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A1KZ92

- PXDNL_HUMAN

UniProt

A1KZ92 - PXDNL_HUMAN

Protein

Peroxidasin-like protein

Gene

PXDNL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.1 Publication

    Catalytic activityi

    2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

    Cofactori

    Binds 1 calcium ion per subunit.By similarity
    Binds 1 heme B (iron-protoporphyrin IX) group covalently per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei812 – 8121Proton acceptorPROSITE-ProRule annotation
    Metal bindingi813 – 8131CalciumPROSITE-ProRule annotation
    Metal bindingi891 – 8911CalciumPROSITE-ProRule annotation
    Metal bindingi893 – 8931Calcium; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi895 – 8951CalciumPROSITE-ProRule annotation
    Metal bindingi897 – 8971CalciumPROSITE-ProRule annotation
    Sitei960 – 9601Transition state stabilizerPROSITE-ProRule annotation
    Metal bindingi1057 – 10571Iron (heme axial ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. endonuclease activity Source: UniProtKB-KW
    2. heme binding Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. peroxidase activity Source: UniProtKB

    GO - Biological processi

    1. hydrogen peroxide catabolic process Source: UniProtKB
    2. oxidation-reduction process Source: UniProtKB

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease, Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Hydrogen peroxide

    Keywords - Ligandi

    Calcium, Heme, Iron, Metal-binding

    Protein family/group databases

    MEROPSiI43.001.
    PeroxiBasei5398. HsPxd02.
    5827. HsPxd03.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxidasin-like protein (EC:1.11.1.7)
    Alternative name(s):
    Cardiac peroxidase
    Vascular peroxidase 2
    polysomal ribonuclease 1
    Short name:
    PRM1
    Gene namesi
    Name:PXDNL
    Synonyms:VPO2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:26359. PXDNL.

    Subcellular locationi

    Secreted Curated
    Isoform PMR1 : Cytoplasm
    Note: Associates with polysomes.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671110.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 14631440Peroxidasin-like proteinPRO_0000330731Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi255 ↔ 305By similarity
    Disulfide bondi351 ↔ 398By similarity
    Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi440 ↔ 488By similarity
    Disulfide bondi532 ↔ 580By similarity
    Disulfide bondi718 ↔ 734By similarity
    Disulfide bondi832 ↔ 842By similarity
    Disulfide bondi836 ↔ 859By similarity
    Disulfide bondi944 ↔ 953By similarity
    Disulfide bondi1160 ↔ 1217By similarity
    Disulfide bondi1258 ↔ 1284By similarity

    Post-translational modificationi

    Phosphorylation by SRC on tyrosine residues is required for targeting to polysomes.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiA1KZ92.
    PRIDEiA1KZ92.

    PTM databases

    PhosphoSiteiA1KZ92.

    Expressioni

    Tissue specificityi

    the 57 kDa isoform PMR1 is the only form detected at protein levels in human cell lines.1 Publication

    Gene expression databases

    ArrayExpressiA1KZ92.
    BgeeiA1KZ92.
    CleanExiHS_PXDNL.
    GenevestigatoriA1KZ92.

    Organism-specific databases

    HPAiHPA007919.

    Interactioni

    Protein-protein interaction databases

    BioGridi126492. 2 interactions.
    STRINGi9606.ENSP00000348645.

    Structurei

    3D structure databases

    ProteinModelPortaliA1KZ92.
    SMRiA1KZ92. Positions 21-599, 708-1297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 5027LRRNTAdd
    BLAST
    Repeati51 – 7222LRR 1Add
    BLAST
    Repeati75 – 9622LRR 2Add
    BLAST
    Repeati99 – 12022LRR 3Add
    BLAST
    Repeati123 – 14422LRR 4Add
    BLAST
    Repeati147 – 16822LRR 5Add
    BLAST
    Domaini180 – 23354LRRCTAdd
    BLAST
    Domaini234 – 32289Ig-like C2-type 1Add
    BLAST
    Domaini330 – 41485Ig-like C2-type 2Add
    BLAST
    Domaini419 – 50486Ig-like C2-type 3Add
    BLAST
    Domaini507 – 59690Ig-like C2-type 4Add
    BLAST
    Domaini1393 – 145159VWFCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation
    Contains 5 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG262194.
    HOGENOMiHOG000016084.
    HOVERGENiHBG108312.
    OMAiRNTRESD.
    PhylomeDBiA1KZ92.
    TreeFamiTF314316.

    Family and domain databases

    Gene3Di1.10.640.10. 2 hits.
    2.60.40.10. 4 hits.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR010255. Haem_peroxidase.
    IPR019791. Haem_peroxidase_animal.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR029610. PXDNL.
    IPR001007. VWF_C.
    [Graphical view]
    PANTHERiPTHR11475:SF38. PTHR11475:SF38. 1 hit.
    PfamiPF03098. An_peroxidase. 1 hit.
    PF07679. I-set. 4 hits.
    PF13855. LRR_8. 2 hits.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PRINTSiPR00457. ANPEROXIDASE.
    SMARTiSM00408. IGc2. 4 hits.
    SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF48113. SSF48113. 1 hit.
    PROSITEiPS50835. IG_LIKE. 4 hits.
    PS51450. LRR. 6 hits.
    PS50292. PEROXIDASE_3. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A1KZ92-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPRLFCWTT LFLLAGWCLP GLPCPSRCLC FKSTVRCMHL MLDHIPQVPQ     50
    QTTVLDLRFN RIREIPGSAF KKLKNLNTLL LNNNHIRKIS RNAFEGLENL 100
    LYLYLYKNEI HALDKQTFKG LISLEHLYIH FNQLEMLQPE TFGDLLRLER 150
    LFLHNNKLSK IPAGSFSNLD SLKRLRLDSN ALVCDCDLMW LGELLQGFAQ 200
    HGHTQAAATC EYPRRLHGRA VASVTVEEFN CQSPRITFEP QDVEVPSGNT 250
    VYFTCRAEGN PKPEIIWIHN NHSLDLEDDT RLNVFDDGTL MIRNTRESDQ 300
    GVYQCMARNS AGEAKTQSAM LRYSSLPAKP SFVIQPQDTE VLIGTSTTLE 350
    CMATGHPHPL ITWTRDNGLE LDGSRHVATS SGLYLQNITQ RDHGRFTCHA 400
    NNSHGTVQAA ANIIVQAPPQ FTVTPKDQVV LEEHAVEWLC EADGNPPPVI 450
    VWTKTGGQLP VEGQHTVLSS GTLRIDRAAQ HDQGQYECQA VSSLGVKKVS 500
    VQLTVKPKAL AVFTQLPQDT SVEVGKNINI SCHAQGEPQP IITWNKEGVQ 550
    ITESGKFHVD DEGTLTIYDA GFPDQGRYEC VARNSFGLAV TNMFLTVTAI 600
    QGRQAGDDFV ESSILDAVQR VDSAINSTRR HLFSQKPHTS SDLLAQFHYP 650
    RDPLIVEMAR AGEIFEHTLQ LIRERVKQGL TVDLEGKEFR YNDLVSPRSL 700
    SLIANLSGCT ARRPLPNCSN RCFHAKYRAH DGTCNNLQQP TWGAALTAFA 750
    RLLQPAYRDG IRAPRGLGLP VGSRQPLPPP RLVATVWARA AAVTPDHSYT 800
    RMLMHWGWFL EHDLDHTVPA LSTARFSDGR PCSSVCTNDP PCFPMNTRHA 850
    DPRGTHAPCM LFARSSPACA SGRPSATVDS VYAREQINQQ TAYIDGSNVY 900
    GSSERESQAL RDPSVPRGLL KTGFPWPPSG KPLLPFSTGP PTECARQEQE 950
    SPCFLAGDHR ANEHLALAAM HTLWFREHNR MATELSALNP HWEGNTVYQE 1000
    ARKIVGAELQ HITYSHWLPK VLGDPGTRML RGYRGYNPNV NAGIINSFAT 1050
    AAFRFGHTLI NPILYRLNAT LGEISEGHLP FHKALFSPSR IIKEGGIDPV 1100
    LRGLFGVAAK WRAPSYLLSP ELTQRLFSAA YSAAVDSAAT IIQRGRDHGI 1150
    PPYVDFRVFC NLTSVKNFED LQNEIKDSEI RQKLRKLYGS PGDIDLWPAL 1200
    MVEDLIPGTR VGPTLMCLFV TQFQRLRDGD RFWYENPGVF TPAQLTQLKQ 1250
    ASLSRVLCDN GDSIQQVQAD VFVKAEYPQD YLNCSEIPKV DLRVWQDCCA 1300
    DCRSRGQFRA VTQESQKKRS AQYSYPVDKD MELSHLRSRQ QDKIYVGEDA 1350
    RNVTVLAKTK FSQDFSTFAA EIQETITALR EQINKLEARL RQAGCTDVRG 1400
    VPRKAEERWM KEDCTHCICE SGQVTCVVEI CPPAPCPSPE LVKGTCCPVC 1450
    RDRGMPSDSP EKR 1463
    Length:1,463
    Mass (Da):163,686
    Last modified:January 11, 2011 - v3
    Checksum:iF6FE8200892CCCAE
    GO
    Isoform 2 (identifier: A1KZ92-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1302-1316: CRSRGQFRAVTQESQ → KQAGGTPEAGRVYRC
         1317-1463: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,316
    Mass (Da):146,935
    Checksum:iB9FD640C9FF6E1FF
    GO
    Isoform PMR1 (identifier: A1KZ92-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-801: Missing.
         1302-1463: CRSRGQFRAV...GMPSDSPEKR → KQAGGTPEAGRVYRC

    Show »
    Length:515
    Mass (Da):57,461
    Checksum:i5A872CB698D94326
    GO

    Sequence cautioni

    The sequence AAX70929.1 differs from that shown. Reason: Frameshift at positions 127 and 132.
    The sequence BAB71713.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAD18663.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence EAW86707.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti781 – 7811R → G in BAD18663. (PubMed:14702039)Curated
    Sequence conflicti833 – 8331S → N in BAD18663. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti343 – 3431I → T.
    Corresponds to variant rs7833909 [ dbSNP | Ensembl ].
    VAR_050488
    Natural varianti583 – 5831R → Q.
    Corresponds to variant rs16916235 [ dbSNP | Ensembl ].
    VAR_050489
    Natural varianti616 – 6161D → A.
    Corresponds to variant rs16916207 [ dbSNP | Ensembl ].
    VAR_050490
    Natural varianti981 – 9811M → V.4 Publications
    Corresponds to variant rs2977020 [ dbSNP | Ensembl ].
    VAR_050491
    Natural varianti1327 – 13271V → D.
    Corresponds to variant rs11774588 [ dbSNP | Ensembl ].
    VAR_050492
    Natural varianti1399 – 13991R → K.1 Publication
    Corresponds to variant rs7827446 [ dbSNP | Ensembl ].
    VAR_050493
    Natural varianti1452 – 14521D → E.1 Publication
    Corresponds to variant rs1052704 [ dbSNP | Ensembl ].
    VAR_050494

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 801801Missing in isoform PMR1. CuratedVSP_044240Add
    BLAST
    Alternative sequencei1302 – 1463162CRSRG…SPEKR → KQAGGTPEAGRVYRC in isoform PMR1. CuratedVSP_044241Add
    BLAST
    Alternative sequencei1302 – 131615CRSRG…TQESQ → KQAGGTPEAGRVYRC in isoform 2. 1 PublicationVSP_033070Add
    BLAST
    Alternative sequencei1317 – 1463147Missing in isoform 2. 1 PublicationVSP_033071Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU170240 mRNA. Translation: ABX24517.1.
    AY877349 mRNA. Translation: AAX70929.1. Frameshift.
    AC090186 Genomic DNA. No translation available.
    AC103958 Genomic DNA. No translation available.
    AC107374 Genomic DNA. No translation available.
    AC011128 Genomic DNA. No translation available.
    AC012413 Genomic DNA. No translation available.
    AK058200 mRNA. Translation: BAB71713.1. Different initiation.
    AK131524 mRNA. Translation: BAD18663.1. Different initiation.
    CH471068 Genomic DNA. Translation: EAW86707.1. Sequence problems.
    CCDSiCCDS47855.1. [A1KZ92-1]
    RefSeqiNP_653252.3. NM_144651.4.
    UniGeneiHs.444882.

    Genome annotation databases

    EnsembliENST00000356297; ENSP00000348645; ENSG00000147485. [A1KZ92-1]
    GeneIDi137902.
    KEGGihsa:137902.
    UCSCiuc003xqu.4. human. [A1KZ92-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU170240 mRNA. Translation: ABX24517.1 .
    AY877349 mRNA. Translation: AAX70929.1 . Frameshift.
    AC090186 Genomic DNA. No translation available.
    AC103958 Genomic DNA. No translation available.
    AC107374 Genomic DNA. No translation available.
    AC011128 Genomic DNA. No translation available.
    AC012413 Genomic DNA. No translation available.
    AK058200 mRNA. Translation: BAB71713.1 . Different initiation.
    AK131524 mRNA. Translation: BAD18663.1 . Different initiation.
    CH471068 Genomic DNA. Translation: EAW86707.1 . Sequence problems.
    CCDSi CCDS47855.1. [A1KZ92-1 ]
    RefSeqi NP_653252.3. NM_144651.4.
    UniGenei Hs.444882.

    3D structure databases

    ProteinModelPortali A1KZ92.
    SMRi A1KZ92. Positions 21-599, 708-1297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126492. 2 interactions.
    STRINGi 9606.ENSP00000348645.

    Protein family/group databases

    MEROPSi I43.001.
    PeroxiBasei 5398. HsPxd02.
    5827. HsPxd03.

    PTM databases

    PhosphoSitei A1KZ92.

    Proteomic databases

    PaxDbi A1KZ92.
    PRIDEi A1KZ92.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356297 ; ENSP00000348645 ; ENSG00000147485 . [A1KZ92-1 ]
    GeneIDi 137902.
    KEGGi hsa:137902.
    UCSCi uc003xqu.4. human. [A1KZ92-1 ]

    Organism-specific databases

    CTDi 137902.
    GeneCardsi GC08M052232.
    HGNCi HGNC:26359. PXDNL.
    HPAi HPA007919.
    neXtProti NX_A1KZ92.
    PharmGKBi PA142671110.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262194.
    HOGENOMi HOG000016084.
    HOVERGENi HBG108312.
    OMAi RNTRESD.
    PhylomeDBi A1KZ92.
    TreeFami TF314316.

    Miscellaneous databases

    GenomeRNAii 137902.
    NextBioi 83705.
    PROi A1KZ92.

    Gene expression databases

    ArrayExpressi A1KZ92.
    Bgeei A1KZ92.
    CleanExi HS_PXDNL.
    Genevestigatori A1KZ92.

    Family and domain databases

    Gene3Di 1.10.640.10. 2 hits.
    2.60.40.10. 4 hits.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR010255. Haem_peroxidase.
    IPR019791. Haem_peroxidase_animal.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR029610. PXDNL.
    IPR001007. VWF_C.
    [Graphical view ]
    PANTHERi PTHR11475:SF38. PTHR11475:SF38. 1 hit.
    Pfami PF03098. An_peroxidase. 1 hit.
    PF07679. I-set. 4 hits.
    PF13855. LRR_8. 2 hits.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PRINTSi PR00457. ANPEROXIDASE.
    SMARTi SM00408. IGc2. 4 hits.
    SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48113. SSF48113. 1 hit.
    PROSITEi PS50835. IG_LIKE. 4 hits.
    PS51450. LRR. 6 hits.
    PS50292. PEROXIDASE_3. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of VPO1, a new animal heme-containing peroxidase."
      Cheng G., Salerno J.C., Cao Z., Pagano P.J., Lambeth J.D.
      Free Radic. Biol. Med. 45:1682-1694(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-981.
    2. "Identification of a novel peroxidase in heart."
      Sum A., Peterfi Z., Geiszt M.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-981; LYS-1399 AND GLU-1452.
      Tissue: Heart.
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 735-1463 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 894-1463 (ISOFORM 1), VARIANT VAL-981.
      Tissue: Pericardium and Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 752-1463, VARIANT VAL-981.
    6. "An endonuclease activity similar to Xenopus PMR1 catalyzes the degradation of normal and nonsense-containing human beta-globin mRNA in erythroid cells."
      Bremer K.A., Stevens A., Schoenberg D.R.
      RNA 9:1157-1167(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION (ISOFORM PMR1), SUBCELLULAR LOCATION.
    7. "Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein."
      Gu S.Q., Bakthavachalu B., Han J., Patil D.P., Otsuka Y., Guda C., Schoenberg D.R.
      RNA 18:1186-1196(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORM PMR1), FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION, INTERACTION WITH SRC.

    Entry informationi

    Entry nameiPXDNL_HUMAN
    AccessioniPrimary (citable) accession number: A1KZ92
    Secondary accession number(s): B5ME43
    , B6CGZ3, H0YBM9, Q6ZMR2, Q96LH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 74 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3