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Protein

Tetraspanin-11

Gene

TSPAN11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-11
Short name:
Tspan-11
Gene namesi
Name:TSPAN11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:30795. TSPAN11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence analysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670687.

Polymorphism and mutation databases

BioMutaiTSPAN11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Tetraspanin-11PRO_0000311905Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA1L157.
PRIDEiA1L157.

PTM databases

SwissPalmiA1L157.

Expressioni

Gene expression databases

BgeeiENSG00000110900.
CleanExiHS_TSPAN11.
ExpressionAtlasiA1L157. baseline and differential.
GenevisibleiA1L157. HS.

Organism-specific databases

HPAiHPA066789.

Interactioni

Protein-protein interaction databases

BioGridi137636. 11 interactions.
STRINGi9606.ENSP00000261177.

Structurei

3D structure databases

ProteinModelPortaliA1L157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230651.
HOVERGENiHBG107306.
InParanoidiA1L157.
KOiK17352.
OMAiFFWVGGA.
OrthoDBiEOG091G0CQO.
PhylomeDBiA1L157.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequencei

Sequence statusi: Complete.

A1L157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHYKTEQDD WLIIYLKYLL FVFNFFFWVG GAAVLAVGIW TLVEKSGYLS
60 70 80 90 100
VLASSTFAAS AYILIFAGVL VMVTGFLGFG AILWERKGCL STYFCLLLVI
110 120 130 140 150
FLVELVAGVL AHVYYQRLSD ELKQHLNRTL AENYGQPGAT QITASVDRLQ
160 170 180 190 200
QDFKCCGSNS SADWQHSTYI LLREAEGRQV PDSCCKTVVV RCGQRAHPSN
210 220 230 240 250
IYKVEGGCLT KLEQFLADHL LLMGAVGIGV ACLQICGMVL TCCLHQRLQR

HFY
Length:253
Mass (Da):28,245
Last modified:December 4, 2007 - v2
Checksum:i231635F1B4117C92
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti190 – 1901V → A.1 Publication
Corresponds to variant rs2075333 [ dbSNP | Ensembl ].
VAR_037337

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008013 Genomic DNA. No translation available.
AC008150 Genomic DNA. No translation available.
BC127660 mRNA. Translation: AAI27661.1.
BC127661 mRNA. Translation: AAI27662.1.
BC146917 mRNA. Translation: AAI46918.1.
BC146922 mRNA. Translation: AAI46923.1.
CCDSiCCDS31765.1.
RefSeqiNP_001073978.1. NM_001080509.2.
XP_011518982.1. XM_011520680.2.
UniGeneiHs.505141.

Genome annotation databases

EnsembliENST00000261177; ENSP00000261177; ENSG00000110900.
ENST00000546076; ENSP00000437403; ENSG00000110900.
GeneIDi441631.
KEGGihsa:441631.
UCSCiuc001rjp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008013 Genomic DNA. No translation available.
AC008150 Genomic DNA. No translation available.
BC127660 mRNA. Translation: AAI27661.1.
BC127661 mRNA. Translation: AAI27662.1.
BC146917 mRNA. Translation: AAI46918.1.
BC146922 mRNA. Translation: AAI46923.1.
CCDSiCCDS31765.1.
RefSeqiNP_001073978.1. NM_001080509.2.
XP_011518982.1. XM_011520680.2.
UniGeneiHs.505141.

3D structure databases

ProteinModelPortaliA1L157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137636. 11 interactions.
STRINGi9606.ENSP00000261177.

PTM databases

SwissPalmiA1L157.

Polymorphism and mutation databases

BioMutaiTSPAN11.

Proteomic databases

PaxDbiA1L157.
PRIDEiA1L157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261177; ENSP00000261177; ENSG00000110900.
ENST00000546076; ENSP00000437403; ENSG00000110900.
GeneIDi441631.
KEGGihsa:441631.
UCSCiuc001rjp.4. human.

Organism-specific databases

CTDi441631.
GeneCardsiTSPAN11.
HGNCiHGNC:30795. TSPAN11.
HPAiHPA066789.
neXtProtiNX_A1L157.
PharmGKBiPA142670687.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230651.
HOVERGENiHBG107306.
InParanoidiA1L157.
KOiK17352.
OMAiFFWVGGA.
OrthoDBiEOG091G0CQO.
PhylomeDBiA1L157.
TreeFamiTF352892.

Miscellaneous databases

ChiTaRSiTSPAN11. human.
GenomeRNAii441631.
PROiA1L157.

Gene expression databases

BgeeiENSG00000110900.
CleanExiHS_TSPAN11.
ExpressionAtlasiA1L157. baseline and differential.
GenevisibleiA1L157. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTSN11_HUMAN
AccessioniPrimary (citable) accession number: A1L157
Secondary accession number(s): A1L158, B2RUX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 7, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.