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Protein

Aspartate ammonia-lyase

Gene

aspA

Organism
Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate = fumarate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

BioCyciNMEN272831:GJDX-1136-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate ammonia-lyaseUniRule annotation (EC:4.3.1.1UniRule annotation)
Short name:
AspartaseUniRule annotation
Gene namesi
Name:aspAImported
Ordered Locus Names:NMC1185Imported
OrganismiNeisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)Imported
Taxonomic identifieri272831 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000002286 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliA1KU87.
SMRiA1KU87. Positions 3-456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 343332Lyase_1InterPro annotationAdd
BLAST
Domaini409 – 46153FumaraseC_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000061737.
KOiK01744.
OMAiEICENYV.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1KU87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVRIEHDLL GDREIPAEVY WGIHTLRAIE NFKISTQKIS DVPQFVRSMV
60 70 80 90 100
MVKKATAQAN GELGAVKPEI AAAIEKACDE VLLNNRCLDQ FPSDVYQGGA
110 120 130 140 150
GTSVNMNTNE VIANLALEAL GYEKGRYDIV NPMDHVNASQ STNDAYPTGF
160 170 180 190 200
RLAVYYSIGE LLDKLTVLKN AFTAKAEEFK DVLKMGRTQL QDAVPMTAGQ
210 220 230 240 250
EFQSFQVLLE EEILNLDRTR QLLLEVNLGA TAIGTGVNTP KGYAELVVKK
260 270 280 290 300
LSEVSGLPCK LTENLIEATS DCGAYVMVHG ALKRTAVKLS KICNDLRLLS
310 320 330 340 350
SGPRAGLKEI NLPELQAGSS IMPAKVNPVI PEVVNQVCFK VIGNDTTITF
360 370 380 390 400
AAEAGQLQLN VMEPVIAQCM FETISLLGNA AVNLSDKCVK GITVNREICE
410 420 430 440 450
RYVFNSIGLV TYLNPYIGHH NGDLVGKICA QTGKGVREVV LERGLLSEEE
460
LNRILSPENL MNPHL
Length:465
Mass (Da):50,763
Last modified:February 6, 2007 - v1
Checksum:iFB60C928F42D6D6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM421808 Genomic DNA. Translation: CAM10429.1.
RefSeqiWP_002220925.1. NC_008767.1.

Genome annotation databases

EnsemblBacteriaiCAM10429; CAM10429; NMC1185.
KEGGinmc:NMC1185.
PATRICi20352371. VBINeiMen17609_1434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM421808 Genomic DNA. Translation: CAM10429.1.
RefSeqiWP_002220925.1. NC_008767.1.

3D structure databases

ProteinModelPortaliA1KU87.
SMRiA1KU87. Positions 3-456.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM10429; CAM10429; NMC1185.
KEGGinmc:NMC1185.
PATRICi20352371. VBINeiMen17609_1434.

Phylogenomic databases

HOGENOMiHOG000061737.
KOiK01744.
OMAiEICENYV.

Enzyme and pathway databases

BioCyciNMEN272831:GJDX-1136-MONOMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA1KU87_NEIMF
AccessioniPrimary (citable) accession number: A1KU87
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.