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A1KQY6

- A1KQY6_RAT

UniProt

A1KQY6 - A1KQY6_RAT

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Protein
Submitted name:

Alpha 2,8-sialyltransferase ST8Sia IV

Gene

Siat 8D

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Source: Ensembl
  2. sialyltransferase activity Source: RGD

GO - Biological processi

  1. ganglioside biosynthetic process Source: Ensembl
  2. negative regulation of cell adhesion Source: RGD
  3. N-glycan processing Source: Ensembl
  4. sialylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseSAAS annotationImported, Transferase

Enzyme and pathway databases

ReactomeiREACT_213723. Sialic acid metabolism.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha 2,8-sialyltransferase ST8Sia IVImported
Submitted name:
Protein St8sia4Imported
Submitted name:
RCG55449Imported
Gene namesi
Name:Siat 8DImported
Synonyms:LOC501189Imported, St8sia4Imported
ORF Names:rCG_55449Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1590766. LOC501189.
621845. St8sia4.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatusSAAS annotation, Membrane

Expressioni

Gene expression databases

GenevestigatoriA1KQY6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026010.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiNOG324948.
GeneTreeiENSGT00550000074407.
HOVERGENiHBG056466.
KOiK06614.
OMAiSVRKRWT.
OrthoDBiEOG7VQJD1.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1KQY6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKVSHLKRN PSPREAAQSD PSPASANCAA GRWAALENRE SSTAERPSDL
60 70 80 90 100
ILGSRLHAPF ANFRFLPLDY FPKTEPLYQE KVPELGQPGL SRAPKMRSIR
110 120 130 140 150
KRWTICTISL LLIFYKTKEI ARTEEHQETQ LIGDGELCLS RSLVNNSDKI
160 170 180 190 200
TRKAGSTIFQ HSVQGWKINS SLVLEIRKNI LRFLDAERDV SVVKSSFKPG
210 220 230 240 250
DVIHYVLDRR RTLNISHDLH SLLPEVSPMK NRRFKTCAVV GNSGILLDSG
260 270 280 290 300
CGKEIDSHNF VIRCNLAPVV EFAADVGTKS DFITMNPSVV QRAFGGFRNE
310 320 330 340 350
SDREKFVHRL SMLNDSVLWI PAFMVKGGEK HVEWVNALIL KNKLKVRTAY
360 370 380 390 400
PSLRLIHAVR GYWLTNKVPI KRPSTGLLMY TLATRFCDEI HLYGFWPFPK
410 420 430 440 450
DLNGKAVKYH YYDDLKYRYF SNASPHRMPL EFKTLNVLHN RGALKLTTGK

CMKQ
Length:454
Mass (Da):51,762
Last modified:February 6, 2007 - v1
Checksum:i4644DA8D857E7D36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06061704 Genomic DNA. No translation available.
AABR06061705 Genomic DNA. No translation available.
AM419015 mRNA. Translation: CAL91579.1.
CH473997 Genomic DNA. Translation: EDL91890.1.
RefSeqiNP_446366.1. NM_053914.1.
UniGeneiRn.234502.

Genome annotation databases

EnsembliENSRNOT00000026010; ENSRNOP00000026010; ENSRNOG00000019128.
GeneIDi116696.
KEGGirno:116696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06061704 Genomic DNA. No translation available.
AABR06061705 Genomic DNA. No translation available.
AM419015 mRNA. Translation: CAL91579.1 .
CH473997 Genomic DNA. Translation: EDL91890.1 .
RefSeqi NP_446366.1. NM_053914.1.
UniGenei Rn.234502.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026010 ; ENSRNOP00000026010 ; ENSRNOG00000019128 .
GeneIDi 116696.
KEGGi rno:116696.

Organism-specific databases

CTDi 7903.
RGDi 1590766. LOC501189.
621845. St8sia4.

Phylogenomic databases

eggNOGi NOG324948.
GeneTreei ENSGT00550000074407.
HOVERGENi HBG056466.
KOi K06614.
OMAi SVRKRWT.
OrthoDBi EOG7VQJD1.

Enzyme and pathway databases

Reactomei REACT_213723. Sialic acid metabolism.

Miscellaneous databases

NextBioi 619584.
PROi A1KQY6.

Gene expression databases

Genevestigatori A1KQY6.

Family and domain databases

InterProi IPR001675. Glyco_trans_29.
[Graphical view ]
Pfami PF00777. Glyco_transf_29. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. "Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia) gene family: tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes."
    Harduin-Lepers A., Petit D., Mollicone R., Delannoy P., Petit J.M., Oriol R.
    BMC Evol. Biol. 8:258-258(2008)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
  5. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiA1KQY6_RAT
AccessioniPrimary (citable) accession number: A1KQY6
Secondary accession number(s): F1MA57
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3