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Protein

Actin-related protein 2/3 complex subunit 5-like protein

Gene

Arpc5l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 5-like protein
Alternative name(s):
Arp2/3 complex 16 kDa subunit 2
Short name:
ARC16-2
Gene namesi
Name:Arpc5l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1308867 Arpc5l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794831 – 153Actin-related protein 2/3 complex subunit 5-like proteinAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1L108
PeptideAtlasiA1L108
PRIDEiA1L108

PTM databases

iPTMnetiA1L108
PhosphoSitePlusiA1L108

Expressioni

Gene expression databases

BgeeiENSRNOG00000014317
GenevisibleiA1L108 RN

Interactioni

Subunit structurei

May be a component of the Arp2/3 complex in which it may replace ARPC5.

GO - Molecular functioni

Protein-protein interaction databases

IntActiA1L108, 1 interactor
STRINGi10116.ENSRNOP00000019405

Structurei

3D structure databases

ProteinModelPortaliA1L108
SMRiA1L108
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC5 family.Curated

Phylogenomic databases

eggNOGiKOG3380 Eukaryota
ENOG4111FGV LUCA
GeneTreeiENSGT00390000014806
HOGENOMiHOG000197215
HOVERGENiHBG050583
InParanoidiA1L108
KOiK05754
OMAiCKSANWL
OrthoDBiEOG091G0R2J
PhylomeDBiA1L108

Family and domain databases

Gene3Di1.25.40.190, 1 hit
InterProiView protein in InterPro
IPR006789 ARPC5
IPR036743 ARPC5_sf
IPR030075 ARPC5L
PANTHERiPTHR12644 PTHR12644, 1 hit
PTHR12644:SF2 PTHR12644:SF2, 1 hit
PfamiView protein in Pfam
PF04699 P16-Arc, 1 hit
PIRSFiPIRSF039096 p16-ARC, 1 hit
SUPFAMiSSF69103 SSF69103, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A1L108-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARNTLSSRF RRVDIDEFDE NKFVDEHEEA AAASGEPGPD PCEVDGLLRQ
60 70 80 90 100
GDMLRAFHAA LRNSPINTKN QAVKERAQGI VLKVLTNFKS SEIEQAVQSL
110 120 130 140 150
DRNGIDLLMK YIYKGFEKPT ENSSAVLLQW HEKALAVGGL GSIIRVLTAR

KTV
Length:153
Mass (Da):17,010
Last modified:March 6, 2007 - v2
Checksum:i60103D7F18376DCC
GO
Isoform 2 (identifier: A1L108-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Note: No experimental confirmation available.
Show »
Length:101
Mass (Da):11,235
Checksum:iF18015F27F1A9746
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0234501 – 52Missing in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BI296526 mRNA No translation available.
BC098820 mRNA Translation: AAH98820.1
BC127445 mRNA Translation: AAI27446.1
RefSeqiNP_001032856.2, NM_001037767.2 [A1L108-1]
UniGeneiRn.110752

Genome annotation databases

EnsembliENSRNOT00000019405; ENSRNOP00000019405; ENSRNOG00000014317 [A1L108-1]
GeneIDi296710
KEGGirno:296710
UCSCiRGD:1308867 rat [A1L108-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARP5L_RAT
AccessioniPrimary (citable) accession number: A1L108
Secondary accession number(s): Q4KM42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: May 23, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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