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A1KZ92

- PXDNL_HUMAN

UniProt

A1KZ92 - PXDNL_HUMAN

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Protein

Peroxidasin-like protein

Gene

PXDNL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.1 Publication

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+By similarityNote: Binds 1 Ca(2+) ion per subunit.By similarity
  • heme bBy similarityNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei812 – 8121Proton acceptorPROSITE-ProRule annotation
Metal bindingi813 – 8131CalciumPROSITE-ProRule annotation
Metal bindingi891 – 8911CalciumPROSITE-ProRule annotation
Metal bindingi893 – 8931Calcium; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi895 – 8951CalciumPROSITE-ProRule annotation
Metal bindingi897 – 8971CalciumPROSITE-ProRule annotation
Sitei960 – 9601Transition state stabilizerPROSITE-ProRule annotation
Metal bindingi1057 – 10571Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. endonuclease activity Source: UniProtKB-KW
  2. heme binding Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. peroxidase activity Source: UniProtKB

GO - Biological processi

  1. hydrogen peroxide catabolic process Source: UniProtKB
  2. oxidation-reduction process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease, Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Protein family/group databases

MEROPSiI43.001.
PeroxiBasei5398. HsPxd02.
5827. HsPxd03.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidasin-like protein (EC:1.11.1.7)
Alternative name(s):
Cardiac peroxidase
Vascular peroxidase 2
polysomal ribonuclease 1
Short name:
PRM1
Gene namesi
Name:PXDNL
Synonyms:VPO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:26359. PXDNL.

Subcellular locationi

Secreted Curated
Isoform PMR1 : Cytoplasm
Note: Associates with polysomes.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671110.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 14631440Peroxidasin-like proteinPRO_0000330731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi255 ↔ 305By similarity
Disulfide bondi351 ↔ 398By similarity
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi440 ↔ 488By similarity
Disulfide bondi532 ↔ 580By similarity
Disulfide bondi718 ↔ 734By similarity
Disulfide bondi832 ↔ 842By similarity
Disulfide bondi836 ↔ 859By similarity
Disulfide bondi944 ↔ 953By similarity
Disulfide bondi1160 ↔ 1217By similarity
Disulfide bondi1258 ↔ 1284By similarity

Post-translational modificationi

Phosphorylation by SRC on tyrosine residues is required for targeting to polysomes.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiA1KZ92.
PaxDbiA1KZ92.
PRIDEiA1KZ92.

PTM databases

PhosphoSiteiA1KZ92.

Expressioni

Tissue specificityi

the 57 kDa isoform PMR1 is the only form detected at protein levels in human cell lines.1 Publication

Gene expression databases

BgeeiA1KZ92.
CleanExiHS_PXDNL.
ExpressionAtlasiA1KZ92. baseline and differential.
GenevestigatoriA1KZ92.

Organism-specific databases

HPAiHPA007919.

Interactioni

Protein-protein interaction databases

BioGridi126492. 3 interactions.
STRINGi9606.ENSP00000348645.

Structurei

3D structure databases

ProteinModelPortaliA1KZ92.
SMRiA1KZ92. Positions 21-599, 708-1297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 5027LRRNTAdd
BLAST
Repeati51 – 7222LRR 1Add
BLAST
Repeati75 – 9622LRR 2Add
BLAST
Repeati99 – 12022LRR 3Add
BLAST
Repeati123 – 14422LRR 4Add
BLAST
Repeati147 – 16822LRR 5Add
BLAST
Domaini180 – 23354LRRCTAdd
BLAST
Domaini234 – 32289Ig-like C2-type 1Add
BLAST
Domaini330 – 41485Ig-like C2-type 2Add
BLAST
Domaini419 – 50486Ig-like C2-type 3Add
BLAST
Domaini507 – 59690Ig-like C2-type 4Add
BLAST
Domaini1393 – 145159VWFCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation
Contains 5 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG262194.
GeneTreeiENSGT00550000074325.
HOGENOMiHOG000016084.
HOVERGENiHBG108312.
InParanoidiA1KZ92.
OMAiRNTRESD.
PhylomeDBiA1KZ92.
TreeFamiTF314316.

Family and domain databases

Gene3Di1.10.640.10. 2 hits.
2.60.40.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR029610. PXDNL.
IPR001007. VWF_C.
[Graphical view]
PANTHERiPTHR11475:SF38. PTHR11475:SF38. 1 hit.
PfamiPF03098. An_peroxidase. 1 hit.
PF07679. I-set. 4 hits.
PF13855. LRR_8. 2 hits.
PF00093. VWC. 1 hit.
[Graphical view]
PRINTSiPR00457. ANPEROXIDASE.
SMARTiSM00408. IGc2. 4 hits.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS50835. IG_LIKE. 4 hits.
PS51450. LRR. 6 hits.
PS50292. PEROXIDASE_3. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A1KZ92-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPRLFCWTT LFLLAGWCLP GLPCPSRCLC FKSTVRCMHL MLDHIPQVPQ
60 70 80 90 100
QTTVLDLRFN RIREIPGSAF KKLKNLNTLL LNNNHIRKIS RNAFEGLENL
110 120 130 140 150
LYLYLYKNEI HALDKQTFKG LISLEHLYIH FNQLEMLQPE TFGDLLRLER
160 170 180 190 200
LFLHNNKLSK IPAGSFSNLD SLKRLRLDSN ALVCDCDLMW LGELLQGFAQ
210 220 230 240 250
HGHTQAAATC EYPRRLHGRA VASVTVEEFN CQSPRITFEP QDVEVPSGNT
260 270 280 290 300
VYFTCRAEGN PKPEIIWIHN NHSLDLEDDT RLNVFDDGTL MIRNTRESDQ
310 320 330 340 350
GVYQCMARNS AGEAKTQSAM LRYSSLPAKP SFVIQPQDTE VLIGTSTTLE
360 370 380 390 400
CMATGHPHPL ITWTRDNGLE LDGSRHVATS SGLYLQNITQ RDHGRFTCHA
410 420 430 440 450
NNSHGTVQAA ANIIVQAPPQ FTVTPKDQVV LEEHAVEWLC EADGNPPPVI
460 470 480 490 500
VWTKTGGQLP VEGQHTVLSS GTLRIDRAAQ HDQGQYECQA VSSLGVKKVS
510 520 530 540 550
VQLTVKPKAL AVFTQLPQDT SVEVGKNINI SCHAQGEPQP IITWNKEGVQ
560 570 580 590 600
ITESGKFHVD DEGTLTIYDA GFPDQGRYEC VARNSFGLAV TNMFLTVTAI
610 620 630 640 650
QGRQAGDDFV ESSILDAVQR VDSAINSTRR HLFSQKPHTS SDLLAQFHYP
660 670 680 690 700
RDPLIVEMAR AGEIFEHTLQ LIRERVKQGL TVDLEGKEFR YNDLVSPRSL
710 720 730 740 750
SLIANLSGCT ARRPLPNCSN RCFHAKYRAH DGTCNNLQQP TWGAALTAFA
760 770 780 790 800
RLLQPAYRDG IRAPRGLGLP VGSRQPLPPP RLVATVWARA AAVTPDHSYT
810 820 830 840 850
RMLMHWGWFL EHDLDHTVPA LSTARFSDGR PCSSVCTNDP PCFPMNTRHA
860 870 880 890 900
DPRGTHAPCM LFARSSPACA SGRPSATVDS VYAREQINQQ TAYIDGSNVY
910 920 930 940 950
GSSERESQAL RDPSVPRGLL KTGFPWPPSG KPLLPFSTGP PTECARQEQE
960 970 980 990 1000
SPCFLAGDHR ANEHLALAAM HTLWFREHNR MATELSALNP HWEGNTVYQE
1010 1020 1030 1040 1050
ARKIVGAELQ HITYSHWLPK VLGDPGTRML RGYRGYNPNV NAGIINSFAT
1060 1070 1080 1090 1100
AAFRFGHTLI NPILYRLNAT LGEISEGHLP FHKALFSPSR IIKEGGIDPV
1110 1120 1130 1140 1150
LRGLFGVAAK WRAPSYLLSP ELTQRLFSAA YSAAVDSAAT IIQRGRDHGI
1160 1170 1180 1190 1200
PPYVDFRVFC NLTSVKNFED LQNEIKDSEI RQKLRKLYGS PGDIDLWPAL
1210 1220 1230 1240 1250
MVEDLIPGTR VGPTLMCLFV TQFQRLRDGD RFWYENPGVF TPAQLTQLKQ
1260 1270 1280 1290 1300
ASLSRVLCDN GDSIQQVQAD VFVKAEYPQD YLNCSEIPKV DLRVWQDCCA
1310 1320 1330 1340 1350
DCRSRGQFRA VTQESQKKRS AQYSYPVDKD MELSHLRSRQ QDKIYVGEDA
1360 1370 1380 1390 1400
RNVTVLAKTK FSQDFSTFAA EIQETITALR EQINKLEARL RQAGCTDVRG
1410 1420 1430 1440 1450
VPRKAEERWM KEDCTHCICE SGQVTCVVEI CPPAPCPSPE LVKGTCCPVC
1460
RDRGMPSDSP EKR
Length:1,463
Mass (Da):163,686
Last modified:January 11, 2011 - v3
Checksum:iF6FE8200892CCCAE
GO
Isoform 2 (identifier: A1KZ92-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1302-1316: CRSRGQFRAVTQESQ → KQAGGTPEAGRVYRC
     1317-1463: Missing.

Note: No experimental confirmation available.

Show »
Length:1,316
Mass (Da):146,935
Checksum:iB9FD640C9FF6E1FF
GO
Isoform PMR1 (identifier: A1KZ92-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-801: Missing.
     1302-1463: CRSRGQFRAV...GMPSDSPEKR → KQAGGTPEAGRVYRC

Show »
Length:515
Mass (Da):57,461
Checksum:i5A872CB698D94326
GO

Sequence cautioni

The sequence AAX70929.1 differs from that shown. Reason: Frameshift at positions 127 and 132. Curated
The sequence BAB71713.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD18663.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW86707.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti781 – 7811R → G in BAD18663. (PubMed:14702039)Curated
Sequence conflicti833 – 8331S → N in BAD18663. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti343 – 3431I → T.
Corresponds to variant rs7833909 [ dbSNP | Ensembl ].
VAR_050488
Natural varianti583 – 5831R → Q.
Corresponds to variant rs16916235 [ dbSNP | Ensembl ].
VAR_050489
Natural varianti616 – 6161D → A.
Corresponds to variant rs16916207 [ dbSNP | Ensembl ].
VAR_050490
Natural varianti981 – 9811M → V.4 Publications
Corresponds to variant rs2977020 [ dbSNP | Ensembl ].
VAR_050491
Natural varianti1327 – 13271V → D.
Corresponds to variant rs11774588 [ dbSNP | Ensembl ].
VAR_050492
Natural varianti1399 – 13991R → K.1 Publication
Corresponds to variant rs7827446 [ dbSNP | Ensembl ].
VAR_050493
Natural varianti1452 – 14521D → E.1 Publication
Corresponds to variant rs1052704 [ dbSNP | Ensembl ].
VAR_050494

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 801801Missing in isoform PMR1. CuratedVSP_044240Add
BLAST
Alternative sequencei1302 – 1463162CRSRG…SPEKR → KQAGGTPEAGRVYRC in isoform PMR1. CuratedVSP_044241Add
BLAST
Alternative sequencei1302 – 131615CRSRG…TQESQ → KQAGGTPEAGRVYRC in isoform 2. 1 PublicationVSP_033070Add
BLAST
Alternative sequencei1317 – 1463147Missing in isoform 2. 1 PublicationVSP_033071Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU170240 mRNA. Translation: ABX24517.1.
AY877349 mRNA. Translation: AAX70929.1. Frameshift.
AC090186 Genomic DNA. No translation available.
AC103958 Genomic DNA. No translation available.
AC107374 Genomic DNA. No translation available.
AC011128 Genomic DNA. No translation available.
AC012413 Genomic DNA. No translation available.
AK058200 mRNA. Translation: BAB71713.1. Different initiation.
AK131524 mRNA. Translation: BAD18663.1. Different initiation.
CH471068 Genomic DNA. Translation: EAW86707.1. Sequence problems.
CCDSiCCDS47855.1. [A1KZ92-1]
RefSeqiNP_653252.3. NM_144651.4.
UniGeneiHs.444882.

Genome annotation databases

EnsembliENST00000356297; ENSP00000348645; ENSG00000147485. [A1KZ92-1]
GeneIDi137902.
KEGGihsa:137902.
UCSCiuc003xqu.4. human. [A1KZ92-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU170240 mRNA. Translation: ABX24517.1 .
AY877349 mRNA. Translation: AAX70929.1 . Frameshift.
AC090186 Genomic DNA. No translation available.
AC103958 Genomic DNA. No translation available.
AC107374 Genomic DNA. No translation available.
AC011128 Genomic DNA. No translation available.
AC012413 Genomic DNA. No translation available.
AK058200 mRNA. Translation: BAB71713.1 . Different initiation.
AK131524 mRNA. Translation: BAD18663.1 . Different initiation.
CH471068 Genomic DNA. Translation: EAW86707.1 . Sequence problems.
CCDSi CCDS47855.1. [A1KZ92-1 ]
RefSeqi NP_653252.3. NM_144651.4.
UniGenei Hs.444882.

3D structure databases

ProteinModelPortali A1KZ92.
SMRi A1KZ92. Positions 21-599, 708-1297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126492. 3 interactions.
STRINGi 9606.ENSP00000348645.

Protein family/group databases

MEROPSi I43.001.
PeroxiBasei 5398. HsPxd02.
5827. HsPxd03.

PTM databases

PhosphoSitei A1KZ92.

Proteomic databases

MaxQBi A1KZ92.
PaxDbi A1KZ92.
PRIDEi A1KZ92.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356297 ; ENSP00000348645 ; ENSG00000147485 . [A1KZ92-1 ]
GeneIDi 137902.
KEGGi hsa:137902.
UCSCi uc003xqu.4. human. [A1KZ92-1 ]

Organism-specific databases

CTDi 137902.
GeneCardsi GC08M052232.
HGNCi HGNC:26359. PXDNL.
HPAi HPA007919.
neXtProti NX_A1KZ92.
PharmGKBi PA142671110.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262194.
GeneTreei ENSGT00550000074325.
HOGENOMi HOG000016084.
HOVERGENi HBG108312.
InParanoidi A1KZ92.
OMAi RNTRESD.
PhylomeDBi A1KZ92.
TreeFami TF314316.

Miscellaneous databases

GenomeRNAii 137902.
NextBioi 83705.
PROi A1KZ92.

Gene expression databases

Bgeei A1KZ92.
CleanExi HS_PXDNL.
ExpressionAtlasi A1KZ92. baseline and differential.
Genevestigatori A1KZ92.

Family and domain databases

Gene3Di 1.10.640.10. 2 hits.
2.60.40.10. 4 hits.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR010255. Haem_peroxidase.
IPR019791. Haem_peroxidase_animal.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR029610. PXDNL.
IPR001007. VWF_C.
[Graphical view ]
PANTHERi PTHR11475:SF38. PTHR11475:SF38. 1 hit.
Pfami PF03098. An_peroxidase. 1 hit.
PF07679. I-set. 4 hits.
PF13855. LRR_8. 2 hits.
PF00093. VWC. 1 hit.
[Graphical view ]
PRINTSi PR00457. ANPEROXIDASE.
SMARTi SM00408. IGc2. 4 hits.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF48113. SSF48113. 1 hit.
PROSITEi PS50835. IG_LIKE. 4 hits.
PS51450. LRR. 6 hits.
PS50292. PEROXIDASE_3. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of VPO1, a new animal heme-containing peroxidase."
    Cheng G., Salerno J.C., Cao Z., Pagano P.J., Lambeth J.D.
    Free Radic. Biol. Med. 45:1682-1694(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-981.
  2. "Identification of a novel peroxidase in heart."
    Sum A., Peterfi Z., Geiszt M.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-981; LYS-1399 AND GLU-1452.
    Tissue: Heart.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 735-1463 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 894-1463 (ISOFORM 1), VARIANT VAL-981.
    Tissue: Pericardium and Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 752-1463, VARIANT VAL-981.
  6. "An endonuclease activity similar to Xenopus PMR1 catalyzes the degradation of normal and nonsense-containing human beta-globin mRNA in erythroid cells."
    Bremer K.A., Stevens A., Schoenberg D.R.
    RNA 9:1157-1167(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORM PMR1), SUBCELLULAR LOCATION.
  7. "Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein."
    Gu S.Q., Bakthavachalu B., Han J., Patil D.P., Otsuka Y., Guda C., Schoenberg D.R.
    RNA 18:1186-1196(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORM PMR1), FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION, INTERACTION WITH SRC.

Entry informationi

Entry nameiPXDNL_HUMAN
AccessioniPrimary (citable) accession number: A1KZ92
Secondary accession number(s): B5ME43
, B6CGZ3, H0YBM9, Q6ZMR2, Q96LH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3