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Protein

Ancient ubiquitous protein 1

Gene

Aup1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ancient ubiquitous protein 1
Gene namesi
Name:Aup1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1591777. Aup1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020LumenalSequence analysisAdd
BLAST
Transmembranei21 – 4121Helical; Signal-anchor for type III membrane proteinSequence analysisAdd
BLAST
Topological domaini42 – 410369CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Ancient ubiquitous protein 1PRO_0000359870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei292 – 2921PhosphoserineBy similarity
Modified residuei363 – 3631PhosphoserineBy similarity
Modified residuei367 – 3671PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiA1L134.
PeptideAtlasiA1L134.
PRIDEiA1L134.

PTM databases

iPTMnetiA1L134.

Expressioni

Gene expression databases

GenevisibleiA1L134. RN.

Interactioni

Subunit structurei

Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi595359. 2 interactions.
STRINGi10116.ENSRNOP00000010602.

Structurei

3D structure databases

ProteinModelPortaliA1L134.
SMRiA1L134. Positions 294-345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini296 – 33843CUEPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the AUP1 family.Curated
Contains 1 CUE domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2898. Eukaryota.
COG0204. LUCA.
GeneTreeiENSGT00390000016110.
HOGENOMiHOG000034232.
HOVERGENiHBG004321.
InParanoidiA1L134.
KOiK19716.
OMAiLKFSSWP.
OrthoDBiEOG7HTHHJ.
PhylomeDBiA1L134.

Family and domain databases

InterProiIPR003892. CUE.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
[Graphical view]
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPPAPGPE RLFDSHRLPS DGFLLLALLL YAPVGLCLLV LRLFLGLHVF
60 70 80 90 100
LVSCALPDSV LRRFVVRTMC AVLGLVARQE DSGLRDHRVR VLISNHVTPF
110 120 130 140 150
DHNIVNLLTT CSTPLLNSPP SFVCWSRGFM EMDRRVELVE SLKKFCASTR
160 170 180 190 200
LPPTPLLLFP EEEATNGREG LLRFSSWPFS IQDVVQPLTL QVQRPLVSVT
210 220 230 240 250
VSDASWVSEL LWSLFVPFTV YQVRWLHPIR RQLGEENEEF ALRVQQLVAK
260 270 280 290 300
ELGQIGTRLT PADKAEHMKR QRHPRLRPQS VQSSFPSPPS PSSDVQLTIL
310 320 330 340 350
AQRVKEVLPH VPLNVIQRDL ARTGCVDLTI TNLLEGAVAF MPEDVTEGSQ
360 370 380 390 400
SLPTASAPKF PSSGLVTPQP TALTFAKSSW ARQESLQERK QALYEYARRR
410
FRERQAQEAE
Length:410
Mass (Da):46,199
Last modified:February 6, 2007 - v1
Checksum:i95B5CC11B18FE441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473957 Genomic DNA. Translation: EDL91111.1.
BC127544 mRNA. Translation: AAI27545.1.
RefSeqiNP_001073368.1. NM_001079899.1.
UniGeneiRn.198163.

Genome annotation databases

EnsembliENSRNOT00000010602; ENSRNOP00000010602; ENSRNOG00000007842.
GeneIDi680423.
KEGGirno:680423.
UCSCiRGD:1591777. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473957 Genomic DNA. Translation: EDL91111.1.
BC127544 mRNA. Translation: AAI27545.1.
RefSeqiNP_001073368.1. NM_001079899.1.
UniGeneiRn.198163.

3D structure databases

ProteinModelPortaliA1L134.
SMRiA1L134. Positions 294-345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi595359. 2 interactions.
STRINGi10116.ENSRNOP00000010602.

PTM databases

iPTMnetiA1L134.

Proteomic databases

PaxDbiA1L134.
PeptideAtlasiA1L134.
PRIDEiA1L134.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010602; ENSRNOP00000010602; ENSRNOG00000007842.
GeneIDi680423.
KEGGirno:680423.
UCSCiRGD:1591777. rat.

Organism-specific databases

CTDi550.
RGDi1591777. Aup1.

Phylogenomic databases

eggNOGiKOG2898. Eukaryota.
COG0204. LUCA.
GeneTreeiENSGT00390000016110.
HOGENOMiHOG000034232.
HOVERGENiHBG004321.
InParanoidiA1L134.
KOiK19716.
OMAiLKFSSWP.
OrthoDBiEOG7HTHHJ.
PhylomeDBiA1L134.

Miscellaneous databases

PROiA1L134.

Gene expression databases

GenevisibleiA1L134. RN.

Family and domain databases

InterProiIPR003892. CUE.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
[Graphical view]
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiAUP1_RAT
AccessioniPrimary (citable) accession number: A1L134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: February 6, 2007
Last modified: July 6, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.