitei A1L167.

Proteomic databases

PaxDbi A1L167.
PRIDEi A1L167.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000399816 ; ENSP00000382713 ; ENSG00000215218 .
GeneIDi 134111.
KEGGi hsa:134111.
UCSCi uc003jdp.4. human.

Organism-specific databases

CTDi 134111.
GeneCardsi GC05P006448.
HGNCi HGNC:37269. UBE2QL1.
HPAi HPA057414.
neXtProti NX_A1L167.
PharmGKBi PA165660602.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272407.
GeneTreei ENSGT00390000018573.
HOGENOMi HOG000007757.
HOVERGENi HBG061368.
InParanoidi A1L167.
KOi K10582.
OMAi QDMKETS.
OrthoDBi EOG7F512D.
PhylomeDBi A1L167.
TreeFami TF313338.

Enzyme and pathway databases

UniPathwayi UPA00143 .
SignaLinki A1L167.

Miscellaneous databases

ChiTaRSi UBE2QL1. human.
GenomeRNAii 134111.
NextBioi 83313.
PROi A1L167.

Gene expression databases

Bgeei A1L167.
Genevestigatori A1L167.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiU2QL1_HUMAN
AccessioniPrimary (citable) accession number: A1L167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3