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Protein

Fas apoptotic inhibitory molecule 3

Gene

Fcmr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Fas apoptotic inhibitory molecule 3By similarity
Alternative name(s):
IgM Fc fragment receptorBy similarityImported
Regulator of Fas-induced apoptosis TosoBy similarity
Gene namesi
Name:FcmrBy similarityImported
Synonyms:Faim3, Toso
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916419. Fcmr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 262245ExtracellularSequence analysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence analysisAdd
BLAST
Topological domaini284 – 422139CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: MGI
  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 422405Fas apoptotic inhibitory molecule 3PRO_0000284422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 103By similarity
Modified residuei91 – 911PhosphothreonineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiA1KXC4.
PRIDEiA1KXC4.

PTM databases

iPTMnetiA1KXC4.
PhosphoSiteiA1KXC4.

Expressioni

Gene expression databases

BgeeiA1KXC4.
CleanExiMM_FAIM3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048303.

Structurei

3D structure databases

ProteinModelPortaliA1KXC4.
SMRiA1KXC4. Positions 30-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 10472Ig-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi285 – 33955Arg-richAdd
BLAST

Domaini

The Ig-like domain is required for the anti-apoptotic ability.By similarity

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ2J. Eukaryota.
ENOG41113GQ. LUCA.
HOGENOMiHOG000013142.
HOVERGENiHBG107910.
InParanoidiA1KXC4.
OrthoDBiEOG73FQNQ.
PhylomeDBiA1KXC4.
TreeFamiTF338713.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1KXC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFWLWLLYF LPVSGALRVL PEVQLNVEWG GSIIIECPLP QLHVRMYLCR
60 70 80 90 100
QMAKPGICST VVSNTFVKKE YERRVTLTPC LDKKLFLVEM TQLTENDDGI
110 120 130 140 150
YACGVGMKTD KGKTQKITLN VHNEYPEPFW EDEWTSERPR WLHRFLQHQM
160 170 180 190 200
PWLHGSEHPS SSGVIAKVTT PAPKTEAPPV HQPSSITSVT QHPRVYRAFS
210 220 230 240 250
VSATKSPALL PATTASKTST QQAIRPLEAS YSHHTRLHEQ RTRHHGPHYG
260 270 280 290 300
REDRGLHIPI PEFHILIPTF LGFLLLVLLG LVVKRAIQRR RASSRRAGRL
310 320 330 340 350
AMRRRGRGAS RPFPTQRRDA SQRPRSQNNV YSACPRRARG PDSLGPAEAP
360 370 380 390 400
LLNAPASASP ASPQVLEAPW PHTPSLKMSC EYVSLGYQPA VNLEDPDSDD
410 420
YINIPDPSHL PSYAPGPRSS CP
Length:422
Mass (Da):47,471
Last modified:April 17, 2007 - v2
Checksum:i24270D3B50AD871E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti172 – 1721A → T in AAP51725 (Ref. 1) Curated
Sequence conflicti172 – 1721A → T in AAP51727 (Ref. 1) Curated
Sequence conflicti172 – 1721A → T in AAP51728 (Ref. 1) Curated
Sequence conflicti172 – 1721A → T in AAP51729 (Ref. 1) Curated
Sequence conflicti172 – 1721A → T in BAE33514 (PubMed:16141072).Curated
Sequence conflicti172 – 1721A → T in BAB25207 (PubMed:16141072).Curated
Sequence conflicti179 – 1791P → L in AAP51728 (Ref. 1) Curated
Sequence conflicti217 – 2171K → R in AAP51728 (Ref. 1) Curated
Sequence conflicti321 – 3211S → P in AAP51723 (Ref. 1) Curated
Sequence conflicti321 – 3211S → P in AAP51724 (Ref. 1) Curated
Sequence conflicti321 – 3211S → P in AAP51725 (Ref. 1) Curated
Sequence conflicti321 – 3211S → P in AAP51726 (Ref. 1) Curated
Sequence conflicti321 – 3211S → P in AAP51730 (Ref. 1) Curated
Sequence conflicti321 – 3211S → P in AAP51731 (Ref. 1) Curated
Sequence conflicti321 – 3211S → P in AAI16675 (PubMed:15489334).Curated
Sequence conflicti321 – 3211S → P in AAI18506 (PubMed:15489334).Curated
Sequence conflicti422 – 4221P → Q in BAE33514 (PubMed:16141072).Curated
Sequence conflicti422 – 4221P → Q in BAB25207 (PubMed:16141072).Curated
Sequence conflicti422 – 4221P → Q in AAI16675 (PubMed:15489334).Curated
Sequence conflicti422 – 4221P → Q in AAI18506 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227385 mRNA. Translation: AAP51723.1.
AY227386 mRNA. Translation: AAP51724.1.
AY227387 mRNA. Translation: AAP51725.1.
AY227388 mRNA. Translation: AAP51726.1.
AY227389 mRNA. Translation: AAP51727.1.
AY227390 mRNA. Translation: AAP51728.1.
AY227391 mRNA. Translation: AAP51729.1.
AY227392 mRNA. Translation: AAP51730.1.
AY227393 mRNA. Translation: AAP51731.1.
AK007714 mRNA. Translation: BAB25207.1.
AK155943 mRNA. Translation: BAE33514.1.
BC118505 mRNA. Translation: AAI18506.1.
BC116674 mRNA. Translation: AAI16675.1.
RefSeqiNP_081252.1. NM_026976.2.
UniGeneiMm.46042.

Genome annotation databases

GeneIDi69169.
KEGGimmu:69169.
UCSCiuc007cmn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227385 mRNA. Translation: AAP51723.1.
AY227386 mRNA. Translation: AAP51724.1.
AY227387 mRNA. Translation: AAP51725.1.
AY227388 mRNA. Translation: AAP51726.1.
AY227389 mRNA. Translation: AAP51727.1.
AY227390 mRNA. Translation: AAP51728.1.
AY227391 mRNA. Translation: AAP51729.1.
AY227392 mRNA. Translation: AAP51730.1.
AY227393 mRNA. Translation: AAP51731.1.
AK007714 mRNA. Translation: BAB25207.1.
AK155943 mRNA. Translation: BAE33514.1.
BC118505 mRNA. Translation: AAI18506.1.
BC116674 mRNA. Translation: AAI16675.1.
RefSeqiNP_081252.1. NM_026976.2.
UniGeneiMm.46042.

3D structure databases

ProteinModelPortaliA1KXC4.
SMRiA1KXC4. Positions 30-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048303.

PTM databases

iPTMnetiA1KXC4.
PhosphoSiteiA1KXC4.

Proteomic databases

PaxDbiA1KXC4.
PRIDEiA1KXC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi69169.
KEGGimmu:69169.
UCSCiuc007cmn.1. mouse.

Organism-specific databases

CTDi9214.
MGIiMGI:1916419. Fcmr.

Phylogenomic databases

eggNOGiENOG410IJ2J. Eukaryota.
ENOG41113GQ. LUCA.
HOGENOMiHOG000013142.
HOVERGENiHBG107910.
InParanoidiA1KXC4.
OrthoDBiEOG73FQNQ.
PhylomeDBiA1KXC4.
TreeFamiTF338713.

Miscellaneous databases

PROiA1KXC4.
SOURCEiSearch...

Gene expression databases

BgeeiA1KXC4.
CleanExiMM_FAIM3.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Song Y., Jacob C.O.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv, BALB/cJ, C3H/HeJ, C57BL/6J, NOD, NZB, NZM2328, NZW/LacJ and SJL.
    Tissue: Spleen.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Pancreas and Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiFAIM3_MOUSE
AccessioniPrimary (citable) accession number: A1KXC4
Secondary accession number(s): A1KXC6
, A1KXC8, A1KXC9, Q148B9, Q9D8T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: June 8, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.