A1L167 (U2QL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-conjugating enzyme E2Q-like protein 1
EC=6.3.2.19

Gene names

Name:

UBE2QL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins Potential.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.
Sequence caution	The sequence AAI27724.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAI50555.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 161	161	Ubiquitin-conjugating enzyme E2Q-like protein 1		PRO_0000335811
Sites
	Active site	88	1	Glycyl thioester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1L167 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: B2062702B5EFB2A2	FASTA	161	18,338
	10 20 30 40 50 60 MKELQDIARL SDRFISVELV DESLFDWNVK LHQVDKDSVL WQDMKETNTE FILLNLTFPD 70 80 90 100 110 120 NFPFSPPFMR VLSPRLENGY VLDGGAICME LLTPRGWSSA YTVEAVMRQF AASLVKGQGR 130 140 150 160 ICRKAGKSKK SFSRKEAEAT FKSLVKTHEK YGWVTPPVSD G

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC127723 mRNA. Translation: AAI27724.1. Different initiation. BC150554 mRNA. Translation: AAI50555.1. Different initiation.
IPI	IPI00740385.
RefSeq	NP_001138633.1. NM_001145161.2.
UniGene	Hs.126856. Hs.731466.
3D structure databases
ProteinModelPortal	A1L167.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000382713.
PTM databases
PhosphoSite	A1L167.
Proteomic databases
PaxDb	A1L167.
PRIDE	A1L167.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000399816; ENSP00000382713; ENSG00000215218.
GeneID	134111.
KEGG	hsa:134111.
UCSC	uc003jdp.4. human.
Organism-specific databases
CTD	134111.
GeneCards	GC05P006448.
HGNC	HGNC:37269. UBE2QL1.
neXtProt	NX_A1L167.
PharmGKB	PA165660602.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG272407.
HOGENOM	HOG000007757.
HOVERGEN	HBG061368.
InParanoid	A1L167.
KO	K10582.
OMA	YILLNLT.
OrthoDB	EOG4QFWFB.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
Bgee	A1L167.
Genevestigator	A1L167.
Family and domain databases
Gene3D	3.10.110.10. 1 hit.
InterPro	IPR000608. UBQ-conjugat_E2. IPR016135. UBQ-conjugating_enzyme/RWD. [Graphical view]
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
SUPFAM	SSF54495. UBQ-conjugat/RWD-like. 1 hit.
PROSITE	PS00183. UBIQUITIN_CONJUGAT_1. False negative. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	UBE2QL1. human.
GenomeRNAi	134111.
NextBio	83313.

Entry information

Entry name

U2QL1_HUMAN

Accession

Primary (citable) accession number: A1L167

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	May 1, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.