A1KYZ2 (TPM_PENMO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tropomyosin

Alternative name(s):
Tropomyosin, fast isoform
Short name=Tm-Penm-fast

Gene names

Name:

TM1

Organism

Penaeus monodon (Giant tiger prawn)

Taxonomic identifier

6687 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Crustacea › Malacostraca › Eumalacostraca › Eucarida › Decapoda › Dendrobranchiata › Penaeoidea › Penaeidae › Penaeus

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction By similarity. UniProtKB Q22866
Subunit structure	Homodimer By similarity. UniProtKB A2V735
Domain	The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Allergenic properties	Causes an allergic reaction in human. Ref.2 Ref.3
Sequence similarities	Belongs to the tropomyosin family.

Ontologies

Keywords
Disease	Allergen
Domain	Coiled coil Repeat
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Tropomyosin		PRO_0000398788
Regions
	Coiled coil	1 – 284	284	By similarity UniProtKB O44119
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	A1KYZ2 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: BE53B602C37E85E2	FASTA	284	32,849
	10 20 30 40 50 60 MDAIKKKMQA MKLEKDNAMD RADTLEQQNK EANNRAEKSE EEVHNLQKRM QQLENDLDQV 70 80 90 100 110 120 QESLLKANIQ LVEKDKALSN AEGEVAALNR RIQLLEEDLE RSEERLNTAT TKLAEASQAA 130 140 150 160 170 180 DESERMRKVL ENRSLSDEER MDALENQLKE ARFLAEEADR KYDEVARKLA MVEADLERAE 190 200 210 220 230 240 ERAETGESKI VELEEELRVV GNNLKSLEVS EEKANQREEA YKEQIKTLTN KLKAAEARAE 250 260 270 280 FAERSVQKLQ KEVDRLEDEL VNEKEKYKSI TDELDQTFSE LSGY

References

[1]	"Cloning of tropomyosin from Penaeus monodon." Chew F.T., Nah H.L. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning of tropomyosins identified as allergens in six species of crustaceans." Motoyama K., Suma Y., Ishizaki S., Nagashima Y., Shiomi K. J. Agric. Food Chem. 55:985-991(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN. Tissue: Muscle.
[3]	"Analysis of the allergenic proteins in black tiger prawn (Penaeus monodon) and characterization of the major allergen tropomyosin using mass spectrometry." Abdel Rahman A.M., Kamath S., Lopata A.L., Helleur R.J. Rapid Commun. Mass Spectrom. 24:2462-2470(2010) Cited for: PROTEIN SEQUENCE, ALLERGENICITY, ACETYLATION AT MET-1. Tissue: Muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY827100 mRNA. Translation: AAX37288.1. AB270629 mRNA. Translation: BAF47262.1.
3D structure databases
ProteinModelPortal	A1KYZ2.
SMR	A1KYZ2. Positions 1-283.
ModBase	Search...
Protein family/group databases
Allergome	3410. Pen m 1.0101. 972. Pen m 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000533. Tropomyosin. [Graphical view]
Pfam	PF00261. Tropomyosin. 1 hit. [Graphical view]
PRINTS	PR00194. TROPOMYOSIN.
PROSITE	PS00326. TROPOMYOSIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPM_PENMO

Accession

Primary (citable) accession number: A1KYZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 5, 2010
Last sequence update:	February 6, 2007
Last modified:	October 3, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)