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A1KP87

- GUAA_MYCBP

UniProt

A1KP87 - GUAA_MYCBP

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Protein

GMP synthase [glutamine-hydrolyzing]

Gene
guaA, BCG_3466c
Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of GMP from XMP By similarity.UniRule annotation

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931Nucleophile By similarity
Active sitei179 – 1791 By similarity
Active sitei181 – 1811 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi233 – 2397ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. GMP synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP
  3. pyrophosphatase activity Source: InterPro

GO - Biological processi

  1. glutamine metabolic process Source: UniProtKB-HAMAP
  2. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOV410289:GJW7-3509-MONOMER.
UniPathwayiUPA00189; UER00296.

Protein family/group databases

MEROPSiC26.957.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing] (EC:6.3.5.2)
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
Gene namesi
Name:guaA
Ordered Locus Names:BCG_3466c
OrganismiMycobacterium bovis (strain BCG / Pasteur 1173P2)
Taxonomic identifieri410289 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001472: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525GMP synthase [glutamine-hydrolyzing]UniRule annotationPRO_1000120337Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi410289.BCG_3466c.

Structurei

3D structure databases

ProteinModelPortaliA1KP87.
SMRiA1KP87. Positions 17-525.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 205190Glutamine amidotransferase type-1Add
BLAST
Domaini206 – 399194GMPS ATP-PPaseAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0519.
HOGENOMiHOG000223964.
KOiK01951.
OMAiDAIVWRQ.
OrthoDBiEOG6JHRJV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00344. GMP_synthase.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1KP87-1 [UniParc]FASTAAdd to Basket

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MVQPADIDVP ETPARPVLVV DFGAQYAQLI ARRVREARVF SEVIPHTASI    50
EEIRARQPVA LVLSGGPASV YADGAPKLDP ALLDLGVPVL GICYGFQAMA 100
QALGGIVAHT GTREYGRTEL KVLGGKLHSD LPEVQPVWMS HGDAVTAAPD 150
GFDVVASSAG APVAAFEAFD RRLAGVQYHP EVMHTPHGQQ VLSRFLHDFA 200
GLGAQWTPAN IANALIEQVR TQIGDGHAIC GLSGGVDSAV AAALVQRAIG 250
DRLTCVFVDH GLLRAGERAQ VQRDFVAATG ANLVTVDAAE TFLEALSGVS 300
APEGKRKIIG RQFIRAFEGA VRDVLDGKTA EFLVQGTLYP DVVESGGGSG 350
TANIKSHHNV GGLPDDLKFT LVEPLRLLFK DEVRAVGREL GLPEEIVARQ 400
PFPGPGLGIR IVGEVTAKRL DTLRHADSIV REELTAAGLD NQIWQCPVVL 450
LADVRSVGVQ GDGRTYGHPI VLRPVSSEDA MTADWTRVPY EVLERISTRI 500
TNEVAEVNRV VLDITSKPPA TIEWE 525
Length:525
Mass (Da):56,060
Last modified:February 6, 2007 - v1
Checksum:iDFBE06100BA16FAF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM408590 Genomic DNA. Translation: CAL73455.1.
RefSeqiYP_979545.1. NC_008769.1.

Genome annotation databases

EnsemblBacteriaiCAL73455; CAL73455; BCG_3466c.
GeneIDi4698540.
KEGGimbb:BCG_3466c.
PATRICi18018068. VBIMycBov80988_3776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM408590 Genomic DNA. Translation: CAL73455.1 .
RefSeqi YP_979545.1. NC_008769.1.

3D structure databases

ProteinModelPortali A1KP87.
SMRi A1KP87. Positions 17-525.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 410289.BCG_3466c.

Protein family/group databases

MEROPSi C26.957.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL73455 ; CAL73455 ; BCG_3466c .
GeneIDi 4698540.
KEGGi mbb:BCG_3466c.
PATRICi 18018068. VBIMycBov80988_3776.

Phylogenomic databases

eggNOGi COG0519.
HOGENOMi HOG000223964.
KOi K01951.
OMAi DAIVWRQ.
OrthoDBi EOG6JHRJV.

Enzyme and pathway databases

UniPathwayi UPA00189 ; UER00296 .
BioCyci MBOV410289:GJW7-3509-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPi MF_00344. GMP_synthase.
InterProi IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
TIGRFAMsi TIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BCG / Pasteur 1173P2.

Entry informationi

Entry nameiGUAA_MYCBP
AccessioniPrimary (citable) accession number: A1KP87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 6, 2007
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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