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A1KRN0

- LPXB_NEIMF

UniProt

A1KRN0 - LPXB_NEIMF

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciNMEN272831:GJDX-192-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:NMC0191
    OrganismiNeisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
    Taxonomic identifieri272831 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000002286: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Lipid-A-disaccharide synthasePRO_1000049405Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272831.NMC0191.

    Structurei

    3D structure databases

    ProteinModelPortaliA1KRN0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1KRN0-1 [UniParc]FASTAAdd to Basket

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    MVDKKSPLIA VSVGEASGDL LGAHLIRAIR KRCPQARFVG IGGELMKAEG    50
    FESLYDQERL AVRGFAEVVR RLPEILRIRR GLVRDLLSLK PDVFVGIDAP 100
    DFNLGVAERL KRSGIPTVHY VSPSVWAWRR ERVGKIVHQV NRVLCLFPME 150
    PQLYLDAGGR AEFVGHPMAQ LMPLEDDRET ARKTLGVDAG IPVFALLPGS 200
    RVSEIDYMAP VFFQTALLLL ERYPAARFLL PAATEATKRR LAEVLQRPEF 250
    AGLPLTVIDR QSETVCRAAD AVLVTSGTAT LEVALCKRPM VISYKISPLT 300
    YAYVKRKIKV PHVGLPNILL GKEAVPELLQ SEAKPEKLAA ALADWYEHPD 350
    KVAALQQDFR ALHLLLKKDT ADLAARAVLE EAGC 384
    Length:384
    Mass (Da):42,446
    Last modified:February 6, 2007 - v1
    Checksum:iFBF9DE7A2ABA7A5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM421808 Genomic DNA. Translation: CAM09508.1.
    RefSeqiYP_974318.1. NC_008767.1.

    Genome annotation databases

    EnsemblBacteriaiCAM09508; CAM09508; NMC0191.
    GeneIDi4675593.
    KEGGinmc:NMC0191.
    PATRICi20349903. VBINeiMen17609_0215.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM421808 Genomic DNA. Translation: CAM09508.1 .
    RefSeqi YP_974318.1. NC_008767.1.

    3D structure databases

    ProteinModelPortali A1KRN0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272831.NMC0191.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM09508 ; CAM09508 ; NMC0191 .
    GeneIDi 4675593.
    KEGGi nmc:NMC0191.
    PATRICi 20349903. VBINeiMen17609_0215.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci NMEN272831:GJDX-192-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700532 / DSM 15464 / FAM18.

    Entry informationi

    Entry nameiLPXB_NEIMF
    AccessioniPrimary (citable) accession number: A1KRN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3