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A1KP30 (A1KP30_MYCBP) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding78 – 803NADP By similarity
Nucleotide binding313 – 3186NADP By similarity
Region97 – 1037Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2551Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2781Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site801Substrate By similarity PIRSR PIRSR000108-2
Binding site851NADP By similarity
Binding site1121Substrate By similarity PIRSR PIRSR000108-2
Binding site1351Substrate By similarity PIRSR PIRSR000108-2
Binding site2631NADP By similarity
Binding site3311NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1421Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2151Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
A1KP30 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 045478F666CCB872

FASTA40945,542
        10         20         30         40         50         60 
MSNAPKIKVS GPVVELDGDE MTRVIWKLIK DMLILPYLDI RLDYYDLGIE HRDATDDQVT 

        70         80         90        100        110        120 
IDAAYAIKKH GVGVKCATIT PDEARVEEFN LKKMWLSPNG TIRNILGGTI FREPIVISNV 

       130        140        150        160        170        180 
PRLVPGWTKP IVIGRHAFGD QYRATNFKVD QPGTVTLTFT PADGSAPIVH EMVSIPEDGG 

       190        200        210        220        230        240 
VVLGMYNFKE SIRDFARVSF SYGLNAKWPV YLSTKNTILK AYDGMFKDEF ERVYEEEFKA 

       250        260        270        280        290        300 
QFEAAGLTYE HRLIDDMVAA CLKWEGGYVW ACKNYDGDVQ SDTVAQGYGS LGLMTSVLMT 

       310        320        330        340        350        360 
ADGKTVEAEA AHGTVTRHYR QYQAGKPTST NPIASIFAWT RGLQHRGKLD GTPEVIDFAH 

       370        380        390        400 
KLESVVIATV ESGKMTKDLA ILIGPEQDWL NSEEFLDAIA DNLEKELAN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM408590 Genomic DNA. Translation: CAL73398.1.
RefSeqYP_979491.1. NC_008769.1.

3D structure databases

ProteinModelPortalA1KP30.
SMRA1KP30. Positions 6-408.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING410289.BCG_3409c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL73398; CAL73398; BCG_3409c.
GeneID4699019.
KEGGmbb:BCG_3409c.
PATRIC18017946. VBIMycBov80988_3715.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAKNTIMKV.
OrthoDBEOG628F3X.

Enzyme and pathway databases

BioCycMBOV410289:GJW7-3452-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1KP30_MYCBP
AccessionPrimary (citable) accession number: A1KP30
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)