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A1KYZ2

- TPM_PENMO

UniProt

A1KYZ2 - TPM_PENMO

Protein

Tropomyosin

Gene

TM1

Organism
Penaeus monodon (Giant tiger prawn)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TropomyosinImported1 Publication
    Alternative name(s):
    Tropomyosin, fast isoformImported1 Publication
    Short name:
    Tm-Penm-fastImported
    Gene namesi
    Name:TM1By similarity
    OrganismiPenaeus monodon (Giant tiger prawn)
    Taxonomic identifieri6687 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaDendrobranchiataPenaeoideaPenaeidaePenaeus

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.2 Publications

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3410. Pen m 1.0101.
    972. Pen m 1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284TropomyosinPRO_0000398788Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA1KYZ2.
    SMRiA1KYZ2. Positions 1-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1 – 284284By similarityAdd
    BLAST

    Domaini

    The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.Curated

    Sequence similaritiesi

    Belongs to the tropomyosin family.Sequence Analysis

    Keywords - Domaini

    Coiled coil, Repeat

    Family and domain databases

    InterProiIPR000533. Tropomyosin.
    [Graphical view]
    PfamiPF00261. Tropomyosin. 1 hit.
    [Graphical view]
    PRINTSiPR00194. TROPOMYOSIN.
    PROSITEiPS00326. TROPOMYOSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1KYZ2-1 [UniParc]FASTAAdd to Basket

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    MDAIKKKMQA MKLEKDNAMD RADTLEQQNK EANNRAEKSE EEVHNLQKRM    50
    QQLENDLDQV QESLLKANIQ LVEKDKALSN AEGEVAALNR RIQLLEEDLE 100
    RSEERLNTAT TKLAEASQAA DESERMRKVL ENRSLSDEER MDALENQLKE 150
    ARFLAEEADR KYDEVARKLA MVEADLERAE ERAETGESKI VELEEELRVV 200
    GNNLKSLEVS EEKANQREEA YKEQIKTLTN KLKAAEARAE FAERSVQKLQ 250
    KEVDRLEDEL VNEKEKYKSI TDELDQTFSE LSGY 284
    Length:284
    Mass (Da):32,849
    Last modified:February 6, 2007 - v1
    Checksum:iBE53B602C37E85E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY827100 mRNA. Translation: AAX37288.1.
    AB270629 mRNA. Translation: BAF47262.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY827100 mRNA. Translation: AAX37288.1 .
    AB270629 mRNA. Translation: BAF47262.1 .

    3D structure databases

    ProteinModelPortali A1KYZ2.
    SMRi A1KYZ2. Positions 1-283.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3410. Pen m 1.0101.
    972. Pen m 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000533. Tropomyosin.
    [Graphical view ]
    Pfami PF00261. Tropomyosin. 1 hit.
    [Graphical view ]
    PRINTSi PR00194. TROPOMYOSIN.
    PROSITEi PS00326. TROPOMYOSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of tropomyosin from Penaeus monodon."
      Chew F.T., Nah H.L.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of tropomyosins identified as allergens in six species of crustaceans."
      Motoyama K., Suma Y., Ishizaki S., Nagashima Y., Shiomi K.
      J. Agric. Food Chem. 55:985-991(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
      Tissue: Muscle1 Publication.
    3. "Analysis of the allergenic proteins in black tiger prawn (Penaeus monodon) and characterization of the major allergen tropomyosin using mass spectrometry."
      Abdel Rahman A.M., Kamath S., Lopata A.L., Helleur R.J.
      Rapid Commun. Mass Spectrom. 24:2462-2470(2010)
      Cited for: PROTEIN SEQUENCE, ALLERGENICITY, ACETYLATION AT MET-1.
      Tissue: Muscle1 Publication.

    Entry informationi

    Entry nameiTPM_PENMO
    AccessioniPrimary (citable) accession number: A1KYZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3