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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401UniRule annotation
Active sitei568 – 5681UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciNMEN272831:GJDX-1939-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:NMC2042
OrganismiNeisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Taxonomic identifieri272831 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000002286 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 900900Phosphoenolpyruvate carboxylasePRO_1000025568Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1KWE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLHILNNPK DAALAADAEF LKQSLFNLLH EEASPLVVET VKLLSTSDDS
60 70 80 90 100
AALIEKVLPQ LDEQQTHDLT LACGLFAQIL NIAEDVHHER RRQIHEEAGR
110 120 130 140 150
GGAEGSLTET VRRLKAGKAD GKSVQRQLDN TSVTAVLTAH PTEVQRQTVL
160 170 180 190 200
SFNRRIRALL PQRERCTNAD ALARLRREID TILLGLWQTS ETRRHKLSVN
210 220 230 240 250
DEINNGVSIF PMSFFEALPK LYRNMEHDFQ MVYPDVCVPN ILKIGGWIGG
260 270 280 290 300
DRDGNPFVSA ETLRFAFRRH ADAVFRFYRG ELDKLYRELP LSIRRVKVND
310 320 330 340 350
DVMALAALSP DEELARTEEP YRRAIAYIMA RAMGKARALG LGMGCKFGFL
360 370 380 390 400
EPYASAQEFL DDLKKLQRSL IDNGSRLLAE GRLADLIRSV SVFGFHMMPL
410 420 430 440 450
DLRQHAGKHA DVVAELFQHA GLEDYNSLNE EQKQAVLLRE LSHQRPLYSP
460 470 480 490 500
FITYSDHTRH ELAIFNEARK IKDEFGEDAV TQSIISNCEQ PSDLLALALL
510 520 530 540 550
LKESGLLAVE NGKPHSRINI VPLFETIEAL ENACPVMETM FRLDWYDALL
560 570 580 590 600
ESRGNIQEIM LGYSDSNKDG GYVTSSWCLY QAELGLVELF KKYDVRMRLF
610 620 630 640 650
HGRGGSVGRG GGPSYQAILA QPAGSVAGQI RITEQGEVIT AKYADPGNAQ
660 670 680 690 700
RNLETLVAAT LEASILPDKK DPDAKLMQAL SDVSFKYYRE LITHPDFIDY
710 720 730 740 750
FLQTSPIQEI ATLNLGSRPA SRKTLARIQD LRAIPWVFSW MQNRLMLPAW
760 770 780 790 800
YGFGSAVETL CEGNPDTLTA LREHAQSNPF FQAMLSNMEQ VMAKTDITLA
810 820 830 840 850
ENYAGLSESP DKAKIIFGMI KEEYRRSRKA LLDLLQTEEL LRDNRSLARS
860 870 880 890 900
LALRIPYLNA LNGLQVAMLK RLRKEPDNPH ALLMVHLTIN GVAQGLRNTG
Length:900
Mass (Da):101,160
Last modified:February 6, 2007 - v1
Checksum:i67602FA07423EF9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM421808 Genomic DNA. Translation: CAM11197.1.

Genome annotation databases

EnsemblBacteriaiCAM11197; CAM11197; NMC2042.
KEGGinmc:NMC2042.
PATRICi20354660. VBINeiMen17609_2552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM421808 Genomic DNA. Translation: CAM11197.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM11197; CAM11197; NMC2042.
KEGGinmc:NMC2042.
PATRICi20354660. VBINeiMen17609_2552.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciNMEN272831:GJDX-1939-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700532 / DSM 15464 / FAM18.

Entry informationi

Entry nameiCAPP_NEIMF
AccessioniPrimary (citable) accession number: A1KWE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: July 22, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.