A1KWH2 (MQO_NEIMF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase
EC=1.1.5.4

Alternative name(s):
MQO
Malate dehydrogenase [quinone]

Gene names

Name:	mqo
Ordered Locus Names:	NMC2076

Organism

Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / FAM18) [Complete proteome] [HAMAP]

Taxonomic identifier

272831 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Probable malate:quinone oxidoreductase HAMAP MF_00212		PRO_1000023811

Sequences

	Sequence		Length	Mass (Da)
	A1KWH2 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 1CF273AE12D36590	FASTA	488	53,897
	10 20 30 40 50 60 MAEATDVVLV GGGIMSATLG VLLKELEPSW EITLIERLED VALESSNAWN NAGTGHSALC 70 80 90 100 110 120 ELNYAPLGAN GIIDPARALN IAEQFHVSRQ FWATLVAEGK LEDNSFINAV PHMSLVMNED 130 140 150 160 170 180 HCSYLQKRYD AFKTQKLFEN MEFSTDRNKI SDWAPLMMRG RDENQPVAAN YSAEGTDVDF 190 200 210 220 230 240 GRLTRQMVKY LQGKGVKTEF NRHVEDIKRE SDGAWVLKTA DTRNPDGQLT LRTRFLFLGA 250 260 270 280 290 300 GGGALTLLQK SGIPEGKGYG GFPVSGLFFR NSTPETAEQH NAKVYGQASV GAPPMSVPHL 310 320 330 340 350 360 DTRNVDGKRH LMFGPYAGFR SNFLKQGSLM DLPLSIHMDN LYPMLCAGWA NMPLTKYLLG 370 380 390 400 410 420 ELRKTKEERF ASLLEYYPEA NPDDWELITA GQRVQIIKKD SEKGGVLQFG TEIVAHADGS 430 440 450 460 470 480 LAALLGASPG ASTAVPLMIR LMHQCFPERA PSWEGRLKEL VPGYGIKLNE NPERADEIIA YTAKVLDI

References

[1]

"Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18." Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C., Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K., Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S., Quail M.A., Achtman M. , Barrell B.G., Saunders N.J., Parkhill J. PLoS Genet. 3:230-240(2007) [PubMed: 17305430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700532 / FAM18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM421808 Genomic DNA. Translation: CAM11229.1.
RefSeq	YP_975996.1. NC_008767.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1KWH2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000007505; EBNEIP00000007274; EBNEIG00000007505.
GeneID	4674863.
GenomeReviews	Gene locus NMC2076 in contig AM421808_GR.
KEGG	nmc:NMC2076.
NMPDR	fig|487.2.peg.1344.
PATRIC	20354746. VBINeiMen17609_2592.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0579.
GeneTree	EBGT00050000020544.
HOGENOM	HBG289663.
OMA	HSANMEL.
PhylomeDB	A1KWH2.
ProtClustDB	PRK05257.
Enzyme and pathway databases
BioCyc	NMEN272831:NMC2076-MONOMER.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO_NEIMF

Accession

Primary (citable) accession number: A1KWH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program