ID   AUP1_RAT                Reviewed;         410 AA.
AC   A1L134;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   14-DEC-2011, entry version 39.
DE   RecName: Full=Ancient ubiquitous protein 1;
GN   Name=Aup1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in the translocation of terminally
CC       misfolded proteins from the endoplasmic reticulum lumen to the
CC       cytoplasm and their degradation by the proteasome (By similarity).
CC   -!- SUBUNIT: Identified in a complex that contains SEL1L, OS9,
CC       FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic
CC       tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC       type III membrane protein; Cytoplasmic side (By similarity).
CC   -!- SIMILARITY: Belongs to the AUP1 family.
CC   -!- SIMILARITY: Contains 1 CUE domain.
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DR   EMBL; CH473957; EDL91111.1; -; Genomic_DNA.
DR   EMBL; BC127544; AAI27545.1; -; mRNA.
DR   IPI; IPI00196841; -.
DR   RefSeq; NP_001073368.1; NM_001079899.1.
DR   UniGene; Rn.198163; -.
DR   ProteinModelPortal; A1L134; -.
DR   SMR; A1L134; 294-345.
DR   STRING; A1L134; -.
DR   PRIDE; A1L134; -.
DR   GeneID; 680423; -.
DR   KEGG; rno:680423; -.
DR   NMPDR; fig|10116.3.peg.21684; -.
DR   CTD; 550; -.
DR   RGD; 1591777; Aup1.
DR   eggNOG; roNOG12028; -.
DR   GeneTree; ENSGT00390000016110; -.
DR   HOVERGEN; HBG004321; -.
DR   InParanoid; A1L134; -.
DR   OrthoDB; EOG47H5Q7; -.
DR   PhylomeDB; A1L134; -.
DR   NextBio; 718673; -.
DR   Genevestigator; A1L134; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:InterPro.
DR   InterPro; IPR002123; Acyltransferase.
DR   InterPro; IPR003892; CUE.
DR   Pfam; PF02845; CUE; 1.
DR   SMART; SM00546; CUE; 1.
DR   SMART; SM00563; PlsC; 1.
DR   PROSITE; PS51140; CUE; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix;
KW   Ubl conjugation pathway.
FT   CHAIN         1    410       Ancient ubiquitous protein 1.
FT                                /FTId=PRO_0000359870.
FT   TOPO_DOM      1     20       Lumenal (Potential).
FT   TRANSMEM     21     41       Helical; Signal-anchor for type III
FT                                membrane protein; (Potential).
FT   TOPO_DOM     42    410       Cytoplasmic (Potential).
FT   DOMAIN      296    338       CUE.
FT   MOD_RES     292    292       Phosphoserine (By similarity).
FT   MOD_RES     356    356       Phosphoserine (By similarity).
FT   MOD_RES     363    363       Phosphoserine (By similarity).
FT   MOD_RES     367    367       Phosphothreonine (By similarity).
SQ   SEQUENCE   410 AA;  46199 MW;  95B5CC11B18FE441 CRC64;
     MEPPPAPGPE RLFDSHRLPS DGFLLLALLL YAPVGLCLLV LRLFLGLHVF LVSCALPDSV
     LRRFVVRTMC AVLGLVARQE DSGLRDHRVR VLISNHVTPF DHNIVNLLTT CSTPLLNSPP
     SFVCWSRGFM EMDRRVELVE SLKKFCASTR LPPTPLLLFP EEEATNGREG LLRFSSWPFS
     IQDVVQPLTL QVQRPLVSVT VSDASWVSEL LWSLFVPFTV YQVRWLHPIR RQLGEENEEF
     ALRVQQLVAK ELGQIGTRLT PADKAEHMKR QRHPRLRPQS VQSSFPSPPS PSSDVQLTIL
     AQRVKEVLPH VPLNVIQRDL ARTGCVDLTI TNLLEGAVAF MPEDVTEGSQ SLPTASAPKF
     PSSGLVTPQP TALTFAKSSW ARQESLQERK QALYEYARRR FRERQAQEAE
//