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A1KRL1

- FABZ_NEIMF

UniProt

A1KRL1 - FABZ_NEIMF

Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotation

    Catalytic activityi

    A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei53 – 531UniRule annotation

    GO - Molecular functioni

    1. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
    2. lipid A biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciNMEN272831:GJDX-172-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
    Alternative name(s):
    (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
    Short name:
    (3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
    Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
    Gene namesi
    Name:fabZUniRule annotation
    Ordered Locus Names:NMC0170
    OrganismiNeisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
    Taxonomic identifieri272831 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000002286: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1491493-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZPRO_0000301905Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272831.NMC0170.

    Structurei

    Secondary structure

    1
    149
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 84
    Helixi9 – 157
    Beta strandi27 – 326
    Turni33 – 353
    Beta strandi36 – 427
    Beta strandi45 – 473
    Helixi48 – 514
    Helixi62 – 8019
    Turni85 – 873
    Beta strandi91 – 955
    Beta strandi97 – 1004
    Beta strandi109 – 12012
    Beta strandi123 – 13210
    Beta strandi135 – 14511

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4I83X-ray2.60A/B/C/D/E/F1-149[»]
    ProteinModelPortaliA1KRL1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0764.
    HOGENOMiHOG000277829.
    KOiK02372.
    OMAiTIEYHMR.
    OrthoDBiEOG6JTCGM.

    Family and domain databases

    Gene3Di3.10.129.10. 1 hit.
    HAMAPiMF_00406. FabZ.
    InterProiIPR013114. FabA_FabZ.
    IPR010084. FabZ.
    IPR029069. HotDog_dom.
    [Graphical view]
    PfamiPF07977. FabA. 1 hit.
    [Graphical view]
    SUPFAMiSSF54637. SSF54637. 1 hit.
    TIGRFAMsiTIGR01750. fabZ. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1KRL1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVQLPIEAK DIQKLIPHRY PFLQLDRITA FEPMKTLTAI KNVSINEPQF    50
    QGHFPDLPVM PGVLIIEAMA QACGTLAILS EGGRKENEFF FFAGIDEARF 100
    KRQVIPGDQL VFEVELLTSR RGIGKFNAVA KVDGQVAVEA IIMCAKRVV 149
    Length:149
    Mass (Da):16,613
    Last modified:February 6, 2007 - v1
    Checksum:iDE6BCB39FB8DACBE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM421808 Genomic DNA. Translation: CAM09489.1.
    RefSeqiYP_974299.1. NC_008767.1.

    Genome annotation databases

    EnsemblBacteriaiCAM09489; CAM09489; NMC0170.
    GeneIDi4675013.
    KEGGinmc:NMC0170.
    PATRICi20349847. VBINeiMen17609_0188.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM421808 Genomic DNA. Translation: CAM09489.1 .
    RefSeqi YP_974299.1. NC_008767.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4I83 X-ray 2.60 A/B/C/D/E/F 1-149 [» ]
    ProteinModelPortali A1KRL1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272831.NMC0170.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM09489 ; CAM09489 ; NMC0170 .
    GeneIDi 4675013.
    KEGGi nmc:NMC0170.
    PATRICi 20349847. VBINeiMen17609_0188.

    Phylogenomic databases

    eggNOGi COG0764.
    HOGENOMi HOG000277829.
    KOi K02372.
    OMAi TIEYHMR.
    OrthoDBi EOG6JTCGM.

    Enzyme and pathway databases

    BioCyci NMEN272831:GJDX-172-MONOMER.

    Family and domain databases

    Gene3Di 3.10.129.10. 1 hit.
    HAMAPi MF_00406. FabZ.
    InterProi IPR013114. FabA_FabZ.
    IPR010084. FabZ.
    IPR029069. HotDog_dom.
    [Graphical view ]
    Pfami PF07977. FabA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54637. SSF54637. 1 hit.
    TIGRFAMsi TIGR01750. fabZ. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700532 / DSM 15464 / FAM18.

    Entry informationi

    Entry nameiFABZ_NEIMF
    AccessioniPrimary (citable) accession number: A1KRL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3