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Reviewed, UniProtKB/Swiss-Prot A1L134 (AUP1_RAT)

Last modified April 14, 2009. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ancient ubiquitous protein 1
Gene names
Name: Aup1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome By similarity.

Subunit structure

Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the AUP1 family.

Contains 1 CUE domain.

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Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentEndoplasmic reticulum
Membrane
   DomainTransmembrane
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological processmodification-dependent protein catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionacyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Ancient ubiquitous protein 1
PRO_0000359870

Regions

Topological domain1 – 2020Lumenal Potential
Transmembrane21 – 4121Signal-anchor for type III membrane protein Potential
Topological domain42 – 410369Cytoplasmic Potential
Domain296 – 33843CUE

Amino acid modifications

Modified residue2921Phosphoserine By similarity
Modified residue3561Phosphoserine By similarity
Modified residue3631Phosphoserine By similarity
Modified residue3671Phosphothreonine By similarity

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Sequences

Sequence LengthMass (Da)Tools
A1L134-1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 95B5CC11B18FE441

FASTA41046,199
        10         20         30         40         50         60 
MEPPPAPGPE RLFDSHRLPS DGFLLLALLL YAPVGLCLLV LRLFLGLHVF LVSCALPDSV 

        70         80         90        100        110        120 
LRRFVVRTMC AVLGLVARQE DSGLRDHRVR VLISNHVTPF DHNIVNLLTT CSTPLLNSPP 

       130        140        150        160        170        180 
SFVCWSRGFM EMDRRVELVE SLKKFCASTR LPPTPLLLFP EEEATNGREG LLRFSSWPFS 

       190        200        210        220        230        240 
IQDVVQPLTL QVQRPLVSVT VSDASWVSEL LWSLFVPFTV YQVRWLHPIR RQLGEENEEF 

       250        260        270        280        290        300 
ALRVQQLVAK ELGQIGTRLT PADKAEHMKR QRHPRLRPQS VQSSFPSPPS PSSDVQLTIL 

       310        320        330        340        350        360 
AQRVKEVLPH VPLNVIQRDL ARTGCVDLTI TNLLEGAVAF MPEDVTEGSQ SLPTASAPKF 

       370        380        390        400        410 
PSSGLVTPQP TALTFAKSSW ARQESLQERK QALYEYARRR FRERQAQEAE

« Hide

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References

[1]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

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Cross-references

Sequence databases

CH473957 Genomic DNA. Translation: EDL91111.1.
BC127544 mRNA. Translation: AAI27545.1.
IPIIPI00196841.
RefSeqNP_001073368.1.
UniGeneRn.198163

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEA1L134.

Genome annotation databases

EnsemblENSRNOG00000007842. Rattus norvegicus. [Contig view]
GeneID680423.
KEGGrno:680423.
NMPDRfig|10116.3.peg.21684.

Organism-specific databases

RGD1591777. Aup1.

Phylogenomic databases

HOVERGENA1L134.

Family and domain databases

InterProIPR002123. Acyltransferase.
IPR003892. CUE.
[Graphical view]
PfamPF02845. CUE. 1 hit.
[Graphical view]
SMARTSM00546. CUE. 1 hit.
SM00563. PlsC. 1 hit.
[Graphical view]
PROSITEPS51140. CUE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio718673.

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Entry information

Entry nameAUP1_RAT
AccessionPrimary (citable) accession number: A1L134
Entry history
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: February 6, 2007
Last modified: April 14, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents