UniProtKB - A1L0Z1 (PO3F4_XENTR)
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Protein
POU domain, class 3, transcription factor 4
Gene
pou3f4
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Transcriptional activator. Induces neural-specific gene expression to act as a key regulator of neural differentiation (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 277 – 336 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding transcription factor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- brain development Source: InterPro
- regulation of transcription by RNA polymerase II Source: InterPro
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: POU domain, class 3, transcription factor 4By similarity |
Gene namesi | Name:pou3f4Imported |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-479667. pou3f4. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000389617 | 1 – 360 | POU domain, class 3, transcription factor 4Add BLAST | 360 |
Proteomic databases
PaxDbi | A1L0Z1. |
Structurei
3D structure databases
ProteinModelPortali | A1L0Z1. |
SMRi | A1L0Z1. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 185 – 259 | POU-specificPROSITE-ProRule annotationAdd BLAST | 75 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG3802. Eukaryota. ENOG410XQ7X. LUCA. |
HOGENOMi | HOG000116303. |
HOVERGENi | HBG053120. |
InParanoidi | A1L0Z1. |
KOi | K09365. |
Family and domain databases
CDDi | cd00086. homeodomain. 1 hit. |
InterProi | View protein in InterPro IPR009057. Homeobox-like_sf. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR010982. Lambda_DNA-bd_dom_sf. IPR013847. POU. IPR000327. POU_dom. IPR016362. TF_POU_3. |
Pfami | View protein in Pfam PF00046. Homeobox. 1 hit. PF00157. Pou. 1 hit. |
PIRSFi | PIRSF002629. Transcription_factor_POU. 1 hit. |
PRINTSi | PR00028. POUDOMAIN. |
SMARTi | View protein in SMART SM00389. HOX. 1 hit. SM00352. POU. 1 hit. |
SUPFAMi | SSF46689. SSF46689. 1 hit. SSF47413. SSF47413. 1 hit. |
PROSITEi | View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00035. POU_1. 1 hit. PS51179. POU_3. 1 hit. |
i Sequence
Sequence statusi: Complete.
A1L0Z1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATAASNPYS ILSSSSLVHD SAIMQQGSPF RNPQKLLQSD YLQGVPSNGH
60 70 80 90 100
PLGHHWVTSL SDANPWSTSL GSSPLDQQDI KPGREDLQLG AIIHHRSPHV
110 120 130 140 150
THHSPHTNHP NAWGASPAHN SSLTSNGQPI NVYSQSGFTV SGMLDHGGLT
160 170 180 190 200
PPPPSGTTQS LHPVLREPVD HGDLGSHHCQ DHSDEETPTS DELEQFAKQF
210 220 230 240 250
KQRRIKLGFT QADVGLALGT LYGNVFSQAT ICRFEALQLS FKNMCKLKPL
260 270 280 290 300
LNKWLEEADS STGSPTSIDK IAAQGRKRKK RTSIEVSVKG VLETHFLKCP
310 320 330 340 350
KPAAQEISSL ADSLQLEKEV VRVWFCNRRQ KEKRMTPPGD PQQHEVYSHS
360
VKTDTSCNEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC127328 mRNA. Translation: AAI27329.1. |
RefSeqi | NP_001090728.1. NM_001097259.1. |
UniGenei | Str.41167. |
Genome annotation databases
GeneIDi | 100036711. |
KEGGi | xtr:100036711. |
Similar proteinsi
Entry informationi
Entry namei | PO3F4_XENTR | |
Accessioni | A1L0Z1Primary (citable) accession number: A1L0Z1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 2009 |
Last sequence update: | February 6, 2007 | |
Last modified: | March 28, 2018 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |