Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin-conjugating enzyme E2Q-like protein 1

Gene

UBE2QL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ligase activity Source: UniProtKB-KW
  3. ubiquitin conjugating enzyme activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiA1L167.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2Q-like protein 1 (EC:6.3.2.19)
Gene namesi
Name:UBE2QL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:37269. UBE2QL1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165660602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Ubiquitin-conjugating enzyme E2Q-like protein 1PRO_0000335811Add
BLAST

Proteomic databases

PaxDbiA1L167.
PRIDEiA1L167.

PTM databases

PhosphoSiteiA1L167.

Expressioni

Gene expression databases

BgeeiA1L167.
GenevestigatoriA1L167.

Organism-specific databases

HPAiHPA057414.

Interactioni

Protein-protein interaction databases

BioGridi126384. 2 interactions.
STRINGi9606.ENSP00000382713.

Structurei

3D structure databases

ProteinModelPortaliA1L167.
SMRiA1L167. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG272407.
GeneTreeiENSGT00390000018573.
HOGENOMiHOG000007757.
HOVERGENiHBG061368.
InParanoidiA1L167.
KOiK10582.
OMAiQDMKETS.
OrthoDBiEOG7F512D.
PhylomeDBiA1L167.
TreeFamiTF313338.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKELQDIARL SDRFISVELV DESLFDWNVK LHQVDKDSVL WQDMKETNTE
60 70 80 90 100
FILLNLTFPD NFPFSPPFMR VLSPRLENGY VLDGGAICME LLTPRGWSSA
110 120 130 140 150
YTVEAVMRQF AASLVKGQGR ICRKAGKSKK SFSRKEAEAT FKSLVKTHEK
160
YGWVTPPVSD G
Length:161
Mass (Da):18,338
Last modified:May 20, 2008 - v2
Checksum:iB2062702B5EFB2A2
GO

Sequence cautioni

The sequence AAI27724.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI50555.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127723 mRNA. Translation: AAI27724.1. Different initiation.
BC150554 mRNA. Translation: AAI50555.1. Different initiation.
CCDSiCCDS47189.1.
RefSeqiNP_001138633.1. NM_001145161.2.
UniGeneiHs.126856.
Hs.731466.

Genome annotation databases

EnsembliENST00000399816; ENSP00000382713; ENSG00000215218.
GeneIDi134111.
KEGGihsa:134111.
UCSCiuc003jdp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC127723 mRNA. Translation: AAI27724.1. Different initiation.
BC150554 mRNA. Translation: AAI50555.1. Different initiation.
CCDSiCCDS47189.1.
RefSeqiNP_001138633.1. NM_001145161.2.
UniGeneiHs.126856.
Hs.731466.

3D structure databases

ProteinModelPortaliA1L167.
SMRiA1L167. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126384. 2 interactions.
STRINGi9606.ENSP00000382713.

PTM databases

PhosphoSiteiA1L167.

Proteomic databases

PaxDbiA1L167.
PRIDEiA1L167.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399816; ENSP00000382713; ENSG00000215218.
GeneIDi134111.
KEGGihsa:134111.
UCSCiuc003jdp.4. human.

Organism-specific databases

CTDi134111.
GeneCardsiGC05P006448.
HGNCiHGNC:37269. UBE2QL1.
HPAiHPA057414.
MIMi615832. gene.
neXtProtiNX_A1L167.
PharmGKBiPA165660602.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG272407.
GeneTreeiENSGT00390000018573.
HOGENOMiHOG000007757.
HOVERGENiHBG061368.
InParanoidiA1L167.
KOiK10582.
OMAiQDMKETS.
OrthoDBiEOG7F512D.
PhylomeDBiA1L167.
TreeFamiTF313338.

Enzyme and pathway databases

UniPathwayiUPA00143.
SignaLinkiA1L167.

Miscellaneous databases

ChiTaRSiUBE2QL1. human.
GenomeRNAii134111.
NextBioi83313.
PROiA1L167.
SOURCEiSearch...

Gene expression databases

BgeeiA1L167.
GenevestigatoriA1L167.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiU2QL1_HUMAN
AccessioniPrimary (citable) accession number: A1L167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: March 4, 2015
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.