A1KVS6 (AROE_NEIMF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	NMC1810

Organism

Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / FAM18) [Complete proteome] [HAMAP]

Taxonomic identifier

272831 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021312
Regions
	Nucleotide binding	130 – 134	5	NADP By similarity
Sites
	Active site	68	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	A1KVS6 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 20D67C86C30DC78B	FASTA	269	28,599
	10 20 30 40 50 60 MTALPRYSVF GNPVAHSKSP QIHQQFALQE GVDIEYERIC ADIGGFAQAV STFFETGGCG 70 80 90 100 110 120 ANVTVPFKQE AFHLADEHSE RALAAGAVNT LIPLKNGKLR GDNTDGIGLT NDITQVKNIA 130 140 150 160 170 180 IEGKTILLLG AGGAVRGVIP VLKEHRPARI VIANRTRAKA EELAQLFGIE AVPMADVNGG 190 200 210 220 230 240 FDIIINGTSG GLNGQIPDIP PDIFQNCALA YDMVYGCAAK PFLDFARQSG AKKTADGLGM 250 260 LVGQAAASYA LWRGFTPDIR PVIEYMKAM

References

[1]

"Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18." Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C., Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K., Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S., Quail M.A., Achtman M. , Barrell B.G., Saunders N.J., Parkhill J. PLoS Genet. 3:230-240(2007) [PubMed: 17305430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700532 / FAM18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM421808 Genomic DNA. Translation: CAM10981.1.
RefSeq	YP_975751.1. NC_008767.1.
3D structure databases
ProteinModelPortal	A1KVS6.
ModBase	Search...
Protein-protein interaction databases
STRING	A1KVS6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000008055; EBNEIP00000007824; EBNEIG00000008055.
GeneID	4676581.
GenomeReviews	Gene locus NMC1810 in contig AM421808_GR.
KEGG	nmc:NMC1810.
NMPDR	fig|487.2.peg.41.
PATRIC	20354039. VBINeiMen17609_2254.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
GeneTree	EBGT00050000020137.
HOGENOM	HBG553408.
OMA	YERICAD.
PhylomeDB	A1KVS6.
ProtClustDB	CLSK877516.
Enzyme and pathway databases
BioCyc	NMEN272831:NMC1810-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_NEIMF

Accession

Primary (citable) accession number: A1KVS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program