pou3f4

Functionⁱ

Transcriptional activator. Induces neural-specific gene expression to act as a key regulator of neural differentiation (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	277 – 336	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

sequence-specific DNA binding Source: InterPro
transcription factor activity, sequence-specific DNA binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

brain development Source: InterPro
regulation of transcription from RNA polymerase II promoter Source: InterPro
transcription, DNA-templated Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: POU domain, class 3, transcription factor 4By similarity
Gene namesⁱ	Name:pou3f4Imported
Organismⁱ	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifierⁱ	8364 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana
Proteomesⁱ	UP000008143 Componentⁱ: Unassembled WGS sequence

Organism-specific databases

Xenbaseⁱ	XB-GENE-479667. pou3f4.

Xenbaseⁱ

XB-GENE-479667. pou3f4.

Subcellular locationⁱ

Nucleus
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU00108
- PROSITE-ProRule:PRU00530
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P49335 (PO3F4_HUMAN)

GO - Cellular componentⁱ

nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000389617	1 – 360	POU domain, class 3, transcription factor 4Add BLAST		360

Proteomic databases

PaxDbⁱ	A1L0Z1.

PaxDbⁱ

A1L0Z1.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	8364.ENSXETP00000031753.

STRINGⁱ

8364.ENSXETP00000031753.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A1L0Z1.
SMRⁱ	A1L0Z1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	185 – 259	POU-specificPROSITE-ProRule annotationAdd BLAST		75

Sequence similaritiesⁱ

Belongs to the POU transcription factor family. Class-3 subfamily.Sequence analysis

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG3802. Eukaryota. ENOG410XQ7X. LUCA.
HOGENOMⁱ	HOG000116303.
HOVERGENⁱ	HBG053120.
InParanoidⁱ	A1L0Z1.
KEGG Orthology (KO) More...KOⁱ	K09365.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009057. Homeobox-like. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR010982. Lambda_DNA-bd_dom. IPR013847. POU. IPR000327. POU_dom. IPR016362. TF_POU_3.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046. Homeobox. 1 hit. PF00157. Pou. 1 hit.
PIRSFⁱ	PIRSF002629. Transcription_factor_POU. 2 hits.
PRINTSⁱ	PR00028. POUDOMAIN.
SMARTⁱ	View protein in SMART SM00389. HOX. 1 hit. SM00352. POU. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit. SSF47413. SSF47413. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00035. POU_1. 1 hit. PS51179. POU_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A1L0Z1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATAASNPYS ILSSSSLVHD SAIMQQGSPF RNPQKLLQSD YLQGVPSNGH 
        60         70         80         90        100
PLGHHWVTSL SDANPWSTSL GSSPLDQQDI KPGREDLQLG AIIHHRSPHV 
       110        120        130        140        150
THHSPHTNHP NAWGASPAHN SSLTSNGQPI NVYSQSGFTV SGMLDHGGLT 
       160        170        180        190        200
PPPPSGTTQS LHPVLREPVD HGDLGSHHCQ DHSDEETPTS DELEQFAKQF 
       210        220        230        240        250
KQRRIKLGFT QADVGLALGT LYGNVFSQAT ICRFEALQLS FKNMCKLKPL 
       260        270        280        290        300
LNKWLEEADS STGSPTSIDK IAAQGRKRKK RTSIEVSVKG VLETHFLKCP 
       310        320        330        340        350
KPAAQEISSL ADSLQLEKEV VRVWFCNRRQ KEKRMTPPGD PQQHEVYSHS 
       360
VKTDTSCNEL

Length:360

Mass (Da):39,539

Last modified:February 6, 2007 - v1

Checksum:ⁱF7AB8DD51864D15B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC127328 mRNA. Translation: AAI27329.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001090728.1. NM_001097259.1.
UniGeneⁱ	Str.41167.

Genome annotation databases

GeneIDⁱ	100036711.
KEGGⁱ	xtr:100036711.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC127328 mRNA. Translation: AAI27329.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001090728.1. NM_001097259.1.
UniGeneⁱ	Str.41167.

3D structure databases

ProteinModelPortalⁱ	A1L0Z1.
SMRⁱ	A1L0Z1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	8364.ENSXETP00000031753.

STRINGⁱ

8364.ENSXETP00000031753.

Proteomic databases

PaxDbⁱ	A1L0Z1.

PaxDbⁱ

A1L0Z1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	100036711.
KEGGⁱ	xtr:100036711.

Organism-specific databases

CTDⁱ	5456.
Xenbaseⁱ	XB-GENE-479667. pou3f4.

Phylogenomic databases

eggNOGⁱ	KOG3802. Eukaryota. ENOG410XQ7X. LUCA.
HOGENOMⁱ	HOG000116303.
HOVERGENⁱ	HBG053120.
InParanoidⁱ	A1L0Z1.
KEGG Orthology (KO) More...KOⁱ	K09365.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009057. Homeobox-like. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR010982. Lambda_DNA-bd_dom. IPR013847. POU. IPR000327. POU_dom. IPR016362. TF_POU_3.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046. Homeobox. 1 hit. PF00157. Pou. 1 hit.
PIRSFⁱ	PIRSF002629. Transcription_factor_POU. 2 hits.
PRINTSⁱ	PR00028. POUDOMAIN.
SMARTⁱ	View protein in SMART SM00389. HOX. 1 hit. SM00352. POU. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit. SSF47413. SSF47413. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00035. POU_1. 1 hit. PS51179. POU_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PO3F4_XENTR
Accessionⁱ	A1L0Z1Primary (citable) accession number: A1L0Z1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 2009
	Last sequence update:	February 6, 2007
	Last modified:	July 5, 2017
	This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A1L0Z1 (PO3F4_XENTR)

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POU domain, class 3, transcription factor 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ