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Protein
Submitted name:

Alpha 2,8-sialyltransferase ST8Sia IV

Gene

LOC501189

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Source: Ensembl
  2. sialyltransferase activity Source: RGD

GO - Biological processi

  1. ganglioside biosynthetic process Source: Ensembl
  2. negative regulation of cell adhesion Source: RGD
  3. N-glycan processing Source: Ensembl
  4. sialylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseSAAS annotationImported, Transferase

Enzyme and pathway databases

ReactomeiREACT_213723. Sialic acid metabolism.
REACT_231038. NCAM1 interactions.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha 2,8-sialyltransferase ST8Sia IVImported
Submitted name:
Protein St8sia4Imported
Submitted name:
RCG55449Imported
Gene namesi
Name:LOC501189Imported
Synonyms:Siat 8DImported, St8sia4Imported
ORF Names:rCG_55449Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1590766. LOC501189.
621845. St8sia4.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatusSAAS annotation, Membrane

Expressioni

Gene expression databases

GenevestigatoriA1KQY6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026010.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiNOG324948.
GeneTreeiENSGT00550000074407.
HOVERGENiHBG056466.
KOiK06614.
OMAiSVRKRWT.
OrthoDBiEOG7VQJD1.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1KQY6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKVSHLKRN PSPREAAQSD PSPASANCAA GRWAALENRE SSTAERPSDL
60 70 80 90 100
ILGSRLHAPF ANFRFLPLDY FPKTEPLYQE KVPELGQPGL SRAPKMRSIR
110 120 130 140 150
KRWTICTISL LLIFYKTKEI ARTEEHQETQ LIGDGELCLS RSLVNNSDKI
160 170 180 190 200
TRKAGSTIFQ HSVQGWKINS SLVLEIRKNI LRFLDAERDV SVVKSSFKPG
210 220 230 240 250
DVIHYVLDRR RTLNISHDLH SLLPEVSPMK NRRFKTCAVV GNSGILLDSG
260 270 280 290 300
CGKEIDSHNF VIRCNLAPVV EFAADVGTKS DFITMNPSVV QRAFGGFRNE
310 320 330 340 350
SDREKFVHRL SMLNDSVLWI PAFMVKGGEK HVEWVNALIL KNKLKVRTAY
360 370 380 390 400
PSLRLIHAVR GYWLTNKVPI KRPSTGLLMY TLATRFCDEI HLYGFWPFPK
410 420 430 440 450
DLNGKAVKYH YYDDLKYRYF SNASPHRMPL EFKTLNVLHN RGALKLTTGK

CMKQ
Length:454
Mass (Da):51,762
Last modified:February 6, 2007 - v1
Checksum:i4644DA8D857E7D36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06061704 Genomic DNA. No translation available.
AABR06061705 Genomic DNA. No translation available.
AM419015 mRNA. Translation: CAL91579.1.
CH473997 Genomic DNA. Translation: EDL91890.1.
RefSeqiNP_446366.1. NM_053914.1.
UniGeneiRn.234502.

Genome annotation databases

EnsembliENSRNOT00000026010; ENSRNOP00000026010; ENSRNOG00000019128.
GeneIDi116696.
KEGGirno:116696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06061704 Genomic DNA. No translation available.
AABR06061705 Genomic DNA. No translation available.
AM419015 mRNA. Translation: CAL91579.1.
CH473997 Genomic DNA. Translation: EDL91890.1.
RefSeqiNP_446366.1. NM_053914.1.
UniGeneiRn.234502.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026010; ENSRNOP00000026010; ENSRNOG00000019128.
GeneIDi116696.
KEGGirno:116696.

Organism-specific databases

CTDi7903.
RGDi1590766. LOC501189.
621845. St8sia4.

Phylogenomic databases

eggNOGiNOG324948.
GeneTreeiENSGT00550000074407.
HOVERGENiHBG056466.
KOiK06614.
OMAiSVRKRWT.
OrthoDBiEOG7VQJD1.

Enzyme and pathway databases

ReactomeiREACT_213723. Sialic acid metabolism.
REACT_231038. NCAM1 interactions.

Miscellaneous databases

NextBioi34016519.
PROiA1KQY6.

Gene expression databases

GenevestigatoriA1KQY6.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. "Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia) gene family: tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes."
    Harduin-Lepers A., Petit D., Mollicone R., Delannoy P., Petit J.M., Oriol R.
    BMC Evol. Biol. 8:258-258(2008)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
  5. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiA1KQY6_RAT
AccessioniPrimary (citable) accession number: A1KQY6
Secondary accession number(s): F1MA57
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: February 4, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.