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A1KW75

- A1KW75_NEIMF

UniProt

A1KW75 - A1KW75_NEIMF

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Protein
Phosphoribosylformylglycinamidine synthase
Gene
purL, NMC1972
Organism
Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate By similarity.UniRule annotation

Catalytic activityi

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei683 – 6831ATP; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi684 – 6841Magnesium By similarityUniRule annotation
Metal bindingi723 – 7231Magnesium By similarityUniRule annotation
Metal bindingi727 – 7271Magnesium By similarityUniRule annotation
Metal bindingi889 – 8891Magnesium By similarityUniRule annotation
Binding sitei891 – 8911ATP By similarityUniRule annotation
Active sitei1167 – 11671Nucleophile By similarityUniRule annotation
Active sitei1290 – 12901 By similarityUniRule annotation
Active sitei1292 – 12921 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi316 – 32712ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. phosphoribosylformylglycinamidine synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciNMEN272831:GJDX-1866-MONOMER.
UniPathwayiUPA00074; UER00128.

Protein family/group databases

MEROPSiC56.972.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine synthaseUniRule annotation (EC:6.3.5.3UniRule annotation)
Short name:
FGAM synthaseUniRule annotation
Short name:
FGAMSUniRule annotation
Alternative name(s):
Formylglycinamide ribonucleotide amidotransferase
Gene namesi
Name:purLUniRule annotationImported
Ordered Locus Names:NMC1972Imported
OrganismiNeisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)Imported
Taxonomic identifieri272831 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000002286: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi272831.NMC1972.

Structurei

3D structure databases

ProteinModelPortaliA1KW75.

Family & Domainsi

Sequence similaritiesi

Contains glutamine amidotransferase type-1 domain.SAAS annotations
Contains glutamine amidotransferase type-domain.SAAS annotations
In the N-terminal section; belongs to the FGAMS family.UniRule annotation

Keywords - Domaini

Glutamine amidotransferaseUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG0046.
HOGENOMiHOG000261359.
KOiK01952.
OMAiGEGHAEF.
OrthoDBiEOG6FNHHR.

Family and domain databases

Gene3Di3.30.1330.10. 2 hits.
3.40.50.880. 1 hit.
HAMAPiMF_00419. PurL_1.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010073. PRibForGlyAmidine_synth.
IPR022940. PRibForGlyAmidine_synth_bac.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 3 hits.
TIGRFAMsiTIGR01735. FGAM_synt. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1KW75-1 [UniParc]FASTAAdd to Basket

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MRAESMSVVL PLRGVTALSD FRVEKLLQKA AALGLPEVKL SSEFWYFAGS     50
EKALDAATVE KLQALLAAQS VEQTPKAREG LHLFLVTPRL GTISPWASKA 100
TNIAENCGLA GIERIERGMA VWLEGALTDE QKQQWAALLH DRMTESVLPD 150
FQTASKLFHH LESETFSTVD VLGGGKEALV KANTEMGLAL SADEIDYLVE 200
NYQALQRNPS DVELMMFAQA NSEHCRHKIF NADFILNGEK QPKSLFGMIR 250
DTHNAHPEGT VVAYKDNSSV IEGAKIERFY PNAAENQGYR FHEEDTHIIM 300
KVETHNHPTA IAPFAGAATG AGGEIRDEGA TGKGSRPKAG LTGFTVSNLN 350
IPGLKQPWEQ DYGKPEHISS PLDIMIEGPI GGAAFNNEFG RPNLLGYFRT 400
FEEKFDGQVR GYHKPIMIAG GLGSIQAQQT HKDEIPEGAL LIQLGGPGML 450
IGLGGGAASS MDTGTNDASL DFNSVQRGNP EIERRAQEVI DRCWQLGDKN 500
PIISIHDVGA GGLSNAFPEL VNDAGRGAVF ELREVPLEEH GLTPLQIWCN 550
ESQERYVLSI LEKDLDTFRA ICERERCPFA VVGTATDDGH LKVRDDLFAN 600
NPIDLPLNVL LGKPPKTTRT DKTVTPSKKP FHADDIDITE AAYRVLHLPA 650
VAAKNFLITI GDRSVGGMTH RDQMVGKYQT PVADCAVTMM GFNTYRGEAM 700
SMGEKPTVAL FDAPASGRMC VGEAITNIAA VNIGDIGNIK LSANWMAACG 750
NEGEDEKLYR TVEAVSKACQ ALDLSIPVGK DSLSMKTVWQ DGEEKKSVVS 800
PLSLIISAFA PVQDVRKTVT PELKNVEDSV LLFVDLGFGK ARMGGSAFGQ 850
VYNNMSGDAP DLDDTGRLKA FYNVIQQLVA EDKLLAYHDR SDGGLFAVLV 900
EMAFAGRCGL DIDLNLLLAQ TFITNHTALS QSLRTEEVKA LAEWQETIAR 950
TLFNEELGAV IQVRKQDVAD IINLFYQQQL HHNVFEIGTL TDENTLIIRD 1000
GQTHLISDNL IKLQQTWQET SHQIQRLRDN PACADSEFAL IGDNDRSALF 1050
ANLKFDVNED IAAPFINSGA KPKIAILREQ GVNGQIEMAA AFTRAGFDAY 1100
DVHMSDLMAG RFRLADFKML AACGGFSYGD VLGAGEGWAK SILFHPALRD 1150
QFAAFFADPD TLTLGVCNGC QMVSNLAEII PGAEAWPKFK RNLSEQFEAR 1200
LSMVHVPKSA SLILNEMQGS SLPVVVSHGE GRADFALHGG NISADLGIAL 1250
QYVDGQNQVT QTYPLNPNGS PQGIAGVTNA DGRVTIMMPH PERVYRAAQM 1300
SWKPEDWTEL SGWYRLFAGA RKALG 1325
Length:1,325
Mass (Da):144,502
Last modified:February 6, 2007 - v1
Checksum:iC2C446817EF39BDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM421808 Genomic DNA. Translation: CAM11131.1.
RefSeqiWP_011799023.1. NC_008767.1.
YP_975899.1. NC_008767.1.

Genome annotation databases

EnsemblBacteriaiCAM11131; CAM11131; NMC1972.
GeneIDi4676582.
KEGGinmc:NMC1972.
PATRICi20354458. VBINeiMen17609_2457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM421808 Genomic DNA. Translation: CAM11131.1 .
RefSeqi WP_011799023.1. NC_008767.1.
YP_975899.1. NC_008767.1.

3D structure databases

ProteinModelPortali A1KW75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272831.NMC1972.

Protein family/group databases

MEROPSi C56.972.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM11131 ; CAM11131 ; NMC1972 .
GeneIDi 4676582.
KEGGi nmc:NMC1972.
PATRICi 20354458. VBINeiMen17609_2457.

Phylogenomic databases

eggNOGi COG0046.
HOGENOMi HOG000261359.
KOi K01952.
OMAi GEGHAEF.
OrthoDBi EOG6FNHHR.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00128 .
BioCyci NMEN272831:GJDX-1866-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 2 hits.
3.40.50.880. 1 hit.
HAMAPi MF_00419. PurL_1.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010073. PRibForGlyAmidine_synth.
IPR022940. PRibForGlyAmidine_synth_bac.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
SSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 3 hits.
TIGRFAMsi TIGR01735. FGAM_synt. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700532 / DSM 15464 / FAM18.

Entry informationi

Entry nameiA1KW75_NEIMF
AccessioniPrimary (citable) accession number: A1KW75
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In Gram-negative bacteria and most eukaryotes, FGAM synthase is only formed by PurL, a single polypeptide of 140 kDa (large PurL). However in Gram-positive bacteria and archaebacteria, phosphoribosylformylglycinamidine synthase is composed of three separate proteins: PurL (small PurL), PurQ and PurS By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi