A1KTV4 (PROA_NEIMF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-glutamyl phosphate reductase
Short name=GPR
EC=1.2.1.41

Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name=GSA dehydrogenase

Gene names

Name:	proA
Ordered Locus Names:	NMC1032

Organism

Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / FAM18) [Complete proteome] [HAMAP]

Taxonomic identifier

272831 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412
Subcellular location	Cytoplasm By similarity HAMAP MF_00412.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	Gamma-glutamyl phosphate reductase HAMAP MF_00412		PRO_1000049970

Sequences

	Sequence		Length	Mass (Da)
	A1KTV4 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 0FE46B0DEA976FAA	FASTA	420	44,928
	10 20 30 40 50 60 MSNTQKQLAL AKAAKKSVNT ADTEEKNRAL LAMADSLEAA AADILAANRQ DLEAAAGKIP 70 80 90 100 110 120 ESMTDRLLLD GKRICAMADG IRAVAALPDP VGEILETSTL PNGLEIVKKR VAMGVIGIIY 130 140 150 160 170 180 ESRPNVTSDA AALALKSGSA VVLRSGKDAF QSARAIVAAL KTGLAQTRID PDALQLIEDT 190 200 210 220 230 240 GREGSYEMMR AKDYLDLLIP RGGAGLIRAV VENAVVPVIE TGTGIVHIYV DKDADLEKAI 250 260 270 280 290 300 RIVRNAKTSR PSVCNSMEVL LVHEDIAADF LPKLERLLVR DRIEAGLPPV RFRLDPQAAR 310 320 330 340 350 360 HIGGEAAGAD DFDTEFLDYI LAVKTVASVE EAVGHIEAHG THHSDGIVTE NRHAADYFTT 370 380 390 400 410 420 HIDSAAVYVN ASTRFTDGGE FGLGCEMGIS TQKLHARGPM GLKELTSYKY IVQGTGQVRE

References

[1]

"Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18." Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C., Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K., Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S., Quail M.A., Achtman M. , Barrell B.G., Saunders N.J., Parkhill J. PLoS Genet. 3:230-240(2007) [PubMed: 17305430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700532 / FAM18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM421808 Genomic DNA. Translation: CAM10294.1.
RefSeq	YP_975083.1. NC_008767.1.
3D structure databases
ProteinModelPortal	A1KTV4.
ModBase	Search...
Protein-protein interaction databases
STRING	A1KTV4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000008690; EBNEIP00000008459; EBNEIG00000008690.
GeneID	4675630.
GenomeReviews	Gene locus NMC1032 in contig AM421808_GR.
KEGG	nmc:NMC1032.
NMPDR	fig|487.2.peg.2023.
PATRIC	20352007. VBINeiMen17609_1256.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0014.
GeneTree	EBGT00050000020602.
HOGENOM	HBG318080.
OMA	QYPAACN.
PhylomeDB	A1KTV4.
ProtClustDB	PRK00197.
Enzyme and pathway databases
BioCyc	NMEN272831:NMC1032-MONOMER.
Family and domain databases
HAMAP	MF_00412. ProA. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR000965. G-glutamylP_reductase. IPR020593. G-glutamylP_reductase_CS. IPR012134. Glu-5-SA_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KO	K00147.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PIRSF	PIRSF000151. GPR. 1 hit.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR00407. ProA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROA_NEIMF

Accession

Primary (citable) accession number: A1KTV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program