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A1KW75 (A1KW75_NEIMF) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase HAMAP-Rule MF_00419

Short name=FGAM synthase HAMAP-Rule MF_00419
Short name=FGAMS HAMAP-Rule MF_00419
EC=6.3.5.3 HAMAP-Rule MF_00419
Alternative name(s):
Formylglycinamide ribotide amidotransferase HAMAP-Rule MF_00419
Formylglycinamide ribotide synthetase HAMAP-Rule MF_00419
Gene names
Name:purL HAMAP-Rule MF_00419 EMBL CAM11131.1
Ordered Locus Names:NMC1972 EMBL CAM11131.1
OrganismNeisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18) [Complete proteome] [HAMAP] EMBL CAM11131.1
Taxonomic identifier272831 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length1325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00419 SAAS SAAS010073

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. SAAS SAAS010073 HAMAP-Rule MF_00419

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00419 SAAS SAAS010073

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00419 SAAS SAAS010073.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_00419

Contains glutamine amidotransferase type-1 domain. SAAS SAAS010073

Contains glutamine amidotransferase type-domain. SAAS SAAS010073

In the N-terminal section; belongs to the FGAMS family. HAMAP-Rule MF_00419

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding316 – 32712ATP By similarity HAMAP-Rule MF_00419

Sites

Active site11671Nucleophile By similarity HAMAP-Rule MF_00419
Active site12901 By similarity HAMAP-Rule MF_00419
Active site12921 By similarity HAMAP-Rule MF_00419

Sequences

Sequence LengthMass (Da)Tools
A1KW75 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: C2C446817EF39BDA

FASTA1,325144,502
        10         20         30         40         50         60 
MRAESMSVVL PLRGVTALSD FRVEKLLQKA AALGLPEVKL SSEFWYFAGS EKALDAATVE 

        70         80         90        100        110        120 
KLQALLAAQS VEQTPKAREG LHLFLVTPRL GTISPWASKA TNIAENCGLA GIERIERGMA 

       130        140        150        160        170        180 
VWLEGALTDE QKQQWAALLH DRMTESVLPD FQTASKLFHH LESETFSTVD VLGGGKEALV 

       190        200        210        220        230        240 
KANTEMGLAL SADEIDYLVE NYQALQRNPS DVELMMFAQA NSEHCRHKIF NADFILNGEK 

       250        260        270        280        290        300 
QPKSLFGMIR DTHNAHPEGT VVAYKDNSSV IEGAKIERFY PNAAENQGYR FHEEDTHIIM 

       310        320        330        340        350        360 
KVETHNHPTA IAPFAGAATG AGGEIRDEGA TGKGSRPKAG LTGFTVSNLN IPGLKQPWEQ 

       370        380        390        400        410        420 
DYGKPEHISS PLDIMIEGPI GGAAFNNEFG RPNLLGYFRT FEEKFDGQVR GYHKPIMIAG 

       430        440        450        460        470        480 
GLGSIQAQQT HKDEIPEGAL LIQLGGPGML IGLGGGAASS MDTGTNDASL DFNSVQRGNP 

       490        500        510        520        530        540 
EIERRAQEVI DRCWQLGDKN PIISIHDVGA GGLSNAFPEL VNDAGRGAVF ELREVPLEEH 

       550        560        570        580        590        600 
GLTPLQIWCN ESQERYVLSI LEKDLDTFRA ICERERCPFA VVGTATDDGH LKVRDDLFAN 

       610        620        630        640        650        660 
NPIDLPLNVL LGKPPKTTRT DKTVTPSKKP FHADDIDITE AAYRVLHLPA VAAKNFLITI 

       670        680        690        700        710        720 
GDRSVGGMTH RDQMVGKYQT PVADCAVTMM GFNTYRGEAM SMGEKPTVAL FDAPASGRMC 

       730        740        750        760        770        780 
VGEAITNIAA VNIGDIGNIK LSANWMAACG NEGEDEKLYR TVEAVSKACQ ALDLSIPVGK 

       790        800        810        820        830        840 
DSLSMKTVWQ DGEEKKSVVS PLSLIISAFA PVQDVRKTVT PELKNVEDSV LLFVDLGFGK 

       850        860        870        880        890        900 
ARMGGSAFGQ VYNNMSGDAP DLDDTGRLKA FYNVIQQLVA EDKLLAYHDR SDGGLFAVLV 

       910        920        930        940        950        960 
EMAFAGRCGL DIDLNLLLAQ TFITNHTALS QSLRTEEVKA LAEWQETIAR TLFNEELGAV 

       970        980        990       1000       1010       1020 
IQVRKQDVAD IINLFYQQQL HHNVFEIGTL TDENTLIIRD GQTHLISDNL IKLQQTWQET 

      1030       1040       1050       1060       1070       1080 
SHQIQRLRDN PACADSEFAL IGDNDRSALF ANLKFDVNED IAAPFINSGA KPKIAILREQ 

      1090       1100       1110       1120       1130       1140 
GVNGQIEMAA AFTRAGFDAY DVHMSDLMAG RFRLADFKML AACGGFSYGD VLGAGEGWAK 

      1150       1160       1170       1180       1190       1200 
SILFHPALRD QFAAFFADPD TLTLGVCNGC QMVSNLAEII PGAEAWPKFK RNLSEQFEAR 

      1210       1220       1230       1240       1250       1260 
LSMVHVPKSA SLILNEMQGS SLPVVVSHGE GRADFALHGG NISADLGIAL QYVDGQNQVT 

      1270       1280       1290       1300       1310       1320 
QTYPLNPNGS PQGIAGVTNA DGRVTIMMPH PERVYRAAQM SWKPEDWTEL SGWYRLFAGA 


RKALG 

« Hide

References

[1]"Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18."
Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C., Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K., Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S., Quail M.A., Achtman M. expand/collapse author list , Barrell B.G., Saunders N.J., Parkhill J.
PLoS Genet. 3:230-240(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700532 / DSM 15464 / FAM18.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM421808 Genomic DNA. Translation: CAM11131.1.
RefSeqYP_975899.1. NC_008767.1.

3D structure databases

ProteinModelPortalA1KW75.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272831.NMC1972.

Protein family/group databases

MEROPSC56.972.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM11131; CAM11131; NMC1972.
GeneID4676582.
KEGGnmc:NMC1972.
PATRIC20354458. VBINeiMen17609_2457.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0046.
HOGENOMHOG000261359.
KOK01952.
OMAGEGHAEF.
OrthoDBEOG6FNHHR.

Enzyme and pathway databases

BioCycNMEN272831:GJDX-1866-MONOMER.
UniPathwayUPA00074; UER00128.

Family and domain databases

Gene3D3.30.1330.10. 2 hits.
3.40.50.880. 1 hit.
HAMAPMF_00419. PurL_1.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010073. PRibForGlyAmidine_synth.
IPR022940. PRibForGlyAmidine_synth_bac.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF52317. SSF52317. 1 hit.
SSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 3 hits.
TIGRFAMsTIGR01735. FGAM_synt. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1KW75_NEIMF
AccessionPrimary (citable) accession number: A1KW75
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)