Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1KS07

- SYL_NEIMF

UniProt

A1KS07 - SYL_NEIMF

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei637 – 6371ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNMEN272831:GJDX-324-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:NMC0326
OrganismiNeisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Taxonomic identifieri272831 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000002286: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 876876Leucine--tRNA ligasePRO_1000009377Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272831.NMC0326.

Structurei

3D structure databases

ProteinModelPortaliA1KS07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi634 – 6385"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1KS07-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEHYQPAAI EPAAQKKWDD ARIFNVSEDA SKPKYYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VLSRFKLLNG FNVMQPMGWD AFGMPAENAA MKNNVAPAAW
110 120 130 140 150
TYDNIEYMKT QLKSLGFAID WARETATCKP EYYRWEQWLF TKLFEKGIVY
160 170 180 190 200
RKNGTVNWDP VDQTVLANEQ VIDGRGWRSG ALIEKREIPM YYFKITDYAE
210 220 230 240 250
ELLNDLDKLE HWPEQVKTMQ RNWIGKSRGM TVRFAVSDDS KQGLEGDYAK
260 270 280 290 300
LLQVYTTRPD TLMGATYVAV AAEHPLAAAA AADKPELQAF IAECKAGSVA
310 320 330 340 350
EADMATMEKK GVPTGRYVVN PLNGDKLEVW IANYVLWGYG DGAVMAVPAH
360 370 380 390 400
DERDFEFAAK YNLPKKQVIA VGDNAFDANR WQEWYADKEN GVLVNSGDLD
410 420 430 440 450
GLDFQTAFDA VAAKLQSQGA GEPKTQYRLR DWGISRQRYW GCPIPIVHCE
460 470 480 490 500
QCGDVPVPAD QLPVVLPENV VPDGMGSPLA KMPEFYETAC PCCGGAAKRE
510 520 530 540 550
TDTMDTFMES SWYFFRYMSP KFSDGMVDPA AAKYWGAVDQ YIGGIEHAIL
560 570 580 590 600
HLLYARFFTK LMRDEGLVNV DEPFERLLTQ GMVVCETYYR ENDKGGKDWI
610 620 630 640 650
NPADVELTFD DKGRPISAVL KADGLPVVIS GTEKMSKSKN NGVDPQELIN
660 670 680 690 700
AYGADTARLF MMFAAPPEQS LEWSDSGVEG AHRFLRRLWR TVYEYLKQGE
710 720 730 740 750
AVKAFAGSQD GLSKELKDLR HKLHATTAKV SDDYGRRQQF NTAIAAVMEL
760 770 780 790 800
LNQYDKTDTG GEQGRAVAQE VLETAVRLLW PIVPHICETL WSELNGAKLW
810 820 830 840 850
EAGWPTVDEA ALVKSEIEVM VQVNGKLRGK ITVAADASKA DLEAAALATE
860 870
GAVKFMEGKP AKKIIVVPGR LVNIVV
Length:876
Mass (Da):97,997
Last modified:February 6, 2007 - v1
Checksum:i9C7BF627B10C836C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM421808 Genomic DNA. Translation: CAM09636.1.
RefSeqiYP_974439.1. NC_008767.1.

Genome annotation databases

EnsemblBacteriaiCAM09636; CAM09636; NMC0326.
GeneIDi4676288.
KEGGinmc:NMC0326.
PATRICi20350241. VBINeiMen17609_0380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM421808 Genomic DNA. Translation: CAM09636.1 .
RefSeqi YP_974439.1. NC_008767.1.

3D structure databases

ProteinModelPortali A1KS07.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272831.NMC0326.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM09636 ; CAM09636 ; NMC0326 .
GeneIDi 4676288.
KEGGi nmc:NMC0326.
PATRICi 20350241. VBINeiMen17609_0380.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci NMEN272831:GJDX-324-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700532 / DSM 15464 / FAM18.

Entry informationi

Entry nameiSYL_NEIMF
AccessioniPrimary (citable) accession number: A1KS07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3