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A1L167 (U2QL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2Q-like protein 1

EC=6.3.2.19
Gene names
Name:UBE2QL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length161 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins Potential.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence caution

The sequence AAI27724.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAI50555.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ubiquitin-protein transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 161161Ubiquitin-conjugating enzyme E2Q-like protein 1
PRO_0000335811

Sites

Active site881Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
A1L167 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: B2062702B5EFB2A2

FASTA16118,338
        10         20         30         40         50         60 
MKELQDIARL SDRFISVELV DESLFDWNVK LHQVDKDSVL WQDMKETNTE FILLNLTFPD 

        70         80         90        100        110        120 
NFPFSPPFMR VLSPRLENGY VLDGGAICME LLTPRGWSSA YTVEAVMRQF AASLVKGQGR 

       130        140        150        160 
ICRKAGKSKK SFSRKEAEAT FKSLVKTHEK YGWVTPPVSD G 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC127723 mRNA. Translation: AAI27724.1. Different initiation.
BC150554 mRNA. Translation: AAI50555.1. Different initiation.
CCDSCCDS47189.1.
RefSeqNP_001138633.1. NM_001145161.2.
UniGeneHs.126856.
Hs.731466.

3D structure databases

ProteinModelPortalA1L167.
SMRA1L167. Positions 1-148.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126384. 2 interactions.
STRING9606.ENSP00000382713.

PTM databases

PhosphoSiteA1L167.

Proteomic databases

PaxDbA1L167.
PRIDEA1L167.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000399816; ENSP00000382713; ENSG00000215218.
GeneID134111.
KEGGhsa:134111.
UCSCuc003jdp.4. human.

Organism-specific databases

CTD134111.
GeneCardsGC05P006448.
HGNCHGNC:37269. UBE2QL1.
HPAHPA057414.
neXtProtNX_A1L167.
PharmGKBPA165660602.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG272407.
HOGENOMHOG000007757.
HOVERGENHBG061368.
InParanoidA1L167.
KOK10582.
OMAQDMKETS.
OrthoDBEOG7F512D.
PhylomeDBA1L167.
TreeFamTF313338.

Enzyme and pathway databases

SignaLinkA1L167.
UniPathwayUPA00143.

Gene expression databases

BgeeA1L167.
GenevestigatorA1L167.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSUBE2QL1. human.
GenomeRNAi134111.
NextBio83313.
PROA1L167.

Entry information

Entry nameU2QL1_HUMAN
AccessionPrimary (citable) accession number: A1L167
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 9, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM