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A1L0Z1

- PO3F4_XENTR

UniProt

A1L0Z1 - PO3F4_XENTR

Protein

POU domain, class 3, transcription factor 4

Gene

pou3f4

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Transcriptional activator. Induces neural-specific gene expression to act as a key regulator of neural differentiation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi277 – 33660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 3, transcription factor 4By similarity
    Gene namesi
    Name:pou3f4Imported
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-479667. pou3f4.

    Subcellular locationi

    Nucleus By similarityPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360POU domain, class 3, transcription factor 4PRO_0000389617Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000031753.

    Structurei

    3D structure databases

    ProteinModelPortaliA1L0Z1.
    SMRiA1L0Z1. Positions 191-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini185 – 25975POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the POU transcription factor family. Class-3 subfamily.Sequence Analysis
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG261729.
    HOGENOMiHOG000116303.
    HOVERGENiHBG053120.
    KOiK09365.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1L0Z1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATAASNPYS ILSSSSLVHD SAIMQQGSPF RNPQKLLQSD YLQGVPSNGH    50
    PLGHHWVTSL SDANPWSTSL GSSPLDQQDI KPGREDLQLG AIIHHRSPHV 100
    THHSPHTNHP NAWGASPAHN SSLTSNGQPI NVYSQSGFTV SGMLDHGGLT 150
    PPPPSGTTQS LHPVLREPVD HGDLGSHHCQ DHSDEETPTS DELEQFAKQF 200
    KQRRIKLGFT QADVGLALGT LYGNVFSQAT ICRFEALQLS FKNMCKLKPL 250
    LNKWLEEADS STGSPTSIDK IAAQGRKRKK RTSIEVSVKG VLETHFLKCP 300
    KPAAQEISSL ADSLQLEKEV VRVWFCNRRQ KEKRMTPPGD PQQHEVYSHS 350
    VKTDTSCNEL 360
    Length:360
    Mass (Da):39,539
    Last modified:February 6, 2007 - v1
    Checksum:iF7AB8DD51864D15B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC127328 mRNA. Translation: AAI27329.1.
    RefSeqiNP_001090728.1. NM_001097259.1.
    UniGeneiStr.41167.

    Genome annotation databases

    GeneIDi100036711.
    KEGGixtr:100036711.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC127328 mRNA. Translation: AAI27329.1 .
    RefSeqi NP_001090728.1. NM_001097259.1.
    UniGenei Str.41167.

    3D structure databases

    ProteinModelPortali A1L0Z1.
    SMRi A1L0Z1. Positions 191-337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000031753.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100036711.
    KEGGi xtr:100036711.

    Organism-specific databases

    CTDi 5456.
    Xenbasei XB-GENE-479667. pou3f4.

    Phylogenomic databases

    eggNOGi NOG261729.
    HOGENOMi HOG000116303.
    HOVERGENi HBG053120.
    KOi K09365.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.

    Entry informationi

    Entry nameiPO3F4_XENTR
    AccessioniPrimary (citable) accession number: A1L0Z1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2009
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3