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A1KRK7 (DADA_NEIMF) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-amino acid dehydrogenase small subunit
EC=1.4.99.1
Gene names
Name:dadA
Ordered Locus Names:NMC0166
OrganismNeisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / FAM18) [Complete proteome] [HAMAP]
Taxonomic identifier272831 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Oxidative deamination of D-amino acids By similarity. HAMAP MF_01202

Catalytic activity

A D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor. HAMAP MF_01202

Cofactor

FAD By similarity. HAMAP MF_01202

Pathway

Amino-acid degradation; D-alanine degradation; NH(3) and pyruvate from D-alanine: step 1/1. HAMAP MF_01202

Subunit structure

Heterodimer of a small and a large subunit By similarity.

Sequence similarities

Belongs to the DadA oxidoreductase family.

Ontologies

Keywords
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionD-amino-acid dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418D-amino acid dehydrogenase small subunit HAMAP MF_01202
PRO_1000066101

Regions

Nucleotide binding3 – 1715FAD Potential

Sequences

Sequence LengthMass (Da)Tools
A1KRK7 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: BB979D6E2AD23F86

FASTA41846,586
        10         20         30         40         50         60 
MKVLVLGAGV AGVSSAWYLA EAGHEVTVID RAKGVAMETS FANAGQLSYG YTTPWAAPGI 

        70         80         90        100        110        120 
PTKALKWLFK SHPPLLFRPD GSLYQIEWLW RMLQNCTAAH YQTNKERMVR ISEYSREMFR 

       130        140        150        160        170        180 
RFEAQTGMNF EERKKGTLQI FRQTKEVEAA EQDIAVLERY GVPYRRLKPE ECAEFEPALA 

       190        200        210        220        230        240 
RVTAKIAGGL HLPADATGDC HLFTENLYKL CQEKGVQFHF NQTISRIDHN GLRIKAVETE 

       250        260        270        280        290        300 
TGRFEADAVV CALGCFSRTV LAQLDLDLPI YPVKGYSLTL PVTNSDGAPV STVLDESYKV 

       310        320        330        340        350        360 
AITRFDNRIR VGGMAELSGY EIKLPEKRRE TLALVVNDLF PEGGDLSQAL FWSGLRPMTP 

       370        380        390        400        410 
DSTPLIGRTR FENLFLNTGH GTLGWTMSLG SAKLTADIVS GKDTEIRSDD LSLSRYQA

« Hide

References

[1]"Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18."
Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C., Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K., Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S., Quail M.A., Achtman M. expand/collapse author list , Barrell B.G., Saunders N.J., Parkhill J.
PLoS Genet. 3:230-240(2007) [PubMed: 17305430] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700532 / FAM18.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM421808 Genomic DNA. Translation: CAM09485.1.
RefSeqYP_974295.1. NC_008767.1.

3D structure databases

ProteinModelPortalA1KRK7.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1KRK7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBNEIT00000007698; EBNEIP00000007467; EBNEIG00000007698.
GeneID4675017.
GenomeReviewsGene locus NMC0166 in contig AM421808_GR.
KEGGnmc:NMC0166.
NMPDRfig|487.2.peg.477.
PATRIC20349839. VBINeiMen17609_0184.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0665.
GeneTreeEBGT00050000020907.
HOGENOMHBG729204.
OMANCTAAHY.
PhylomeDBA1KRK7.
ProtClustDBPRK00711.

Enzyme and pathway databases

BioCycNMEN272831:NMC0166-MONOMER.

Family and domain databases

HAMAPMF_01202. DadA.
[Tree]
InterProIPR023080. D-aa_DH_ssu_DadA.
IPR006076. FAD-dep_OxRdtase.
[Graphical view]
KOK00285.
PfamPF01266. DAO. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDADA_NEIMF
AccessionPrimary (citable) accession number: A1KRK7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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