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Protein
Submitted name:

TNS1 protein

Gene

TNS1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiA1L0S7.

Names & Taxonomyi

Protein namesi
Submitted name:
TNS1 proteinImported
Gene namesi
Name:TNS1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36660.

PTM / Processingi

Proteomic databases

PaxDbiA1L0S7.
PeptideAtlasiA1L0S7.
PRIDEiA1L0S7.

Expressioni

Gene expression databases

GenevisibleiA1L0S7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000171887.

Structurei

3D structure databases

ProteinModelPortaliA1L0S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 230Phosphatase tensin-typeInterPro annotationAdd BLAST173
Domaini235 – 361C2 tensin-typeInterPro annotationAdd BLAST127
Domaini1496 – 1605SH2InterPro annotationAdd BLAST110

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
COG2453. LUCA.
HOGENOMiHOG000060090.
HOVERGENiHBG060186.
KOiK18080.

Family and domain databases

CDDicd01213. PTB_tensin. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR033929. Tensin_PTB.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A1L0S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NHELVPITTE NAPKNVVDKG EGASRGGNTR KSLEDNGSTR VTPSVQPHLQ
60 70 80 90 100
PIRNMSVSRT MEDSCELDLV YVTERIIAVS FPSTANEENF RSNLREVAQM
110 120 130 140 150
LKSKHGGNYL LFNLSERRPD ITKLHAKVLE FGWPDLHTPA LEKICSICKA
160 170 180 190 200
MDTWLNADPH NVVVLHNKGN RGRIGVVIAA YMHYSNISAS ADQALDRFAM
210 220 230 240 250
KRFYEDKIVP IGQPSQRRYV HYFSGLLSGS IKMNNKPLFL HHVIMHGIPN
260 270 280 290 300
FESKGGCRPF LRIYQAMQPV YTSGIYNIPG DSQTSVCITI EPGLLLKGDI
310 320 330 340 350
LLKCYHKKFR SPARDVIFRV QFHTCAIHDL GVVFGKEDLD DAFKDDRFPE
360 370 380 390 400
YGKVEFVFSY GPEKIQGMEH LENGPSVSVD YNTSDPLIRW DSYDNFSGHR
410 420 430 440 450
DDGMEEVVGH TQGPLDGSLY AKVKKKDSLH GSTGAVNATR PTLSATPNHV
460 470 480 490 500
EHTLSVSSDS GNSTASTKTD KTDEPVPGAS SATAALSPQE KRELDRLLSG
510 520 530 540 550
FGLEREKQGA MYHTQHLRSR PAGGSAVPSS GRHVVPAQVH VNGGALASER
560 570 580 590 600
ETDILDDELP NQDGHSAGSM GTLSSLDGVT NISEGGYPEA LSPLTNGLDK
610 620 630 640 650
SYPMEPMVNG GGYPYESASR AGPAHAGHTA PMRPSYSAQE GLAGYQREGP
660 670 680 690 700
HPAWPQPVTT SHYAHDPSGM FRSQSFSEAE PQLPPAPVRG GSSREAVQRG
710 720 730 740 750
LNSWQQQQQQ QQQPRPPPRQ QERAHLESLV ASRPSPQPLA ETPIPSLPEF
760 770 780 790 800
PRAASQQEIE QSIETLNMLM LDLEPASAAA PLHKSQSVPG AWPGASPLSS
810 820 830 840 850
QPLSGSSRQS HPLTQSRSGY IPSGHSLGTP EPAPRASLES VPPGRSYSPY
860 870 880 890 900
DYQPCLAGPN QDFHSKSPAS SSLPAFLPTT HSPPGPQQPP ASLPGLTAQP
910 920 930 940 950
LLSPKEATSD PSRTPEEEPL NLEGLVAHRV AGVQAREKQP AEPPAPLRRR
960 970 980 990 1000
AASDGQYENQ SPEATSPRSP GVRSPVQCVS PELALTIALN PGGRPKEPHL
1010 1020 1030 1040 1050
HSYKEAFEEM EGTSPSSPPP SGVRSPPGLA KTPLSALGLK PHNPADILLH
1060 1070 1080 1090 1100
PTGEPRSYVE SVARTAVAGP RAQDSEPKSF SAPATQAYGH EIPLRNGTLG
1110 1120 1130 1140 1150
GSFVSPSPLS TSSPILSADS TSVGSFPSGE SSDQGPRTPT QPLLESGFRS
1160 1170 1180 1190 1200
GSLGQPSPSA QRNYQSSSPL PTVGSSYSSP DYSLQHFSSS PESQARAQFS
1210 1220 1230 1240 1250
VAGVHTVPGS PQARHRTVGT NTPPSPGFGR RAINSSMAAP SSPSLSHHQM
1260 1270 1280 1290 1300
MGPPGTGFHG STVSSPQSSA ATTPGSPSLC RHPAGVYQVS GLHNKVATTP
1310 1320 1330 1340 1350
GSPSLGRHPG AHQGNLASGL HSNAIASPGS PSLGRHLGGS GSVVPGSPCL
1360 1370 1380 1390 1400
DRHVAYGGYS TPEDRRPTLS RQSSASGYQA PSTPSFPVSP AYYPGLSSPA
1410 1420 1430 1440 1450
TSPSPDSAAF RQGSPTPALP EKRRMSVGDR AGSLPNYATI NGKVSSPVAS
1460 1470 1480 1490 1500
GMSSPSGGST VSFSHTLPDF SKYSMPDNSP ETRAKVKFVQ DTSKYWYKPE
1510 1520 1530 1540 1550
ISREQAIALL KDQEPGAFII RDSHSFRGAY GLAMKVSSPP PTIMQQNKKG
1560 1570 1580 1590 1600
DMTHELVRHF LIETGPRGVK LKGCPNEPNF GSLSALVYQH SIIPLALPCK
1610 1620 1630 1640 1650
LVIPNRDPTD ESKDSSGPTN STADLLKQGA ACNVLFINSV DMESLTGPQA
1660 1670 1680 1690 1700
ISKATSETLA ADPTPAATIV HFKVSAQGIT LTDNQRKLFF RRHYPLNTVT
1710 1720 1730 1740 1750
FCDLDPQERK WMKTEGGAPA KLFGFVARKQ GSTTDNACHL FAELDPNQPA
1760
SAIVNFVSKV MLNAGQKR
Length:1,768
Mass (Da):189,039
Last modified:May 15, 2007 - v2
Checksum:i56822A7AD0C0821C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126910 mRNA. Translation: AAI26911.2.
RefSeqiNP_072174.3. NM_022648.5.
UniGeneiHs.471381.

Genome annotation databases

GeneIDi7145.
KEGGihsa:7145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC126910 mRNA. Translation: AAI26911.2.
RefSeqiNP_072174.3. NM_022648.5.
UniGeneiHs.471381.

3D structure databases

ProteinModelPortaliA1L0S7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000171887.

Proteomic databases

PaxDbiA1L0S7.
PeptideAtlasiA1L0S7.
PRIDEiA1L0S7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7145.
KEGGihsa:7145.

Organism-specific databases

CTDi7145.
PharmGKBiPA36660.

Phylogenomic databases

eggNOGiKOG1930. Eukaryota.
KOG2283. Eukaryota.
COG2453. LUCA.
HOGENOMiHOG000060090.
HOVERGENiHBG060186.
KOiK18080.

Enzyme and pathway databases

SignaLinkiA1L0S7.

Miscellaneous databases

ChiTaRSiTNS1. human.
GenomeRNAii7145.

Gene expression databases

GenevisibleiA1L0S7. HS.

Family and domain databases

CDDicd01213. PTB_tensin. 1 hit.
Gene3Di2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR013625. PTB.
IPR006020. PTB/PI_dom.
IPR000980. SH2.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR033929. Tensin_PTB.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF08416. PTB. 1 hit.
PF10409. PTEN_C2. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
SM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA1L0S7_HUMAN
AccessioniPrimary (citable) accession number: A1L0S7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.