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Protein

Fas apoptotic inhibitory molecule 3

Gene

Fcmr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Fas apoptotic inhibitory molecule 3By similarity
Alternative name(s):
IgM Fc fragment receptorBy similarityImported
Regulator of Fas-induced apoptosis TosoBy similarity
Gene namesi
Name:FcmrBy similarityImported
Synonyms:Faim3, Toso
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916419. Fcmr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 262ExtracellularSequence analysisAdd BLAST245
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 422CytoplasmicSequence analysisAdd BLAST139

GO - Cellular componenti

  • cell surface Source: MGI
  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000028442218 – 422Fas apoptotic inhibitory molecule 3Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 103By similarity
Modified residuei91PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiA1KXC4.
PRIDEiA1KXC4.

PTM databases

iPTMnetiA1KXC4.
PhosphoSitePlusiA1KXC4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042474.
CleanExiMM_FAIM3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048303.

Structurei

3D structure databases

ProteinModelPortaliA1KXC4.
SMRiA1KXC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 104Ig-likeAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi285 – 339Arg-richAdd BLAST55

Domaini

The Ig-like domain is required for the anti-apoptotic ability.By similarity

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ2J. Eukaryota.
ENOG41113GQ. LUCA.
HOGENOMiHOG000013142.
HOVERGENiHBG107910.
InParanoidiA1KXC4.
PhylomeDBiA1KXC4.
TreeFamiTF338713.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1KXC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFWLWLLYF LPVSGALRVL PEVQLNVEWG GSIIIECPLP QLHVRMYLCR
60 70 80 90 100
QMAKPGICST VVSNTFVKKE YERRVTLTPC LDKKLFLVEM TQLTENDDGI
110 120 130 140 150
YACGVGMKTD KGKTQKITLN VHNEYPEPFW EDEWTSERPR WLHRFLQHQM
160 170 180 190 200
PWLHGSEHPS SSGVIAKVTT PAPKTEAPPV HQPSSITSVT QHPRVYRAFS
210 220 230 240 250
VSATKSPALL PATTASKTST QQAIRPLEAS YSHHTRLHEQ RTRHHGPHYG
260 270 280 290 300
REDRGLHIPI PEFHILIPTF LGFLLLVLLG LVVKRAIQRR RASSRRAGRL
310 320 330 340 350
AMRRRGRGAS RPFPTQRRDA SQRPRSQNNV YSACPRRARG PDSLGPAEAP
360 370 380 390 400
LLNAPASASP ASPQVLEAPW PHTPSLKMSC EYVSLGYQPA VNLEDPDSDD
410 420
YINIPDPSHL PSYAPGPRSS CP
Length:422
Mass (Da):47,471
Last modified:April 17, 2007 - v2
Checksum:i24270D3B50AD871E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172A → T in AAP51725 (Ref. 1) Curated1
Sequence conflicti172A → T in AAP51727 (Ref. 1) Curated1
Sequence conflicti172A → T in AAP51728 (Ref. 1) Curated1
Sequence conflicti172A → T in AAP51729 (Ref. 1) Curated1
Sequence conflicti172A → T in BAE33514 (PubMed:16141072).Curated1
Sequence conflicti172A → T in BAB25207 (PubMed:16141072).Curated1
Sequence conflicti179P → L in AAP51728 (Ref. 1) Curated1
Sequence conflicti217K → R in AAP51728 (Ref. 1) Curated1
Sequence conflicti321S → P in AAP51723 (Ref. 1) Curated1
Sequence conflicti321S → P in AAP51724 (Ref. 1) Curated1
Sequence conflicti321S → P in AAP51725 (Ref. 1) Curated1
Sequence conflicti321S → P in AAP51726 (Ref. 1) Curated1
Sequence conflicti321S → P in AAP51730 (Ref. 1) Curated1
Sequence conflicti321S → P in AAP51731 (Ref. 1) Curated1
Sequence conflicti321S → P in AAI16675 (PubMed:15489334).Curated1
Sequence conflicti321S → P in AAI18506 (PubMed:15489334).Curated1
Sequence conflicti422P → Q in BAE33514 (PubMed:16141072).Curated1
Sequence conflicti422P → Q in BAB25207 (PubMed:16141072).Curated1
Sequence conflicti422P → Q in AAI16675 (PubMed:15489334).Curated1
Sequence conflicti422P → Q in AAI18506 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227385 mRNA. Translation: AAP51723.1.
AY227386 mRNA. Translation: AAP51724.1.
AY227387 mRNA. Translation: AAP51725.1.
AY227388 mRNA. Translation: AAP51726.1.
AY227389 mRNA. Translation: AAP51727.1.
AY227390 mRNA. Translation: AAP51728.1.
AY227391 mRNA. Translation: AAP51729.1.
AY227392 mRNA. Translation: AAP51730.1.
AY227393 mRNA. Translation: AAP51731.1.
AK007714 mRNA. Translation: BAB25207.1.
AK155943 mRNA. Translation: BAE33514.1.
BC118505 mRNA. Translation: AAI18506.1.
BC116674 mRNA. Translation: AAI16675.1.
RefSeqiNP_081252.1. NM_026976.2.
UniGeneiMm.46042.

Genome annotation databases

GeneIDi69169.
KEGGimmu:69169.
UCSCiuc007cmn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227385 mRNA. Translation: AAP51723.1.
AY227386 mRNA. Translation: AAP51724.1.
AY227387 mRNA. Translation: AAP51725.1.
AY227388 mRNA. Translation: AAP51726.1.
AY227389 mRNA. Translation: AAP51727.1.
AY227390 mRNA. Translation: AAP51728.1.
AY227391 mRNA. Translation: AAP51729.1.
AY227392 mRNA. Translation: AAP51730.1.
AY227393 mRNA. Translation: AAP51731.1.
AK007714 mRNA. Translation: BAB25207.1.
AK155943 mRNA. Translation: BAE33514.1.
BC118505 mRNA. Translation: AAI18506.1.
BC116674 mRNA. Translation: AAI16675.1.
RefSeqiNP_081252.1. NM_026976.2.
UniGeneiMm.46042.

3D structure databases

ProteinModelPortaliA1KXC4.
SMRiA1KXC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048303.

PTM databases

iPTMnetiA1KXC4.
PhosphoSitePlusiA1KXC4.

Proteomic databases

PaxDbiA1KXC4.
PRIDEiA1KXC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi69169.
KEGGimmu:69169.
UCSCiuc007cmn.1. mouse.

Organism-specific databases

CTDi9214.
MGIiMGI:1916419. Fcmr.

Phylogenomic databases

eggNOGiENOG410IJ2J. Eukaryota.
ENOG41113GQ. LUCA.
HOGENOMiHOG000013142.
HOVERGENiHBG107910.
InParanoidiA1KXC4.
PhylomeDBiA1KXC4.
TreeFamiTF338713.

Miscellaneous databases

PROiA1KXC4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042474.
CleanExiMM_FAIM3.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFAIM3_MOUSE
AccessioniPrimary (citable) accession number: A1KXC4
Secondary accession number(s): A1KXC6
, A1KXC8, A1KXC9, Q148B9, Q9D8T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.