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A1KYZ2 (TPM_PENMO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 3, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tropomyosin
Alternative name(s):
Tropomyosin, fast isoform
Short name=Tm-Penm-fast
Gene names
Name:TM1
OrganismPenaeus monodon (Giant tiger prawn)
Taxonomic identifier6687 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaDendrobranchiataPenaeoideaPenaeidaePenaeus

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction By similarity. UniProtKB Q22866

Subunit structure

Homodimer By similarity. UniProtKB A2V735

Domain

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Allergenic properties

Causes an allergic reaction in human. Ref.2 Ref.3

Sequence similarities

Belongs to the tropomyosin family.

Ontologies

Keywords
   DiseaseAllergen
   DomainCoiled coil
Repeat
   PTMAcetylation
   Technical termDirect protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Tropomyosin
PRO_0000398788

Regions

Coiled coil1 – 284284 By similarity UniProtKB O44119

Amino acid modifications

Modified residue11N-acetylmethionine Ref.3

Sequences

Sequence LengthMass (Da)Tools
A1KYZ2 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: BE53B602C37E85E2

FASTA28432,849
        10         20         30         40         50         60 
MDAIKKKMQA MKLEKDNAMD RADTLEQQNK EANNRAEKSE EEVHNLQKRM QQLENDLDQV 

        70         80         90        100        110        120 
QESLLKANIQ LVEKDKALSN AEGEVAALNR RIQLLEEDLE RSEERLNTAT TKLAEASQAA 

       130        140        150        160        170        180 
DESERMRKVL ENRSLSDEER MDALENQLKE ARFLAEEADR KYDEVARKLA MVEADLERAE 

       190        200        210        220        230        240 
ERAETGESKI VELEEELRVV GNNLKSLEVS EEKANQREEA YKEQIKTLTN KLKAAEARAE 

       250        260        270        280 
FAERSVQKLQ KEVDRLEDEL VNEKEKYKSI TDELDQTFSE LSGY 

« Hide

References

[1]"Cloning of tropomyosin from Penaeus monodon."
Chew F.T., Nah H.L.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning of tropomyosins identified as allergens in six species of crustaceans."
Motoyama K., Suma Y., Ishizaki S., Nagashima Y., Shiomi K.
J. Agric. Food Chem. 55:985-991(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
Tissue: Muscle.
[3]"Analysis of the allergenic proteins in black tiger prawn (Penaeus monodon) and characterization of the major allergen tropomyosin using mass spectrometry."
Abdel Rahman A.M., Kamath S., Lopata A.L., Helleur R.J.
Rapid Commun. Mass Spectrom. 24:2462-2470(2010)
Cited for: PROTEIN SEQUENCE, ALLERGENICITY, ACETYLATION AT MET-1.
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY827100 mRNA. Translation: AAX37288.1.
AB270629 mRNA. Translation: BAF47262.1.

3D structure databases

ProteinModelPortalA1KYZ2.
SMRA1KYZ2. Positions 1-283.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3410. Pen m 1.0101.
972. Pen m 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000533. Tropomyosin.
[Graphical view]
PfamPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSPR00194. TROPOMYOSIN.
PROSITEPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPM_PENMO
AccessionPrimary (citable) accession number: A1KYZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: February 6, 2007
Last modified: October 3, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families