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A1KXE4

- F168B_HUMAN

UniProt

A1KXE4 - F168B_HUMAN

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Protein

Myelin-associated neurite-outgrowth inhibitor

Gene

FAM168B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin-associated neurite-outgrowth inhibitor
Short name:
Mani
Alternative name(s):
p20
Gene namesi
Name:FAM168B
Synonyms:KIAA0280L, MANI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:27016. FAM168B.

Subcellular locationi

Cytoplasmperinuclear region By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell projectionaxon By similarity
Note: Expressed in neuronal cell bodies and axonal fibers.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei19 – 4224HelicalSequence AnalysisAdd
BLAST
Topological domaini43 – 142100ExtracellularSequence AnalysisAdd
BLAST
Transmembranei143 – 16422HelicalSequence AnalysisAdd
BLAST
Topological domaini165 – 19531CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-KW
  3. extracellular vesicular exosome Source: UniProtKB
  4. integral component of membrane Source: UniProtKB-KW
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162387098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 195195Myelin-associated neurite-outgrowth inhibitorPRO_0000325978Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiA1KXE4.
PaxDbiA1KXE4.
PRIDEiA1KXE4.

PTM databases

PhosphoSiteiA1KXE4.

Expressioni

Tissue specificityi

Expressed in the brain, within neuronal axonal fibers and associated with myelin sheets (at protein level). Expression tends to be lower in the brain of Alzheimer disease patients compared to healthy individuals (at protein level).1 Publication

Gene expression databases

BgeeiA1KXE4.
CleanExiHS_FAM168B.
GenevestigatoriA1KXE4.

Organism-specific databases

HPAiHPA043778.

Interactioni

Subunit structurei

May form homodimers. May interact with DAZAP2, FAM168A, PRDX6, RBM6, TMTC1 and YPEL2. Interacts with CDC27.2 Publications

Protein-protein interaction databases

BioGridi126221. 1 interaction.
IntActiA1KXE4. 2 interactions.
MINTiMINT-6768637.
STRINGi9606.ENSP00000374565.

Structurei

3D structure databases

ProteinModelPortaliA1KXE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM168 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG28430.
GeneTreeiENSGT00390000005140.
HOGENOMiHOG000073527.
HOVERGENiHBG052179.
InParanoidiA1KXE4.
OMAiPFTNTKG.
OrthoDBiEOG7HB5BT.
PhylomeDBiA1KXE4.
TreeFamiTF331128.

Family and domain databases

InterProiIPR029247. FAM168A/MANI.
[Graphical view]
PfamiPF14944. TCRP1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A1KXE4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPVYSPGSS GVPYANAKGI GYPAGFPMGY AAAAPAYSPN MYPGANPTFQ
60 70 80 90 100
TGYTPGTPYK VSCSPTSGAV PPYSSSPNPY QTAVYPVRSA YPQQSPYAQQ
110 120 130 140 150
GTYYTQPLYA APPHVIHHTT VVQPNGMPAT VYPAPIPPPR GNGVTMGMVA
160 170 180 190
GTTMAMSAGT LLTAHSPTPV APHPVTVPTY RAPGTPTYSY VPPQW
Length:195
Mass (Da):20,324
Last modified:February 20, 2007 - v1
Checksum:i27A0D0D74AB44A10
GO
Isoform 2 (identifier: A1KXE4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-195: NPYQTAVYPV...PTYSYVPPQW → QAVPMSPCAD...EALESLMDCN

Show »
Length:123
Mass (Da):12,707
Checksum:i3602279D84F60ECE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71P → L in AAI10643. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei78 – 195118NPYQT…VPPQW → QAVPMSPCADQWARQLGQIS GQPFVLLAGLLCWPHGEALE SLMDCN in isoform 2. 1 PublicationVSP_032508Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY253283 mRNA. Translation: AAP79599.1.
CH471250 Genomic DNA. Translation: EAW51267.1.
BC066347 mRNA. Translation: AAH66347.1.
BC110642 mRNA. Translation: AAI10643.1.
CCDSiCCDS42755.1. [A1KXE4-1]
RefSeqiNP_001009993.2. NM_001009993.2. [A1KXE4-1]
XP_005263648.1. XM_005263591.2. [A1KXE4-1]
XP_006712326.1. XM_006712263.1. [A1KXE4-1]
XP_006712327.1. XM_006712264.1. [A1KXE4-1]
XP_006712328.1. XM_006712265.1. [A1KXE4-1]
XP_006712329.1. XM_006712266.1. [A1KXE4-1]
UniGeneiHs.534679.

Genome annotation databases

EnsembliENST00000389915; ENSP00000374565; ENSG00000152102. [A1KXE4-1]
ENST00000409185; ENSP00000387051; ENSG00000152102. [A1KXE4-1]
GeneIDi130074.
KEGGihsa:130074.
UCSCiuc002tsd.3. human. [A1KXE4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY253283 mRNA. Translation: AAP79599.1 .
CH471250 Genomic DNA. Translation: EAW51267.1 .
BC066347 mRNA. Translation: AAH66347.1 .
BC110642 mRNA. Translation: AAI10643.1 .
CCDSi CCDS42755.1. [A1KXE4-1 ]
RefSeqi NP_001009993.2. NM_001009993.2. [A1KXE4-1 ]
XP_005263648.1. XM_005263591.2. [A1KXE4-1 ]
XP_006712326.1. XM_006712263.1. [A1KXE4-1 ]
XP_006712327.1. XM_006712264.1. [A1KXE4-1 ]
XP_006712328.1. XM_006712265.1. [A1KXE4-1 ]
XP_006712329.1. XM_006712266.1. [A1KXE4-1 ]
UniGenei Hs.534679.

3D structure databases

ProteinModelPortali A1KXE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126221. 1 interaction.
IntActi A1KXE4. 2 interactions.
MINTi MINT-6768637.
STRINGi 9606.ENSP00000374565.

PTM databases

PhosphoSitei A1KXE4.

Proteomic databases

MaxQBi A1KXE4.
PaxDbi A1KXE4.
PRIDEi A1KXE4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389915 ; ENSP00000374565 ; ENSG00000152102 . [A1KXE4-1 ]
ENST00000409185 ; ENSP00000387051 ; ENSG00000152102 . [A1KXE4-1 ]
GeneIDi 130074.
KEGGi hsa:130074.
UCSCi uc002tsd.3. human. [A1KXE4-1 ]

Organism-specific databases

CTDi 130074.
GeneCardsi GC02M131805.
HGNCi HGNC:27016. FAM168B.
HPAi HPA043778.
neXtProti NX_A1KXE4.
PharmGKBi PA162387098.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG28430.
GeneTreei ENSGT00390000005140.
HOGENOMi HOG000073527.
HOVERGENi HBG052179.
InParanoidi A1KXE4.
OMAi PFTNTKG.
OrthoDBi EOG7HB5BT.
PhylomeDBi A1KXE4.
TreeFami TF331128.

Miscellaneous databases

ChiTaRSi FAM168B. human.
GenomeRNAii 130074.
NextBioi 82696.
PROi A1KXE4.

Gene expression databases

Bgeei A1KXE4.
CleanExi HS_FAM168B.
Genevestigatori A1KXE4.

Family and domain databases

InterProi IPR029247. FAM168A/MANI.
[Graphical view ]
Pfami PF14944. TCRP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The novel protein MANI modulates neurogenesis and neurite-cone growth."
    Mishra M., Akatsu H., Heese K.
    J. Cell. Mol. Med. 15:1713-1725(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), HOMODIMERIZATION, INTERACTION WITH CDC27; PRDX6 AND RBM6, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Eye.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Characterizing the neurite outgrowth inhibitory effect of Mani."
    Mishra M., Lee S., Lin M.K., Yamashita T., Heese K.
    FEBS Lett. 586:3018-3023(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DAZAP2; FAM168A; TMTC1 AND YPEL2.

Entry informationi

Entry nameiF168B_HUMAN
AccessioniPrimary (citable) accession number: A1KXE4
Secondary accession number(s): Q2TAZ6, Q6NZ40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3