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Protein

RNA-binding protein MEX3A

Gene

MEX3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri469 – 50941RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein MEX3A
Alternative name(s):
RING finger and KH domain-containing protein 4
Gene namesi
Name:MEX3A
Synonyms:RKHD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:33482. MEX3A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162395812.

Polymorphism and mutation databases

BioMutaiMEX3A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520RNA-binding protein MEX3APRO_0000281013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei338 – 3381PhosphoserineCombined sources
Modified residuei462 – 4621PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA1L020.
MaxQBiA1L020.
PaxDbiA1L020.
PeptideAtlasiA1L020.
PRIDEiA1L020.

PTM databases

iPTMnetiA1L020.
PhosphoSiteiA1L020.

Expressioni

Tissue specificityi

Highest levels found in fetal brain and testis. Detected also in thymus, salivary gland and uterus.1 Publication

Gene expression databases

BgeeiA1L020.
CleanExiHS_MEX3A.
GenevisibleiA1L020. HS.

Interactioni

Protein-protein interaction databases

BioGridi124933. 3 interactions.
STRINGi9606.ENSP00000432845.

Structurei

3D structure databases

ProteinModelPortaliA1L020.
SMRiA1L020. Positions 144-193, 223-293, 468-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini132 – 19362KH 1PROSITE-ProRule annotationAdd
BLAST
Domaini223 – 28462KH 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi53 – 10755Pro-richAdd
BLAST
Compositional biasi406 – 41510Poly-Ser
Compositional biasi456 – 4594Poly-Gly

Domaini

Binds RNA through its KH domains.By similarity

Sequence similaritiesi

Contains 2 KH domains.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri469 – 50941RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2113. Eukaryota.
ENOG410ZSHJ. LUCA.
GeneTreeiENSGT00390000018714.
HOVERGENiHBG071698.
InParanoidiA1L020.
KOiK15686.
OMAiCIGECAV.
OrthoDBiEOG7D85WG.
PhylomeDBiA1L020.
TreeFamiTF315107.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1L020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLVVSGIM ERNGGFGELG CFGGSAKDRG LLEDERALQL ALDQLCLLGL
60 70 80 90 100
GEPPAPTAGE DGGGGGGGAP AQPAAPPQPA PPPPPAAPPA APTAAPAAQT
110 120 130 140 150
PQPPTAPKGA SDAKLCALYK EAELRLKGSS NTTECVPVPT SEHVAEIVGR
160 170 180 190 200
QGCKIKALRA KTNTYIKTPV RGEEPVFMVT GRREDVATAR REIISAAEHF
210 220 230 240 250
SMIRASRNKS GAAFGVAPAL PGQVTIRVRV PYRVVGLVVG PKGATIKRIQ
260 270 280 290 300
QQTNTYIITP SRDRDPVFEI TGAPGNVERA REEIETHIAV RTGKILEYNN
310 320 330 340 350
ENDFLAGSPD AAIDSRYSDA WRVHQPGCKP LSTFRQNSLG CIGECGVDSG
360 370 380 390 400
FEAPRLGEQG GDFGYGGYLF PGYGVGKQDV YYGVAETSPP LWAGQENATP
410 420 430 440 450
TSVLFSSASS SSSSSAKARA GPPGAHRSPA TSAGPELAGL PRRPPGEPLQ
460 470 480 490 500
GFSKLGGGGL RSPGGGRDCM VCFESEVTAA LVPCGHNLFC MECAVRICER
510 520
TDPECPVCHI TATQAIRIFS
Length:520
Mass (Da):54,173
Last modified:February 6, 2007 - v1
Checksum:i78C5A5253B2673BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY950677 mRNA. Translation: AAY34145.1.
CCDSiCCDS53377.1.
RefSeqiNP_001087194.1. NM_001093725.1.
UniGeneiHs.591496.

Genome annotation databases

EnsembliENST00000532414; ENSP00000432845; ENSG00000254726.
GeneIDi92312.
KEGGihsa:92312.
UCSCiuc001fnd.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY950677 mRNA. Translation: AAY34145.1.
CCDSiCCDS53377.1.
RefSeqiNP_001087194.1. NM_001093725.1.
UniGeneiHs.591496.

3D structure databases

ProteinModelPortaliA1L020.
SMRiA1L020. Positions 144-193, 223-293, 468-514.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124933. 3 interactions.
STRINGi9606.ENSP00000432845.

PTM databases

iPTMnetiA1L020.
PhosphoSiteiA1L020.

Polymorphism and mutation databases

BioMutaiMEX3A.

Proteomic databases

EPDiA1L020.
MaxQBiA1L020.
PaxDbiA1L020.
PeptideAtlasiA1L020.
PRIDEiA1L020.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000532414; ENSP00000432845; ENSG00000254726.
GeneIDi92312.
KEGGihsa:92312.
UCSCiuc001fnd.4. human.

Organism-specific databases

CTDi92312.
GeneCardsiMEX3A.
HGNCiHGNC:33482. MEX3A.
MIMi611007. gene.
neXtProtiNX_A1L020.
PharmGKBiPA162395812.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2113. Eukaryota.
ENOG410ZSHJ. LUCA.
GeneTreeiENSGT00390000018714.
HOVERGENiHBG071698.
InParanoidiA1L020.
KOiK15686.
OMAiCIGECAV.
OrthoDBiEOG7D85WG.
PhylomeDBiA1L020.
TreeFamiTF315107.

Miscellaneous databases

ChiTaRSiMEX3A. human.
GenomeRNAii92312.
PROiA1L020.
SOURCEiSearch...

Gene expression databases

BgeeiA1L020.
CleanExiHS_MEX3A.
GenevisibleiA1L020. HS.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies."
    Buchet-Poyau K., Courchet J., Le Hir H., Seraphin B., Scoazec J.-Y., Duret L., Domon-Dell C., Freund J.-N., Billaud M.
    Nucleic Acids Res. 35:1289-1300(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, PHOSPHORYLATION, TISSUE SPECIFICITY.
  2. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338 AND SER-462, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiMEX3A_HUMAN
AccessioniPrimary (citable) accession number: A1L020
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: February 6, 2007
Last modified: July 6, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.