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A1KSY2 (A1KSY2_NEIMF) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Threonine--tRNA ligase HAMAP MF_00184
EC=6.1.1.3 HAMAP MF_00184
Alternative name(s):
Threonyl-tRNA synthetase HAMAP MF_00184
Gene names
Name:thrS HAMAP MF_00184 EMBL CAM09963.1
Ordered Locus Names:NMC0672
OrganismNeisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / FAM18) [Complete proteome] [HAMAP]
Taxonomic identifier272831 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length648 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). HAMAP MF_00184

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00184

Subunit structure

Homodimer By similarity. HAMAP MF_00184

Subcellular location

Cytoplasm By similarity HAMAP MF_00184.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. HAMAP MF_00184 RuleBase RU003746

Sequences

Sequence LengthMass (Da)Tools
A1KSY2 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 03638CFB5FDE0466

FASTA64874,098
        10         20         30         40         50         60 
MPLFFNLSER LMLNITLPDG SVRQYESPVT VAQIAASIGV GLARAAVAGR VNGKLVDACD 

        70         80         90        100        110        120 
PIVENSAVQI ITPKDQEGIE IIRHSCAHLV GHAVKQLYPN AKMVIGPVIE EGFYYDIATE 

       130        140        150        160        170        180 
KPFTPEDVAA IEARMKELIA QDYDVVKIMT PRAEAIKIFQ ERGEEYKLRL IDDMPEVEAM 

       190        200        210        220        230        240 
GMYHHQEYVD MCRGPHVPNT RFLKNFKLTK LAGAYWRGDS NNEMLQRIYG TAWATKDELK 

       250        260        270        280        290        300 
AYIQRIEEAE KRDHRKLGKQ LDLFHLQDEA PGMVFWHPKG WALWQVIEQH MRKELNAAGY 

       310        320        330        340        350        360 
KEVKTPQIMD KTFWEKSGHW DNYKDNMFVT SSEKREYAVK PMNCPGHVQI FNNGLRSYRD 

       370        380        390        400        410        420 
LPMRLAEFGS CHRNEPSGAL HGLMRVRGFV QDDAHIFCTE DQIVSEARAF NELLVRIYKQ 

       430        440        450        460        470        480 
FGFHDVAVKL SLRPEQRAGS DEVWDKAEQG LRDALTACGV EWEELPGEGA FYGPKIEYHV 

       490        500        510        520        530        540 
KDALGRSWQC GTLQLDFVLP ERLDAEYVTE NNDRARPVML HRAILGSLER FIGILIENHA 

       550        560        570        580        590        600 
GSFPLWLAPV QMVIMNITEN QADYCREVAA KLQAAGFRAE LDLRNEKIGY KIRDNSQYRF 

       610        620        630        640 
PYQIVVGDKE KQENKVAVRR KAEDLGSLDL DDFIAQLQQE ITDALVNH

« Hide

References

[1]"Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18."
Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C., Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K., Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S., Quail M.A., Achtman M. expand/collapse author list , Barrell B.G., Saunders N.J., Parkhill J.
PLoS Genet. 3:230-240(2007) [PubMed: 17305430] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM421808 Genomic DNA. Translation: CAM09963.1.
RefSeqYP_974762.1. NC_008767.1.

3D structure databases

ProteinModelPortalA1KSY2.
SMRA1KSY2. Positions 15-641.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1KSY2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000007560; EBNEIP00000007329; EBNEIG00000007560.
GeneID4675203.
GenomeReviewsGene locus NMC0672 in contig AM421808_GR.
KEGGnmc:NMC0672.
NMPDRfig|487.2.peg.1795.
PATRIC20351131. VBINeiMen17609_0820.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0441.
GeneTreeEBGT00050000021120.
HOGENOMHBG352811.
OMAVGSDALW.
PhylomeDBA1KSY2.
ProtClustDBPRK00413.

Family and domain databases

HAMAPMF_00184. Thr_tRNA_synth.
[Tree]
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_ferredoxin-type.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-synth_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
Gene3DG3DSA:3.40.50.800. Anticodon_bd. 1 hit.
G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
KOK01868.
PfamPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSPR01047. TRNASYNTHTHR.
SMARTSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMSSF52954. Anticodon_bd. 1 hit.
SSF81271. TGS-like. 1 hit.
SSF55186. Thr/Ala-tRNA-synth_IIc_edit. 1 hit.
TIGRFAMsTIGR00418. ThrS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1KSY2_NEIMF
AccessionPrimary (citable) accession number: A1KSY2
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info