Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1KQY6

- A1KQY6_RAT

UniProt

A1KQY6 - A1KQY6_RAT

Protein
Submitted name:

Alpha 2,8-sialyltransferase ST8Sia IV

Gene

Siat 8D

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Source: Ensembl
    2. sialyltransferase activity Source: RGD

    GO - Biological processi

    1. ganglioside biosynthetic process Source: Ensembl
    2. negative regulation of cell adhesion Source: RGD
    3. N-glycan processing Source: Ensembl
    4. sialylation Source: GOC

    Keywords - Molecular functioni

    GlycosyltransferaseSAAS annotationImported, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_213723. Sialic acid metabolism.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Alpha 2,8-sialyltransferase ST8Sia IVImported
    Submitted name:
    Protein St8sia4Imported
    Submitted name:
    RCG55449Imported
    Gene namesi
    Name:Siat 8DImported
    Synonyms:LOC501189Imported, St8sia4Imported
    ORF Names:rCG_55449Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi1590766. LOC501189.
    621845. St8sia4.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatusSAAS annotation, Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriA1KQY6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000026010.

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    eggNOGiNOG324948.
    GeneTreeiENSGT00550000074407.
    HOVERGENiHBG056466.
    KOiK06614.
    OMAiSVRKRWT.
    OrthoDBiEOG7VQJD1.

    Family and domain databases

    InterProiIPR001675. Glyco_trans_29.
    [Graphical view]
    PfamiPF00777. Glyco_transf_29. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1KQY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHKVSHLKRN PSPREAAQSD PSPASANCAA GRWAALENRE SSTAERPSDL    50
    ILGSRLHAPF ANFRFLPLDY FPKTEPLYQE KVPELGQPGL SRAPKMRSIR 100
    KRWTICTISL LLIFYKTKEI ARTEEHQETQ LIGDGELCLS RSLVNNSDKI 150
    TRKAGSTIFQ HSVQGWKINS SLVLEIRKNI LRFLDAERDV SVVKSSFKPG 200
    DVIHYVLDRR RTLNISHDLH SLLPEVSPMK NRRFKTCAVV GNSGILLDSG 250
    CGKEIDSHNF VIRCNLAPVV EFAADVGTKS DFITMNPSVV QRAFGGFRNE 300
    SDREKFVHRL SMLNDSVLWI PAFMVKGGEK HVEWVNALIL KNKLKVRTAY 350
    PSLRLIHAVR GYWLTNKVPI KRPSTGLLMY TLATRFCDEI HLYGFWPFPK 400
    DLNGKAVKYH YYDDLKYRYF SNASPHRMPL EFKTLNVLHN RGALKLTTGK 450
    CMKQ 454
    Length:454
    Mass (Da):51,762
    Last modified:February 6, 2007 - v1
    Checksum:i4644DA8D857E7D36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06061704 Genomic DNA. No translation available.
    AABR06061705 Genomic DNA. No translation available.
    AM419015 mRNA. Translation: CAL91579.1.
    CH473997 Genomic DNA. Translation: EDL91890.1.
    RefSeqiNP_446366.1. NM_053914.1.
    UniGeneiRn.234502.

    Genome annotation databases

    EnsembliENSRNOT00000026010; ENSRNOP00000026010; ENSRNOG00000019128.
    GeneIDi116696.
    KEGGirno:116696.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06061704 Genomic DNA. No translation available.
    AABR06061705 Genomic DNA. No translation available.
    AM419015 mRNA. Translation: CAL91579.1 .
    CH473997 Genomic DNA. Translation: EDL91890.1 .
    RefSeqi NP_446366.1. NM_053914.1.
    UniGenei Rn.234502.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000026010.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026010 ; ENSRNOP00000026010 ; ENSRNOG00000019128 .
    GeneIDi 116696.
    KEGGi rno:116696.

    Organism-specific databases

    CTDi 7903.
    RGDi 1590766. LOC501189.
    621845. St8sia4.

    Phylogenomic databases

    eggNOGi NOG324948.
    GeneTreei ENSGT00550000074407.
    HOVERGENi HBG056466.
    KOi K06614.
    OMAi SVRKRWT.
    OrthoDBi EOG7VQJD1.

    Enzyme and pathway databases

    Reactomei REACT_213723. Sialic acid metabolism.

    Miscellaneous databases

    NextBioi 619584.
    PROi A1KQY6.

    Gene expression databases

    Genevestigatori A1KQY6.

    Family and domain databases

    InterProi IPR001675. Glyco_trans_29.
    [Graphical view ]
    Pfami PF00777. Glyco_transf_29. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. "Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia) gene family: tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes."
      Harduin-Lepers A., Petit D., Mollicone R., Delannoy P., Petit J.M., Oriol R.
      BMC Evol. Biol. 8:258-258(2008)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WistarImported.
    5. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiA1KQY6_RAT
    AccessioniPrimary (citable) accession number: A1KQY6
    Secondary accession number(s): F1MA57
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3