Reviewed, UniProtKB/Swiss-Prot A1KRK7 (DADA_NEIMF)

Names and origin

Protein names

Recommended name:
    D-amino acid dehydrogenase small subunit
    EC=1.4.99.1

Gene names

Name:	dadA
Ordered Locus Names:	NMC0166

Organism

Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / FAM18) [Complete proteome] [HAMAP]

Taxonomic identifier

272831 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Oxidative deamination of D-amino acids By similarity.
Catalytic activity	A D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor. HAMAP MF_01202
Cofactor	FAD By similarity.
Pathway	Amino-acid degradation; D-alanine degradation; NH(3) and pyruvate from D-alanine: step 1/1. HAMAP MF_01202
Subunit structure	Heterodimer of a small and a large subunit By similarity.
Sequence similarities	Belongs to the dadA oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-amino-acid dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	D-amino acid dehydrogenase small subunit HAMAP MF_01202		PRO_1000066101
Regions
	Nucleotide binding	3 – 17	15	FAD Potential

Sequences

	Sequence		Length	Mass (Da)
	A1KRK7-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: BB979D6E2AD23F86	FASTA	418	46,586
	10 20 30 40 50 60 MKVLVLGAGV AGVSSAWYLA EAGHEVTVID RAKGVAMETS FANAGQLSYG YTTPWAAPGI 70 80 90 100 110 120 PTKALKWLFK SHPPLLFRPD GSLYQIEWLW RMLQNCTAAH YQTNKERMVR ISEYSREMFR 130 140 150 160 170 180 RFEAQTGMNF EERKKGTLQI FRQTKEVEAA EQDIAVLERY GVPYRRLKPE ECAEFEPALA 190 200 210 220 230 240 RVTAKIAGGL HLPADATGDC HLFTENLYKL CQEKGVQFHF NQTISRIDHN GLRIKAVETE 250 260 270 280 290 300 TGRFEADAVV CALGCFSRTV LAQLDLDLPI YPVKGYSLTL PVTNSDGAPV STVLDESYKV 310 320 330 340 350 360 AITRFDNRIR VGGMAELSGY EIKLPEKRRE TLALVVNDLF PEGGDLSQAL FWSGLRPMTP 370 380 390 400 410 DSTPLIGRTR FENLFLNTGH GTLGWTMSLG SAKLTADIVS GKDTEIRSDD LSLSRYQA

References

[1]

"Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18." Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C., Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K., Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S., Quail M.A., Achtman M. , Barrell B.G., Saunders N.J., Parkhill J. PLoS Genet. 3:230-240(2007) [PubMed: 17305430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM421808 Genomic DNA. Translation: CAM09485.1.
RefSeq	YP_974295.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1KRK7.
Genome annotation databases
GeneID	4675017.
GenomeReviews	Gene locus NMC0166 in contig AM421808_GR.
KEGG	nmc:NMC0166.
NMPDR	fig|487.2.peg.477.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MFQKHAP.
Family and domain databases
HAMAP	MF_01202. [Tree]
InterPro	IPR006076. FAD-dep_OxRdtase. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DADA_NEIMF

Accession

Primary (citable) accession number: A1KRK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)