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A1KU62 (RIBA_NEIMF) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase-2
EC=3.5.4.25
Alternative name(s):
GTP cyclohydrolase II
Gene names
Name:ribA
Ordered Locus Names:NMC1155
OrganismNeisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / FAM18) [Complete proteome] [HAMAP]
Taxonomic identifier272831 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate By similarity. HAMAP MF_00179

Catalytic activity

GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate. HAMAP MF_00179

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00179

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4. HAMAP MF_00179

Sequence similarities

Belongs to the GTP cyclohydrolase II family.

Ontologies

Keywords
   Biological processRiboflavin biosynthesis
   LigandGTP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processriboflavin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTP cyclohydrolase II activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 197197GTP cyclohydrolase-2 HAMAP MF_00179
PRO_1000040571

Regions

Nucleotide binding50 – 545GTP By similarity
Nucleotide binding93 – 953GTP By similarity

Sites

Active site1271Proton acceptor Potential
Active site1291Nucleophile By similarity
Metal binding551Zinc; catalytic By similarity
Metal binding661Zinc; catalytic By similarity
Metal binding681Zinc; catalytic By similarity
Binding site711GTP By similarity
Binding site1151GTP By similarity
Binding site1501GTP By similarity
Binding site1551GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1KU62 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: FDC2DA4AF94C61EF

FASTA19721,930
        10         20         30         40         50         60 
MSEMLNHVAS CRLPTEWGVF TMHGFEEANG QEHVALTVGN FSDGNPVLTR IHSECLTGDA 

        70         80         90        100        110        120 
LFSRKCDCGP QLEAAMRAVQ TEGRGIIVYL RQEGRGIGLI NKIRAYHLQD QGMDTVEANL 

       130        140        150        160        170        180 
ALGLPVDARD FRLAQSIYEY LGIRSVKLLT NNPEKIQTLK DAGINVVERI PLHVGENLEN 

       190 
KRYLQTKADK LGHLMSE

« Hide

References

[1]"Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18."
Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C., Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K., Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S., Quail M.A., Achtman M. expand/collapse author list , Barrell B.G., Saunders N.J., Parkhill J.
PLoS Genet. 3:230-240(2007) [PubMed: 17305430] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700532 / FAM18.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM421808 Genomic DNA. Translation: CAM10403.1.
RefSeqYP_975191.1. NC_008767.1.

3D structure databases

ProteinModelPortalA1KU62.
SMRA1KU62. Positions 5-174.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1KU62.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000007055; EBNEIP00000006824; EBNEIG00000007055.
GeneID4676360.
GenomeReviewsGene locus NMC1155 in contig AM421808_GR.
KEGGnmc:NMC1155.
PATRIC20352297. VBINeiMen17609_1397.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0807.
GeneTreeEBGT00050000021611.
HOGENOMHBG735778.
OMAQGFILYL.
PhylomeDBA1KU62.
ProtClustDBPRK00393.

Enzyme and pathway databases

BioCycNMEN272831:NMC1155-MONOMER.

Family and domain databases

HAMAPMF_00179. RibA.
[Tree]
InterProIPR000926. GTP_CycHdrlaseII_RibA.
[Graphical view]
KOK01497.
PfamPF00925. GTP_cyclohydro2. 1 hit.
[Graphical view]
TIGRFAMsTIGR00505. RibA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRIBA_NEIMF
AccessionPrimary (citable) accession number: A1KU62
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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