A1KZ92 (PXDNL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxidasin-like protein
EC=1.11.1.7

Alternative name(s):
Cardiac peroxidase
Vascular peroxidase 2
polysomal ribonuclease 1
Short name=PRM1

Gene names

Name:	PXDNL
Synonyms:	VPO2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs. Ref.6 Ref.7
Catalytic activity	2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.
Cofactor	Binds 1 calcium ion per subunit By similarity. Binds 1 heme B (iron-protoporphyrin IX) group covalently per subunit By similarity.
Subcellular location	Secreted Potential Ref.6. Isoform PMR1: Cytoplasm. Note: Associates with polysomes. Ref.6
Tissue specificity	the 57 kDa isoform PMR1 is the only form detected at protein levels in human cell lines. Ref.7
Post-translational modification	Phosphorylation by SRC on tyrosine residues is required for targeting to polysomes.
Sequence similarities	Belongs to the peroxidase family. XPO subfamily. Contains 4 Ig-like C2-type (immunoglobulin-like) domains. Contains 5 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Contains 1 VWFC domain.
Sequence caution	The sequence AAX70929.1 differs from that shown. Reason: Frameshift at positions 127 and 132. The sequence BAB71713.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAD18663.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence EAW86707.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Cytoplasm Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Leucine-rich repeat Repeat Signal
Ligand	Calcium Heme Iron Metal-binding
Molecular function	Endonuclease Hydrolase Nuclease Oxidoreductase Peroxidase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	hydrogen peroxide catabolic process Inferred from sequence or structural similarity. Source: UniProtKB nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular space Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW heme binding Inferred from sequence or structural similarity. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW peroxidase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A1KZ92-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A1KZ92-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1302-1316: CRSRGQFRAVTQESQ → KQAGGTPEAGRVYRC
     1317-1463: Missing.

Note: No experimental confirmation available.

Isoform PMR1 (identifier: A1KZ92-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-801: Missing.
     1302-1463: CRSRGQFRAV...GMPSDSPEKR → KQAGGTPEAGRVYRC

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 1463	1440	Peroxidasin-like protein		PRO_0000330731
Regions
	Domain	24 – 50	27	LRRNT
	Repeat	51 – 72	22	LRR 1
	Repeat	75 – 96	22	LRR 2
	Repeat	99 – 120	22	LRR 3
	Repeat	123 – 144	22	LRR 4
	Repeat	147 – 168	22	LRR 5
	Domain	180 – 233	54	LRRCT
	Domain	234 – 322	89	Ig-like C2-type 1
	Domain	330 – 414	85	Ig-like C2-type 2
	Domain	419 – 504	86	Ig-like C2-type 3
	Domain	507 – 596	90	Ig-like C2-type 4
	Domain	1393 – 1451	59	VWFC
Sites
	Active site	812	1	Proton acceptor By similarity
	Metal binding	813	1	Calcium By similarity
	Metal binding	891	1	Calcium By similarity
	Metal binding	893	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	895	1	Calcium By similarity
	Metal binding	897	1	Calcium By similarity
	Metal binding	1057	1	Iron (heme axial ligand) By similarity
	Site	960	1	Transition state stabilizer By similarity
Amino acid modifications
	Glycosylation	387	1	N-linked (GlcNAc...) Potential
	Disulfide bond	255 ↔ 305		By similarity
	Disulfide bond	351 ↔ 398		By similarity
	Disulfide bond	440 ↔ 488		By similarity
	Disulfide bond	532 ↔ 580		By similarity
	Disulfide bond	718 ↔ 734		By similarity
	Disulfide bond	832 ↔ 842		By similarity
	Disulfide bond	836 ↔ 859		By similarity
	Disulfide bond	944 ↔ 953		By similarity
	Disulfide bond	1160 ↔ 1217		By similarity
	Disulfide bond	1258 ↔ 1284		By similarity
Natural variations
	Alternative sequence	1 – 801	801	Missing in isoform PMR1.		VSP_044240
	Alternative sequence	1302 – 1463	162	CRSRG…SPEKR → KQAGGTPEAGRVYRC in isoform PMR1.		VSP_044241
	Alternative sequence	1302 – 1316	15	CRSRG…TQESQ → KQAGGTPEAGRVYRC in isoform 2.		VSP_033070
	Alternative sequence	1317 – 1463	147	Missing in isoform 2.		VSP_033071
	Natural variant	343	1	I → T. Corresponds to variant rs7833909 [ dbSNP | Ensembl ].		VAR_050488
	Natural variant	583	1	R → Q. Corresponds to variant rs16916235 [ dbSNP | Ensembl ].		VAR_050489
	Natural variant	616	1	D → A. Corresponds to variant rs16916207 [ dbSNP | Ensembl ].		VAR_050490
	Natural variant	981	1	M → V. Ref.1 Ref.2 Ref.4 Ref.5 Corresponds to variant rs2977020 [ dbSNP | Ensembl ].		VAR_050491
	Natural variant	1327	1	V → D. Corresponds to variant rs11774588 [ dbSNP | Ensembl ].		VAR_050492
	Natural variant	1399	1	R → K. Ref.2 Corresponds to variant rs7827446 [ dbSNP | Ensembl ].		VAR_050493
	Natural variant	1452	1	D → E. Ref.2 Corresponds to variant rs1052704 [ dbSNP | Ensembl ].		VAR_050494
Experimental info
	Sequence conflict	781	1	R → G in BAD18663. Ref.4
	Sequence conflict	833	1	S → N in BAD18663. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 3. Checksum: F6FE8200892CCCAE	FASTA	1,463	163,686
	10 20 30 40 50 60 MEPRLFCWTT LFLLAGWCLP GLPCPSRCLC FKSTVRCMHL MLDHIPQVPQ QTTVLDLRFN 70 80 90 100 110 120 RIREIPGSAF KKLKNLNTLL LNNNHIRKIS RNAFEGLENL LYLYLYKNEI HALDKQTFKG 130 140 150 160 170 180 LISLEHLYIH FNQLEMLQPE TFGDLLRLER LFLHNNKLSK IPAGSFSNLD SLKRLRLDSN 190 200 210 220 230 240 ALVCDCDLMW LGELLQGFAQ HGHTQAAATC EYPRRLHGRA VASVTVEEFN CQSPRITFEP 250 260 270 280 290 300 QDVEVPSGNT VYFTCRAEGN PKPEIIWIHN NHSLDLEDDT RLNVFDDGTL MIRNTRESDQ 310 320 330 340 350 360 GVYQCMARNS AGEAKTQSAM LRYSSLPAKP SFVIQPQDTE VLIGTSTTLE CMATGHPHPL 370 380 390 400 410 420 ITWTRDNGLE LDGSRHVATS SGLYLQNITQ RDHGRFTCHA NNSHGTVQAA ANIIVQAPPQ 430 440 450 460 470 480 FTVTPKDQVV LEEHAVEWLC EADGNPPPVI VWTKTGGQLP VEGQHTVLSS GTLRIDRAAQ 490 500 510 520 530 540 HDQGQYECQA VSSLGVKKVS VQLTVKPKAL AVFTQLPQDT SVEVGKNINI SCHAQGEPQP 550 560 570 580 590 600 IITWNKEGVQ ITESGKFHVD DEGTLTIYDA GFPDQGRYEC VARNSFGLAV TNMFLTVTAI 610 620 630 640 650 660 QGRQAGDDFV ESSILDAVQR VDSAINSTRR HLFSQKPHTS SDLLAQFHYP RDPLIVEMAR 670 680 690 700 710 720 AGEIFEHTLQ LIRERVKQGL TVDLEGKEFR YNDLVSPRSL SLIANLSGCT ARRPLPNCSN 730 740 750 760 770 780 RCFHAKYRAH DGTCNNLQQP TWGAALTAFA RLLQPAYRDG IRAPRGLGLP VGSRQPLPPP 790 800 810 820 830 840 RLVATVWARA AAVTPDHSYT RMLMHWGWFL EHDLDHTVPA LSTARFSDGR PCSSVCTNDP 850 860 870 880 890 900 PCFPMNTRHA DPRGTHAPCM LFARSSPACA SGRPSATVDS VYAREQINQQ TAYIDGSNVY 910 920 930 940 950 960 GSSERESQAL RDPSVPRGLL KTGFPWPPSG KPLLPFSTGP PTECARQEQE SPCFLAGDHR 970 980 990 1000 1010 1020 ANEHLALAAM HTLWFREHNR MATELSALNP HWEGNTVYQE ARKIVGAELQ HITYSHWLPK 1030 1040 1050 1060 1070 1080 VLGDPGTRML RGYRGYNPNV NAGIINSFAT AAFRFGHTLI NPILYRLNAT LGEISEGHLP 1090 1100 1110 1120 1130 1140 FHKALFSPSR IIKEGGIDPV LRGLFGVAAK WRAPSYLLSP ELTQRLFSAA YSAAVDSAAT 1150 1160 1170 1180 1190 1200 IIQRGRDHGI PPYVDFRVFC NLTSVKNFED LQNEIKDSEI RQKLRKLYGS PGDIDLWPAL 1210 1220 1230 1240 1250 1260 MVEDLIPGTR VGPTLMCLFV TQFQRLRDGD RFWYENPGVF TPAQLTQLKQ ASLSRVLCDN 1270 1280 1290 1300 1310 1320 GDSIQQVQAD VFVKAEYPQD YLNCSEIPKV DLRVWQDCCA DCRSRGQFRA VTQESQKKRS 1330 1340 1350 1360 1370 1380 AQYSYPVDKD MELSHLRSRQ QDKIYVGEDA RNVTVLAKTK FSQDFSTFAA EIQETITALR 1390 1400 1410 1420 1430 1440 EQINKLEARL RQAGCTDVRG VPRKAEERWM KEDCTHCICE SGQVTCVVEI CPPAPCPSPE 1450 1460 LVKGTCCPVC RDRGMPSDSP EKR
	Isoform 2 [UniParc]. Checksum: B9FD640C9FF6E1FF	FASTA	1,316	146,935
	10 20 30 40 50 60 MEPRLFCWTT LFLLAGWCLP GLPCPSRCLC FKSTVRCMHL MLDHIPQVPQ QTTVLDLRFN 70 80 90 100 110 120 RIREIPGSAF KKLKNLNTLL LNNNHIRKIS RNAFEGLENL LYLYLYKNEI HALDKQTFKG 130 140 150 160 170 180 LISLEHLYIH FNQLEMLQPE TFGDLLRLER LFLHNNKLSK IPAGSFSNLD SLKRLRLDSN 190 200 210 220 230 240 ALVCDCDLMW LGELLQGFAQ HGHTQAAATC EYPRRLHGRA VASVTVEEFN CQSPRITFEP 250 260 270 280 290 300 QDVEVPSGNT VYFTCRAEGN PKPEIIWIHN NHSLDLEDDT RLNVFDDGTL MIRNTRESDQ 310 320 330 340 350 360 GVYQCMARNS AGEAKTQSAM LRYSSLPAKP SFVIQPQDTE VLIGTSTTLE CMATGHPHPL 370 380 390 400 410 420 ITWTRDNGLE LDGSRHVATS SGLYLQNITQ RDHGRFTCHA NNSHGTVQAA ANIIVQAPPQ 430 440 450 460 470 480 FTVTPKDQVV LEEHAVEWLC EADGNPPPVI VWTKTGGQLP VEGQHTVLSS GTLRIDRAAQ 490 500 510 520 530 540 HDQGQYECQA VSSLGVKKVS VQLTVKPKAL AVFTQLPQDT SVEVGKNINI SCHAQGEPQP 550 560 570 580 590 600 IITWNKEGVQ ITESGKFHVD DEGTLTIYDA GFPDQGRYEC VARNSFGLAV TNMFLTVTAI 610 620 630 640 650 660 QGRQAGDDFV ESSILDAVQR VDSAINSTRR HLFSQKPHTS SDLLAQFHYP RDPLIVEMAR 670 680 690 700 710 720 AGEIFEHTLQ LIRERVKQGL TVDLEGKEFR YNDLVSPRSL SLIANLSGCT ARRPLPNCSN 730 740 750 760 770 780 RCFHAKYRAH DGTCNNLQQP TWGAALTAFA RLLQPAYRDG IRAPRGLGLP VGSRQPLPPP 790 800 810 820 830 840 RLVATVWARA AAVTPDHSYT RMLMHWGWFL EHDLDHTVPA LSTARFSDGR PCSSVCTNDP 850 860 870 880 890 900 PCFPMNTRHA DPRGTHAPCM LFARSSPACA SGRPSATVDS VYAREQINQQ TAYIDGSNVY 910 920 930 940 950 960 GSSERESQAL RDPSVPRGLL KTGFPWPPSG KPLLPFSTGP PTECARQEQE SPCFLAGDHR 970 980 990 1000 1010 1020 ANEHLALAAM HTLWFREHNR MATELSALNP HWEGNTVYQE ARKIVGAELQ HITYSHWLPK 1030 1040 1050 1060 1070 1080 VLGDPGTRML RGYRGYNPNV NAGIINSFAT AAFRFGHTLI NPILYRLNAT LGEISEGHLP 1090 1100 1110 1120 1130 1140 FHKALFSPSR IIKEGGIDPV LRGLFGVAAK WRAPSYLLSP ELTQRLFSAA YSAAVDSAAT 1150 1160 1170 1180 1190 1200 IIQRGRDHGI PPYVDFRVFC NLTSVKNFED LQNEIKDSEI RQKLRKLYGS PGDIDLWPAL 1210 1220 1230 1240 1250 1260 MVEDLIPGTR VGPTLMCLFV TQFQRLRDGD RFWYENPGVF TPAQLTQLKQ ASLSRVLCDN 1270 1280 1290 1300 1310 GDSIQQVQAD VFVKAEYPQD YLNCSEIPKV DLRVWQDCCA DKQAGGTPEA GRVYRC
	Isoform PMR1 [UniParc]. Checksum: 5A872CB698D94326	FASTA	515	57,461
	10 20 30 40 50 60 MLMHWGWFLE HDLDHTVPAL STARFSDGRP CSSVCTNDPP CFPMNTRHAD PRGTHAPCML 70 80 90 100 110 120 FARSSPACAS GRPSATVDSV YAREQINQQT AYIDGSNVYG SSERESQALR DPSVPRGLLK 130 140 150 160 170 180 TGFPWPPSGK PLLPFSTGPP TECARQEQES PCFLAGDHRA NEHLALAAMH TLWFREHNRM 190 200 210 220 230 240 ATELSALNPH WEGNTVYQEA RKIVGAELQH ITYSHWLPKV LGDPGTRMLR GYRGYNPNVN 250 260 270 280 290 300 AGIINSFATA AFRFGHTLIN PILYRLNATL GEISEGHLPF HKALFSPSRI IKEGGIDPVL 310 320 330 340 350 360 RGLFGVAAKW RAPSYLLSPE LTQRLFSAAY SAAVDSAATI IQRGRDHGIP PYVDFRVFCN 370 380 390 400 410 420 LTSVKNFEDL QNEIKDSEIR QKLRKLYGSP GDIDLWPALM VEDLIPGTRV GPTLMCLFVT 430 440 450 460 470 480 QFQRLRDGDR FWYENPGVFT PAQLTQLKQA SLSRVLCDNG DSIQQVQADV FVKAEYPQDY 490 500 510 LNCSEIPKVD LRVWQDCCAD KQAGGTPEAG RVYRC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of VPO1, a new animal heme-containing peroxidase." Cheng G., Salerno J.C., Cao Z., Pagano P.J., Lambeth J.D. Free Radic. Biol. Med. 45:1682-1694(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-981.
[2]	"Identification of a novel peroxidase in heart." Sum A., Peterfi Z., Geiszt M. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-981; LYS-1399 AND GLU-1452. Tissue: Heart.
[3]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 735-1463 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 894-1463 (ISOFORM 1), VARIANT VAL-981. Tissue: Pericardium and Testis.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 752-1463, VARIANT VAL-981.
[6]	"An endonuclease activity similar to Xenopus PMR1 catalyzes the degradation of normal and nonsense-containing human beta-globin mRNA in erythroid cells." Bremer K.A., Stevens A., Schoenberg D.R. RNA 9:1157-1167(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION (ISOFORM PMR1), SUBCELLULAR LOCATION.
[7]	"Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein." Gu S.Q., Bakthavachalu B., Han J., Patil D.P., Otsuka Y., Guda C., Schoenberg D.R. RNA 18:1186-1196(2012) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORM PMR1), FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION, INTERACTION WITH SRC.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU170240 mRNA. Translation: ABX24517.1. AY877349 mRNA. Translation: AAX70929.1. Frameshift. AC090186 Genomic DNA. No translation available. AC103958 Genomic DNA. No translation available. AC107374 Genomic DNA. No translation available. AC011128 Genomic DNA. No translation available. AC012413 Genomic DNA. No translation available. AK058200 mRNA. Translation: BAB71713.1. Different initiation. AK131524 mRNA. Translation: BAD18663.1. Different initiation. CH471068 Genomic DNA. Translation: EAW86707.1. Sequence problems.
IPI	IPI00065049. IPI00890814.
RefSeq	NP_653252.3. NM_144651.4.
UniGene	Hs.444882.
3D structure databases
ProteinModelPortal	A1KZ92.
SMR	A1KZ92. Positions 21-599, 708-1297.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000348645.
Protein family/group databases
MEROPS	I43.001.
PeroxiBase	5398. HsPxd02. 5827. HsPxd03.
PTM databases
PhosphoSite	A1KZ92.
Proteomic databases
PaxDb	A1KZ92.
PRIDE	A1KZ92.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000356297; ENSP00000348645; ENSG00000147485. ENST00000543296; ENSP00000444865; ENSG00000147485.
GeneID	137902.
KEGG	hsa:137902.
UCSC	uc003xqu.4. human.
Organism-specific databases
CTD	137902.
GeneCards	GC08M052232.
HGNC	HGNC:26359. PXDNL.
HPA	HPA007919.
neXtProt	NX_A1KZ92.
PharmGKB	PA142671110.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG262194.
HOGENOM	HOG000016084.
HOVERGEN	HBG108312.
OMA	EFRYNDL.
OrthoDB	EOG4HDSSN.
Gene expression databases
ArrayExpress	A1KZ92.
Bgee	A1KZ92.
CleanEx	HS_PXDNL.
Genevestigator	A1KZ92.
Family and domain databases
Gene3D	1.10.640.10. 2 hits. 2.60.40.10. 4 hits.
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR010255. Haem_peroxidase. IPR002007. Haem_peroxidase_animal. IPR019791. Haem_peroxidase_animal_subgr. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. IPR001007. VWF_C. [Graphical view]
Pfam	PF03098. An_peroxidase. 1 hit. PF07679. I-set. 4 hits. PF00093. VWC. 1 hit. [Graphical view]
PRINTS	PR00457. ANPEROXIDASE.
SMART	SM00408. IGc2. 4 hits. SM00369. LRR_TYP. 3 hits. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. SM00214. VWC. 1 hit. [Graphical view]
SUPFAM	SSF48113. Peroxidase_super. 1 hit.
PROSITE	PS50835. IG_LIKE. 4 hits. PS51450. LRR. 6 hits. PS00435. PEROXIDASE_1. False negative. PS00436. PEROXIDASE_2. False negative. PS50292. PEROXIDASE_3. 1 hit. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	137902.
NextBio	83705.

Entry information

Entry name

PXDNL_HUMAN

Accession

Primary (citable) accession number: A1KZ92
Secondary accession number(s): B5ME43 , B6CGZ3, H0YBM9, Q6ZMR2, Q96LH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 64 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.