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Protein

Actin-related protein 2/3 complex subunit 5-like protein

Gene

Arpc5l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5-like protein
Alternative name(s):
Arp2/3 complex 16 kDa subunit 2
Short name:
ARC16-2
Gene namesi
Name:Arpc5l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1308867. Arpc5l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Actin-related protein 2/3 complex subunit 5-like proteinPRO_0000279483Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1L108.
PRIDEiA1L108.

Expressioni

Gene expression databases

ExpressionAtlasiA1L108. baseline.
GenevisibleiA1L108. RN.

Interactioni

Subunit structurei

May be a component of the Arp2/3 complex in which it may replace ARPC5.

Protein-protein interaction databases

IntActiA1L108. 1 interaction.
MINTiMINT-4571079.
STRINGi10116.ENSRNOP00000019405.

Structurei

3D structure databases

ProteinModelPortaliA1L108.
SMRiA1L108. Positions 8-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
HOGENOMiHOG000197215.
HOVERGENiHBG050583.
InParanoidiA1L108.
KOiK05754.
PhylomeDBiA1L108.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
IPR030075. ARPC5L.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PTHR12644:SF2. PTHR12644:SF2. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A1L108-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARNTLSSRF RRVDIDEFDE NKFVDEHEEA AAASGEPGPD PCEVDGLLRQ
60 70 80 90 100
GDMLRAFHAA LRNSPINTKN QAVKERAQGI VLKVLTNFKS SEIEQAVQSL
110 120 130 140 150
DRNGIDLLMK YIYKGFEKPT ENSSAVLLQW HEKALAVGGL GSIIRVLTAR

KTV
Length:153
Mass (Da):17,010
Last modified:March 6, 2007 - v2
Checksum:i60103D7F18376DCC
GO
Isoform 2 (identifier: A1L108-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Note: No experimental confirmation available.
Show »
Length:101
Mass (Da):11,235
Checksum:iF18015F27F1A9746
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5252Missing in isoform 2. 1 PublicationVSP_023450Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BI296526 mRNA. No translation available.
BC098820 mRNA. Translation: AAH98820.1.
BC127445 mRNA. Translation: AAI27446.1.
RefSeqiNP_001032856.2. NM_001037767.2. [A1L108-1]
UniGeneiRn.110752.

Genome annotation databases

EnsembliENSRNOT00000019405; ENSRNOP00000019405; ENSRNOG00000014317. [A1L108-1]
GeneIDi296710.
KEGGirno:296710.
UCSCiRGD:1308867. rat. [A1L108-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BI296526 mRNA. No translation available.
BC098820 mRNA. Translation: AAH98820.1.
BC127445 mRNA. Translation: AAI27446.1.
RefSeqiNP_001032856.2. NM_001037767.2. [A1L108-1]
UniGeneiRn.110752.

3D structure databases

ProteinModelPortaliA1L108.
SMRiA1L108. Positions 8-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA1L108. 1 interaction.
MINTiMINT-4571079.
STRINGi10116.ENSRNOP00000019405.

Proteomic databases

PaxDbiA1L108.
PRIDEiA1L108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019405; ENSRNOP00000019405; ENSRNOG00000014317. [A1L108-1]
GeneIDi296710.
KEGGirno:296710.
UCSCiRGD:1308867. rat. [A1L108-1]

Organism-specific databases

CTDi81873.
RGDi1308867. Arpc5l.

Phylogenomic databases

eggNOGiKOG3380. Eukaryota.
ENOG4111FGV. LUCA.
HOGENOMiHOG000197215.
HOVERGENiHBG050583.
InParanoidiA1L108.
KOiK05754.
PhylomeDBiA1L108.

Miscellaneous databases

NextBioi641705.
PROiA1L108.

Gene expression databases

ExpressionAtlasiA1L108. baseline.
GenevisibleiA1L108. RN.

Family and domain databases

Gene3Di1.25.40.190. 1 hit.
InterProiIPR006789. ARPC5.
IPR030075. ARPC5L.
[Graphical view]
PANTHERiPTHR12644. PTHR12644. 1 hit.
PTHR12644:SF2. PTHR12644:SF2. 1 hit.
PfamiPF04699. P16-Arc. 1 hit.
[Graphical view]
PIRSFiPIRSF039096. p16-ARC. 1 hit.
SUPFAMiSSF69103. SSF69103. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Normalization and subtraction: two approaches to facilitate gene discovery."
    Bonaldo M.F., Lennon G., Soares M.B.
    Genome Res. 6:791-806(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Sprague-Dawley.
    Tissue: Eye.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-153 (ISOFORM 1).
    Tissue: Spleen.
  3. Lubec G., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 90-102 AND 134-145, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARP5L_RAT
AccessioniPrimary (citable) accession number: A1L108
Secondary accession number(s): Q4KM42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: December 9, 2015
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.