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A1L0Z1 (PO3F4_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
POU domain, class 3, transcription factor 4
Gene names
Name:pou3f4
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional activator. Induces neural-specific gene expression to act as a key regulator of neural differentiation By similarity. UniProtKB P31364

Subcellular location

Nucleus By similarity UniProtKB P49335.

Sequence similarities

Belongs to the POU transcription factor family. Class-3 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360POU domain, class 3, transcription factor 4
PRO_0000389617

Regions

Domain185 – 25975POU-specific
DNA binding277 – 33660Homeobox

Sequences

Sequence LengthMass (Da)Tools
A1L0Z1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: F7AB8DD51864D15B

FASTA36039,539
        10         20         30         40         50         60 
MATAASNPYS ILSSSSLVHD SAIMQQGSPF RNPQKLLQSD YLQGVPSNGH PLGHHWVTSL 

        70         80         90        100        110        120 
SDANPWSTSL GSSPLDQQDI KPGREDLQLG AIIHHRSPHV THHSPHTNHP NAWGASPAHN 

       130        140        150        160        170        180 
SSLTSNGQPI NVYSQSGFTV SGMLDHGGLT PPPPSGTTQS LHPVLREPVD HGDLGSHHCQ 

       190        200        210        220        230        240 
DHSDEETPTS DELEQFAKQF KQRRIKLGFT QADVGLALGT LYGNVFSQAT ICRFEALQLS 

       250        260        270        280        290        300 
FKNMCKLKPL LNKWLEEADS STGSPTSIDK IAAQGRKRKK RTSIEVSVKG VLETHFLKCP 

       310        320        330        340        350        360 
KPAAQEISSL ADSLQLEKEV VRVWFCNRRQ KEKRMTPPGD PQQHEVYSHS VKTDTSCNEL

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC127328 mRNA. Translation: AAI27329.1.
RefSeqNP_001090728.1. NM_001097259.1.
UniGeneStr.41167.

3D structure databases

ProteinModelPortalA1L0Z1.
SMRA1L0Z1. Positions 191-337.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000031753.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100036711.
KEGGxtr:100036711.

Organism-specific databases

CTD5456.
XenbaseXB-GENE-479667. pou3f4.

Phylogenomic databases

eggNOGNOG261729.
HOGENOMHOG000116303.
HOVERGENHBG053120.
KOK09365.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePO3F4_XENTR
AccessionPrimary (citable) accession number: A1L0Z1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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