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A1L167

- U2QL1_HUMAN

UniProt

A1L167 - U2QL1_HUMAN

Protein

Ubiquitin-conjugating enzyme E2Q-like protein 1

Gene

UBE2QL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei88 – 881Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiA1L167.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2Q-like protein 1 (EC:6.3.2.19)
    Gene namesi
    Name:UBE2QL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:37269. UBE2QL1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165660602.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161Ubiquitin-conjugating enzyme E2Q-like protein 1PRO_0000335811Add
    BLAST

    Proteomic databases

    PaxDbiA1L167.
    PRIDEiA1L167.

    PTM databases

    PhosphoSiteiA1L167.

    Expressioni

    Gene expression databases

    BgeeiA1L167.
    GenevestigatoriA1L167.

    Organism-specific databases

    HPAiHPA057414.

    Interactioni

    Protein-protein interaction databases

    BioGridi126384. 2 interactions.
    STRINGi9606.ENSP00000382713.

    Structurei

    3D structure databases

    ProteinModelPortaliA1L167.
    SMRiA1L167. Positions 1-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG272407.
    HOGENOMiHOG000007757.
    HOVERGENiHBG061368.
    InParanoidiA1L167.
    KOiK10582.
    OMAiQDMKETS.
    OrthoDBiEOG7F512D.
    PhylomeDBiA1L167.
    TreeFamiTF313338.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1L167-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKELQDIARL SDRFISVELV DESLFDWNVK LHQVDKDSVL WQDMKETNTE    50
    FILLNLTFPD NFPFSPPFMR VLSPRLENGY VLDGGAICME LLTPRGWSSA 100
    YTVEAVMRQF AASLVKGQGR ICRKAGKSKK SFSRKEAEAT FKSLVKTHEK 150
    YGWVTPPVSD G 161
    Length:161
    Mass (Da):18,338
    Last modified:May 20, 2008 - v2
    Checksum:iB2062702B5EFB2A2
    GO

    Sequence cautioni

    The sequence AAI27724.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAI50555.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC127723 mRNA. Translation: AAI27724.1. Different initiation.
    BC150554 mRNA. Translation: AAI50555.1. Different initiation.
    CCDSiCCDS47189.1.
    RefSeqiNP_001138633.1. NM_001145161.2.
    UniGeneiHs.126856.
    Hs.731466.

    Genome annotation databases

    EnsembliENST00000399816; ENSP00000382713; ENSG00000215218.
    GeneIDi134111.
    KEGGihsa:134111.
    UCSCiuc003jdp.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC127723 mRNA. Translation: AAI27724.1 . Different initiation.
    BC150554 mRNA. Translation: AAI50555.1 . Different initiation.
    CCDSi CCDS47189.1.
    RefSeqi NP_001138633.1. NM_001145161.2.
    UniGenei Hs.126856.
    Hs.731466.

    3D structure databases

    ProteinModelPortali A1L167.
    SMRi A1L167. Positions 1-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126384. 2 interactions.
    STRINGi 9606.ENSP00000382713.

    PTM databases

    PhosphoSitei A1L167.

    Proteomic databases

    PaxDbi A1L167.
    PRIDEi A1L167.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399816 ; ENSP00000382713 ; ENSG00000215218 .
    GeneIDi 134111.
    KEGGi hsa:134111.
    UCSCi uc003jdp.4. human.

    Organism-specific databases

    CTDi 134111.
    GeneCardsi GC05P006448.
    HGNCi HGNC:37269. UBE2QL1.
    HPAi HPA057414.
    neXtProti NX_A1L167.
    PharmGKBi PA165660602.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272407.
    HOGENOMi HOG000007757.
    HOVERGENi HBG061368.
    InParanoidi A1L167.
    KOi K10582.
    OMAi QDMKETS.
    OrthoDBi EOG7F512D.
    PhylomeDBi A1L167.
    TreeFami TF313338.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    SignaLinki A1L167.

    Miscellaneous databases

    ChiTaRSi UBE2QL1. human.
    GenomeRNAii 134111.
    NextBioi 83313.
    PROi A1L167.

    Gene expression databases

    Bgeei A1L167.
    Genevestigatori A1L167.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiU2QL1_HUMAN
    AccessioniPrimary (citable) accession number: A1L167
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3