A1L134 (AUP1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ancient ubiquitous protein 1

Gene names

Name:

Aup1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome By similarity.
Subunit structure	Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side By similarity.
Sequence similarities	Belongs to the AUP1 family. Contains 1 CUE domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Ancient ubiquitous protein 1		PRO_0000359870
Regions
	Topological domain	1 – 20	20	Lumenal Potential
	Transmembrane	21 – 41	21	Helical; Signal-anchor for type III membrane protein; Potential
	Topological domain	42 – 410	369	Cytoplasmic Potential
	Domain	296 – 338	43	CUE
Amino acid modifications
	Modified residue	292	1	Phosphoserine By similarity
	Modified residue	356	1	Phosphoserine By similarity
	Modified residue	363	1	Phosphoserine By similarity
	Modified residue	367	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1L134 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 95B5CC11B18FE441	FASTA	410	46,199
	10 20 30 40 50 60 MEPPPAPGPE RLFDSHRLPS DGFLLLALLL YAPVGLCLLV LRLFLGLHVF LVSCALPDSV 70 80 90 100 110 120 LRRFVVRTMC AVLGLVARQE DSGLRDHRVR VLISNHVTPF DHNIVNLLTT CSTPLLNSPP 130 140 150 160 170 180 SFVCWSRGFM EMDRRVELVE SLKKFCASTR LPPTPLLLFP EEEATNGREG LLRFSSWPFS 190 200 210 220 230 240 IQDVVQPLTL QVQRPLVSVT VSDASWVSEL LWSLFVPFTV YQVRWLHPIR RQLGEENEEF 250 260 270 280 290 300 ALRVQQLVAK ELGQIGTRLT PADKAEHMKR QRHPRLRPQS VQSSFPSPPS PSSDVQLTIL 310 320 330 340 350 360 AQRVKEVLPH VPLNVIQRDL ARTGCVDLTI TNLLEGAVAF MPEDVTEGSQ SLPTASAPKF 370 380 390 400 410 PSSGLVTPQP TALTFAKSSW ARQESLQERK QALYEYARRR FRERQAQEAE

References

[1]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH473957 Genomic DNA. Translation: EDL91111.1. BC127544 mRNA. Translation: AAI27545.1.
IPI	IPI00196841.
RefSeq	NP_001073368.1. NM_001079899.1.
UniGene	Rn.198163.
3D structure databases
ProteinModelPortal	A1L134.
SMR	A1L134. Positions 294-345.
ModBase	Search...
Protein-protein interaction databases
STRING	A1L134.
Proteomic databases
PRIDE	A1L134.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	680423.
KEGG	rno:680423.
Organism-specific databases
CTD	550.
RGD	1591777. Aup1.
Phylogenomic databases
eggNOG	NOG271344.
HOGENOM	HOG000034232.
HOVERGEN	HBG004321.
InParanoid	A1L134.
OrthoDB	EOG47H5Q7.
Gene expression databases
Genevestigator	A1L134.
Family and domain databases
InterPro	IPR002123. Acyltransferase. IPR003892. CUE. [Graphical view]
Pfam	PF02845. CUE. 1 hit. [Graphical view]
SMART	SM00546. CUE. 1 hit. SM00563. PlsC. 1 hit. [Graphical view]
PROSITE	PS51140. CUE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	718673.

Entry information

Entry name

AUP1_RAT

Accession

Primary (citable) accession number: A1L134

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	February 6, 2007
Last modified:	May 16, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program