A1KV07 (HIS7_NEIMF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Imidazoleglycerol-phosphate dehydratase
Short name=IGPD
EC=4.2.1.19

Gene names

Name:	hisB
Ordered Locus Names:	NMC1503

Organism

Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / FAM18) [Complete proteome] [HAMAP]

Taxonomic identifier

272831 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › Neisseria meningitidis › Neisseria meningitidis serogroup C

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP-Rule MF_00076
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP-Rule MF_00076
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00076.
Sequence similarities	Belongs to the imidazoleglycerol-phosphate dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	imidazoleglycerol-phosphate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Imidazoleglycerol-phosphate dehydratase HAMAP-Rule MF_00076		PRO_0000336327

Sequences

	Sequence		Length	Mass (Da)
	A1KV07 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 03C6BA9EB5DCE1A7	FASTA	305	33,739
	10 20 30 40 50 60 MNLTKTQRQL HNFLTLAQEA GSLSKLAKLC GYRTPVALYK LKQRLEKQAE DPDARGIRPS 70 80 90 100 110 120 LMAKLEKHTG KPKGWLDRKH RERTVPETAA ESTGTAETQI AETASAAGCR SVTVNRNTCE 130 140 150 160 170 180 TQITVSINLD GSGKSRLDTG VPFLEHMIDQ IARHGMIDID ISCKGDLHID DHHTAEDIGI 190 200 210 220 230 240 TLGQAIRQAL GDKKGIRRYG HSYVPLDEAL SRVVIDLSGR PGLVYNIEFT RALIGRFDVD 250 260 270 280 290 300 LFEEFFHGIV NHSMMTLHID NLSGKNAHHQ AETVFKAFGR ALRMAVEHDP RMAGQTPSTK GTLTA

References

[1]

"Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18." Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C., Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K., Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S., Quail M.A., Achtman M. , Barrell B.G., Saunders N.J., Parkhill J. PLoS Genet. 3:230-240(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700532 / FAM18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM421808 Genomic DNA. Translation: CAM10706.1.
RefSeq	YP_975485.2. NC_008767.1.
3D structure databases
ProteinModelPortal	A1KV07.
SMR	A1KV07. Positions 110-291.
ModBase	Search...
Protein-protein interaction databases
STRING	272831.NMC1503.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAM10706; CAM10706; NMC1503.
GeneID	4676431.
KEGG	nmc:NMC1503.
PATRIC	20353230. VBINeiMen17609_1864.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0131.
HOGENOM	HOG000228064.
KO	K01693.
OMA	HHIVEAC.
ProtClustDB	PRK00951.
Enzyme and pathway databases
BioCyc	NMEN272831:GJDX-1417-MONOMER.
UniPathway	UPA00031; UER00011.
Family and domain databases
HAMAP	MF_00076. HisB. Divergent sequence.
InterPro	IPR000807. ImidazoleglycerolP_deHydtase. IPR020565. ImidazoleglycerP_deHydtase_CS. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
PANTHER	PTHR23133:SF2. PTHR23133:SF2. 1 hit.
Pfam	PF00475. IGPD. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
PROSITE	PS00954. IGP_DEHYDRATASE_1. 1 hit. PS00955. IGP_DEHYDRATASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS7_NEIMF

Accession

Primary (citable) accession number: A1KV07

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 6, 2007
Last modified:	May 29, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program