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A1KYZ2

- TPM_PENMO

UniProt

A1KYZ2 - TPM_PENMO

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Protein

Tropomyosin

Gene

TM1

Organism
Penaeus monodon (Giant tiger prawn)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
TropomyosinImported1 Publication
Alternative name(s):
Tropomyosin, fast isoformImported1 Publication
Short name:
Tm-Penm-fastImported
Gene namesi
Name:TM1By similarity
OrganismiPenaeus monodon (Giant tiger prawn)
Taxonomic identifieri6687 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaDendrobranchiataPenaeoideaPenaeidaePenaeus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.2 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3410. Pen m 1.0101.
972. Pen m 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284TropomyosinPRO_0000398788Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliA1KYZ2.
SMRiA1KYZ2. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 284284By similarityAdd
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.Curated

Sequence similaritiesi

Belongs to the tropomyosin family.Sequence Analysis

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1KYZ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAIKKKMQA MKLEKDNAMD RADTLEQQNK EANNRAEKSE EEVHNLQKRM
60 70 80 90 100
QQLENDLDQV QESLLKANIQ LVEKDKALSN AEGEVAALNR RIQLLEEDLE
110 120 130 140 150
RSEERLNTAT TKLAEASQAA DESERMRKVL ENRSLSDEER MDALENQLKE
160 170 180 190 200
ARFLAEEADR KYDEVARKLA MVEADLERAE ERAETGESKI VELEEELRVV
210 220 230 240 250
GNNLKSLEVS EEKANQREEA YKEQIKTLTN KLKAAEARAE FAERSVQKLQ
260 270 280
KEVDRLEDEL VNEKEKYKSI TDELDQTFSE LSGY
Length:284
Mass (Da):32,849
Last modified:February 6, 2007 - v1
Checksum:iBE53B602C37E85E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY827100 mRNA. Translation: AAX37288.1.
AB270629 mRNA. Translation: BAF47262.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY827100 mRNA. Translation: AAX37288.1 .
AB270629 mRNA. Translation: BAF47262.1 .

3D structure databases

ProteinModelPortali A1KYZ2.
SMRi A1KYZ2. Positions 1-283.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 3410. Pen m 1.0101.
972. Pen m 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR000533. Tropomyosin.
[Graphical view ]
Pfami PF00261. Tropomyosin. 1 hit.
[Graphical view ]
PRINTSi PR00194. TROPOMYOSIN.
PROSITEi PS00326. TROPOMYOSIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of tropomyosin from Penaeus monodon."
    Chew F.T., Nah H.L.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of tropomyosins identified as allergens in six species of crustaceans."
    Motoyama K., Suma Y., Ishizaki S., Nagashima Y., Shiomi K.
    J. Agric. Food Chem. 55:985-991(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
    Tissue: Muscle1 Publication.
  3. "Analysis of the allergenic proteins in black tiger prawn (Penaeus monodon) and characterization of the major allergen tropomyosin using mass spectrometry."
    Abdel Rahman A.M., Kamath S., Lopata A.L., Helleur R.J.
    Rapid Commun. Mass Spectrom. 24:2462-2470(2010)
    Cited for: PROTEIN SEQUENCE, ALLERGENICITY, ACETYLATION AT MET-1.
    Tissue: Muscle1 Publication.

Entry informationi

Entry nameiTPM_PENMO
AccessioniPrimary (citable) accession number: A1KYZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: February 6, 2007
Last modified: October 1, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3