Reviewed, UniProtKB/Swiss-Prot A1KU16 (GLND_NEIMF)

Names and origin

Protein names

Recommended name:
    [Protein-PII] uridylyltransferase
      Short name=PII uridylyl-transferase
    EC=2.7.7.59
Alternative name(s):
    Uridylyl-removing enzyme
    UTase

Gene names

Name:	glnD
Ordered Locus Names:	NMC1104

Organism

Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / FAM18) [Complete proteome] [HAMAP]

Taxonomic identifier

272831 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	852 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Modifies, by uridylylation or deuridylylation the PII (glnB) regulatory protein By similarity.
Catalytic activity	UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII]. HAMAP MF_00277
Sequence similarities	Belongs to the glnD family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	[protein-PII] uridylyltransferase activity Inferred from electronic annotation. Source: HAMAP amino acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 852	852	[Protein-PII] uridylyltransferase HAMAP MF_00277		PRO_1000022347

Sequences

	Sequence		Length	Mass (Da)
	A1KU16-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: D9A8CF7651CA2409	FASTA	852	96,831
	10 20 30 40 50 60 MPANLSSALE TFKQQRDAAE AHYLKTNRVS VFFREYTAAV ETLLAALWVE HFQNSALCLM 70 80 90 100 110 120 AVGGFGRGEL YPCSDVDLAV VSPAPLSDGI QEQIARFVQT LWDCKLMPSV KSGGIDELCE 130 140 150 160 170 180 SVRNDITGDT AFLEARFLFG NRQTADELAE KMNAQRNVAA FIEAKLVEME HRHAKSQGSG 190 200 210 220 230 240 AVLEPNIKSC PGGLRDIHTL LWIAKAQGLA TNLPALVKQG ILTRTEAGML SHGYRRLAHI 250 260 270 280 290 300 RIHLHLNAKR AEDRLLFDLQ PQVAESMGYQ GLNLRRQSEE LMRVFYRAIK TVKQLSGILT 310 320 330 340 350 360 PMLQSRVSST PLRVTLRIDD DYIQVNNQIA ARHTDIFFRR PEHIFKIVEI MQQRNDITAL 370 380 390 400 410 420 EPQTLRAWWG ATRKINRSFY QNSENRHRFA GFFRNGNGLT QTLRFLNLYG VLGRYLPAWE 430 440 450 460 470 480 KIVGLLQHDL FHIYPVDDHI LTVVRNVRRL ALDMHSHELP YASALMQSFE RQDILYLAAF 490 500 510 520 530 540 FHDIAKGRGG DHAIQGIADA RQFAADHFLT EEESDLLAWL VENHLLMSTV AQKEDIQDPS 550 560 570 580 590 600 VLDAFCKRVQ THERLSALYL LTISDIRGTN PKLWNAWRAS LLESLFHAAG RYLAGNGGNP 610 620 630 640 650 660 HALFGRRQQE AADLLTRAAV PEKQQKKLWN ALGSAYFARH QSREILWHAA NLVHDFETPI 670 680 690 700 710 720 VRSRILPQSD SFQVMVFMPN GPRLFARLCR IFSRHGFDIL AARAFITEHD YILDTFIVQI 730 740 750 760 770 780 PSQHAPEDYP DIQSALEAEL NSFIHGHTVA EISSHSRRIS RRSRYMPIAP SITITPEEDY 790 800 810 820 830 840 PDWYSVEITA VNRPFLLADM AEIFFAHNVS LRYAKISTLD ERAEDSFTVF SPDLKNPKIQ 850 SSLKQALLEQ LA

References

[1]

"Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18." Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C., Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K., Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S., Quail M.A., Achtman M. , Barrell B.G., Saunders N.J., Parkhill J. PLoS Genet. 3:230-240(2007) [PubMed: 17305430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM421808 Genomic DNA. Translation: CAM10357.1.
RefSeq	YP_975145.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1KU16.
Genome annotation databases
GeneID	4676490.
GenomeReviews	Gene locus NMC1104 in contig AM421808_GR.
KEGG	nmc:NMC1104.
NMPDR	fig|487.2.peg.2226.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MQHDLFH.
Family and domain databases
HAMAP	MF_00277. [Tree]
InterPro	IPR002912. ACT_bd. IPR005105. DUF294_Ntrans. IPR010043. GlnD_Uridyltrans. IPR003607. Met-dep_phosphohydro_HD. IPR006674. Met-dep_phosphohydro_HD_sub. IPR013546. PII_UdlTrfase/GS_AdlTrfase. [Graphical view]
PANTHER	PTHR13734:SF1. GlnD_Uridyltrans. 1 hit.
Pfam	PF01842. ACT. 2 hits. PF03445. DUF294. 1 hit. PF08335. GlnD_UR_UTase. 1 hit. PF01966. HD. 1 hit. [Graphical view]
PIRSF	PIRSF006288. PII_uridyltransf. 1 hit.
SMART	SM00471. HDc. 1 hit. [Graphical view]
TIGRFAMs	TIGR01693. UTase_glnD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLND_NEIMF

Accession

Primary (citable) accession number: A1KU16

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)