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A1KP87 (GUAA_MYCBP) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing]

EC=6.3.5.2
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
Gene names
Name:guaA
Ordered Locus Names:BCG_3466c
OrganismMycobacterium bovis (strain BCG / Pasteur 1173P2) [Complete proteome] [HAMAP]
Taxonomic identifier410289 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length525 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP-Rule MF_00344

Catalytic activity

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP-Rule MF_00344

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP-Rule MF_00344

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00344

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 525525GMP synthase [glutamine-hydrolyzing] HAMAP-Rule MF_00344
PRO_1000120337

Regions

Domain16 – 205190Glutamine amidotransferase type-1
Domain206 – 399194GMPS ATP-PPase
Nucleotide binding233 – 2397ATP By similarity

Sites

Active site931Nucleophile By similarity
Active site1791 By similarity
Active site1811 By similarity

Sequences

Sequence LengthMass (Da)Tools
A1KP87 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: DFBE06100BA16FAF

FASTA52556,060
        10         20         30         40         50         60 
MVQPADIDVP ETPARPVLVV DFGAQYAQLI ARRVREARVF SEVIPHTASI EEIRARQPVA 

        70         80         90        100        110        120 
LVLSGGPASV YADGAPKLDP ALLDLGVPVL GICYGFQAMA QALGGIVAHT GTREYGRTEL 

       130        140        150        160        170        180 
KVLGGKLHSD LPEVQPVWMS HGDAVTAAPD GFDVVASSAG APVAAFEAFD RRLAGVQYHP 

       190        200        210        220        230        240 
EVMHTPHGQQ VLSRFLHDFA GLGAQWTPAN IANALIEQVR TQIGDGHAIC GLSGGVDSAV 

       250        260        270        280        290        300 
AAALVQRAIG DRLTCVFVDH GLLRAGERAQ VQRDFVAATG ANLVTVDAAE TFLEALSGVS 

       310        320        330        340        350        360 
APEGKRKIIG RQFIRAFEGA VRDVLDGKTA EFLVQGTLYP DVVESGGGSG TANIKSHHNV 

       370        380        390        400        410        420 
GGLPDDLKFT LVEPLRLLFK DEVRAVGREL GLPEEIVARQ PFPGPGLGIR IVGEVTAKRL 

       430        440        450        460        470        480 
DTLRHADSIV REELTAAGLD NQIWQCPVVL LADVRSVGVQ GDGRTYGHPI VLRPVSSEDA 

       490        500        510        520 
MTADWTRVPY EVLERISTRI TNEVAEVNRV VLDITSKPPA TIEWE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM408590 Genomic DNA. Translation: CAL73455.1.
RefSeqYP_979545.1. NC_008769.1.

3D structure databases

ProteinModelPortalA1KP87.
SMRA1KP87. Positions 17-525.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING410289.BCG_3466c.

Protein family/group databases

MEROPSC26.957.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL73455; CAL73455; BCG_3466c.
GeneID4698540.
KEGGmbb:BCG_3466c.
PATRIC18018068. VBIMycBov80988_3776.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0519.
HOGENOMHOG000223964.
KOK01951.
OMADAIVWRQ.
OrthoDBEOG6JHRJV.

Enzyme and pathway databases

BioCycMBOV410289:GJW7-3509-MONOMER.
UniPathwayUPA00189; UER00296.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPMF_00344. GMP_synthase.
InterProIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
SUPFAMSSF52317. SSF52317. 1 hit.
TIGRFAMsTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAA_MYCBP
AccessionPrimary (citable) accession number: A1KP87
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 6, 2007
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways