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A1KP87

- GUAA_MYCBP

UniProt

A1KP87 - GUAA_MYCBP

Protein

GMP synthase [glutamine-hydrolyzing]

Gene

guaA

Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the synthesis of GMP from XMP.UniRule annotation

    Catalytic activityi

    ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei93 – 931NucleophileUniRule annotation
    Active sitei179 – 1791UniRule annotation
    Active sitei181 – 1811UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi233 – 2397ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. GMP synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP
    3. pyrophosphatase activity Source: InterPro

    GO - Biological processi

    1. glutamine metabolic process Source: UniProtKB-HAMAP
    2. GMP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    GMP biosynthesis, Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMBOV410289:GJW7-3509-MONOMER.
    UniPathwayiUPA00189; UER00296.

    Protein family/group databases

    MEROPSiC26.957.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GMP synthase [glutamine-hydrolyzing]UniRule annotation (EC:6.3.5.2UniRule annotation)
    Alternative name(s):
    GMP synthetaseUniRule annotation
    Glutamine amidotransferaseUniRule annotation
    Gene namesi
    Name:guaAUniRule annotation
    Ordered Locus Names:BCG_3466c
    OrganismiMycobacterium bovis (strain BCG / Pasteur 1173P2)
    Taxonomic identifieri410289 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001472: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525GMP synthase [glutamine-hydrolyzing]PRO_1000120337Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi410289.BCG_3466c.

    Structurei

    3D structure databases

    ProteinModelPortaliA1KP87.
    SMRiA1KP87. Positions 17-525.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 205190Glutamine amidotransferase type-1UniRule annotationAdd
    BLAST
    Domaini206 – 399194GMPS ATP-PPaseUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation
    Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG0519.
    HOGENOMiHOG000223964.
    KOiK01951.
    OMAiDAIVWRQ.
    OrthoDBiEOG6JHRJV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPiMF_00344. GMP_synthase.
    InterProiIPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR001674. GMP_synth_C.
    IPR004739. GMP_synth_N.
    IPR022955. GMP_synthase.
    IPR025777. GMPS_ATP_PPase_dom.
    IPR022310. NAD/GMP_synthase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00117. GATase. 1 hit.
    PF00958. GMP_synt_C. 1 hit.
    PF02540. NAD_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.
    TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
    TIGR00888. guaA_Nterm. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    PS51553. GMPS_ATP_PPASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1KP87-1 [UniParc]FASTAAdd to Basket

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    MVQPADIDVP ETPARPVLVV DFGAQYAQLI ARRVREARVF SEVIPHTASI    50
    EEIRARQPVA LVLSGGPASV YADGAPKLDP ALLDLGVPVL GICYGFQAMA 100
    QALGGIVAHT GTREYGRTEL KVLGGKLHSD LPEVQPVWMS HGDAVTAAPD 150
    GFDVVASSAG APVAAFEAFD RRLAGVQYHP EVMHTPHGQQ VLSRFLHDFA 200
    GLGAQWTPAN IANALIEQVR TQIGDGHAIC GLSGGVDSAV AAALVQRAIG 250
    DRLTCVFVDH GLLRAGERAQ VQRDFVAATG ANLVTVDAAE TFLEALSGVS 300
    APEGKRKIIG RQFIRAFEGA VRDVLDGKTA EFLVQGTLYP DVVESGGGSG 350
    TANIKSHHNV GGLPDDLKFT LVEPLRLLFK DEVRAVGREL GLPEEIVARQ 400
    PFPGPGLGIR IVGEVTAKRL DTLRHADSIV REELTAAGLD NQIWQCPVVL 450
    LADVRSVGVQ GDGRTYGHPI VLRPVSSEDA MTADWTRVPY EVLERISTRI 500
    TNEVAEVNRV VLDITSKPPA TIEWE 525
    Length:525
    Mass (Da):56,060
    Last modified:February 6, 2007 - v1
    Checksum:iDFBE06100BA16FAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM408590 Genomic DNA. Translation: CAL73455.1.
    RefSeqiYP_979545.1. NC_008769.1.

    Genome annotation databases

    EnsemblBacteriaiCAL73455; CAL73455; BCG_3466c.
    GeneIDi4698540.
    KEGGimbb:BCG_3466c.
    PATRICi18018068. VBIMycBov80988_3776.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM408590 Genomic DNA. Translation: CAL73455.1 .
    RefSeqi YP_979545.1. NC_008769.1.

    3D structure databases

    ProteinModelPortali A1KP87.
    SMRi A1KP87. Positions 17-525.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 410289.BCG_3466c.

    Protein family/group databases

    MEROPSi C26.957.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL73455 ; CAL73455 ; BCG_3466c .
    GeneIDi 4698540.
    KEGGi mbb:BCG_3466c.
    PATRICi 18018068. VBIMycBov80988_3776.

    Phylogenomic databases

    eggNOGi COG0519.
    HOGENOMi HOG000223964.
    KOi K01951.
    OMAi DAIVWRQ.
    OrthoDBi EOG6JHRJV.

    Enzyme and pathway databases

    UniPathwayi UPA00189 ; UER00296 .
    BioCyci MBOV410289:GJW7-3509-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPi MF_00344. GMP_synthase.
    InterProi IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR001674. GMP_synth_C.
    IPR004739. GMP_synth_N.
    IPR022955. GMP_synthase.
    IPR025777. GMPS_ATP_PPase_dom.
    IPR022310. NAD/GMP_synthase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00117. GATase. 1 hit.
    PF00958. GMP_synt_C. 1 hit.
    PF02540. NAD_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    TIGRFAMsi TIGR00884. guaA_Cterm. 1 hit.
    TIGR00888. guaA_Nterm. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    PS51553. GMPS_ATP_PPASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BCG / Pasteur 1173P2.

    Entry informationi

    Entry nameiGUAA_MYCBP
    AccessioniPrimary (citable) accession number: A1KP87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3